IL151149A0 - Zinc finger domains and methods of identifying same - Google Patents

Zinc finger domains and methods of identifying same

Info

Publication number
IL151149A0
IL151149A0 IL15114901A IL15114901A IL151149A0 IL 151149 A0 IL151149 A0 IL 151149A0 IL 15114901 A IL15114901 A IL 15114901A IL 15114901 A IL15114901 A IL 15114901A IL 151149 A0 IL151149 A0 IL 151149A0
Authority
IL
Israel
Prior art keywords
zinc finger
finger domains
methods
identifying same
identifying
Prior art date
Application number
IL15114901A
Other languages
English (en)
Original Assignee
Toolgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toolgen Inc filed Critical Toolgen Inc
Publication of IL151149A0 publication Critical patent/IL151149A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702Regulators; Modulating activity

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Finger-Pressure Massage (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Materials For Medical Uses (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Adornments (AREA)
IL15114901A 2000-02-18 2001-02-17 Zinc finger domains and methods of identifying same IL151149A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20000007730 2000-02-18
PCT/KR2001/000244 WO2001060970A2 (en) 2000-02-18 2001-02-17 Zinc finger domains and methods of identifying same

Publications (1)

Publication Number Publication Date
IL151149A0 true IL151149A0 (en) 2003-04-10

Family

ID=36628390

Family Applications (1)

Application Number Title Priority Date Filing Date
IL15114901A IL151149A0 (en) 2000-02-18 2001-02-17 Zinc finger domains and methods of identifying same

Country Status (11)

Country Link
US (2) US20020061512A1 (de)
EP (1) EP1259597B1 (de)
JP (2) JP4156840B2 (de)
CN (1) CN1416467B (de)
AT (1) ATE359365T1 (de)
AU (1) AU781103B2 (de)
CA (1) CA2400772C (de)
DE (1) DE60127819T2 (de)
IL (1) IL151149A0 (de)
NZ (1) NZ521293A (de)
WO (1) WO2001060970A2 (de)

