WO2001012597A3 - Procede de preparation de quinoleine-5,8-diones - Google Patents

Procede de preparation de quinoleine-5,8-diones Download PDF

Info

Publication number
WO2001012597A3
WO2001012597A3 PCT/FR2000/002295 FR0002295W WO0112597A3 WO 2001012597 A3 WO2001012597 A3 WO 2001012597A3 FR 0002295 W FR0002295 W FR 0002295W WO 0112597 A3 WO0112597 A3 WO 0112597A3
Authority
WO
WIPO (PCT)
Prior art keywords
diones
preparing quinoline
quinoline
preparing
hydroxyquinoline
Prior art date
Application number
PCT/FR2000/002295
Other languages
English (en)
Other versions
WO2001012597A2 (fr
Inventor
Janine Cossy
Damien Belotti
Original Assignee
Lafon Labor
Janine Cossy
Damien Belotti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to PL353457A priority Critical patent/PL203362B1/pl
Priority to EP00958663A priority patent/EP1202972A2/fr
Application filed by Lafon Labor, Janine Cossy, Damien Belotti filed Critical Lafon Labor
Priority to CA2393951A priority patent/CA2393951C/fr
Priority to MXPA02001494A priority patent/MXPA02001494A/es
Priority to BR0013547-0A priority patent/BR0013547A/pt
Priority to HU0202890A priority patent/HUP0202890A3/hu
Priority to NZ517041A priority patent/NZ517041A/en
Priority to AU70112/00A priority patent/AU779500B2/en
Priority to JP2001516898A priority patent/JP2003507363A/ja
Priority to US10/049,375 priority patent/US6515127B1/en
Priority to SK205-2002A priority patent/SK287416B6/sk
Priority to IL14804200A priority patent/IL148042A0/xx
Publication of WO2001012597A2 publication Critical patent/WO2001012597A2/fr
Publication of WO2001012597A3 publication Critical patent/WO2001012597A3/fr
Priority to IL148042A priority patent/IL148042A/en
Priority to NO20020670A priority patent/NO322649B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne un procédé de préparation de quinoléine-5,8-diones de formule (I) dans laquelle: R1, R2 et R3 sont tels que définis à la revendication 1, par photo-oxygénation d'une 8-hydroxyquinoléine.
PCT/FR2000/002295 1999-08-13 2000-08-10 Procede de preparation de quinoleine-5,8-diones WO2001012597A2 (fr)

Priority Applications (14)

Application Number Priority Date Filing Date Title
JP2001516898A JP2003507363A (ja) 1999-08-13 2000-08-10 キノリン−５，８−ジオンの製造方法
AU70112/00A AU779500B2 (en) 1999-08-13 2000-08-10 Method for preparing quinoline-5,8-diones
CA2393951A CA2393951C (fr) 1999-08-13 2000-08-10 Procede de preparation de quinoleine-5,8-diones
EP00958663A EP1202972A2 (fr) 1999-08-13 2000-08-10 Procede de preparation de quinoleine-5,8-diones
BR0013547-0A BR0013547A (pt) 1999-08-13 2000-08-10 Processo de preparação de quinoleìna-5,8-dionas
HU0202890A HUP0202890A3 (en) 1999-08-13 2000-08-10 Method for preparing quinoline-5,8-diones
US10/049,375 US6515127B1 (en) 1999-08-13 2000-08-10 Method for preparing quinoline-5,8-diones
PL353457A PL203362B1 (pl) 1999-08-13 2000-08-10 Sposób otrzymywania chinolino-5,8-dionów oraz chinolino-5,8-diony
MXPA02001494A MXPA02001494A (es) 1999-08-13 2000-08-10 Procedimiento de preparacion de quinolein-5, 8-dionas.
NZ517041A NZ517041A (en) 1999-08-13 2000-08-10 Method for preparing quinoline-5,8-diones
SK205-2002A SK287416B6 (sk) 1999-08-13 2000-08-10 Spôsob prípravy chinoleín-5,8-diónov
IL14804200A IL148042A0 (en) 1999-08-13 2000-08-10 Method for preparing quinoline-5,8-diones
IL148042A IL148042A (en) 1999-08-13 2002-02-06 Method for making quinoline – 5,8 – deion
NO20020670A NO322649B1 (no) 1999-08-13 2002-02-11 Kinolin-5,8-dioner, og fremgangsmate for fremstilling av kinolin-5,8-dioner

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9910491A FR2797443B1 (fr) 1999-08-13 1999-08-13 Procede de prepartion de quinoleine-5,8-diones
FR99/10491 1999-08-13

Publications (2)

Publication Number Publication Date
WO2001012597A2 WO2001012597A2 (fr) 2001-02-22
WO2001012597A3 true WO2001012597A3 (fr) 2001-07-19

Family

ID=9549144

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2000/002295 WO2001012597A2 (fr) 1999-08-13 2000-08-10 Procede de preparation de quinoleine-5,8-diones

Country Status (19)

