IL153375A0 - Agonist anti-trk-c monoclonal antibodies - Google Patents

Agonist anti-trk-c monoclonal antibodies

Info

Publication number
IL153375A0
IL153375A0 IL15337501A IL15337501A IL153375A0 IL 153375 A0 IL153375 A0 IL 153375A0 IL 15337501 A IL15337501 A IL 15337501A IL 15337501 A IL15337501 A IL 15337501A IL 153375 A0 IL153375 A0 IL 153375A0
Authority
IL
Israel
Prior art keywords
monoclonal antibodies
agonist anti
trk
trkc
antibodies
Prior art date
Application number
IL15337501A
Other languages
English (en)
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of IL153375A0 publication Critical patent/IL153375A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL15337501A 2000-06-22 2001-06-22 Agonist anti-trk-c monoclonal antibodies IL153375A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21314100P 2000-06-22 2000-06-22
US23831900P 2000-10-05 2000-10-05
PCT/US2001/020153 WO2001098361A2 (fr) 2000-06-22 2001-06-22 Anticorps monoclonaux anti-trk-c agonistes

Publications (1)

Publication Number Publication Date
IL153375A0 true IL153375A0 (en) 2003-07-06

Family

ID=26907807

Family Applications (2)

Application Number Title Priority Date Filing Date
IL15337501A IL153375A0 (en) 2000-06-22 2001-06-22 Agonist anti-trk-c monoclonal antibodies
IL153375A IL153375A (en) 2000-06-22 2002-12-11 Monoclonal antibodies to the anti-C-TRK agonist

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL153375A IL153375A (en) 2000-06-22 2002-12-11 Monoclonal antibodies to the anti-C-TRK agonist

Country Status (17)

