IL152741A0 - Neural progenitor cell populations - Google Patents

Neural progenitor cell populations

Info

Publication number
IL152741A0
IL152741A0 IL15274101A IL15274101A IL152741A0 IL 152741 A0 IL152741 A0 IL 152741A0 IL 15274101 A IL15274101 A IL 15274101A IL 15274101 A IL15274101 A IL 15274101A IL 152741 A0 IL152741 A0 IL 152741A0
Authority
IL
Israel
Prior art keywords
cell populations
progenitor cell
neural progenitor
neural
populations
Prior art date
Application number
IL15274101A
Other languages
English (en)
Original Assignee
Geron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26900583&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL152741(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Geron Corp filed Critical Geron Corp
Publication of IL152741A0 publication Critical patent/IL152741A0/xx

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0623—Stem cells
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/01—Modulators of cAMP or cGMP, e.g. non-hydrolysable analogs, phosphodiesterase inhibitors, cholera toxin
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/105—Insulin-like growth factors [IGF]
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/119—Other fibroblast growth factors, e.g. FGF-4, FGF-8, FGF-10
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/135—Platelet-derived growth factor [PDGF]
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    • C12N2503/00—Use of cells in diagnostics
    • C12N2503/02—Drug screening
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
    • C—CHEMISTRY; METALLURGY
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    • C12N2510/00—Genetically modified cells
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
IL15274101A 2000-05-17 2001-05-16 Neural progenitor cell populations IL152741A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20560000P 2000-05-17 2000-05-17
US25760800P 2000-12-22 2000-12-22
PCT/US2001/015861 WO2001088104A2 (en) 2000-05-17 2001-05-16 Neural progenitor cell populations

Publications (1)

Publication Number Publication Date
IL152741A0 true IL152741A0 (en) 2003-06-24

Family

ID=26900583

Family Applications (2)

Application Number Title Priority Date Filing Date
IL15274101A IL152741A0 (en) 2000-05-17 2001-05-16 Neural progenitor cell populations
IL152741A IL152741A (en) 2000-05-17 2002-11-10 Cell populations give birth to nerve cells

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL152741A IL152741A (en) 2000-05-17 2002-11-10 Cell populations give birth to nerve cells

Country Status (11)

Country Link
US (6) US20020009743A1 (de)
EP (1) EP1287116A2 (de)
JP (5) JP5943533B2 (de)
KR (1) KR100903755B1 (de)
CN (1) CN100580079C (de)
AU (2) AU2001263199B2 (de)
CA (1) CA2409698C (de)
GB (1) GB2379447B (de)
HK (1) HK1055765A1 (de)
IL (2) IL152741A0 (de)
WO (1) WO2001088104A2 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9018010B2 (en) 2009-11-12 2015-04-28 Technion Research & Development Foundation Limited Culture media, cell cultures and methods of culturing pluripotent stem cells in an undifferentiated state

