IL153476A0 - Novel heteroaryl derivatives and the use thereof as pharmaceuticals - Google Patents

Novel heteroaryl derivatives and the use thereof as pharmaceuticals

Info

Publication number
IL153476A0
IL153476A0 IL15347601A IL15347601A IL153476A0 IL 153476 A0 IL153476 A0 IL 153476A0 IL 15347601 A IL15347601 A IL 15347601A IL 15347601 A IL15347601 A IL 15347601A IL 153476 A0 IL153476 A0 IL 153476A0
Authority
IL
Israel
Prior art keywords
pharmaceuticals
heteroaryl derivatives
novel heteroaryl
novel
derivatives
Prior art date
Application number
IL15347601A
Other languages
English (en)
Original Assignee
Zentaris Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentaris Ag filed Critical Zentaris Ag
Publication of IL153476A0 publication Critical patent/IL153476A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL15347601A 2000-07-21 2001-07-18 Novel heteroaryl derivatives and the use thereof as pharmaceuticals IL153476A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10035927A DE10035927A1 (de) 2000-07-21 2000-07-21 Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel
PCT/EP2001/008263 WO2002008194A1 (de) 2000-07-21 2001-07-18 Acridin-derivate und deren verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
IL153476A0 true IL153476A0 (en) 2003-07-06

Family

ID=7649979

Family Applications (1)

Application Number Title Priority Date Filing Date
IL15347601A IL153476A0 (en) 2000-07-21 2001-07-18 Novel heteroaryl derivatives and the use thereof as pharmaceuticals

Country Status (29)

Country Link
US (1) US6706722B2 (cs)
EP (1) EP1301485B1 (cs)
JP (1) JP2004504382A (cs)
KR (1) KR20030022296A (cs)
CN (1) CN1296359C (cs)
AR (1) AR033383A1 (cs)
AT (1) ATE365717T1 (cs)
AU (2) AU8967501A (cs)
BG (1) BG107507A (cs)
BR (1) BR0112591A (cs)
CA (1) CA2353360A1 (cs)
CY (1) CY1106890T1 (cs)
CZ (1) CZ2003427A3 (cs)
DE (2) DE10035927A1 (cs)
DK (1) DK1301485T3 (cs)
ES (1) ES2291349T3 (cs)
HK (1) HK1057549A1 (cs)
HU (1) HUP0303729A3 (cs)
IL (1) IL153476A0 (cs)
MX (1) MXPA02012564A (cs)
NO (1) NO324939B1 (cs)
NZ (1) NZ524155A (cs)
PL (1) PL358808A1 (cs)
PT (1) PT1301485E (cs)
RU (1) RU2267488C2 (cs)
SK (1) SK1932003A3 (cs)
UA (1) UA75085C2 (cs)
WO (1) WO2002008194A1 (cs)
ZA (1) ZA200210411B (cs)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10035928A1 (de) * 2000-07-21 2002-03-07 Asta Medica Ag Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel
DE10037310A1 (de) * 2000-07-28 2002-02-07 Asta Medica Ag Neue Indolderivate und deren Verwendung als Arzneimittel
MXPA04012959A (es) * 2002-06-29 2005-05-16 Zentaris Gmbh Arilcarbonilpiperacinas y heteroarilcarbonilpiperacinas y su uso para tratamiento de enfermedades de tumor benigno y maligno.
EP1521748A1 (de) * 2002-07-17 2005-04-13 Zentaris GmbH Neue anthracen-derivate und deren verwendung als arzneimittel
US7125461B2 (en) * 2003-05-07 2006-10-24 L & L Products, Inc. Activatable material for sealing, baffling or reinforcing and method of forming same
AR044586A1 (es) * 2003-06-04 2005-09-21 Aventis Pharma Sa Productos aril - heteroaromaticos, composiciones que los contienen y su utilizacion
FR2855825B1 (fr) * 2003-06-04 2008-08-22 Aventis Pharma Sa Produits aryl-heteroaromatiques, compositions les contenant et utilisation
US7249415B2 (en) * 2003-06-26 2007-07-31 Zephyros, Inc. Method of forming members for sealing or baffling
DE10331500A1 (de) * 2003-07-11 2005-02-24 Zentaris Gmbh Neue Acridin-Derivate und deren Verwendung als Arzneimittel
US20070299093A1 (en) * 2005-01-27 2007-12-27 Alma Mater Studiorum-Universitá Di Bologna Organic Compounds Useful for the Treatment of Alzheimer's Disease, Their Use and Method of Preparation
CN101146800A (zh) * 2005-01-27 2008-03-19 生物工程大学精神物质实验室 用于治疗阿尔茨海默病的有机化合物，它们的用途和制备方法
EP2125750B1 (en) * 2007-02-26 2014-05-21 Vitae Pharmaceuticals, Inc. Cyclic urea and carbamate inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CL2008002199A1 (es) * 2007-07-26 2009-10-23 Vitae Pharmaceuticals Inc Compuestos derivados de 1,3-oxazin-2-ona; composicion farmaceutica que comprende a dichos compuestos; y uso para tratar una enfermedad asociada con la actividad de la 11beta-hidroxiesteroide deshidrogenasa tipo 1 (11beta-hsd1) tales como dislipidemia, hiperlipidemia, hipertension, obesidad y enfermedad cardiovascular, entre otras.
AR069207A1 (es) * 2007-11-07 2010-01-06 Vitae Pharmaceuticals Inc Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1
JP5490014B2 (ja) 2007-12-11 2014-05-14 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の環状尿素阻害剤
TW200934490A (en) * 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
EP2252601B1 (en) * 2008-01-24 2012-12-19 Vitae Pharmaceuticals, Inc. Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CA2714532A1 (en) * 2008-02-11 2009-08-20 Vitae Pharmaceuticals, Inc. 1,3-oxazepan-2-one and 1,3-diazepan-2-one inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1
EP2254872A2 (en) * 2008-02-15 2010-12-01 Vitae Pharmaceuticals, Inc. Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
JP5538356B2 (ja) * 2008-03-18 2014-07-02 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の阻害剤
CL2009001058A1 (es) 2008-05-01 2010-09-10 Vitae Pharmaceuticals Inc Compuestos derivados de oxazinas sustituidas, inhibidores de la 11b-hidroxiesteroide deshidrogenasa de tipo-1; composicion farmaceutica; y uso del compuesto para inhibir la actividad de 11b-hsd1, como en el tratamiento de la diabetes, dislipidemia, hipertension, obesidad, cancer, glaucoma, entre otras.
CA2723034A1 (en) 2008-05-01 2009-11-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
BRPI0911764A2 (pt) * 2008-05-01 2015-10-06 Boehringer Ingelheim Int inibidores cíclicos de 11beta-hidroxiesteroide desigrogenase 1
JP5451752B2 (ja) * 2008-05-01 2014-03-26 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状インヒビター
US8114868B2 (en) 2008-07-25 2012-02-14 Boehringer Ingelheim International Gmbh Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1
TW201016691A (en) 2008-07-25 2010-05-01 Boehringer Ingelheim Int Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
WO2010089303A1 (en) 2009-02-04 2010-08-12 Boehringer Ingelheim International Gmbh CYCLIC INHIBITORS OF 11 β-HYDROXYSTEROID DEHYDROGENASE 1
TW201039034A (en) * 2009-04-27 2010-11-01 Chunghwa Picture Tubes Ltd Pixel structure and the method of forming the same
MA33216B1 (fr) 2009-04-30 2012-04-02 Boehringer Ingelheim Int Inhibiteurs cycliques de la 11béta-hydroxysteroïde déshydrogénase 1
KR20120061771A (ko) * 2009-04-30 2012-06-13 비타이 파마슈티컬즈, 인코포레이티드 11베타-하이드록시스테로이드 탈수소효소 1의 고리형 억제제
US8927539B2 (en) 2009-06-11 2015-01-06 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 based on the 1,3-oxazinan-2-one structure
WO2011002910A1 (en) 2009-07-01 2011-01-06 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2582698B1 (en) 2010-06-16 2016-09-14 Vitae Pharmaceuticals, Inc. Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
EP2585444B1 (en) 2010-06-25 2014-10-22 Boehringer Ingelheim International GmbH Azaspirohexanones as inhibitors of 11-beta-hsd1 for the treatment of metabolic disorders
BR112013010021A2 (pt) 2010-11-02 2019-09-24 Boehringer Ingelheim Int combinações farmacêuticas para o tratamento de distúrbios metabólicos.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2538388B1 (fr) 1982-12-24 1985-06-21 Pharmuka Lab Nouveaux derives de naphtalene- ou azanaphtalenecarboxamide, leurs procedes de preparation et leur utilisation comme medicaments
US5030631A (en) * 1989-11-27 1991-07-09 Schering Corporation Tricylclic arylsulfonamides
ATE241600T1 (de) * 1996-06-29 2003-06-15 Samjin Pharm Co Ltd Piperazin-derivate und verfahren zu ihrer herstellung
US5861395A (en) 1996-09-13 1999-01-19 Schering Corporation Compounds useful for inhibition of farnesyl proteins transferase
FR2753706B1 (fr) 1996-09-20 1998-10-30 Nouvelles amines cycliques n-substituees, leur procede de preparation et les compositions pharmaceutiques les renfermant
DE19743435A1 (de) 1997-10-01 1999-04-08 Merck Patent Gmbh Benzamidinderivate
US6410540B1 (en) 1998-08-28 2002-06-25 Scios, Inc. Inhibitors of p38-αkinase
WO2000051614A1 (en) 1999-03-03 2000-09-08 Merck & Co., Inc. Inhibitors of prenyl-protein transferases