Families Citing this family (209)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7655249B2 (en) 1998-09-30 2010-02-02 Corixa Corporation Compositions and methods for WT1 specific immunotherapy
US7144581B2 (en) 2000-10-09 2006-12-05 Corixa Corporation Compositions and methods for WT1 specific immunotherapy
US7329410B1 (en) 1998-09-30 2008-02-12 Corixa Corporation Compositions and method for WT1 specific immunotherapy
US7901693B2 (en) 1998-09-30 2011-03-08 Corixa Corporation Compositions and methods for WT1 specific immunotherapy
US7115272B1 (en) 1998-09-30 2006-10-03 Corixa Corporation Compositions and methods for WT1 specific immunotherapy
US7063854B1 (en) 1998-09-30 2006-06-20 Corixa Corporation Composition and methods for WTI specific immunotherapy
WO2001088197A2 (en) * 2000-05-16 2001-11-22 Massachusetts Institute Of Technology Methods and compositions for interaction trap assays
US7029847B2 (en) 2000-05-16 2006-04-18 Massachusetts Institute Of Technology Methods and compositions for interaction trap assays
WO2002057308A2 (en) * 2001-01-22 2002-07-25 Sangamo Biosciences, Inc. Zinc finger polypeptides and their use
CN1289522C (zh) * 2001-08-17 2006-12-13 图尔金株式会社 锌指结构域文库
US7553494B2 (en) 2001-08-24 2009-06-30 Corixa Corporation WT1 fusion proteins
WO2003048345A1 (en) * 2001-12-07 2003-06-12 Toolgen, Inc. Phenotypic screen of chimeric proteins
US8799501B2 (en) * 2002-04-30 2014-08-05 Hewlett-Packard Development Company, L. P. System and method for anonymously sharing and scoring information pointers, within a system for harvesting community knowledge
EP1532178A4 (de) * 2002-06-11 2006-10-25 Scripps Research Inst Synthetische transkriptionsfaktoren
WO2004022575A2 (en) * 2002-09-05 2004-03-18 Toolgen, Inc. Bioinformatics analysis of cellular effects of artificial transcription factors
KR100766952B1 (ko) * 2002-12-09 2007-10-17 주식회사 툴젠 조절성 징크 핑거 단백질
CN1836048A (zh) * 2003-06-10 2006-09-20 图尔金株式会社 可转导的dna结合蛋白
US20120196370A1 (en) 2010-12-03 2012-08-02 Fyodor Urnov Methods and compositions for targeted genomic deletion
US7888121B2 (en) 2003-08-08 2011-02-15 Sangamo Biosciences, Inc. Methods and compositions for targeted cleavage and recombination
ES2808687T3 (es) 2003-08-08 2021-03-01 Sangamo Therapeutics Inc Métodos y composiciones para escisión dirigida y recombinación
WO2005028630A2 (en) 2003-09-19 2005-03-31 Sangamo Biosciences, Inc. Engineered zinc finger proteins for regulation of gene expression
KR20060123382A (ko) * 2003-12-23 2006-12-01 주식회사 툴젠 징크 핑거 단백질을 이용한 원핵세포의 유전자 발현 조절
CA2561714A1 (en) * 2004-04-08 2005-10-27 Sangamo Biosciences, Inc. Methods and compositions for treating neuropathic and neurodegenerative conditions
KR100857125B1 (ko) 2004-05-25 2008-09-11 주식회사 툴젠 단일클론 항체 생산을 증가시키는 폴리펩타이드, 이를코드하는 핵산 및 이의 용도
US20060063231A1 (en) 2004-09-16 2006-03-23 Sangamo Biosciences, Inc. Compositions and methods for protein production
JP2009502170A (ja) 2005-07-26 2009-01-29 サンガモ バイオサイエンシズ インコーポレイテッド 外来核酸配列の標的化された組込み及び発現
JP5266210B2 (ja) 2006-05-25 2013-08-21 サンガモ バイオサイエンシズ インコーポレイテッド 改変開裂ハーフドメイン
EP2447279B1 (de) 2006-05-25 2014-04-09 Sangamo BioSciences, Inc. Verfahren und Zusammensetzungen zur Gendeaktivierung
US9428756B2 (en) 2006-08-11 2016-08-30 Dow Agrosciences Llc Zinc finger nuclease-mediated homologous recombination
KR100812110B1 (ko) * 2006-10-24 2008-03-12 한국과학기술원 징크 핑거 단백질과 원핵 생물의 전사 인자를 포함하는인공 전사 인자의 제조 및 이의 이용
WO2008060510A2 (en) * 2006-11-13 2008-05-22 Sangamo Biosciences, Inc. Zinc finger nuclease for targeting the human glucocorticoid receptor locus
HUE029238T2 (en) 2006-12-14 2017-02-28 Dow Agrosciences Llc Optimized non-canonical zinc finger proteins
ATE489465T1 (de) 2007-04-26 2010-12-15 Sangamo Biosciences Inc Gezielte integration in die ppp1r12c-position
EP2171052B1 (de) 2007-07-12 2014-08-27 Sangamo BioSciences, Inc. Verfahren und zusammensetzung zur deaktivierung der alpha-1,6-fucosyltransferase-genexpression
US11235026B2 (en) 2007-09-27 2022-02-01 Sangamo Therapeutics, Inc. Methods and compositions for modulating PD1
EP2188384B1 (de) 2007-09-27 2015-07-15 Sangamo BioSciences, Inc. Schnelle in-vivo-identifizierung von biologisch aktiven nukleasen
US20110014616A1 (en) 2009-06-30 2011-01-20 Sangamo Biosciences, Inc. Rapid screening of biologically active nucleases and isolation of nuclease-modified cells