Families Citing this family (202)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6667176B1 (en) 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
US7410798B2 (en) * 2001-01-10 2008-08-12 Geron Corporation Culture system for rapid expansion of human embryonic stem cells
EP1173548B1 (de) 1999-05-03 2007-06-13 Neuro Therapeutics AB Materialien und methoden zur entwicklung von dopaminergen neuronen
US20030087263A1 (en) * 1999-12-16 2003-05-08 Renu Wadhwa Method of screening remedy for cancer with the use of interaction domain of p53 and mortalin
US20050042749A1 (en) * 2001-05-16 2005-02-24 Carpenter Melissa K. Dopaminergic neurons and proliferation-competent precursor cells for treating Parkinson's disease
US7011828B2 (en) * 2000-03-14 2006-03-14 Es Cell International Pte. Ltd. Implanting neural progenitor cells derived for human embryonic stem cells
JP4889902B2 (ja) 2000-03-14 2012-03-07 イーエス・セル・インターナショナル・プライヴェート・リミテッド ヒト胚性幹（ｈＥＳ）細胞からヒト神経前駆細胞を作製する方法、並びに、該方法を利用したニューロンの作製方法、稀突起膠細胞又は星状細胞の作製方法
US7250294B2 (en) * 2000-05-17 2007-07-31 Geron Corporation Screening small molecule drugs using neural cells differentiated from human embryonic stem cells
CN100580079C (zh) 2000-05-17 2010-01-13 杰龙公司 神经祖细胞群体
US6921665B2 (en) * 2000-11-27 2005-07-26 Roslin Institute (Edinburgh) Selective antibody targeting of undifferentiated stem cells
US6576464B2 (en) 2000-11-27 2003-06-10 Geron Corporation Methods for providing differentiated stem cells
JP3763749B2 (ja) * 2001-03-28 2006-04-05 独立行政法人科学技術振興機構 脊髄におけるシナプス形成ニューロンを誘導する中枢神経系前駆細胞
US7943376B2 (en) 2001-04-27 2011-05-17 Stem Cell Therapuetics Inc. Platelet derived growth factor (PDGF)-derived neurospheres define a novel class of progenitor cells
CN101029302B (zh) * 2001-06-21 2011-03-30 杰龙公司 用于治疗帕金森病的多巴胺能神经元和具有增殖能力的前体细胞
JP3886346B2 (ja) * 2001-06-22 2007-02-28 サンバイオ，インコーポレイティド 骨髄間質細胞由来Ｓｃｈｗａｎｎ細胞を含む神経再生用医薬組成物
DE10134667A1 (de) * 2001-07-20 2003-02-06 Neuroprogen Gmbh Leipzig Verfahren zur Herstellung isolierter Zellkulturen, Kulturmedium zur Kultivierung von Zellkulturen und Zellkultur
US8153424B2 (en) * 2001-10-03 2012-04-10 Wisconsin Alumni Research Foundation Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells
US6887706B2 (en) 2001-10-03 2005-05-03 Wisconsin Alumni Research Foundation Method of in vitro differentiation of transplantable neural precursor cells from primate embryonic stem cells
US7588937B2 (en) 2001-10-03 2009-09-15 Wisconsin Alumni Research Foundation Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells
US7129034B2 (en) * 2001-10-25 2006-10-31 Cedars-Sinai Medical Center Differentiation of whole bone marrow
EP2292734A1 (de) 2001-12-07 2011-03-09 Geron Corporation Hämatopoietische Zellen aus menschlichen Embryostammzellen
US20050129664A1 (en) * 2002-01-09 2005-06-16 Hideyuki Okano Remedy for dysmnesia
AU2003216058A1 (en) 2002-01-14 2003-07-30 The Board Of Trustees Of The University Of Illinois Mammalian neural stem cells, compositions and uses thereof
US20050214940A1 (en) * 2002-01-23 2005-09-29 Rao Mahendra S Pure populations of astrocyte restricted precursor cells and methods for isolation and use thereof
AU2003228517B2 (en) * 2002-04-16 2007-06-21 Dana-Farber Cancer Institute, Inc. Cancer models
AU2003229132B9 (en) * 2002-06-05 2009-07-23 Es Cell International Pte Ltd Generation of neural stem cells from undifferentiated human embryonic stem cells
EP2360241A1 (de) 2002-06-05 2011-08-24 ES Cell International Pte Ltd. Stammzellen
US7285415B2 (en) 2002-07-11 2007-10-23 The Regents Of The University Of California Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury
US20050101014A1 (en) 2002-07-11 2005-05-12 Keirstead Hans S. Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury
US20040224302A1 (en) * 2002-07-16 2004-11-11 Thomas Jessel Systems and methods for screening for modulators of neural differentiation
US7632679B2 (en) * 2002-07-16 2009-12-15 The Trustees Of Columbia University In The City Of New York Systems and methods for screening for modulators of neural differentiation
WO2004029229A2 (en) * 2002-09-24 2004-04-08 Neuro Therapeutics Ab Methods for promoting dopaminergic neuronal development by using ng4a-subfamily and wnt-ligands
AU2003276924A1 (en) * 2002-09-25 2004-04-19 Bresagen, Inc. Compositions and methods for enrichment of neural stem cells using ceramide analogs
AU2003286808A1 (en) * 2002-11-01 2004-06-07 The Regents Of The University Of Colorado Dopamine neurons from human embryonic stem cells
US20050265983A1 (en) * 2002-11-17 2005-12-01 Eldad Melamed Methods, nucleic acid constructs and cells for treating neurodegenerative disorders