Country Link
US (1) US6515127B1 (fr)
EP (1) EP1202972A2 (fr)
JP (1) JP2003507363A (fr)
KR (1) KR100719398B1 (fr)
CN (1) CN1139575C (fr)
AU (1) AU779500B2 (fr)
BR (1) BR0013547A (fr)
CA (1) CA2393951C (fr)
CZ (1) CZ2002530A3 (fr)
FR (1) FR2797443B1 (fr)
HU (1) HUP0202890A3 (fr)
IL (2) IL148042A0 (fr)
MX (1) MXPA02001494A (fr)
NO (1) NO322649B1 (fr)
NZ (1) NZ517041A (fr)
PL (1) PL203362B1 (fr)
SK (1) SK287416B6 (fr)
WO (1) WO2001012597A2 (fr)
ZA (1) ZA200200970B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100519533C (zh) * 2006-12-01 2009-07-29 广东工业大学 5-芳胺喹啉-7,8-二酮类衍生物及其在制备抗菌药物中的应用
WO2010127208A1 (fr) * 2009-04-30 2010-11-04 Forest Laboratories Holdings Limited Inhibiteurs de l'acétyl-coa carboxylase

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0433679A2 (fr) * 1989-11-20 1991-06-26 Senju Pharmaceutical Co., Ltd. Compositions pharmaceutiques pour l'inhibition de la réaction de maillard

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4742059A (en) * 1986-06-20 1988-05-03 American Cyanamide Company Substituted quinoxalinediones and their methods of use
US4692449A (en) * 1986-06-20 1987-09-08 American Cyanamid Company Substituted quinolinediones
JPH04336792A (ja) * 1991-05-13 1992-11-24 Nippon Musen Denki Saabisushiya:Kk グラフィック表示処理装置
FR2790954B1 (fr) * 1999-03-18 2003-08-08 Lafon Labor Composition pharmaceutique a base de composes polyaromatiques

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0433679A2 (fr) * 1989-11-20 1991-06-26 Senju Pharmaceutical Co., Ltd. Compositions pharmaceutiques pour l'inhibition de la réaction de maillard

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
C. AVENDAÑO ET AL.: "A comparative study of synthetic approaches ...", SYNTHESIS., - 1991, GEORG THIEME VERLAG. STUTTGART., DE, pages 727 - 730, XP002139239, ISSN: 0039-7881 *
CARROLL TEMPLE, JR. ET AL.: "Synthesis of potential antimalarial agents. Preparation of ...", JOURNAL OF MEDICINAL CHEMISTRY., vol. 17, no. 6, - 1974, AMERICAN CHEMICAL SOCIETY. WASHINGTON., US, pages 615 - 619, XP002139242, ISSN: 0022-2623 *
CHEMICAL ABSTRACTS, vol. 69, no. 3, 15 July 1968, Columbus, Ohio, US; abstract no. 10339f, BABU, B. HARINATH ET AL.: "Synthesis of 5:6- and 5:8-quinolinequinones" XP002139244 *
DATABASE CHEMICAL ABSTRACTS XP002139245 *
GOH MATSUO ET AL.: "Two-step synthesis of C-glycosyl juglones from unprotected sugars: a novel approach to angucycline antibiotics", CHEMICAL COMMUNICATIONS., - 1996, ROYAL SOCIETY OF CHEMISTRY., GB, pages 2173 - 2174, XP002139243, ISSN: 1359-7345 *
KEVIN T. POTTS ET AL.: "Cycloaddition routes to azaanthraquinone deriatives. Use of azadienophiles", JOURNAL OF ORGANIC CHEMISTRY., vol. 51, no. 11, - 1986, AMERICAN CHEMICAL SOCIETY. EASTON., US, pages 2011 - 2021, XP002139241, ISSN: 0022-3263 *
MARTINE CROISY-DELCEY ET AL.: "Synthesis of 4-amino-substituted-6-hydroxy and 11-hydroxy-naphtho(2,3-g)quinoline-5,12-diones ...", JOURNAL OF HETEROCYCLIC CHEMISTRY., vol. 30, no. 1, - 1993, HETEROCORPORATION. PROVO., US, pages 55 - 60, XP002139238, ISSN: 0022-152X *
PETER WITHOPF ET AL.: "Synthese von 8-Azajuglon( 4-hydroxy-5,8-chinolinchinon)", TETRAHEDRON., vol. 43, no. 20, - 1987, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM., NL, pages 4549 - 4554, XP002139240, ISSN: 0040-4020 *
SOMMATH GHOSH ET AL.: "(4+2)-Cycloaddition reactions employing 2-fluoro-2-alkenal N, N-dimethylhydrazones: synthsis of 3-fluoropyridines and dihydro or tetrahydro derivatives thereof", JOURNAL OF FLUORINE CHEMISTRY., vol. 67, no. 1, - 1994, ELSEVIER SEQUOIA. LAUSANNE., CH, pages 53 - 56, XP002139237, ISSN: 0022-1139 *
SYMP. SYN. HETEROCYCL. COMPOUNDS PHYSIOL. INTEREST, HYDERABAD, INDIA 1964, - 1966, pages 114 - 118 *