WO2009042164A1 (en) 2007-09-27 2009-04-02 Dow Agrosciences Llc Engineered zinc finger proteins targeting 5-enolpyruvyl shikimate-3-phosphate synthase genes
US8563314B2 (en) 2007-09-27 2013-10-22 Sangamo Biosciences, Inc. Methods and compositions for modulating PD1
WO2009054985A1 (en) 2007-10-25 2009-04-30 Sangamo Biosciences, Inc. Methods and compositions for targeted integration
ES2459880T3 (es) 2008-04-14 2014-05-12 Sangamo Biosciences, Inc. Construcciones donantes lineales para integración dirigida
KR101598867B1 (ko) 2008-04-30 2016-03-03 산바이오 인코포레이티드 Dna 메틸화에 변형을 가진 신경 재생 세포
AU2009260888B2 (en) 2008-05-28 2014-09-11 Sangamo Therapeutics, Inc. Compositions for linking DNA-binding domains and cleavage domains
US8597912B2 (en) 2008-06-10 2013-12-03 Sangamo Biosciences, Inc. Methods and compositions for generation of Bax-and Bak-deficient cell lines
KR20160015400A (ko) 2008-08-22 2016-02-12 상가모 바이오사이언스 인코포레이티드 표적화된 단일가닥 분할 및 표적화된 통합을 위한 방법 및 조성물
AU2009311697B2 (en) 2008-10-29 2014-12-18 Sangamo Therapeutics, Inc. Methods and compositions for inactivating glutamine synthetase gene expression
WO2010065123A1 (en) 2008-12-04 2010-06-10 Sangamo Biosciences, Inc. Genome editing in rats using zinc-finger nucleases
CA2747124C (en) 2008-12-17 2018-09-04 Dow Agrosciences Llc Targeted integration into the zp15 locus
JP5827132B2 (ja) 2009-02-04 2015-12-02 サンガモ バイオサイエンシズ インコーポレイテッド ニューロパチーを治療するための方法および組成物
EP2408921B1 (de) 2009-03-20 2017-04-19 Sangamo BioSciences, Inc. Modifikation von cxcr4 mit manipulierten zink-fingerproteinen
WO2010117464A1 (en) 2009-04-09 2010-10-14 Sangamo Biosciences, Inc. Targeted integration into stem cells
US8772008B2 (en) 2009-05-18 2014-07-08 Sangamo Biosciences, Inc. Methods and compositions for increasing nuclease activity
JP5866283B2 (ja) 2009-07-28 2016-02-17 サンガモ バイオサイエンシーズ, インコーポレイテッド トリヌクレオチド反復疾患を治療するための方法および組成物
NZ598457A (en) 2009-08-03 2014-06-27 Recombinetics Inc Methods and compositions for targeted gene modification
KR102262704B1 (ko) 2009-08-11 2021-06-09 상가모 테라퓨틱스, 인코포레이티드 표적화 변형에 대한 동형접합성 유기체
UA109418C2 (uk) 2009-10-22 2015-08-25 Конструйований білок з цинковими пальцями, направлений на гени рослин, залучені до біосинтезу жирних кислот
US8956828B2 (en) 2009-11-10 2015-02-17 Sangamo Biosciences, Inc. Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases
WO2011090804A1 (en) 2010-01-22 2011-07-28 Dow Agrosciences Llc Targeted genomic alteration
FR2955480B1 (fr) 2010-01-26 2012-01-06 Christian Choux Dispositif d'osteosynthese de la paroi thoracique
WO2011097036A1 (en) 2010-02-08 2011-08-11 Sangamo Biosciences, Inc. Engineered cleavage half-domains
EP2534163B1 (de) 2010-02-09 2015-11-04 Sangamo BioSciences, Inc. Gezielte genommodifikation mit partiell einsträngigen donatormolekülen
JP5952263B2 (ja) 2010-04-26 2016-07-13 サンガモ バイオサイエンシーズ, インコーポレイテッド ジンクフィンガーヌクレアーゼを使ったrosa遺伝子座のゲノム編集
WO2011139349A1 (en) 2010-05-03 2011-11-10 Sangamo Biosciences, Inc. Compositions for linking zinc finger modules
CN103025344B (zh) 2010-05-17 2016-06-29 桑格摩生物科学股份有限公司 新型dna-结合蛋白及其用途
JP6050230B2 (ja) 2010-07-21 2016-12-21 サンガモ バイオサイエンシーズ, インコーポレイテッド Hla遺伝子座の修飾のための方法及び組成物
US9566352B2 (en) 2010-09-27 2017-02-14 Sangamo Biosciences, Inc. Methods and compositions for inhibiting viral entry into cells
ES2562421T3 (es) 2010-10-12 2016-03-04 The Children's Hospital Of Philadelphia Métodos y composiciones para tratar la hemofilia B
US9267123B2 (en) 2011-01-05 2016-02-23 Sangamo Biosciences, Inc. Methods and compositions for gene correction
EP2694554A1 (de) 2011-04-08 2014-02-12 Gilead Biologics, Inc. Verfahren und zusammensetzungen zur normalisierung einer tumorvaskulatur mittels loxl2-hemmung
CA2841541C (en) 2011-07-25 2019-11-12 Sangamo Biosciences, Inc. Methods and compositions for alteration of a cystic fibrosis transmembrane conductance regulator (cftr) gene
SG10201811736QA (en) 2011-09-21 2019-02-27 Sangamo Therapeutics Inc Methods and compositions for regulation of transgene expression
BR112014008456A2 (pt) * 2011-10-11 2017-04-11 Aliophtha Ag regulação da expressão de receptor mediante distribuição de fatores de transcrição artificiais
WO2013063315A2 (en) 2011-10-27 2013-05-02 Sangamo Biosciences, Inc. Methods and compositions for modification of the hprt locus