Country Link
US (4) US7384632B2 (fr)
EP (1) EP1292680B1 (fr)
JP (1) JP2004500873A (fr)
KR (1) KR100823764B1 (fr)
CN (1) CN100519749C (fr)
AT (1) ATE446366T1 (fr)
AU (2) AU2001271422B2 (fr)
BR (1) BR0112272A (fr)
CA (1) CA2412494C (fr)
DE (1) DE60140252D1 (fr)
DK (1) DK1292680T3 (fr)
HU (1) HU228310B1 (fr)
IL (2) IL153375A0 (fr)
MX (1) MXPA02012602A (fr)
NZ (1) NZ523105A (fr)
PL (1) PL208113B1 (fr)
WO (1) WO2001098361A2 (fr)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877016A (en) * 1994-03-18 1999-03-02 Genentech, Inc. Human trk receptors and neurotrophic factor inhibitors
EP3333182A1 (fr) 2000-06-05 2018-06-13 The Brigham and Women's Hospital, Inc. Gène encodant un homologue p-glycoprotéine humain multi-résistant aux médicaments pour le chromosome 7p15-21 et utilisations associées
DE60140252D1 (de) * 2000-06-22 2009-12-03 Genentech Inc Agonistische monoklonale antikörper gegen trkc
GB0210783D0 (en) * 2002-05-10 2002-06-19 Polonelli Luciano Anti-microbial polypeptides
WO2004044584A1 (fr) * 2002-11-13 2004-05-27 Micromet Ag Procede d'identification de cellules b specifiques d'un antigene
EP1581759B1 (fr) * 2002-12-23 2009-05-13 Rinat Neuroscience Corp. Methodes de traitement de la neuropathie sensorielle induite par le taxol
DE10303974A1 (de) 2003-01-31 2004-08-05 Abbott Gmbh & Co. Kg Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung
JP2006520806A (ja) * 2003-03-20 2006-09-14 ライナット ニューロサイエンス コーポレイション タキソール誘導性腸障害を処置する方法
KR20070001932A (ko) * 2003-12-23 2007-01-04 리나트 뉴로사이언스 코퍼레이션 작용물질 항 티알케이씨 항체 및 그의 사용 방법
AR054260A1 (es) * 2005-04-26 2007-06-13 Rinat Neuroscience Corp Metodos de tratamiento de enfermedades de la neurona motora inferior y composiciones utilizadas en los mismos
MX2007015292A (es) * 2005-06-06 2008-02-21 Wyeth Corp Anticuerpos monoclonales anti-trkb y sus usos.
CN103145842A (zh) * 2005-06-30 2013-06-12 Abbvie公司 Il-12/p40结合蛋白
PT2289909E (pt) 2005-11-30 2015-02-10 Abbvie Inc Método de rastreio, processo de purificação de globulómeros a-beta não difundíveis, anticorpos selectivos contra os referidos globulómeros a-beta não difundíveis e processo para o fabrico dos referidos anticorpos
KR20140087058A (ko) 2005-11-30 2014-07-08 애브비 인코포레이티드 아밀로이드 베타 단백질에 대한 모노클로날 항체 및 이의 용도
JP2009528985A (ja) 2006-02-02 2009-08-13 ライナット ニューロサイエンス コーポレイション ｔｒｋＢアゴニストを投与することにより望まれない体重減少または摂食障害を治療する方法
PL2772535T3 (pl) 2006-05-31 2022-09-05 Children's Medical Center Corporation Mezenchymalne komórki macierzyste ABC5 dodatnie jako immunomodulatory
US8455626B2 (en) 2006-11-30 2013-06-04 Abbott Laboratories Aβ conformer selective anti-aβ globulomer monoclonal antibodies
US8648169B2 (en) * 2006-12-05 2014-02-11 The Royal Institution For The Advancement Of Learning/Mcgill University Methods of use of Trk receptor modulators
IL199534A (en) 2007-01-05 2013-01-31 Univ Zuerich An isolated human antibody capable of detecting a neoepitope in a disease-related protein, a polynucleotide encoding an antibody, a vector containing the polynucleotide, a host cell containing the polynucleotide or vector, a preparation containing the antibody and related methods and uses.
US20100311767A1 (en) 2007-02-27 2010-12-09 Abbott Gmbh & Co. Kg Method for the treatment of amyloidoses
JP5889527B2 (ja) 2007-04-12 2016-03-22 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドＴｈｅ Ｂｒｉｇｈａｍ ａｎｄ Ｗｏｍｅｎ’ｓ Ｈｏｓｐｉｔａｌ， Ｉｎｃ． 癌療法のためのａｂｃｂ５標的化
EP2262837A4 (fr) * 2008-03-12 2011-04-06 Merck Sharp & Dohme Protéines de liaison avec pd-1
JP5758289B2 (ja) * 2008-05-21 2015-08-05 サントル、ナショナール、ド、ラ、ルシェルシュ、シアンティフィク、（セーエヌエルエス） ＮＴ−３：ＴｒｋＣ結合の阻害および神経芽腫などの癌の処置へのその適用
RS53350B (en) 2008-09-22 2014-10-31 Array Biopharma, Inc. SUBSTITUTED COMPOUNDS OF IMIDASO [1,2-B] PYRIDASINE AS INK KINASE INHIBITORS
SG10201914059WA (en) 2008-10-22 2020-03-30 Array Biopharma Inc Substituted pyrazolo[1,5-a]pyrimidine compounds as trk kinase inhibitors
WO2010056332A1 (fr) 2008-11-14 2010-05-20 The Brigham And Women's Hospital, Inc. Méthodes diagnostiques et thérapeutiques se rapportant à des cellules souches cancéreuses
US11542328B2 (en) 2008-11-14 2023-01-03 The Brigham And Women's Hospital, Inc. Therapeutic and diagnostic methods relating to cancer stem cells
MX2011006422A (es) 2008-12-19 2011-09-15 Panima Pharmaceuticals Ag Autoanticuerpos humanos anti-alfa-sinucleina.
EP2421900A1 (fr) 2009-04-24 2012-02-29 Alper Biotech, Llc Anticorps monoclonaux dirigés contre des antigènes pcbp-1 et leurs utilisations
AR077468A1 (es) 2009-07-09 2011-08-31 Array Biopharma Inc Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