Also Published As

Publication number Publication date
JP2004504382A (ja) 2004-02-12
ZA200210411B (en) 2003-02-26
HUP0303729A3 (en) 2009-01-28
MXPA02012564A (es) 2003-09-22
WO2002008194A1 (de) 2002-01-31
UA75085C2 (en) 2006-03-15
EP1301485A1 (de) 2003-04-16
NO20030301D0 (no) 2003-01-20
PL358808A1 (en) 2004-08-23
CZ2003427A3 (cs) 2003-06-18
SK1932003A3 (en) 2003-10-07
AR033383A1 (es) 2003-12-17
ES2291349T3 (es) 2008-03-01
CN1296359C (zh) 2007-01-24
HUP0303729A2 (hu) 2004-03-01
AU2001289675B2 (en) 2005-04-07
DE50112669D1 (de) 2007-08-09
DK1301485T3 (da) 2007-11-05
CY1106890T1 (el) 2012-09-26
CA2353360A1 (en) 2002-01-21
BR0112591A (pt) 2003-07-22
CN1443172A (zh) 2003-09-17
NO324939B1 (no) 2008-01-07
AU8967501A (en) 2002-02-05
HK1057549A1 (en) 2004-04-08
US20020132821A1 (en) 2002-09-19
RU2267488C2 (ru) 2006-01-10
NO20030301L (no) 2003-03-11
NZ524155A (en) 2005-04-29
KR20030022296A (ko) 2003-03-15
EP1301485B1 (de) 2007-06-27
US6706722B2 (en) 2004-03-16
WO2002008194A8 (de) 2003-05-08
BG107507A (bg) 2003-09-30
PT1301485E (pt) 2007-08-30
DE10035927A1 (de) 2002-03-07
ATE365717T1 (de) 2007-07-15

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