IL155089A0 - Aza and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors - Google Patents

Aza and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors

Info

Publication number
IL155089A0
IL155089A0 IL15508901A IL15508901A IL155089A0 IL 155089 A0 IL155089 A0 IL 155089A0 IL 15508901 A IL15508901 A IL 15508901A IL 15508901 A IL15508901 A IL 15508901A IL 155089 A0 IL155089 A0 IL 155089A0
Authority
IL
Israel
Prior art keywords
polyaza
aza
hiv integrase
integrase inhibitors
carboxamides useful
Prior art date
Application number
IL15508901A
Other languages
English (en)
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of IL155089A0 publication Critical patent/IL155089A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL15508901A 2000-10-12 2001-10-09 Aza and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors IL155089A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23970700P 2000-10-12 2000-10-12
US28165601P 2001-04-05 2001-04-05
PCT/US2001/042564 WO2002030931A2 (en) 2000-10-12 2001-10-09 Aza- and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors

Publications (1)

Publication Number Publication Date
IL155089A0 true IL155089A0 (en) 2003-10-31

Family

ID=26932782

Family Applications (1)

Application Number Title Priority Date Filing Date
IL15508901A IL155089A0 (en) 2000-10-12 2001-10-09 Aza and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors

Country Status (26)

Country Link
US (2) US6921759B2 (cs)
EP (1) EP1326865B1 (cs)
JP (1) JP4252797B2 (cs)
KR (1) KR20030036922A (cs)
CN (1) CN1469878A (cs)
AR (1) AR033845A1 (cs)
AT (1) ATE430745T1 (cs)
AU (3) AU2002211874A1 (cs)
BG (1) BG107677A (cs)
BR (1) BR0114610A (cs)
CA (1) CA2425440C (cs)
CZ (1) CZ20031028A3 (cs)
DE (1) DE60138635D1 (cs)
EA (1) EA200300449A1 (cs)
EE (1) EE200300145A (cs)
HU (1) HUP0302367A2 (cs)
IL (1) IL155089A0 (cs)
IS (1) IS6760A (cs)
MX (1) MXPA03003263A (cs)
NO (1) NO20031672L (cs)
NZ (1) NZ525088A (cs)
PE (1) PE20020509A1 (cs)
PL (1) PL360944A1 (cs)
SK (1) SK4322003A3 (cs)
WO (2) WO2002030930A2 (cs)
YU (1) YU27903A (cs)