EP2473531A4 (fr) 2009-09-03 2013-05-01 Merck Sharp & Dohme Anticorps anti-gitr
ES2684475T3 (es) 2010-04-15 2018-10-03 Abbvie Inc. Proteínas que se unen a beta amiloide
SG10201506591TA (en) 2010-05-20 2015-09-29 Array Biopharma Inc Macrocyclic compounds as trk kinase inhibitors
KR20130048240A (ko) 2010-07-14 2013-05-09 알퍼 바이오테크, 엘엘씨 Ｐｃｂｐ―１ 항원에 대한 모노클로날 항체, 및 그의 용도
MX358739B (es) 2010-08-14 2018-09-03 Abbvie Inc Star Proteinas de union a amiloide beta.
US9200080B2 (en) 2010-09-03 2015-12-01 Horacio Uri Saragovi Agonistic antibodies to TrkC receptors and uses thereof
US11214610B2 (en) 2010-12-01 2022-01-04 H. Lundbeck A/S High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris
MX359070B (es) 2010-12-01 2018-09-13 Alderbio Holdings Llc Composiciones anti-ngf y uso de las mismas.
US9884909B2 (en) 2010-12-01 2018-02-06 Alderbio Holdings Llc Anti-NGF compositions and use thereof
US9078878B2 (en) 2010-12-01 2015-07-14 Alderbio Holdings Llc Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75
US9539324B2 (en) 2010-12-01 2017-01-10 Alderbio Holdings, Llc Methods of preventing inflammation and treating pain using anti-NGF compositions
US9067988B2 (en) 2010-12-01 2015-06-30 Alderbio Holdings Llc Methods of preventing or treating pain using anti-NGF antibodies
EP4086338A1 (fr) * 2011-03-17 2022-11-09 Minerva Biotechnologies Corporation Procédé d'obtention de cellules souches pluripotentes
EA030777B9 (ru) 2011-06-23 2019-02-28 Байоджен Интернэшнл Нейросайенз Гмбх Анти-альфа-синуклеинсвязывающие молекулы
AU2012279288B2 (en) * 2011-07-01 2017-07-20 The Trustees Of The University Of Pennsylvania Anti-properdin antibodies and uses thereof
RU2635289C2 (ru) * 2012-05-09 2017-11-09 Конинклейке Филипс Н.В. Медицинский интерфейс слежения, обеспечивающий интервенционную информацию
AU2013326932B2 (en) 2012-10-04 2019-06-06 Novelmed Therapeutics, Inc. Alternative pathway specific antibodies for treating hemolytic diseases
CN107428760B (zh) 2014-11-16 2021-04-27 阵列生物制药公司 (s)-n-(5-((r)-2-(2,5-二氟苯基)-吡咯烷-1-基)-吡唑并[1,5-a]嘧啶-3-基)-3-羟基吡咯烷-1-甲酰胺硫酸氢盐的晶型
MA41115A (fr) 2014-12-02 2017-10-10 Biogen Int Neuroscience Gmbh Procédé de traitement de la maladie d'alzheimer
JP2018526324A (ja) 2015-06-01 2018-09-13 ロクソ オンコロジー， インコーポレイテッドＬｏｘｏ Ｏｎｃｏｌｏｇｙ， Ｉｎｃ． がんの診断および処置の方法
WO2016193872A2 (fr) 2015-06-05 2016-12-08 Novartis Ag Anticorps ciblant la protéine morphogénétique osseuse 9 (bmp9) et méthodes associées
CA2992586A1 (fr) 2015-07-16 2017-01-19 Array Biopharma, Inc. Composes substitues de pyrazolo[1,5-a]pyridines comme inhibiteurs de la kinase ret
KR20180037994A (ko) 2015-07-28 2018-04-13 오토노미, 인코포레이티드 TrkB 또는 TrkC 아고니스트 조성물 및 귀 병태의 치료 방법
CA3003153A1 (fr) 2015-10-26 2017-05-04 Loxo Oncology, Inc. Mutations ponctuelles dans le cancer resistant aux inhibiteurs de trk et methodes associees
PL3370768T3 (pl) 2015-11-03 2022-06-13 Janssen Biotech, Inc. Przeciwciała specyficznie wiążące pd-1 i ich zastosowania
TW201736399A (zh) 2015-12-31 2017-10-16 財團法人生物技術開發中心 抗vegfr抗體及其應用
AU2017246547B2 (en) 2016-04-04 2023-02-23 Loxo Oncology, Inc. Methods of treating pediatric cancers
UA125026C2 (uk) 2016-04-04 2021-12-29 Локсо Онколоджі, Інк. РІДКІ КОМПОЗИЦІЇ (S)-N-(5-((R)-2-(2,5-ДИФТОРФЕНІЛ)ПІРОЛІДИН-1-ІЛ)ПІРАЗОЛО[1,5-a]ПІРИМІДИН-3-ІЛ)-3-ГІДРОКСИПІРОЛІДИН-1-КАРБОКСАМІДУ
US10045991B2 (en) 2016-04-04 2018-08-14 Loxo Oncology, Inc. Methods of treating pediatric cancers
UA127826C2 (uk) 2016-05-18 2024-01-17 Локсо Онколоджі, Інк. СПОСІБ ОДЕРЖАННЯ (S)-N-(5-((R)-2-(2,5-ДИФТОРФЕНІЛ)ПІРОЛІДИН-1-ІЛ)-ПІРАЗОЛО[1,5-а]ПІРИМІДИН-3-ІЛ)-3-ГІДРОКСИПІРОЛІДИН-1-КАРБОКСАМІДУ
CA3029281A1 (fr) 2016-06-29 2018-01-04 Otonomy, Inc. Formulations otiques a base de triglycerides et leurs utilisations
TWI704148B (zh) 2016-10-10 2020-09-11 美商亞雷生物製藥股份有限公司 作為ｒｅｔ激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物
JOP20190077A1 (ar) 2016-10-10 2019-04-09 Array Biopharma Inc مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret
JOP20190092A1 (ar) 2016-10-26 2019-04-25 Array Biopharma Inc عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها
RU2766582C2 (ru) 2016-12-23 2022-03-15 Ремд Биотерапьютикс, Инк. Иммунотерапия с применением антител, связывающих лиганд 1 белка программируемой смерти клеток (PD-L1)
US11168090B2 (en) 2017-01-18 2021-11-09 Array Biopharma Inc. Substituted pyrazolo[1,5-a]pyrazines as RET kinase inhibitors
WO2018136663A1 (fr) 2017-01-18 2018-07-26 Array Biopharma, Inc. Inhibiteurs de ret