US20040185429A1 (en) * 2002-12-09 2004-09-23 Judith Kelleher-Andersson Method for discovering neurogenic agents
JP4613069B2 (ja) 2002-12-16 2011-01-12 テクニオン リサーチ アンド ディベロップメント ファウンデーション リミテッド 支持細胞非含有、異種非含有のヒト胚性幹細胞の調製方法およびこれらを使用して調製された幹細胞培養物
AU2003303741A1 (en) * 2002-12-18 2004-09-17 Bresagen, Inc. Compositions and methods for neural cell production and stabilization
US8642332B2 (en) * 2003-03-07 2014-02-04 Cornell Research Foundation, Inc. Identification and isolation of multipotential neural progenitor cells from the subcortical white matter of the adult human brain
RU2345133C2 (ru) * 2003-03-12 2009-01-27 Релайанс Лайф Сайенсиз Пвт. Лтд. Получение терминально дифференцированных дофаминергических нейронов из эмбриональных стволовых клеток человека
ZA200401646B (en) * 2003-03-12 2004-06-07 Reliance Life Sciences Pvt Ltd Derivation of terminally differentiated dopaminergic neurons from human embryonic stem cells.
US7153650B2 (en) 2003-03-13 2006-12-26 Geron Corporation Marker system for preparing and characterizing high-quality human embryonic stem cells
US20060183221A1 (en) * 2003-03-31 2006-08-17 Schulz Thomas C Method for neural differentiation of embryonic stem cells using protease passaging techniques
US20070020608A1 (en) * 2003-05-08 2007-01-25 Peter Eriksson Method for the generation of neural progenitor cells
EP1702062A2 (de) * 2003-06-11 2006-09-20 Jan Remmereit Kern-umprogrammierung von zellen für die therapeutische verwendung
WO2004111210A1 (en) * 2003-06-12 2004-12-23 Yeda Research & Development Co.Ltd Enhancement of oligodendrocyte differentiation
AU2004269361B2 (en) * 2003-08-29 2010-05-20 Wisconsin Alumni Research Foundation Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells
US7820439B2 (en) * 2003-09-03 2010-10-26 Reliance Life Sciences Pvt Ltd. In vitro generation of GABAergic neurons from pluripotent stem cells
EP1670897A4 (de) * 2003-09-24 2008-02-27 Univ Leland Stanford Junior Igf-1 weist multipotente adulte neurale zns-stammzellen in eine oligodendrogliazellinie
US20070269412A1 (en) 2003-12-02 2007-11-22 Celavie Biosciences, Llc Pluripotent cells
CA2551266C (en) 2003-12-30 2011-07-26 Seoul National University Industry Foundation Embryonic stem cell line and method for preparing the same
WO2005079250A2 (en) * 2004-02-13 2005-09-01 Cornell Research Foundation, Inc. Purines are self-renewal signals for neural stem cells, and purine receptor antagonists promote neuronal and glial differentiation therefrom
JP5226928B2 (ja) * 2004-04-16 2013-07-03 株式会社カネカ 細胞の分化転換方法
US20050272149A1 (en) * 2004-06-02 2005-12-08 Life & Brain Gmbh Therapeutic delivery of adenosine into a tissue
JP2008501356A (ja) 2004-06-09 2008-01-24 ザ・ユニバーシティ・コート・オブ・ザ・ユニバーシティ・オブ・エディンバラ 神経幹細胞
EP1809739B1 (de) 2004-07-13 2014-10-15 Asterias Biotherapeutics, Inc. Wachstumsmedium für menschliche embryonale stammzellen
EP1786471B1 (de) 2004-07-30 2015-02-11 Mayo Foundation For Medical Education And Research Behandlung von kardiovaskulärem gewebe
AU2005272814B2 (en) 2004-08-12 2010-12-23 Neuro Probe Incorporated Point source diffusion cell activity assay apparatuses and methods
US20060040389A1 (en) * 2004-08-17 2006-02-23 Murry Charles E Purified compositions of stem cell derived differentiating cells
CA2578685A1 (en) * 2004-09-06 2006-03-16 Tanabe Seiyaku Co., Ltd. Method for preparing conditioned medium of astrocyte-like cells
CA2583473A1 (en) * 2004-10-05 2007-04-04 University Of Georgia Research Foundation, Inc. Neuronal progenitors from feeder-free human embryonic stem cell culture
US8192988B2 (en) * 2004-10-22 2012-06-05 University Of Central Florida Research Foundation, Inc. Methods for increasing potency of adult mesenchymal stem cells
US7629169B2 (en) 2004-12-01 2009-12-08 Stem Cell Therapeutics Corp. Methods for the production of platelet-derived growth factor-responsive neural precursor cells
WO2006072005A2 (en) * 2004-12-30 2006-07-06 The Johns Hopkins University Methods for high efficiency survival/proliferation of human embyonic stem cells and human embyro survival in culture
EP1844139A1 (de) * 2004-12-30 2007-10-17 Stemlifeline, Inc. Verfahren und systeme in verbindung mit embryonalen stammzellinien
US20060275899A1 (en) * 2004-12-30 2006-12-07 Stemlifeline, Inc. Methods and compositions relating to embryonic stem cell lines
EP1856248A4 (de) * 2005-02-09 2010-01-20 Burnham Inst Medical Research Homogene neurale vorläuferzellen
AU2006220696B2 (en) 2005-03-07 2010-08-19 Sanbio, Inc. Use of neuronal precursor cells for treatment of central nervous system lesions