JP6144691B2 (ja) 2011-11-16 2017-06-07 サンガモ セラピューティクス, インコーポレイテッド 修飾されたdna結合タンパク質およびその使用
AU2013211934B2 (en) 2012-01-27 2017-09-14 Sanbio, Inc. Methods and compositions for modulating angiogenesis and vasculogenesis
EP2820159B1 (de) 2012-02-29 2019-10-23 Sangamo Therapeutics, Inc. Verfahren und zusammensetzungen zur behandlung der huntington-krankheit
CN102634535B (zh) * 2012-04-12 2014-11-26 西北农林科技大学 一种基于锌指蛋白插入载体的随机锌指蛋白库的构建方法
KR102091298B1 (ko) 2012-05-02 2020-03-19 다우 아그로사이언시즈 엘엘씨 말산 탈수소효소의 표적화된 변형
JP6559063B2 (ja) 2012-05-07 2019-08-14 サンガモ セラピューティクス, インコーポレイテッド 導入遺伝子のヌクレアーゼ媒介標的化組み込みのための方法および組成物
EP3444342B1 (de) 2012-07-11 2020-05-27 Sangamo Therapeutics, Inc. Verfahren und zusammensetzungen zur behandlung von lysosomalen speicherkrankheiten
EP2872154B1 (de) 2012-07-11 2017-05-31 Sangamo BioSciences, Inc. Verfahren und zusammensetzungen zur freisetzung von biologischen wirkstoffen
US10648001B2 (en) 2012-07-11 2020-05-12 Sangamo Therapeutics, Inc. Method of treating mucopolysaccharidosis type I or II
KR102474010B1 (ko) 2012-08-29 2022-12-02 상가모 테라퓨틱스, 인코포레이티드 유전적 병태를 치료하기 위한 방법 및 조성물
UA118090C2 (uk) 2012-09-07 2018-11-26 ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі Спосіб інтегрування послідовності нуклеїнової кислоти, що представляє інтерес, у ген fad2 у клітині сої та специфічний для локусу fad2 білок, що зв'язується, здатний індукувати спрямований розрив
UA119135C2 (uk) 2012-09-07 2019-05-10 ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі Спосіб отримання трансгенної рослини
US9914930B2 (en) 2012-09-07 2018-03-13 Dow Agrosciences Llc FAD3 performance loci and corresponding target site specific binding proteins capable of inducing targeted breaks
JP6401704B2 (ja) 2012-10-10 2018-10-10 サンガモ セラピューティクス, インコーポレイテッド T細胞を修飾する化合物およびその使用
AU2013355327A1 (en) 2012-12-05 2015-06-11 Sangamo Therapeutics, Inc. Methods and compositions for regulation of metabolic disorders
RU2015128052A (ru) 2012-12-13 2017-01-19 Дау Агросайенсиз Ллс Точный таргетинг генов в отношении конкретного локуса кукурузы
JP6491113B2 (ja) 2013-02-25 2019-03-27 サンガモ セラピューティクス, インコーポレイテッド ヌクレアーゼ媒介性遺伝子破壊を増強するための方法および組成物
CA2906970C (en) 2013-03-21 2021-05-18 Ospedale San Raffaele Srl Targeted disruption of t cell receptor genes using engineered zinc finger protein nucleases
EP2981166B1 (de) 2013-04-05 2020-09-09 Dow AgroSciences LLC Verfahren und zusammensetzungen zur integration einer exogenen sequenz in das genom von pflanzen
EP3730615A3 (de) 2013-05-15 2020-12-09 Sangamo Therapeutics, Inc. Verfahren und zusammensetzungen zur behandlung eines genetischen leidens
JP6588438B2 (ja) 2013-08-28 2019-10-09 サンガモ セラピューティクス, インコーポレイテッド Dna結合ドメインと切断ドメインとを連結するための組成物
CN105899665B (zh) 2013-10-17 2019-10-22 桑格摩生物科学股份有限公司 用于核酸酶介导的基因组工程改造的递送方法和组合物
CA2926078C (en) 2013-10-17 2021-11-16 Sangamo Biosciences, Inc. Delivery methods and compositions for nuclease-mediated genome engineering in hematopoietic stem cells
EP3065540B1 (de) 2013-11-04 2021-12-15 Corteva Agriscience LLC Optimale maispflanzen
TWI721478B (zh) 2013-11-04 2021-03-11 美商陶氏農業科學公司 最適玉米基因座(二)
EP3066202B1 (de) 2013-11-04 2021-03-03 Dow AgroSciences LLC Optimale sojabohnen-loci
TWI659103B (zh) 2013-11-04 2019-05-11 陶氏農業科學公司 最適大豆基因座(二)
US10369201B2 (en) 2013-11-11 2019-08-06 Sangamo Therapeutics, Inc. Methods and compositions for treating Huntington's disease
SI3068881T1 (sl) 2013-11-13 2019-05-31 Children's Medical Center Corporation Z nukleazo posredovano uravnavanje izražanja genov
JP6535684B2 (ja) 2013-12-09 2019-06-26 サンガモ セラピューティクス, インコーポレイテッド ゲノム操作のための方法および組成物
CA2939942A1 (en) 2014-02-24 2015-08-27 Sangamo Biosciences, Inc. Methods and compositions for nuclease-mediated targeted integration
WO2015143046A2 (en) 2014-03-18 2015-09-24 Sangamo Biosciences, Inc. Methods and compositions for regulation of zinc finger protein expression
WO2015164748A1 (en) 2014-04-24 2015-10-29 Sangamo Biosciences, Inc. Engineered transcription activator like effector (tale) proteins
WO2015171932A1 (en) 2014-05-08 2015-11-12 Sangamo Biosciences, Inc. Methods and compositions for treating huntington's disease
WO2015175642A2 (en) 2014-05-13 2015-11-19 Sangamo Biosciences, Inc. Methods and compositions for prevention or treatment of a disease