WO2018166495A1 (fr) * 2017-03-15 2018-09-20 Tsinghua University Nouveaux anticorps anti-trkb
JOP20190213A1 (ar) 2017-03-16 2019-09-16 Array Biopharma Inc مركبات حلقية ضخمة كمثبطات لكيناز ros1
JP2020525470A (ja) * 2017-07-03 2020-08-27 ディヴェロップメント センター フォー バイオテクノロジー 抗ｖｅｇｆｒ抗体及びその使用
IL272773B2 (en) 2017-08-22 2024-06-01 Biogen Ma Inc Pharmaceutical preparations containing anti-amyloid cell antibodies
US11786551B2 (en) 2017-09-26 2023-10-17 The Trustees Of The University Of Pennsylvania Methods for treating heart disease via redirected T cell immunotherapies
TWI812649B (zh) 2017-10-10 2023-08-21 美商絡速藥業公司 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物
TWI791053B (zh) 2017-10-10 2023-02-01 美商亞雷生物製藥股份有限公司 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物
EP3695003A4 (fr) * 2017-10-13 2021-12-22 Adimab, LLC Anticorps contre le virus respiratoire syncytial et méthodes pour leurs génération et utilisation
EP3700576A1 (fr) 2017-10-26 2020-09-02 Array Biopharma Inc. Formulations d'un inhibiteur de kinase trk macrocyclique
JP7061195B2 (ja) 2018-01-18 2022-04-27 アレイ バイオファーマ インコーポレイテッド ＲＥＴキナーゼ阻害剤としての置換ピラゾロ［３，４－ｄ］ピリミジン化合物
CN111615514B (zh) 2018-01-18 2022-10-11 奥瑞生物药品公司 作为ret激酶抑制剂的取代的吡唑并[4,3-c]吡啶化合物
WO2019143977A1 (fr) 2018-01-18 2019-07-25 Array Biopharma Inc. Composés de pyrrolo[2,3-d]pyrimidines substitués utilisés en tant qu'inhibiteurs de la kinase ret
US20210023086A1 (en) 2018-03-29 2021-01-28 Loxo Oncology, Inc. Treatment of trk-associated cancers
CA3108065A1 (fr) 2018-07-31 2020-02-06 Loxo Oncology, Inc. Dispersions sechees par pulverisation, formulations et polymorphies de (s)-5-amino-3-(4-((5 fluoro-2-methoxybenzamido)methyl)phenyl)(1,1,1-trifluoropropan-2-yl)-1h-pyrazole-4-carboxamide
ES2922314T3 (es) 2018-09-10 2022-09-13 Array Biopharma Inc Compuestos heterocíclicos condensados como inhibidores de cinasa RET
JP2022515197A (ja) 2018-12-19 2022-02-17 アレイ バイオファーマ インコーポレイテッド がんを治療するためのｆｇｆｒ阻害剤としての７－（（３，５－ジメトキシフェニル）アミノ）キノキサリン誘導体
EP3898626A1 (fr) 2018-12-19 2021-10-27 Array Biopharma, Inc. Composés pyrazolo[1,5-a]pyridine substitués servant d'inhibiteurs de tyrosine kinases fgfr
US20210087295A1 (en) * 2019-09-23 2021-03-25 The Trustees Of The University Of Pennsylvania Disrupting tumor tissues by targeting fibroblast activation protein (fap)
CN117447602B (zh) * 2023-12-22 2024-03-19 北京索莱宝科技有限公司 猪IgM的抗体及其应用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
CA2040099A1 (fr) 1990-05-01 1991-11-02 Mariano Barbacid Tyrosine-kinase-negative trkb
US5364769A (en) * 1990-09-25 1994-11-15 Genentech, Inc. Nucleic acid encoding neurotrophic factor four (NT-4), vectors, host cells and methods of production
US5348856A (en) * 1991-07-08 1994-09-20 E. R. Squibb & Sons, Inc. DNA encoding TRKC protein
EP0573904B1 (fr) * 1992-06-08 2001-09-26 Takeda Chemical Industries, Ltd. Agent thérapeutique pour neutropénie
US5855885A (en) * 1993-01-22 1999-01-05 Smith; Rodger Isolation and production of catalytic antibodies using phage technology
US5659791A (en) * 1993-04-26 1997-08-19 Microsoft Corporation Encapsulation of extracted portions of documents into objects
WO1995014776A1 (fr) * 1993-11-23 1995-06-01 Genentech, Inc. TYROSINE KINASES PROTEIQUES APPELEES Rse
ES2116066T3 (es) 1993-11-23 1998-07-01 Genentech Inc Ensayo de activacion del receptor quinasa.
US5753225A (en) * 1993-12-03 1998-05-19 The Regents Of The University Of California Antibodies that mimic actions of neurotrophins
US5877016A (en) * 1994-03-18 1999-03-02 Genentech, Inc. Human trk receptors and neurotrophic factor inhibitors
JPH07285912A (ja) * 1994-04-19 1995-10-31 Asahi Chem Ind Co Ltd 新規化合物ａｍ５２２１
WO1996036361A1 (fr) * 1995-05-18 1996-11-21 The Regents Of The University Of Michigan Anticorps se fixant a un adn
AU690474B2 (en) * 1995-09-11 1998-04-23 Kyowa Hakko Kirin Co., Ltd. Antibody againts alpha-chain of human interleukin 5 receptor
GB9525180D0 (en) 1995-12-08 1996-02-07 Univ Mcgill Design of hormone-like antibodies with agonistic and antagonistic fuctions
JP2001527402A (ja) 1997-04-25 2001-12-25 ジェネンテック，インコーポレーテッド Ｎｇｆ変異体
ATE406907T1 (de) 1998-10-28 2008-09-15 Cornell Res Foundation Inc Methoden zur regulierung der angiogenese und vaskuläre integrität mittels trk rezeptor liganden bdnf, nt-3 und nt-4
US6656474B1 (en) * 1999-01-15 2003-12-02 Regeneron Pharmaceuticals, Inc. Methods of using a neurotrophin and its analogues for the treatment of gastrointestinal hypomotility disorders
DE60140252D1 (de) * 2000-06-22 2009-12-03 Genentech Inc Agonistische monoklonale antikörper gegen trkc