Families Citing this family (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60138635D1 (de) * 2000-10-12 2009-06-18 Merck & Co Inc Aza- und polyaza naphthalenyl karboxamide als inhibitoren der hiv-integrase
TWI243164B (en) 2001-02-13 2005-11-11 Aventis Pharma Gmbh Acylated indanyl amines and their use as pharmaceuticals
EP2033952B1 (en) 2001-03-01 2012-08-29 Shionogi&Co., Ltd. Nitrogen-containing Heteroaryl compounds having HIV Integrase Inhibitory Activity
CA2452769C (en) 2001-08-10 2012-08-21 Shionogi & Co., Ltd. Antiviral agent
AR036256A1 (es) * 2001-08-17 2004-08-25 Merck & Co Inc Sal sodica de un inhibidor de integrasa del vih, procesos para su preparacion, composiciones farmaceuticas que lo contienen y su uso para la manufactura de un medicamento
WO2003016294A1 (en) * 2001-08-17 2003-02-27 Merck & Co., Inc. Process for preparing sultams
JP2005504770A (ja) * 2001-08-17 2005-02-17 メルク　エンド　カムパニー　インコーポレーテッド ５−スルホンアミド−８−ヒドロキシ−１，６−ナフチリジン−７−カルボキサミドの製造方法
US7232819B2 (en) * 2001-10-26 2007-06-19 Istituto Di Ricerche Di Biologia P. Angeletti S.P.A. Dihydroxypyrimidine carboxamide inhibitors of HIV integrase
PT1441735E (pt) * 2001-10-26 2006-06-30 Istituto Di Ricerche Di B Mo P Inibidores de integrase do hiv a base de hidroxipirimidinona carboxamida n-substituida
DE10155075A1 (de) 2001-11-09 2003-05-22 Merck Patent Gmbh Cyclische Sulfonamide
DE60315796T2 (de) 2002-01-17 2008-06-05 Merck & Co., Inc. Hydroxynaphthyridinoncarbonsäureamide, die sich als inhibitoren der hiv-integrase eignen
AU2003220170B2 (en) * 2002-03-15 2008-12-11 Merck Sharp & Dohme Corp. N-(Substituted benzyl)-8-hydroxy-1,6-naphthyridine-7- carboxamides useful as HIV integrase inhibitors
US20050165000A1 (en) * 2002-04-10 2005-07-28 Robertson Sandra K. Pharmaceutical compositions containing an hiv integrase inhibitor and a nonionic surfactant
US7109233B2 (en) * 2002-05-22 2006-09-19 Smithkline Beecham Corporation Protease inhibitors
EP1388535A1 (en) * 2002-08-07 2004-02-11 Aventis Pharma Deutschland GmbH Acylated arylcycloalkylamines and their use as pharmaceuticals
WO2004024693A1 (ja) * 2002-08-13 2004-03-25 Shionogi & Co., Ltd. Ｈｉｖインテグラーゼ阻害活性を有するヘテロ環化合物
US7517532B2 (en) 2002-09-11 2009-04-14 Merck & Co., Inc. Dihydroxypyridopyrazine-1,6-dione compounds useful as HIV integrase inhibitors
EP1539714B1 (en) 2002-09-11 2008-08-13 Merck & Co., Inc. 8-hydroxy-1-oxo-tetrahydropyrrolopyrazine compounds useful as hiv integrase inhibitors
KR101122782B1 (ko) 2002-10-04 2012-04-12 프라나 바이오테크놀로지 리미티드 신경 활성 화합물
AU2003284001A1 (en) 2002-10-07 2004-05-04 Bristol-Myers Squibb Company Triazolone and triazolethione derivatives
WO2004035577A2 (en) 2002-10-16 2004-04-29 Gilead Sciences, Inc. Pre-organized tricyclic integrase inhibitor compounds
JP4733986B2 (ja) 2002-12-27 2011-07-27 イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー ＨＩＶインテグラーゼ阻害薬として有用なテトラヒドロ−４Ｈ−ピリド［１，２−ａ］ピリミジン類および関連する化合物
US20040220273A1 (en) * 2003-03-12 2004-11-04 Jaemoon Lee Preparation of 2-aminomethyl-5-fluorobenzamides
WO2004080402A2 (en) * 2003-03-12 2004-09-23 Merck & Co. Inc. Potassium salt of an hiv integrase inhibitor
WO2004101512A2 (en) 2003-05-13 2004-11-25 Smithkline Beecham Corporation Naphthyridine integrase inhibitors
CN100418948C (zh) * 2003-07-15 2008-09-17 麦克公司 羟基吡啶cgrp受体抗拮抗剂
TW200510425A (en) 2003-08-13 2005-03-16 Japan Tobacco Inc Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
US7462721B2 (en) 2003-09-19 2008-12-09 Gilead Sciences, Inc. Aza-quinolinol phosphonate integrase inhibitor compounds