US9970001B2 (en) 2014-06-05 2018-05-15 Sangamo Therapeutics, Inc. Methods and compositions for nuclease design
CA2954201A1 (en) 2014-07-08 2016-01-14 Vib Vzw Means and methods to increase plant yield
EP3169778B1 (de) 2014-07-14 2023-10-25 Washington State University Nanos-knock-out zur abladierung von keimbahnzellen
US11278572B2 (en) 2014-07-18 2022-03-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Reducing CXCR4 expression and/or function to enhance engraftment of hematopoietic stem cells
US9757420B2 (en) 2014-07-25 2017-09-12 Sangamo Therapeutics, Inc. Gene editing for HIV gene therapy
WO2016014794A1 (en) 2014-07-25 2016-01-28 Sangamo Biosciences, Inc. Methods and compositions for modulating nuclease-mediated genome engineering in hematopoietic stem cells
WO2016019144A2 (en) 2014-07-30 2016-02-04 Sangamo Biosciences, Inc. Gene correction of scid-related genes in hematopoietic stem and progenitor cells
EP3878948A1 (de) 2014-09-16 2021-09-15 Sangamo Therapeutics, Inc. Verfahren und zusammensetzungen für nukleasevermitteltes genom-engineering und korrektur bei hämotopoietischen stammzellen
US10889834B2 (en) 2014-12-15 2021-01-12 Sangamo Therapeutics, Inc. Methods and compositions for enhancing targeted transgene integration
EP3247366A4 (de) 2015-01-21 2018-10-31 Sangamo Therapeutics, Inc. Verfahren und zusammensetzungen zur identifizierung hochspezifischer nukleasen
WO2016161446A1 (en) 2015-04-03 2016-10-06 Dana-Farber Cancer Institute, Inc. Composition and methods of genome editing of b-cells
US10179918B2 (en) 2015-05-07 2019-01-15 Sangamo Therapeutics, Inc. Methods and compositions for increasing transgene activity
SG10202112057QA (en) 2015-05-12 2021-12-30 Sangamo Therapeutics Inc Nuclease-mediated regulation of gene expression
US9957501B2 (en) 2015-06-18 2018-05-01 Sangamo Therapeutics, Inc. Nuclease-mediated regulation of gene expression
CA2991301A1 (en) 2015-07-13 2017-01-19 Sangamo Therapeutics, Inc. Delivery methods and compositions for nuclease-mediated genome engineering
EP4361279A2 (de) 2015-08-06 2024-05-01 The Curators of the University of Missouri Pathogenresistente tiere mit modifizierten cd163-genen
EP3352776A4 (de) 2015-09-23 2019-03-13 Sangamo Therapeutics, Inc. Htt-repressoren und verwendungen davon
CA3004349A1 (en) 2015-11-23 2017-06-01 Sangamo Therapeutics, Inc. Methods and compositions for engineering immunity
US11352631B2 (en) 2015-12-18 2022-06-07 Sangamo Therapeutics, Inc. Targeted disruption of the T cell receptor
IL297018A (en) 2015-12-18 2022-12-01 Sangamo Therapeutics Inc Directed cleavage of cell mhc receptor
SG11201805680SA (en) 2016-01-15 2018-07-30 Sangamo Therapeutics Inc Methods and compositions for the treatment of neurologic disease
JP7012650B2 (ja) 2016-02-02 2022-01-28 サンガモ セラピューティクス, インコーポレイテッド Dna結合ドメインと切断ドメインとを連結するための組成物
WO2017165655A1 (en) 2016-03-23 2017-09-28 Dana-Farber Cancer Institute, Inc. Methods for enhancing the efficiency of gene editing
WO2018013840A1 (en) 2016-07-13 2018-01-18 Vertex Pharmaceuticals Incorporated Methods, compositions and kits for increasing genome editing efficiency
CA3031818A1 (en) 2016-07-27 2018-02-01 Case Western Reserve University Compounds and methods of promoting myelination
US11193136B2 (en) 2016-08-09 2021-12-07 Vib Vzw Cellulose synthase inhibitors and mutant plants
IL264639B2 (en) 2016-08-24 2024-01-01 Sangamo Therapeutics Inc Regulation of globulin gene expression using transgenic nucleases with zinc neurites
BR112019003327A2 (pt) 2016-08-24 2019-07-02 Sangamo Therapeutics Inc nucleases manipuladas de alvo específico
US10960085B2 (en) 2016-09-07 2021-03-30 Sangamo Therapeutics, Inc. Modulation of liver genes
EP3519433A1 (de) 2016-10-03 2019-08-07 Juno Therapeutics, Inc. Hpv-spezifische bindungsmoleküle
DK3757120T3 (da) 2016-10-04 2022-07-25 Prec Biosciences Inc Co-stimulerende domæner til anvendelse i genetisk modificerede celler
CN110022904B (zh) 2016-10-20 2024-04-19 桑格摩生物治疗股份有限公司 用于治疗法布里病的方法和组合物
AU2017347928A1 (en) 2016-10-31 2019-05-09 Sangamo Therapeutics, Inc. Gene correction of scid-related genes in hematopoietic stem and progenitor cells
AU2017367722B2 (en) 2016-12-01 2024-02-01 Sangamo Therapeutics, Inc. Tau modulators and methods and compositions for delivery thereof
CA3046199A1 (en) 2016-12-08 2018-06-14 Case Western Reserve University Methods and compositions for enhancing functional myelin production