Also Published As

Publication number Publication date
PL353457A1 (en) 2003-11-17
NO20020670D0 (no) 2002-02-11
US6515127B1 (en) 2003-02-04
FR2797443A1 (fr) 2001-02-16
CN1139575C (zh) 2004-02-25
CN1370149A (zh) 2002-09-18
CZ2002530A3 (cs) 2002-05-15
CA2393951C (fr) 2010-05-25
AU779500B2 (en) 2005-01-27
NZ517041A (en) 2003-09-26
CA2393951A1 (fr) 2001-02-22
HUP0202890A2 (hu) 2003-01-28
IL148042A0 (en) 2002-09-12
NO322649B1 (no) 2006-11-13
KR100719398B1 (ko) 2007-05-17
PL203362B1 (pl) 2009-09-30
SK2052002A3 (en) 2002-09-10
SK287416B6 (sk) 2010-09-07
MXPA02001494A (es) 2002-07-02
JP2003507363A (ja) 2003-02-25
EP1202972A2 (fr) 2002-05-08
KR20020023418A (ko) 2002-03-28
IL148042A (en) 2007-06-03
WO2001012597A2 (fr) 2001-02-22
NO20020670L (no) 2002-04-15
FR2797443B1 (fr) 2003-10-31
HUP0202890A3 (en) 2003-04-28
AU7011200A (en) 2001-03-13
ZA200200970B (en) 2003-04-30
BR0013547A (pt) 2002-04-09

Similar Documents

Publication Publication Date Title
IL165502A0 (en) Method for preparing 3-halo-4,5-dihydro-1h-pyrazoles
ZA200203252B (en) Process for preparing 4"-substituted-9-deoxo-9A-AZA-9A-homoerythromycina derivatives.
WO2001047928A3 (fr) Nouveaux imidazo[1,3,5]triazinones et leur utilisation
WO2000023407A3 (fr) Composes chimiques
EP1380564A4 (fr) Derive de binaphtol et son procede de production
BG103310A (en) Benzonaphthyridins as bronchial therapeutical means
WO2002092602A3 (fr) Procedes de synthese de derives de 2,3-dihydro-1,4-dioxino-[2,3-f] quinoline
WO2000046210A3 (fr) Nouveau procede de preparation d'intermediaires pesticides
WO2001009122A3 (fr) Benzofuranes serotoninergiques
CA2275253A1 (fr) Procede pour la preparation de 3-hydroxypyrazols n-substitues
AU2909400A (en) 1-aryl-1,3,5-triazine-4-thione-2,6-diones, production thereof and use thereof as herbicides
AU8631698A (en) A process for the preparation of tetraazamacrocycles
BG106002A (en) Process for preparing pesticidal intermediates
WO2001010861A3 (fr) Heterocyclyl-2h-chromenes substitues
WO2001012597A3 (fr) Procede de preparation de quinoleine-5,8-diones
WO1999048851A3 (fr) Procedes de preparation d'intermediaires
WO2002046152A3 (fr) Coniosetine et ses derives, leur procede de production et leur utilisation
MY130656A (en) Benzo [g] quinoline derivatives for treating glaucoma and myopia
AU7773700A (en) Method for the production or preparation of 2,6-dichlorotoluol
AU6870500A (en) Process for the preparation of 2,3-dihydroazepine derivatives
AU6870600A (en) Process for the preparation of 2,3-dihydroazepine compounds
CA2276310A1 (fr) Procede de production de tetrazolylbenzopyrannes
CA2257646A1 (fr) Derives de benzo[g]quinoline
CA2366600A1 (fr) Procede de preparation de 1,4,7,10-tetraazacyclododecane
WO2001010849A3 (fr) Arylalkylamino-1,3,5-triazines substituees

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 2000958663

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2002/00970

Country of ref document: ZA

Ref document number: 200200970

Country of ref document: ZA

Ref document number: 70112/00

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 517041

Country of ref document: NZ

WWE Wipo information: entry into national phase

Ref document number: 148042

Country of ref document: IL

WWE Wipo information: entry into national phase

Ref document number: 2052002

Country of ref document: SK

Ref document number: 2393951

Country of ref document: CA

Ref document number: 1020027001774

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: 008116423

Country of ref document: CN

WWE Wipo information: entry into national phase

Ref document number: PA/a/2002/001494

Country of ref document: MX

Ref document number: PV2002-530

Country of ref document: CZ

Ref document number: 10049375

Country of ref document: US

WWP Wipo information: published in national office

Ref document number: 1020027001774

Country of ref document: KR

WWP Wipo information: published in national office

Ref document number: 2000958663

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: PV2002-530

Country of ref document: CZ

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: 517041

Country of ref document: NZ

WWG Wipo information: grant in national office

Ref document number: 517041

Country of ref document: NZ

WWG Wipo information: grant in national office

Ref document number: 70112/00

Country of ref document: AU