ES2524996T3 (es) * 2005-06-16 2014-12-16 Ramot At Tel Aviv University Ltd. Células aisladas y poblaciones que comprenden a las mismas para el tratamiento de enfermedades del SNC
CN101233226B (zh) * 2005-06-22 2017-08-11 阿斯特利亚斯生物治疗股份公司 人胚胎干细胞的悬浮培养物
WO2007002568A1 (en) * 2005-06-22 2007-01-04 Geron Corporation Reporter hepatocytes and other cells for drug screening and toxicity testing
US20060292695A1 (en) * 2005-06-22 2006-12-28 Roslin Institute Methods and kits for drug screening and toxicity testing using promoter-reporter cells derived from embryonic stem cells
US20060292694A1 (en) * 2005-06-22 2006-12-28 Roslin Institute Reporter hepatocytes and other cells for drug screening and toxicity testing
CA2614289A1 (en) * 2005-07-08 2007-01-18 Braincells, Inc. Methods for identifying agents and conditions that modulate neurogenesis
CN101351544B (zh) * 2005-08-26 2013-06-12 罗切斯特大学 胶质限制性前体衍生的星形胶质细胞移植以促进轴突生长
EP3354723B1 (de) 2005-08-29 2023-12-13 Technion Research & Development Foundation Ltd. Medien zur züchtung von stammzellen
KR20080056182A (ko) 2005-09-02 2008-06-20 에이전시 포 사이언스, 테크놀로지 앤드 리서치 간엽 줄기 세포의 유도 방법
US8986676B2 (en) 2005-11-10 2015-03-24 Genervon Biopharmaceuticals Llc MNTF differentiation and growth of stem cells
WO2007066338A1 (en) * 2005-12-08 2007-06-14 Ramot At Tel Aviv University Ltd. Isolated oligodendrocyte-like cells and populations comprising same for the treatment of cns diseases
US8278104B2 (en) * 2005-12-13 2012-10-02 Kyoto University Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2
EP3418297B1 (de) 2005-12-13 2023-04-05 Kyoto University Nuklearumprogrammierungsfaktor
US8129187B2 (en) 2005-12-13 2012-03-06 Kyoto University Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2
KR100683199B1 (ko) 2006-01-09 2007-02-15 주식회사 휴림바이오셀 신경전구세포를 콜린성 신경세포로 분화시키는 방법 및그에 사용되는 배지
KR100683198B1 (ko) 2006-01-09 2007-02-15 주식회사 휴림바이오셀 신경전구세포를 도파민성 신경세포로 분화시키는 방법 및그에 사용되는 배지
WO2007091790A1 (en) * 2006-02-07 2007-08-16 Korea Institute Of Radiological & Medical Sciences A composition for treating damage of central or peripheral nerve system
KR100838013B1 (ko) * 2006-06-07 2008-06-12 제일약품주식회사 인간배아줄기세포로부터 단계적 선별법을 통해 고수율로신경전구세포, 신경세포 및 기능성 도파민신경세포를생성하는 방법
US20080003676A1 (en) * 2006-06-26 2008-01-03 Millipore Corporation Growth of embryonic stem cells
US9765298B2 (en) * 2006-07-24 2017-09-19 Mayo Foundation For Medical Education And Research Methods and materials for providing cardiac cells
EP2733203B1 (de) 2006-08-02 2018-10-10 Technion Research & Development Foundation Ltd. Verfahren zur Expansion embryonaler Stammzellen in einer Suspensionskultur
WO2008100168A1 (en) * 2007-02-16 2008-08-21 Universidade De Coimbra Method for the functional identification of new neurons, neural progenitors, astrocytes and immature cells from stem cell cultures and uses thereof
WO2008127974A1 (en) * 2007-04-13 2008-10-23 The Trustees Of Columbia University In The City Of New York Stem cell-based culture system for drug development
US9029147B2 (en) * 2007-06-15 2015-05-12 Massachusetts Institute Of Technology Methods and compositions for enhanced differentiation from embryonic stem cells
US9213999B2 (en) 2007-06-15 2015-12-15 Kyoto University Providing iPSCs to a customer
JP2008307007A (ja) 2007-06-15 2008-12-25 Bayer Schering Pharma Ag 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞
EP2185694A2 (de) 2007-08-02 2010-05-19 California Stem Cell, Inc. Neuronale vorläuferzellen und verfahren zur ableitung und reinigung neuronaler vorläuferzellen aus embryonischen stammzellen
KR100941036B1 (ko) 2007-10-05 2010-02-05 고려대학교 산학협력단 인간 배아줄기세포로부터 척수신경계 희소돌기 아교세포생산을 위한 삼단계 분화기법
WO2009066817A1 (en) * 2007-11-23 2009-05-28 Seoul National University Industry Foundation Method for inducing differentiation of human mesenchymal stem cells into motor neurons
CA2714010C (en) 2008-01-30 2020-06-16 Corning Incorporated Synthetic surfaces for culturing stem cell derived oligodendrocyte progenitor cells
SG10201400329YA (en) 2008-05-02 2014-05-29 Univ Kyoto Method of nuclear reprogramming
WO2009145761A1 (en) * 2008-05-27 2009-12-03 Mayo Foundation For Medical Education And Research Methods and materials for using cells to treat heart tissue
EP2285951B1 (de) 2008-05-28 2018-07-04 Ramot at Tel-Aviv University Ltd. Mesenchymale stammzellen zur behandlung von erkrankungen des zentralnervensystems
US8969081B2 (en) * 2008-12-10 2015-03-03 The Trustees Of Columbia University In The City Of New York Caudal motor neuron derived from embryonic stem cells under conditions essentially free of any retinoid
CN102325878A (zh) 2008-12-23 2012-01-18 斯特姆塞尔思加利福尼亚有限公司 少突胶质前体细胞的靶向细胞群及制备与使用方法
