IL152873A0 - beta-CARBOLINE DERIVATIVES USEFUL AS INHIBITORS OF PHOSPHODIESTERASE - Google Patents
beta-CARBOLINE DERIVATIVES USEFUL AS INHIBITORS OF PHOSPHODIESTERASEInfo
- Publication number
- IL152873A0 IL152873A0 IL15287301A IL15287301A IL152873A0 IL 152873 A0 IL152873 A0 IL 152873A0 IL 15287301 A IL15287301 A IL 15287301A IL 15287301 A IL15287301 A IL 15287301A IL 152873 A0 IL152873 A0 IL 152873A0
- Authority
- IL
- Israel
- Prior art keywords
- phosphodiesterase
- inhibitors
- beta
- derivatives useful
- carboline derivatives
- Prior art date
Links
- 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 title 1
- 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- AIFRHYZBTHREPW-UHFFFAOYSA-N β-carboline Chemical class N1=CC=C2C3=CC=CC=C3NC2=C1 AIFRHYZBTHREPW-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Gynecology & Obstetrics (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20466700P | 2000-05-17 | 2000-05-17 | |
PCT/US2001/014357 WO2001087038A2 (en) | 2000-05-17 | 2001-05-03 | β-CARBOLINE DERIVATIVES USEFUL AS INHIBITORS OF PHOSPHODIESTERASE |
Publications (1)
Publication Number | Publication Date |
---|---|
IL152873A0 true IL152873A0 (en) | 2003-06-24 |
Family
ID=22758909
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL15287301A IL152873A0 (en) | 2000-05-17 | 2001-05-03 | beta-CARBOLINE DERIVATIVES USEFUL AS INHIBITORS OF PHOSPHODIESTERASE |
IL152873A IL152873A (en) | 2000-05-17 | 2002-11-15 | Beta-carboline derivatives for use as phosphodiesterase inhibitors |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL152873A IL152873A (en) | 2000-05-17 | 2002-11-15 | Beta-carboline derivatives for use as phosphodiesterase inhibitors |
Country Status (32)
Country | Link |
---|---|
US (2) | US6492358B2 (hu) |
EP (1) | EP1289985B1 (hu) |
JP (1) | JP5014551B2 (hu) |
KR (1) | KR20030031482A (hu) |
CN (1) | CN1255403C (hu) |
AR (1) | AR028576A1 (hu) |
AT (1) | ATE256127T1 (hu) |
AU (2) | AU2001261167B2 (hu) |
BG (1) | BG66141B1 (hu) |
CA (1) | CA2409715C (hu) |
CZ (1) | CZ20023934A3 (hu) |
DE (1) | DE60101479T2 (hu) |
DK (1) | DK1289985T3 (hu) |
ES (1) | ES2211806T3 (hu) |
GE (1) | GEP20053511B (hu) |
HK (1) | HK1051368A1 (hu) |
HR (1) | HRP20020910B1 (hu) |
HU (1) | HUP0302412A3 (hu) |
IL (2) | IL152873A0 (hu) |
MX (1) | MXPA02011426A (hu) |
MY (1) | MY128479A (hu) |
NO (1) | NO324251B1 (hu) |
NZ (1) | NZ522731A (hu) |
PL (1) | PL205507B1 (hu) |
PT (1) | PT1289985E (hu) |
RU (1) | RU2271358C2 (hu) |
SK (1) | SK16972002A3 (hu) |
TR (1) | TR200302309T4 (hu) |
TW (1) | TWI286553B (hu) |
UA (1) | UA74826C2 (hu) |
WO (1) | WO2001087038A2 (hu) |
ZA (1) | ZA200210111B (hu) |
Families Citing this family (52)
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US6987115B2 (en) * | 2000-12-08 | 2006-01-17 | Smithkline Beecham Corporation | Antibacterial compounds |
US6900220B2 (en) * | 2001-01-02 | 2005-05-31 | Syntex (U.S.A.) Llc | Quinazolone derivatives as alpha 1A/B adrenergic receptor antagonists |
DE60216233T2 (de) * | 2001-02-12 | 2007-09-27 | Lilly Icos Llc, Wilmington | Carbolinderivate |
DE60112974T2 (de) * | 2001-02-12 | 2006-02-16 | Lilly Icos Llc, Wilmington | Carbolinderivate |