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US20040137513A1 (en) 2004-07-15
AU2001271422B2 (en) 2005-12-22
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IL153375A (en) 2009-06-15
US7615383B2 (en) 2009-11-10
US20120045443A1 (en) 2012-02-23
US20070036794A1 (en) 2007-02-15
AU7142201A (en) 2002-01-02
PL359926A1 (en) 2004-09-06
HUP0300841A3 (en) 2005-11-28
HUP0300841A2 (hu) 2004-06-28
ATE446366T1 (de) 2009-11-15
WO2001098361A2 (fr) 2001-12-27
US7384632B2 (en) 2008-06-10
NZ523105A (en) 2004-07-30
KR20030036240A (ko) 2003-05-09
EP1292680A2 (fr) 2003-03-19
WO2001098361A9 (fr) 2003-03-06
CA2412494A1 (fr) 2001-12-27
EP1292680B1 (fr) 2009-10-21
CN100519749C (zh) 2009-07-29
BR0112272A (pt) 2003-05-06
US20100003261A1 (en) 2010-01-07
DK1292680T3 (da) 2010-03-08
CA2412494C (fr) 2012-10-23
CN1447857A (zh) 2003-10-08
PL208113B1 (pl) 2011-03-31
HU228310B1 (en) 2013-03-28
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JP2004500873A (ja) 2004-01-15
WO2001098361A3 (fr) 2002-05-02

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