SG11201906948UA (en) 2017-04-20 2019-08-27 Univ Oregon Health & Science Human gene correction
AU2018261366A1 (en) 2017-05-03 2019-10-31 Sangamo Therapeutics, Inc. Methods and compositions for modification of a cystic fibrosis transmembrane conductance regulator (CTFR) gene
CA3062698A1 (en) 2017-05-08 2018-11-15 Precision Biosciences, Inc. Nucleic acid molecules encoding an engineered antigen receptor and an inhibitory nucleic acid molecule and methods of use thereof
US11512287B2 (en) 2017-06-16 2022-11-29 Sangamo Therapeutics, Inc. Targeted disruption of T cell and/or HLA receptors
US11053484B2 (en) 2017-06-30 2021-07-06 Precision Biosciences, Inc. Genetically-modified T cells comprising a modified intron in the T cell receptor alpha gene
SG11202002728VA (en) 2017-10-03 2020-04-29 Juno Therapeutics Inc Hpv-specific binding molecules
US20200239544A1 (en) 2017-10-03 2020-07-30 Precision Biosciences, Inc. Modified epidermal growth factor receptor peptides for use in genetically-modified cells
WO2019089913A1 (en) 2017-11-01 2019-05-09 Precision Biosciences, Inc. Engineered nucleases that target human and canine factor viii genes as a treatment for hemophilia a
SG11202004003YA (en) 2017-11-09 2020-05-28 Sangamo Therapeutics Inc Genetic modification of cytokine inducible sh2-containing protein (cish) gene
IL276080B2 (en) 2018-01-17 2023-10-01 Vertex Pharma DNA-PK suppressor compounds, UTP-containing preparations and their uses
KR20200110687A (ko) 2018-01-17 2020-09-24 버텍스 파마슈티칼스 인코포레이티드 유전체 편집 효율을 증가시키기 위한 퀴녹살리논 화합물, 조성물, 방법 및 키트
WO2019143675A1 (en) 2018-01-17 2019-07-25 Vertex Pharmaceuticals Incorporated Dna-pk inhibitors
AU2019218118A1 (en) 2018-02-08 2020-08-13 Sangamo Therapeutics, Inc. Engineered target specific nucleases
PE20201345A1 (es) 2018-04-05 2020-11-25 Juno Therapeutics Inc Receptores de celulas t, y celulas disenadas que expresan los mismos
EP3775238A1 (de) 2018-04-05 2021-02-17 Juno Therapeutics, Inc. Verfahren zur herstellung von zellen, die einen rekombinanten rezeptor exprimieren, und verwandte zusammensetzungen
CA3095084A1 (en) 2018-04-05 2019-10-10 Juno Therapeutics, Inc. T cells expressing a recombinant receptor, related polynucleotides and methods
CN112313246A (zh) 2018-04-18 2021-02-02 桑格摩生物治疗股份有限公司 用于调节亨廷顿蛋白(htt)的锌指蛋白组合物
US11690921B2 (en) 2018-05-18 2023-07-04 Sangamo Therapeutics, Inc. Delivery of target specific nucleases
CA3109592A1 (en) 2018-08-23 2020-02-27 Sangamo Therapeutics, Inc. Engineered target specific base editors
CN113015741A (zh) 2018-09-18 2021-06-22 桑格摩生物治疗股份有限公司 程序性细胞死亡1(pd1)特异性核酸酶
EP3898661A1 (de) 2018-12-21 2021-10-27 Precision BioSciences, Inc. Genetische modifikation des hydroxysäure-oxidase-1-gens zur behandlung von primärer hyperoxalurie
AU2020205717A1 (en) 2019-01-11 2021-08-12 Acuitas Therapeutics, Inc. Lipids for lipid nanoparticle delivery of active agents
CN112805026A (zh) 2019-02-06 2021-05-14 桑格摩生物治疗股份有限公司 用于治疗i型黏多糖贮积症的方法
SG11202110776TA (en) 2019-04-02 2021-10-28 Sangamo Therapeutics Inc Methods for the treatment of beta-thalassemia
CA3135799A1 (en) 2019-04-03 2020-10-08 Precision Biosciences, Inc. Genetically-modified immune cells comprising a microrna-adapted shrna (shrnamir)
WO2020206231A1 (en) 2019-04-05 2020-10-08 Precision Biosciences, Inc. Methods of preparing populations of genetically-modified immune cells
TW202104249A (zh) 2019-04-23 2021-02-01 美商聖加莫治療股份有限公司 染色體9開放讀框72基因表現之調節子及其用途
BR112021021200A2 (pt) 2019-05-01 2021-12-21 Juno Therapeutics Inc Células expressando um receptor quimérico de um locus cd247 modificado, polinucleotídeos relacionados e métodos
BR112021021075A2 (pt) 2019-05-01 2021-12-14 Editas Medicine Inc Células que expressam um receptor recombinante de um locus de tgfbr2 modificado, polinucleotídeos relacionados e métodos
US20220273715A1 (en) 2019-07-25 2022-09-01 Precision Biosciences, Inc. Compositions and methods for sequential stacking of nucleic acid sequences into a genomic locus
JP2022544825A (ja) 2019-08-20 2022-10-21 プレシジョン バイオサイエンシズ,インク. 細胞免疫療法のためのリンパ球枯渇投与レジメン
WO2021035170A1 (en) 2019-08-21 2021-02-25 Precision Biosciences, Inc. Compositions and methods for tcr reprogramming using fusion proteins