CN1870896A (zh) 2003-10-20 2006-11-29 默克公司 用作hiv整合酶抑制剂的羟基吡啶并吡咯并吡嗪二酮化合物
TW200533357A (en) 2004-01-08 2005-10-16 Millennium Pharm Inc 2-(amino-substituted)-4-aryl pyrimidines and related compounds useful for treating inflammatory diseases
CA2554120A1 (en) * 2004-01-30 2005-08-18 Merck & Co., Inc. N-benzyl-3,4-dihydroxypyridine-2-carboxamide and n-benzyl-2,3-dihydroxypyridine-4-carboxamide compounds useful as hiv integras inhibitors
US7919623B2 (en) 2004-02-04 2011-04-05 Shionogi & Co., Ltd. Naphthyridine derivatives having inhibitory activity against HIV integrase
AU2005211733A1 (en) 2004-02-11 2005-08-25 Shionogi & Co., Ltd HIV integrase inhibitors
JP2007528396A (ja) * 2004-03-09 2007-10-11 メルク　エンド　カムパニー　インコーポレーテッド Ｈｉｖインテグラーゼ阻害薬
CN1929737A (zh) * 2004-03-09 2007-03-14 默克公司 Hiv整合酶抑制剂
WO2005087766A1 (en) * 2004-03-09 2005-09-22 Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa Hiv integrase inhibitors
WO2005087768A1 (en) * 2004-03-09 2005-09-22 Merck & Co., Inc. Hiv integrase inhibitors
WO2005110414A2 (en) 2004-05-07 2005-11-24 Merck & Co., Inc. Hiv integrase inhibitors
AU2005251820A1 (en) * 2004-06-09 2005-12-22 Merck & Co., Inc. HIV integrase inhibitors
UA87884C2 (uk) 2004-12-03 2009-08-25 Мерк Энд Ко., Инк. Безводна кристалічна калієва сіль інгібітора віл-інтегрази
RU2403066C2 (ru) * 2004-12-03 2010-11-10 Мерк Шарп Энд Домэ Корп Применение атазанавира для улучшения фармакокинетики лекарственных средств, метаболизируемых ugt1a1
WO2006088173A1 (ja) * 2005-02-21 2006-08-24 Shionogi & Co., Ltd. Ｈｉｖインテグラーゼ阻害活性を有する２環性カルバモイルピリドン誘導体
EP1866313A1 (en) * 2005-03-31 2007-12-19 Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. Hiv integrase inhibitors
EP1881825B1 (en) * 2005-05-10 2013-07-24 Merck Sharp & Dohme Corp. Hiv integrase inhibitors
US20070072831A1 (en) * 2005-05-16 2007-03-29 Gilead Sciences, Inc. Integrase inhibitor compounds
EP1909578A4 (en) * 2005-08-04 2010-07-14 Glaxosmithkline Llc INHIBITORS OF HIV INTEGRASE
JP2009503083A (ja) * 2005-08-04 2009-01-29 スミスクライン ビーチャム コーポレーション Ｈｉｖインテグラーゼ阻害薬
EP1910363A4 (en) * 2005-08-04 2010-05-26 Glaxosmithkline Llc INHIBITORS OF HIV INTEGRASE
EP1910355A4 (en) * 2005-08-04 2010-11-24 Glaxosmithkline Llc HIV integrase
AU2006299042B8 (en) * 2005-10-04 2011-09-15 Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa HIV integrase inhibitors
EP1942736A2 (en) * 2005-10-27 2008-07-16 Merck & Co., Inc. Hiv integrase inhibitors
EP1950212B1 (en) * 2005-10-27 2016-02-24 Shionogi Co., Ltd. Polycyclic carbamoylpyridone derivative having inhibitory activity on hiv integrase
ATE475660T1 (de) * 2005-12-21 2010-08-15 Abbott Lab Antivirale verbindungen
US8008287B2 (en) 2006-05-16 2011-08-30 Gilead Sciences, Inc. Integrase inhibitors
AU2007275816A1 (en) * 2006-07-17 2008-01-24 Merck Sharp & Dohme Corp. 1-hydroxy naphthyridine compounds as anti-HIV agents
WO2008014602A1 (en) * 2006-07-25 2008-02-07 Envivo Pharmaceuticals, Inc. Quinoline derivatives
JP2010502730A (ja) * 2006-09-05 2010-01-28 バイパー サイエンシズ，インコーポレイティド 癌の治療法
JP2010504978A (ja) 2006-09-29 2010-02-18 アイデニクス ファーマシューティカルズ，インコーポレーテッド Ｈｉｖ阻害剤としての鏡像異性的に純粋なホスホインドール
US20100216834A1 (en) * 2006-10-18 2010-08-26 Isaacs Richard C A Hiv integrase inhibitors
US20090291921A1 (en) * 2007-11-20 2009-11-26 Gilead Sciences, Inc. Integrase inhibitors
CN105055432A (zh) 2008-01-25 2015-11-18 奇默里克斯公司 治疗病毒感染的方法
EP2318406B1 (en) 2008-07-17 2016-01-27 Critical Outcome Technologies, Inc. Thiosemicarbazone inhibitor compounds and cancer treatment methods