US20100209399A1 (en) * 2009-02-13 2010-08-19 Celavie Biosciences, Llc Brain-derived stem cells for repair of musculoskeletal system in vertebrate subjects
WO2010096496A2 (en) 2009-02-17 2010-08-26 Memorial Sloan-Kettering Cancer Center Methods of neural conversion of human embryonic stem cells
CN102803472B (zh) * 2009-06-25 2014-04-23 吉隆公司 去除了外来表型的由多能干细胞分化的子代细胞
WO2011005326A1 (en) 2009-07-09 2011-01-13 Massachusetts Institute Of Technology Methods and compositions for increased safety of stem cell-derived populations
US11261425B2 (en) 2009-08-12 2022-03-01 Kyoto University Method for inducing differentiation of pluripotent stem cells into neural precursor cells
EP2464723B1 (de) * 2009-08-12 2016-06-22 Kyoto University Verfahren zur herbeiführung der differenzierung pluripotenter stammzellen in nervenvorläuferzellen
US20120244567A1 (en) * 2009-09-04 2012-09-27 Buck Institute For Research On Aging Human embryonic stem cells for high throughout drug screening
JP5902092B2 (ja) 2009-10-19 2016-04-13 セルラー ダイナミクス インターナショナル， インコーポレイテッド 心筋細胞の生成
EP2499241B8 (de) 2009-11-10 2018-02-21 The J. David Gladstone Institutes Verfahren zur produktion neuraler stammzellen
IL301479A (en) 2009-11-17 2023-05-01 Astellas Inst For Regenerative Medicine Methods for preparing human RPE cells and pharmaceutical preparations of human RPE cells
KR20120093407A (ko) * 2009-12-02 2012-08-22 리서치 디벨럽먼트 파운데이션 제한된 분화력을 가진 줄기세포 클론의 선별
US8481317B2 (en) 2010-04-13 2013-07-09 Cellular Dynamics International, Inc. Hepatocyte production by forward programming
CA2796616A1 (en) 2010-04-21 2011-10-27 Research Development Foundation Methods and compositions related to dopaminergic neuronal cells
US20110312001A1 (en) 2010-06-15 2011-12-22 Emile Nuwaysir Compendium of ready-built stem cell models for interrogation of biological response
JP6039551B2 (ja) 2010-06-18 2016-12-07 セルラー ダイナミクス インターナショナル， インコーポレイテッド 透析された血清を有する心筋細胞培地
EP2591093B1 (de) 2010-07-07 2018-11-28 FUJIFILM Cellular Dynamics, Inc. Endothelzellenproduktion durch programmierung
EP2593117B1 (de) 2010-07-12 2019-03-20 University of Southern California Biokompatibles substrat zur förderung von vernetzungen zwischen stammzellen und zielgeweben sowie verfahren zu seiner implantation
EP2573168A4 (de) * 2010-07-22 2014-04-02 Affiliated Hospital Of Ningxia Medical University Verfahren zur erzeugung von nervenzellen aus stammzellen, nervenzellen und verwendungen dafür
US20130149287A1 (en) * 2010-07-30 2013-06-13 Cambridge Enterprise Limited Corticogenesis of Human Pluripotent Cells
US8765470B2 (en) 2010-08-04 2014-07-01 Cellular Dynamics International, Inc. Reprogramming immortalized B-cells to induced pluripotent stem cells
EP2625577B1 (de) 2010-10-08 2019-06-26 Terumo BCT, Inc. Anpassbares verfahren und systeme für züchtung und ernte von zellen in einem hohlfaser-bioreaktorsystem
ES2682962T3 (es) * 2010-11-05 2018-09-24 The Board Of Trustees Of The Leland Stanford Junior University Control y caracterización de estados psicóticos
CN103687941A (zh) * 2011-01-12 2014-03-26 城户常雄 获得和维持易于在体外分化成少突胶质细胞谱系细胞的纯化或富集的哺乳动物神经干细胞群和/或神经祖细胞群的培养方法
EP2673358B1 (de) 2011-02-08 2019-01-09 FUJIFILM Cellular Dynamics, Inc. Herstellung blutbildender vorläuferzellen durch programmierung
WO2012118988A1 (en) * 2011-03-01 2012-09-07 The Scripps Research Institute Direct reprogramming of human fibroblasts to functional neurons under defined conditions
EP2691512B1 (de) 2011-03-29 2019-05-01 Asterias Biotherapeutics, Inc. Angereicherte populationen von herzmuskelzellen aus pluripotenten stammzellen
EP2694644B1 (de) 2011-03-30 2018-01-24 Cellular Dynamics International, Inc. Priming pluripotenter stammzellen für neurale differenzierung
US8877489B2 (en) 2011-12-05 2014-11-04 California Institute Of Technology Ultrathin parylene-C semipermeable membranes for biomedical applications
WO2012149468A2 (en) 2011-04-29 2012-11-01 University Of Southern California Instruments and methods for the implantation of cell-seeded substrates
CA2841165A1 (en) 2011-07-11 2013-01-17 Cellular Dynamics International, Inc. Methods for cell reprogramming and genome engineering
US9034584B2 (en) 2011-07-29 2015-05-19 Cellular Dynamics International, Inc. Metabolic maturation in stem cell-derived tissue cells
CN102899285A (zh) * 2011-07-29 2013-01-30 复旦大学 一种体外诱导胚胎干细胞分化成为神经细胞方法
CN110684733A (zh) 2011-11-04 2020-01-14 纪念斯隆-凯特琳癌症中心 用于植入的中脑多巴胺（da）神经元
US9248013B2 (en) 2011-12-05 2016-02-02 California Institute Of Technology 3-Dimensional parylene scaffold cage
US9447378B2 (en) 2012-04-27 2016-09-20 Massachusetts Institute Of Technology Method for differentiating human embryonic stem cells into β-cells for the treatment of type I diabetes