US20230002459A1 (en) 2019-10-02 2023-01-05 Sangamo Therapeutics, Inc. Zinc Finger Protein Transcription Factors for Treatment of Prion Disease
EP4041754A1 (de) 2019-10-02 2022-08-17 Sangamo Therapeutics, Inc. Zinkfingerprotein-transkriptionsfaktoren zur hemmung der alpha-synnuclein expression
WO2021087305A1 (en) 2019-10-30 2021-05-06 Precision Biosciences, Inc. Cd20 chimeric antigen receptors and methods of use for immunotherapy
EP4051787A1 (de) 2019-11-01 2022-09-07 Sangamo Therapeutics, Inc. Gin-rekombinasevarianten
US20230036065A1 (en) 2019-12-06 2023-02-02 Precision Biosciences, Inc. Methods for cancer immunotherapy
AU2021209699A1 (en) 2020-01-22 2022-07-21 Sangamo Therapeutics, Inc. Zinc finger protein transcription factors for repressing tau expression
WO2021158915A1 (en) 2020-02-06 2021-08-12 Precision Biosciences, Inc. Recombinant adeno-associated virus compositions and methods for producing and using the same
US20230263121A1 (en) 2020-03-31 2023-08-24 Elo Life Systems Modulation of endogenous mogroside pathway genes in watermelon and other cucurbits
AU2021268253A1 (en) 2020-05-06 2022-12-08 Cellectis S.A. Methods for targeted insertion of exogenous sequences in cellular genomes
JP2023525510A (ja) 2020-05-06 2023-06-16 セレクティス ソシエテ アノニム 治療用タンパク質の送達のために細胞を遺伝子改変する方法
US20230183664A1 (en) 2020-05-11 2023-06-15 Precision Biosciences, Inc. Self-limiting viral vectors encoding nucleases
KR20230022868A (ko) 2020-05-13 2023-02-16 주노 쎄러퓨티크스 인코퍼레이티드 재조합 수용체를 발현하는 공여자-배치 세포의 제조 방법
EP4171616A1 (de) 2020-06-26 2023-05-03 Juno Therapeutics GmbH Manipulierte t-zellen zur bedingten expression eines rekombinanten rezeptors, zugehörige polynukleotide und verfahren
AU2021308681A1 (en) 2020-07-16 2023-03-09 Acuitas Therapeutics, Inc. Cationic lipids for use in lipid nanoparticles
WO2022035793A1 (en) 2020-08-10 2022-02-17 Precision Biosciences, Inc. Antibodies and fragments specific for b-cell maturation antigen and uses thereof
US20220064596A1 (en) 2020-08-25 2022-03-03 Kite Pharma, Inc. T cells with improved functionality
CN116261594A (zh) 2020-09-25 2023-06-13 桑格摩生物治疗股份有限公司 用于核碱基编辑的锌指融合蛋白
US20230365995A1 (en) 2020-10-07 2023-11-16 Precision Biosciences, Inc. Lipid nanoparticle compositions
MX2023004761A (es) 2020-10-23 2023-07-17 Elo Life Systems Inc Metodos para producir plantas de vainilla con mejor sabor y produccion agronomica.
US20230398148A1 (en) 2020-11-04 2023-12-14 Juno Therapeutics, Inc. Cells expressing a chimeric receptor from a modified invariant cd3 immunoglobulin superfamily chain locus and related polynucleotides and methods
EP4243609A1 (de) 2020-11-16 2023-09-20 Pig Improvement Company UK Limited Influenza-a-resistente tiere mit bearbeiteten anp32-genen
WO2022165111A1 (en) 2021-01-28 2022-08-04 Precision Biosciences, Inc. Modulation of tgf beta signaling in genetically-modified eukaryotic cells
US20240141311A1 (en) 2021-04-22 2024-05-02 North Carolina State University Compositions and methods for generating male sterile plants
WO2023064872A1 (en) 2021-10-14 2023-04-20 Precision Biosciences, Inc. Combinations of anti-bcma car t cells and gamma secretase inhibitors
CA3235185A1 (en) 2021-10-19 2023-04-27 Cassandra GORSUCH Gene editing methods for treating alpha-1 antitrypsin (aat) deficiency
WO2023081900A1 (en) 2021-11-08 2023-05-11 Juno Therapeutics, Inc. Engineered t cells expressing a recombinant t cell receptor (tcr) and related systems and methods
WO2023091910A1 (en) 2021-11-16 2023-05-25 Precision Biosciences, Inc. Methods for cancer immunotherapy
WO2023105244A1 (en) 2021-12-10 2023-06-15 Pig Improvement Company Uk Limited Editing tmprss2/4 for disease resistance in livestock
WO2023122722A1 (en) 2021-12-22 2023-06-29 Sangamo Therapeutics, Inc. Novel zinc finger fusion proteins for nucleobase editing
WO2023131616A1 (en) 2022-01-05 2023-07-13 Vib Vzw Means and methods to increase abiotic stress tolerance in plants
WO2023131637A1 (en) 2022-01-06 2023-07-13 Vib Vzw Improved silage grasses
WO2023144199A1 (en) 2022-01-26 2023-08-03 Vib Vzw Plants having reduced levels of bitter taste metabolites
WO2024013514A2 (en) 2022-07-15 2024-01-18 Pig Improvement Company Uk Limited Gene edited livestock animals having coronavirus resistance
WO2024100604A1 (en) 2022-11-09 2024-05-16 Juno Therapeutics Gmbh Methods for manufacturing engineered immune cells