US7115621B2 (en) * | 2001-04-25 | 2006-10-03 | Lilly Icos Llc | Chemical compounds |
CA2445460A1 (en) | 2001-06-05 | 2002-12-12 | Lilly Icos Llc | Carboline derivatives as pde-5 inhibitors |
ES2269679T3 (es) * | 2001-06-21 | 2007-04-01 | Lilly Icos Llc | Derivados de carbolina como inhibidores de pdev. |
JP4484517B2 (ja) | 2001-11-14 | 2010-06-16 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | ホスホジエステラーゼ阻害剤として有用な置換された四環式ピロロキノロン誘導体 |
WO2003065992A2 (en) * | 2002-02-07 | 2003-08-14 | Gtx, Inc. | Treating benign prostate hyperplasia with sarms |
DE60317684D1 (de) * | 2002-06-19 | 2008-01-03 | Janssen Pharmaceutica Nv | SUBSTITUIERTE 2,4-DIHYDROPYRROLOc3,4BÜCHINOLIN-9-ONDERIVATE, DIE SICH ALS PHOSPHODIESTERASEINHIBITOREN EIGNEN |
EP1637521B1 (en) * | 2003-06-23 | 2013-06-19 | Ono Pharmaceutical Co., Ltd. | Novel tricyclic heterocycle compound |
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US7767689B2 (en) | 2004-03-15 | 2010-08-03 | Ptc Therapeutics, Inc. | Carboline derivatives useful in the treatment of cancer |
US8076352B2 (en) | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Administration of carboline derivatives useful in the treatment of cancer and other diseases |
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US7678363B2 (en) | 2005-08-26 | 2010-03-16 | Braincells Inc | Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs |
EP2258358A3 (en) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
EP1940389A2 (en) | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
US20070112017A1 (en) | 2005-10-31 | 2007-05-17 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
AU2007249399A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
MX2008014320A (es) | 2006-05-09 | 2009-03-25 | Braincells Inc | Neurogenesis mediada por el receptor de 5-hidroxitriptamina. |
JP2010502722A (ja) * | 2006-09-08 | 2010-01-28 | ブレインセルス,インコーポレイティド | 4−アシルアミノピリジン誘導体を含む組み合わせ |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
EP2178537A4 (en) * | 2007-07-19 | 2011-08-17 | Merck Sharp & Dohme | BETA-CARBOLIN DERIVATIVES AS ANTIDIBLE COMPOUNDS |
EP2225250A2 (en) | 2007-11-30 | 2010-09-08 | Biota Scientific Management Pty Ltd | Bicyclic ppat inhibitors as antibacterial agents |
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US20150119399A1 (en) | 2012-01-10 | 2015-04-30 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
US10092574B2 (en) | 2012-09-26 | 2018-10-09 | Valorisation-Recherche, Limited Partnership | Inhibitors of polynucleotide repeat-associated RNA foci and uses thereof |
WO2017168174A1 (en) | 2016-04-02 | 2017-10-05 | N4 Pharma Uk Limited | New pharmaceutical forms of sildenafil |
CN107216327A (zh) * | 2017-06-27 | 2017-09-29 | 山东大学 | 5型磷酸二酯酶抑制剂及其制备方法和用途 |
US20220402914A1 (en) * | 2019-09-03 | 2022-12-22 | The Regents Of The University Of Colorado, A Body Corporate | Tryptoline-Based Benzothiazoles and their use as Antibiotics and Antibiotic Resistance-Modifying Agents |
EP4011877A3 (en) * | 2020-12-11 | 2023-01-11 | Institut de Cardiologie de Montréal | Method of treating elevated plasma cholesterol |