WO2014104409A1 (en) 2012-12-28 2014-07-03 Kyoto University Method for inducing astrocytes
JP6541577B2 (ja) * 2013-02-06 2019-07-10 ユニバーシティー オブ ロチェスター ミエリン障害の治療のための誘導多能性細胞由来オリゴデンドロサイト前駆細胞
EP2958992A1 (de) 2013-02-22 2015-12-30 Cellular Dynamics International, Inc. Hepatozytenproduktion über vorwärtsprogrammierung durch kombination aus gentechnik und chemotechnik
JP2016520291A (ja) 2013-03-14 2016-07-14 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア ｉｎｖｉｔｒｏでの内側神経節隆起前駆細胞の作製
US10266807B2 (en) 2013-04-03 2019-04-23 FUJIFILM Cellular Dynamics, Inc. Methods and compositions for culturing endoderm progenitor cells in suspension
WO2014176606A1 (en) 2013-04-26 2014-10-30 Memorial Sloan-Kettering Center Center Cortical interneurons and other neuronal cells produced by the directed differentiation of pluripotent and multipotent cells
EP3008169B1 (de) 2013-06-10 2021-11-10 Academisch Ziekenhuis Leiden Differenzierung und erweiterung von endothelzellen aus pluripotenten stammzellen und in-vitro-bildung von gefässähnlichen strukturen
MX2015017103A (es) 2013-06-11 2016-11-07 Harvard College Celulas beta derivadas de células madre ( sc-beta ) y composiciones y métodos para generarlas.
US9816070B2 (en) 2013-06-14 2017-11-14 Massachusetts Institute Of Technology Articles and methods for stem cell differentiation
ES2721440T3 (es) * 2013-09-05 2019-07-31 Univ Kyoto Nuevo método para inducir células precursoras neurales productoras de dopamina
AU2014335680A1 (en) * 2013-10-14 2016-04-07 Hadasit Medical Research Services & Development Limited Method of obtaining terminally differentiated neuronal lineages and uses thereof
JP6633522B2 (ja) 2013-11-16 2020-01-22 テルモ ビーシーティー、インコーポレーテッド バイオリアクターにおける細胞増殖
KR20230008892A (ko) 2013-11-21 2023-01-16 메모리얼 슬로안 케터링 캔서 센터 인간 다능성 줄기 세포로부터 기능적 두개 기원판 유도체의 전문화
WO2015143342A1 (en) 2014-03-21 2015-09-24 Cellular Dynamics International, Inc. Production of midbrain dopaminergic neurons and methods for the use thereof
WO2015148704A1 (en) 2014-03-25 2015-10-01 Terumo Bct, Inc. Passive replacement of media
WO2015164228A1 (en) 2014-04-21 2015-10-29 Cellular Dynamics International, Inc. Hepatocyte production via forward programming by combined genetic and chemical engineering
WO2015164740A1 (en) 2014-04-24 2015-10-29 Board Of Regents, The University Of Texas System Application of induced pluripotent stem cells to generate adoptive cell therapy products
US11001803B2 (en) * 2014-07-31 2021-05-11 Association Francaise Contre Les Myopathies Method for generating neuronal and muscular cells
WO2016049421A1 (en) 2014-09-26 2016-03-31 Terumo Bct, Inc. Scheduled feed
US10047341B2 (en) 2014-10-14 2018-08-14 FUJIFILM Cellular Dynamics, Inc. Generation of keratinocytes from pluripotent stem cells and maintenance of keratinocyte cultures
CN105624116B (zh) * 2014-11-07 2020-04-07 中国科学院上海生命科学研究院 利用多能干细胞制备神经前体细胞的方法
EP3234110B1 (de) 2014-12-18 2024-02-28 President and Fellows of Harvard College Verfahren zur generierung von stammzell-abgeleiteten beta-zellen und verwendungen davon
WO2016100930A1 (en) 2014-12-18 2016-06-23 President And Fellows Of Harvard College Methods for generating stem cell-derived b cells and methods of use thereof
WO2016100898A1 (en) 2014-12-18 2016-06-23 President And Fellows Of Harvard College Serum-free in vitro directed differentiation protocol for generating stem cell-derived b cells and uses thereof
US9724432B2 (en) 2015-04-30 2017-08-08 University Of Rochester Non-human mammal model of human degenerative disorder, uses thereof, and method of treating human degenerative disorder
WO2016196661A1 (en) * 2015-06-01 2016-12-08 Memorial Sloan-Kettering Cancer Center Methods of in vitro differentiation of midbrain dopamine (mda) neurons
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
US10384207B2 (en) 2015-07-21 2019-08-20 Neuro Probe Incorporated Assay apparatus and methods
AU2016321170B2 (en) 2015-09-08 2022-09-01 Fujifilm Cellular Dynamics Method for reproducible differentiation of clinical-grade retinal pigment epithelium cells
AU2016318774B2 (en) 2015-09-08 2022-08-18 FUJIFILM Cellular Dynamics, Inc. MACS-based purification of stem cell-derived retinal pigment epithelium
US20180369287A1 (en) 2015-10-08 2018-12-27 Neurona Therapeutics Inc. Neural precursor cell populations and uses thereof
WO2017075389A1 (en) 2015-10-30 2017-05-04 The Regents Of The Universtiy Of California Methods of generating t-cells from stem cells and immunotherapeutic methods using the t-cells