JP2012513464A (ja) 2008-12-23 2012-06-14 ザ トラスティーズ オブ コロンビア ユニヴァーシティ イン ザ シティ オブ ニューヨーク ホスホジエステラーゼ阻害剤及びその使用
US8497383B2 (en) 2009-05-27 2013-07-30 Merck Sharp & Dohme Corp. HIV protease inhibitors
EP2488521B1 (en) * 2009-10-13 2013-12-18 Elanco Animal Health Ireland Limited Macrocyclic integrase inhibitors
RS62600B1 (sr) 2009-10-26 2021-12-31 Merck Sharp & Dohme Čvrste farmaceutske kompozicije koje sadrže inhibitor integraze
EP2345641A1 (en) 2009-12-29 2011-07-20 Polichem S.A. New secondary 8-hydroxyquinoline-7-carboxamide derivatives
EP2345643A1 (en) 2009-12-29 2011-07-20 Polichem S.A. New tertiary 8-hydroxyquinoline-7-carboxamide derivatives and uses thereof
EP2345642A1 (en) * 2009-12-29 2011-07-20 Polichem S.A. Secondary 8-hydroxyquinoline-7-carboxamide derivatives for use as antifungal agents
CA2789443C (en) 2010-02-12 2016-09-13 Chimerix, Inc. Nucleoside phosphonate salts
WO2011120153A1 (en) 2010-04-01 2011-10-06 Critical Outcome Technologies Inc. Compounds and method for treatment of hiv
BR112012024796A2 (pt) 2010-04-02 2016-06-07 Janssen R&D Ireland inibidores de integrase macrocíclicos
US9079834B2 (en) 2010-10-28 2015-07-14 Merck Canada Inc. HIV protease inhibitors
BR112013015397A2 (pt) 2010-12-23 2016-09-20 Merck Sharp & Dohme composto, composição farmacêutica, e, uso de um composto
EP2661265B1 (en) * 2010-12-23 2017-03-08 Merck Sharp & Dohme Corp. Quinolines and aza-quinolines as crth2 receptor modulators
EP2487176A1 (en) * 2011-02-14 2012-08-15 Elanco Animal Health Ireland Limited Macrocyclic integrase inhibitors for use in the treatment of feline immunodeficiency virus
BR112013020874A2 (pt) 2011-02-18 2019-05-21 Endo Pharmaceuticals Inc. composto, regime, método para a preparação do referido composto, e, uso de um composto
EP2771332B1 (en) 2011-10-26 2016-06-29 Merck Canada Inc. Thiophen and thiazol sulfonamid derivatives as HIV protease inhibitors for the treatment of AIDS
US9044482B2 (en) 2012-08-15 2015-06-02 Asana Biosciences, Llc Use of aminoindane compounds in treating overactive bladder and interstitial cystitis
BR112015005347A2 (pt) 2012-09-11 2017-08-08 Merck Sharp & Dohme Corp E Merck Canada Inc composto, composição farmacêutica, e, método para tratamento ou profilaxia de infecção por hiv ou para tratamento, profilaxia, ou atraso no início de aids
CN103709162B (zh) * 2012-09-29 2016-12-07 中国科学院上海药物研究所 三取代咪唑并二氮杂萘酮化合物及其制备方法和用途
CN104003986B (zh) * 2013-02-22 2016-06-08 中国科学院上海药物研究所 吡啶骈环类化合物及其制备方法、其药物组合物和用途
WO2015013835A1 (en) 2013-07-31 2015-02-05 Merck Sharp & Dohme Corp. Piperazine derivatives as hiv protease inhibitors
EP3083609B1 (en) 2013-12-19 2018-08-15 Merck Sharp & Dohme Corp. Hiv protease inhibitors
EP3082822B1 (en) 2013-12-19 2020-01-15 Merck Sharp & Dohme Corp. Hiv protease inhibitors
US9994587B2 (en) 2014-03-06 2018-06-12 Merck Sharp & Dohme Corp. HIV protease inhibitors
EP3116862B1 (en) 2014-03-10 2019-04-17 Merck Sharp & Dohme Corp. Piperazine derivatives as hiv protease inhibitors
WO2017151922A1 (en) 2016-03-02 2017-09-08 The Board Of Regents Of The University Of Texas System Sting activating nanovaccine for immunotherapy
CN106588922B (zh) * 2017-01-17 2018-04-27 北京工业大学 二取代八氢-1,6-萘啶类化合物及其制备方法和应用
WO2019018354A1 (en) * 2017-07-18 2019-01-24 Merck Patent Gmbh ANTAGONISTS OF TLR7 / 8 AND USES THEREOF
CN109776415B (zh) * 2019-03-07 2020-11-17 福建南方制药股份有限公司 一种Roxadustat中间体的制备方法
CN115710249B (zh) * 2022-11-14 2024-11-19 广东工业大学 一种多取代异喹啉和1,6-萘啶化合物的制备方法及光电材料常见分子骨架
CN119841471B (zh) * 2025-03-24 2025-06-03 杭州汇能实业有限公司 一种热镀锌冷却循环水的处理方法