WO2022140744A1 (en) | 2020-12-23 | 2022-06-30 | Recurium Ip Holdings, Llc | Estrogen receptor modulators |
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DE3855147D1 (de) | 1987-07-20 | 1996-05-02 | Duphar Int Res | 8,9-Anellierte 1,2,3,4-Tetrahydro-beta-carbolin-Derivate |
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AU4919099A (en) | 1998-07-11 | 2000-02-01 | University Of Bristol, The | Compounds having activity at imidazoline receptors |
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-
2001
- 2001-03-05 UA UA2002119179A patent/UA74826C2/uk unknown
- 2001-05-02 US US09/847,767 patent/US6492358B2/en not_active Expired - Lifetime
- 2001-05-03 AU AU2001261167A patent/AU2001261167B2/en not_active Ceased
- 2001-05-03 AT AT01935038T patent/ATE256127T1/de active
- 2001-05-03 HU HU0302412A patent/HUP0302412A3/hu unknown
- 2001-05-03 PL PL365445A patent/PL205507B1/pl unknown
- 2001-05-03 CN CNB018128432A patent/CN1255403C/zh not_active Expired - Fee Related
- 2001-05-03 DK DK01935038T patent/DK1289985T3/da active
- 2001-05-03 WO PCT/US2001/014357 patent/WO2001087038A2/en active IP Right Grant
- 2001-05-03 KR KR1020027015581A patent/KR20030031482A/ko not_active Application Discontinuation
- 2001-05-03 AU AU6116701A patent/AU6116701A/xx active Pending
- 2001-05-03 SK SK1697-2002A patent/SK16972002A3/sk unknown
- 2001-05-03 MX MXPA02011426A patent/MXPA02011426A/es active IP Right Grant
- 2001-05-03 DE DE60101479T patent/DE60101479T2/de not_active Expired - Lifetime
- 2001-05-03 EP EP01935038A patent/EP1289985B1/en not_active Expired - Lifetime
- 2001-05-03 ES ES01935038T patent/ES2211806T3/es not_active Expired - Lifetime
- 2001-05-03 PT PT01935038T patent/PT1289985E/pt unknown
- 2001-05-03 CA CA2409715A patent/CA2409715C/en not_active Expired - Fee Related
- 2001-05-03 GE GE5003A patent/GEP20053511B/en unknown
- 2001-05-03 CZ CZ20023934A patent/CZ20023934A3/cs unknown
- 2001-05-03 NZ NZ522731A patent/NZ522731A/en not_active IP Right Cessation
- 2001-05-03 IL IL15287301A patent/IL152873A0/xx unknown
- 2001-05-03 RU RU2002133867/04A patent/RU2271358C2/ru not_active IP Right Cessation
- 2001-05-03 TR TR2003/02309T patent/TR200302309T4/xx unknown
- 2001-05-03 JP JP2001583517A patent/JP5014551B2/ja not_active Expired - Fee Related
- 2001-05-16 AR ARP010102326A patent/AR028576A1/es unknown
- 2001-05-16 MY MYPI20012323A patent/MY128479A/en unknown
-
2002
- 2002-01-21 TW TW091100842A patent/TWI286553B/zh not_active IP Right Cessation
- 2002-10-01 US US10/261,861 patent/US6864253B2/en not_active Expired - Lifetime
- 2002-11-15 IL IL152873A patent/IL152873A/en not_active IP Right Cessation
- 2002-11-15 HR HR20020910A patent/HRP20020910B1/xx not_active IP Right Cessation
- 2002-11-18 BG BG107285A patent/BG66141B1/bg unknown
- 2002-11-18 NO NO20025527A patent/NO324251B1/no not_active IP Right Cessation
- 2002-12-12 ZA ZA200210111A patent/ZA200210111B/en unknown
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2003
- 2003-05-22 HK HK03103637A patent/HK1051368A1/xx not_active IP Right Cessation
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