US11920155B2 (en) 2016-03-30 2024-03-05 Asterias Biotherapeutics, Inc. Oligodendrocyte progenitor cell compositions
US11965175B2 (en) 2016-05-25 2024-04-23 Terumo Bct, Inc. Cell expansion
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
EP4328301A3 (de) 2016-08-16 2024-06-19 FUJIFILM Cellular Dynamics, Inc. Verfahren zur differenzierung pluripotenter zellen
AU2018239426A1 (en) * 2017-03-21 2019-10-03 Memorial Sloan-Kettering Cancer Center Stem cell-derived astrocytes, methods of making and methods of use
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
EP3656841A1 (de) 2017-03-31 2020-05-27 Terumo BCT, Inc. Zellexpansion
JP7457505B2 (ja) 2017-05-10 2024-03-28 ユニバーシティー オブ ロチェスター 神経精神障害を処置する方法
IL305391B2 (en) 2017-11-15 2024-09-01 Vertex Pharma Preparations for the production of islet cells and methods of use
EP3781675A1 (de) 2018-04-20 2021-02-24 FUJIFILM Cellular Dynamics, Inc. Verfahren zur differenzierung von augenzellen und deren verwendung
RU2690498C1 (ru) * 2018-05-17 2019-06-04 Федеральное государственное бюджетное научное учреждение "Медико-генетический научный центр" Способ получения ноотропной композиции на основе полипептидных комплексов, выделенных из нейронов и глиальных клеток, полученных методом направленной дифференцировки индуцированных плюрипотентных стволовых клеток человека
RU2690846C1 (ru) * 2018-05-17 2019-06-06 Федеральное государственное бюджетное научное учреждение "Медико-генетический научный центр" Ноотропная композиция на основе полипептидных комплексов, выделенных из нейронов и глиальных клеток, полученных методом направленной дифференцировки индуцированных плюрипотентных стволовых клеток человека
EP3833365A4 (de) 2018-08-10 2022-05-11 Vertex Pharmaceuticals Incorporated Aus stammzellen gewonnene inseldifferenzierung
CN117982733A (zh) 2018-11-19 2024-05-07 美国政府(由卫生和人类服务部的部长所代表) 可生物降解的组织置换植入物及其用途
KR20200077222A (ko) 2018-12-20 2020-06-30 (주)영인바이오텍 통증완화부를 가지는 회복 운동 장치
KR20200077218A (ko) 2018-12-20 2020-06-30 (주)영인바이오텍 교체가능한 부품을 가지는 회복 운동 장치
US20220119765A1 (en) * 2019-01-22 2022-04-21 Korea University Research And Business Foundation Differentiation method of neural stem cells manufactured by direct cell conversion into astrocytes
AU2020256247A1 (en) * 2019-04-03 2021-10-28 The Johns Hopkins University Methods, compositions, and kits for producing skeletal muscle stem cells and treating disorders
EP3792346B1 (de) 2019-09-13 2023-07-26 Miltenyi Biotec B.V. & Co. KG Verfahren zur erzeugung einer zellzusammensetzung von dopaminergen vorläuferzellen des ventralen mittelhirns
WO2021097346A1 (en) 2019-11-14 2021-05-20 Amgen Inc. Hematopoietic precursor cell production
JP2023502785A (ja) * 2019-11-25 2023-01-25 ザ・ペン・ステイト・リサーチ・ファウンデイション ヒトグリア細胞をニューロンに変換するための組成物および方法
RU2732600C1 (ru) * 2019-12-26 2020-09-21 Федеральное государственное бюджетное научное учреждение "Медико-генетический научный центр имени академика Н.П. Бочкова" Ноотропная композиция на основе полипептидных комплексов, выделенных из нейрональных прогениторных клеток в условиях гипоксии, и способ ее получения
RU2752906C2 (ru) * 2019-12-26 2021-08-11 Федеральное государственное бюджетное научное учреждение "Медико-генетический научный центр имени академика Н.П. Бочкова" Ноотропная композиция на основе полипептидных комплексов, выделенных из нейрональных прогениторных клеток в условиях теплового шока, и способ ее получения
RU2732599C1 (ru) * 2019-12-26 2020-09-21 Федеральное государственное бюджетное научное учреждение "Медико-генетический научный центр имени академика Н.П. Бочкова" Ноотропная композиция на основе полипептидных комплексов, выделенных из глиальных прогениторных клеток в условиях теплового шока, и способ её получения
JP2023536210A (ja) 2020-05-29 2023-08-24 フジフィルム セルラー ダイナミクス，インコーポレイテッド 網膜色素上皮及び光受容体の二重層、並びにその使用
AU2021280343A1 (en) 2020-05-29 2022-12-08 FUJIFILM Cellular Dynamics, Inc. Retinal pigmented epithelium and photoreceptor dual cell aggregates and methods of use thereof
US12043823B2 (en) 2021-03-23 2024-07-23 Terumo Bct, Inc. Cell capture and expansion
US20240219375A1 (en) 2021-04-07 2024-07-04 FUJIFILM Cellular Dynamics, Inc. Dopaminergic precursor cells and methods of use
AU2022282379A1 (en) 2021-05-28 2023-11-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Biodegradable tissue scaffold with secondary matrix to host weakly adherent cells
EP4347795A1 (de) 2021-05-28 2024-04-10 The United States of America, as represented by The Secretary, Department of Health and Human Services Verfahren zur erzeugung von makula-, zentralen und peripheren retinapigmentepithelzellen
CN116478923B (zh) * 2022-04-26 2024-01-02 浙江霍德生物工程有限公司 一种星形胶质细胞的制备方法