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5751837B2 (cs) * 1973-04-05 1982-11-04
US4416884A (en) 1978-04-12 1983-11-22 Otsuka Pharmaceutical Co., Ltd. Piperazinylbenzoheterocyclic compounds
FR2632639B1 (fr) 1988-06-09 1990-10-05 Sanofi Sa Derives d'amino-4 carboxy-3 naphtyridines, leur preparation et compositions pharmaceutiques qui les contiennent
IL101860A0 (en) 1991-05-31 1992-12-30 Ici Plc Heterocyclic derivatives
US5681832A (en) * 1995-02-17 1997-10-28 The United States Of America As Represented By The Department Of Health And Human Services Aroylaniline compounds, pharmaceutical compositions, and methods of using same to inhibit viral activity
US5633362A (en) * 1995-05-12 1997-05-27 E. I. Du Pont De Nemours And Company Production of 1,3-propanediol from glycerol by recombinant bacteria expressing recombinant diol dehydratase
CA2225555A1 (en) * 1995-08-02 1997-02-13 Chiroscience Limited Quinolones and their therapeutic use
US5945431A (en) 1996-03-15 1999-08-31 Biochem Therapeutics Incorporated Cytomegalovirus inhibiting compounds
JP2002505660A (ja) * 1996-09-10 2002-02-19 ファルマシア・アンド・アップジョン・カンパニー 抗ウィルス剤としての８―ヒドロキシ―７―置換キノリン
CA2263479A1 (en) 1996-09-25 1998-04-02 Zeneca Limited Quinoline derivatives inhibiting the effect of growth factors such as vegf
US5766944A (en) * 1996-12-31 1998-06-16 Ruiz; Margaret Eileen T cell differentiation of CD34+ stem cells in cultured thymic epithelial fragments
WO1999000388A1 (en) 1997-06-30 1999-01-07 Nippon Kayaku Kabushiki Kaisha Novel naphthyridine derivatives or salts thereof
CN1268136A (zh) 1997-08-25 2000-09-27 纽罗根公司 用作γ－氨基丁酸脑受体配位体的取代4－氧代－二氮杂萘－3－甲酰胺
GB9720052D0 (en) 1997-09-19 1997-11-19 Smithkline Beecham Plc Novel compounds
DK1031563T3 (da) 1997-09-30 2006-05-08 Daiichi Seiyaku Co Sulfonylderivater
NZ505362A (en) 1997-12-22 2004-12-24 Upjohn Co 4-hydroxyquinoline-3-carboxamides and -hydrazides useful as antiviral agents
US6380249B1 (en) 1998-06-03 2002-04-30 Merck & Co., Inc. HIV integrase inhibitors
US6262055B1 (en) 1998-06-03 2001-07-17 Merck & Co., Inc. HIV integrase inhibitors
US6306891B1 (en) 1998-06-03 2001-10-23 Merck & Co., Inc. HIV integrase inhibitors
SE9802550D0 (sv) 1998-07-15 1998-07-15 Active Biotech Ab Quinoline derivatives
WO2001000578A1 (en) 1999-06-25 2001-01-04 Merck & Co., Inc. 1-(aromatic- or heteroaromatic-substituted)-3-(heteroaromatic substituted)-1,3-propanediones and uses thereof
US6730682B2 (en) 2000-07-12 2004-05-04 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
GB0017676D0 (en) 2000-07-19 2000-09-06 Angeletti P Ist Richerche Bio Inhibitors of viral polymerase
DE60138635D1 (de) * 2000-10-12 2009-06-18 Merck & Co Inc Aza- und polyaza naphthalenyl karboxamide als inhibitoren der hiv-integrase
CN1336363A (zh) 2001-07-25 2002-02-20 张元宾 乙酰磺胺酸钾的合成制备方法
AR036256A1 (es) * 2001-08-17 2004-08-25 Merck & Co Inc Sal sodica de un inhibidor de integrasa del vih, procesos para su preparacion, composiciones farmaceuticas que lo contienen y su uso para la manufactura de un medicamento
JP2005504770A (ja) 2001-08-17 2005-02-17 メルク　エンド　カムパニー　インコーポレーテッド ５−スルホンアミド−８−ヒドロキシ−１，６−ナフチリジン−７−カルボキサミドの製造方法
PT1441735E (pt) 2001-10-26 2006-06-30 Istituto Di Ricerche Di B Mo P Inibidores de integrase do hiv a base de hidroxipirimidinona carboxamida n-substituida
US7232819B2 (en) 2001-10-26 2007-06-19 Istituto Di Ricerche Di Biologia P. Angeletti S.P.A. Dihydroxypyrimidine carboxamide inhibitors of HIV integrase
US20050165000A1 (en) * 2002-04-10 2005-07-28 Robertson Sandra K. Pharmaceutical compositions containing an hiv integrase inhibitor and a nonionic surfactant