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE239072T1 (de) 1991-06-18 2003-05-15 Arnold I Caplan Menschliche mesenchym-stammzellen aus dem mark und monoklonale antikörper spezifisch gegen diese zellen
ES2179821T3 (es) 1991-06-24 2003-02-01 Hcell Technology Inc Celulas pancreaticas secretoras de hormonas y mantenimiento en cultivo a largo plazo.
US5851832A (en) * 1991-07-08 1998-12-22 Neurospheres, Ltd. In vitro growth and proliferation of multipotent neural stem cells and their progeny
US5981165A (en) * 1991-07-08 1999-11-09 Neurospheres Holdings Ltd. In vitro induction of dopaminergic cells
EP0594669B9 (de) 1991-07-08 2008-03-19 NeuroSpheres Holdings Ltd. Auf Wachstumsfaktoren reagierende neurale Vorläuferzellen, die in vitro vermehrt werden können.
EP0597964A4 (de) 1991-08-07 1994-11-30 Einstein Coll Med Proliferation von vorläufern von hepatocyten.
US5849553A (en) * 1992-07-27 1998-12-15 California Institute Of Technology Mammalian multipotent neural stem cells
US5672499A (en) * 1992-07-27 1997-09-30 California Institute Of Technology Immoralized neural crest stem cells and methods of making
WO1994003199A1 (en) 1992-08-04 1994-02-17 Regeneron Pharmaceuticals, Inc. Method of enhancing differentiation and survival of neuronal precursor cells
US5766948A (en) * 1993-01-06 1998-06-16 The Regents Of The University Of California Method for production of neuroblasts
US5534404A (en) 1993-12-10 1996-07-09 Cytotherapeutics, Inc. Glucose responsive insulin secreting β-cell lines and method for producing same
US5639618A (en) * 1994-05-13 1997-06-17 Plurion, Inc. Method of isolating a lineage specific stem cell in vitro
US5476975A (en) * 1994-07-08 1995-12-19 Ruddick; John N. R. Extraction of toxic organic contaminants from wood and photodegradation of toxic organic contaminants
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
GB9807935D0 (en) * 1998-04-14 1998-06-10 Univ Edinburgh Lineage specific cells and progenitor cells
US5753506A (en) * 1996-05-23 1998-05-19 Cns Stem Cell Technology, Inc. Isolation propagation and directed differentiation of stem cells from embryonic and adult central nervous system of mammals
US6090622A (en) 1997-03-31 2000-07-18 The Johns Hopkins School Of Medicine Human embryonic pluripotent germ cells
US6361996B1 (en) * 1997-05-07 2002-03-26 University Of Utah Research Foundation Neuroepithelial stem cells and glial-restricted intermediate precursors
US6235527B1 (en) * 1997-11-29 2001-05-22 University Of Utah Research Foundation Lineage restricted glial precursors from the central nervous system
WO1999001159A1 (en) * 1997-07-04 1999-01-14 University Of Utah Research Foundation Lineage-restricted neuronal precursors
US7144997B2 (en) 1997-07-24 2006-12-05 Curis, Inc. Vertebrate embryonic patterning-inducing proteins, compositions and uses related therto
US5968829A (en) 1997-09-05 1999-10-19 Cytotherapeutics, Inc. Human CNS neural stem cells
JP3880795B2 (ja) 1997-10-23 2007-02-14 ジェロン・コーポレーション フィーダー細胞を含まない培養物中で、霊長類由来始原幹細胞を増殖させるための方法
DE19756864C5 (de) * 1997-12-19 2014-07-10 Oliver Brüstle Neurale Vorläuferzellen, Verfahren zu ihrer Herstellung und ihre Verwendung zur Therapie von neuralen Defekten
WO1999043785A1 (en) 1998-02-27 1999-09-02 Medical College Of Hampton Roads Derivation of cells and tissues from embryonic pre-stem cells for transplantation therapies
CA2324591A1 (en) 1998-04-09 1999-10-21 Bresagen Limited Cell differentiation/proliferation and maintenance factor and uses thereof
US5958767A (en) 1998-08-14 1999-09-28 The Children's Medical Center Corp. Engraftable human neural stem cells
DE19843234A1 (de) * 1998-09-09 2000-03-23 Inst Pflanzengenetik & Kultur Differenzierte Herzzellen mit pathologischen Merkmalen als in vitro-Modell für Herzerkrankungen
JP4709382B2 (ja) 1998-09-22 2011-06-22 ニューラルステム バイオファーマシューティカルズ、リミテッド 安定な神経幹細胞系
US6667176B1 (en) * 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
US6087168A (en) 1999-01-20 2000-07-11 Cedars Sinai Medical Center Conversion of non-neuronal cells into neurons: transdifferentiation of epidermal cells
EP1144671B1 (de) 1999-02-12 2007-11-07 StemCells, Inc. Angereicherte zentralnervensystem-zellpopulationen
US6238922B1 (en) * 1999-02-26 2001-05-29 Stemcells, Inc. Use of collagenase in the preparation of neural stem cell cultures
NZ514846A (en) 1999-03-17 2003-04-29 Univ Tennessee Res Corp RT-PCR of clonal neurospheres
WO2001000650A1 (en) 1999-06-30 2001-01-04 Advanced Cell Technology, Inc. Cytoplasmic transfer to de-differentiate recipient cells
WO2001046384A2 (en) 1999-12-23 2001-06-28 Cornell Research Foundation, Inc. A method for isolating and purifying multipotential neural progenitor cells and multipotential neural progenitor cells
US20050042749A1 (en) * 2001-05-16 2005-02-24 Carpenter Melissa K. Dopaminergic neurons and proliferation-competent precursor cells for treating Parkinson's disease
US6602711B1 (en) 2000-02-21 2003-08-05 Wisconsin Alumni Research Foundation Method of making embryoid bodies from primate embryonic stem cells
JP4889902B2 (ja) 2000-03-14 2012-03-07 イーエス・セル・インターナショナル・プライヴェート・リミテッド ヒト胚性幹（ｈＥＳ）細胞からヒト神経前駆細胞を作製する方法、並びに、該方法を利用したニューロンの作製方法、稀突起膠細胞又は星状細胞の作製方法
US6458589B1 (en) 2000-04-27 2002-10-01 Geron Corporation Hepatocyte lineage cells derived from pluripotent stem cells
AU2001259323A1 (en) 2000-05-01 2001-11-12 Sang-Hun Lee Derivation of midbrain dopaminergic neurons from embryonic stem cells
US8273570B2 (en) 2000-05-16 2012-09-25 Riken Process of inducing differentiation of embryonic cell to cell expressing neural surface marker using OP9 or PA6 cells
CN100580079C (zh) 2000-05-17 2010-01-13 杰龙公司 神经祖细胞群体
US7250294B2 (en) 2000-05-17 2007-07-31 Geron Corporation Screening small molecule drugs using neural cells differentiated from human embryonic stem cells
IL153095A0 (en) 2000-06-20 2003-06-24 Es Cell Int Pte Ltd Embryonic stem cells, methods for culturing the same and methods utilizing the same
JP3660601B2 (ja) 2001-03-30 2005-06-15 独立行政法人科学技術振興機構 胚性幹細胞からの神経幹細胞、運動ニューロン及びｇａｂａ作動性ニューロンの製造法
US20040247571A1 (en) 2001-04-23 2004-12-09 Xia Meijer Neural cells expressing tyrosine hydroxylase
US20030113910A1 (en) 2001-12-18 2003-06-19 Mike Levanduski Pluripotent stem cells derived without the use of embryos or fetal tissue
US7285415B2 (en) 2002-07-11 2007-10-23 The Regents Of The University Of California Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury
US7629169B2 (en) * 2004-12-01 2009-12-08 Stem Cell Therapeutics Corp. Methods for the production of platelet-derived growth factor-responsive neural precursor cells

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9018010B2 (en) 2009-11-12 2015-04-28 Technion Research & Development Foundation Limited Culture media, cell cultures and methods of culturing pluripotent stem cells in an undifferentiated state

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