Also Published As

Publication number Publication date
CN1469878A (zh) 2004-01-21
CA2425440C (en) 2010-04-13
KR20030036922A (ko) 2003-05-09
US20030055071A1 (en) 2003-03-20
PL360944A1 (en) 2004-09-20
ATE430745T1 (de) 2009-05-15
EP1326865A2 (en) 2003-07-16
IS6760A (is) 2003-03-27
CZ20031028A3 (cs) 2003-08-13
CA2425440A1 (en) 2002-04-18
AU2002211527B2 (en) 2006-08-24
AR033845A1 (es) 2004-01-07
US20050176718A1 (en) 2005-08-11
NO20031672D0 (no) 2003-04-11
US6921759B2 (en) 2005-07-26
SK4322003A3 (en) 2003-09-11
HUP0302367A2 (hu) 2003-11-28
NZ525088A (en) 2004-11-26
MXPA03003263A (es) 2003-06-06
AU1152702A (en) 2002-04-22
EA200300449A1 (ru) 2003-10-30
WO2002030930A2 (en) 2002-04-18
YU27903A (sh) 2006-05-25
DE60138635D1 (de) 2009-06-18
BR0114610A (pt) 2005-12-13
EE200300145A (et) 2003-06-16
WO2002030931A3 (en) 2002-10-24
WO2002030931A2 (en) 2002-04-18
JP2004511483A (ja) 2004-04-15
BG107677A (bg) 2003-11-28
PE20020509A1 (es) 2002-06-20
WO2002030930A3 (en) 2002-08-29
AU2002211874A1 (en) 2002-04-22
NO20031672L (no) 2003-06-05
JP4252797B2 (ja) 2009-04-08
EP1326865B1 (en) 2009-05-06

Similar Documents

Publication Publication Date Title
IL155089A0 (en) Aza and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors
SI1347955T1 (sl) Novi derivati mandljeve kisline in njihova uporaba kot trombinski inhibitorji
SI1564210T1 (sl) 4-oksokinolinske spojine in njihova uporaba kot inhibitorji HIV integraze
EP1544199A4 (en) NITROGEN CONDENSED NITROGEN COMPOUND AND ITS USE AS INHIBITOR OF HIV INTEGRASE
AU2001264313A1 (en) Pyrazolopyridine compounds and use thereof as drugs
AU2003248872A8 (en) Hiv integrase inhibitors
HUP0302693A3 (en) Phenylalanin-derivatives, integrin inhibitors of alpha4, their use and process for their preparation
PT1296974E (pt) Derivados 2-cianopirrolidina e sua utilização como medicamentos
HUP0301146A3 (en) 2-chlor-5-nitrophenyl carboxamide derivatives, pharmaceutical compositions containing them and their use
ZA200100608B (en) Use of amide or imided co-catalysts for nitroxide mediated oxidation.
AU2001280188A1 (en) Pyrazolopyridine compound and pharmaceutical use thereof
AU6616400A (en) Hiv integrase inhibitors
PL370664A1 (en) Hiv integrase inhibitors
HUP0301773A3 (en) Apomorphine derivatives and methods for their use
AU6989501A (en) Hiv integrase inhibitors
AU2001265253A1 (en) Treatment of hiv using hyperthermia
EP1086091A4 (en) INTEGRASE HIV INHIBITORS
AU8009900A (en) Hiv integrase inhibitors
IL153487A0 (en) Pharmaceutical compositions and methods for use
IL153897A0 (en) Pharmaceutical compositions and methods for use
EP1407771A4 (en) SOPHORIDINE AND ITS USE AS ANALYZIC
AU2001259564A1 (en) Pharmaceutical compositions and methods for use
HUP0301925A3 (en) A combination kit used in the treatment of malaria containing quinoline derivatives
AU2002216939A1 (en) Quinoline derivatives and their use as anti-epileptics
GB0021927D0 (en) Use of pharmaceutical combination