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5763209A (en) * 1988-09-26 1998-06-09 Arch Development Corporation Methods and materials relating to the functional domains of DNA binding proteins
US5223409A (en) * 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5096815A (en) * 1989-01-06 1992-03-17 Protein Engineering Corporation Generation and selection of novel dna-binding proteins and polypeptides
US5283173A (en) * 1990-01-24 1994-02-01 The Research Foundation Of State University Of New York System to detect protein-protein interactions
US6107059A (en) * 1992-04-29 2000-08-22 Affymax Technologies N.V. Peptide library and screening method
DE69333969T2 (de) * 1992-10-30 2006-09-14 The General Hospital Corp., Boston Wechselwirkendes Fallensystem zur Isolierung von Proteinen
US6242568B1 (en) * 1994-01-18 2001-06-05 The Scripps Research Institute Zinc finger protein derivatives and methods therefor
US6140466A (en) * 1994-01-18 2000-10-31 The Scripps Research Institute Zinc finger protein derivatives and methods therefor
US5882941A (en) * 1994-05-04 1999-03-16 Massachusette Institute Of Technology Programmable genotoxic agents and uses therefor
AU698152B2 (en) * 1994-08-20 1998-10-22 Gendaq Limited Improvements in or relating to binding proteins for recognition of DNA
US6326166B1 (en) * 1995-12-29 2001-12-04 Massachusetts Institute Of Technology Chimeric DNA-binding proteins
US5789538A (en) * 1995-02-03 1998-08-04 Massachusetts Institute Of Technology Zinc finger proteins with high affinity new DNA binding specificities
US5869250A (en) * 1996-12-02 1999-02-09 The University Of North Carolina At Chapel Hill Method for the identification of peptides that recognize specific DNA sequences
GB9710809D0 (en) * 1997-05-23 1997-07-23 Medical Res Council Nucleic acid binding proteins
US20030166109A1 (en) * 1997-09-18 2003-09-04 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US6453242B1 (en) * 1999-01-12 2002-09-17 Sangamo Biosciences, Inc. Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
US6534261B1 (en) * 1999-01-12 2003-03-18 Sangamo Biosciences, Inc. Regulation of endogenous gene expression in cells using zinc finger proteins
US6599692B1 (en) * 1999-09-14 2003-07-29 Sangamo Bioscience, Inc. Functional genomics using zinc finger proteins
IL150069A0 (en) * 1999-12-06 2002-12-01 Sangamo Biosciences Inc Methods of using randomized libraries of zinc finger proteins for the identification of gene function
US6689558B2 (en) * 2000-02-08 2004-02-10 Sangamo Biosciences, Inc. Cells for drug discovery
WO2001088197A2 (en) * 2000-05-16 2001-11-22 Massachusetts Institute Of Technology Methods and compositions for interaction trap assays
AU2002228841C1 (en) * 2000-12-07 2006-11-23 Sangamo Biosciences, Inc Regulation of angiogenesis with zinc finger proteins

Also Published As

Publication number Publication date
NZ521293A (en) 2004-06-25
WO2001060970A2 (en) 2001-08-23
US20020061512A1 (en) 2002-05-23
EP1259597A4 (de) 2003-08-27
JP4156840B2 (ja) 2008-09-24
WO2001060970A3 (en) 2002-02-07
ATE359365T1 (de) 2007-05-15
AU3771901A (en) 2001-08-27
JP2003523195A (ja) 2003-08-05
CN1416467B (zh) 2012-07-04
DE60127819T2 (de) 2007-12-27
CA2400772C (en) 2008-05-13
EP1259597B1 (de) 2007-04-11
CA2400772A1 (en) 2001-08-23
US20070087371A1 (en) 2007-04-19
DE60127819D1 (de) 2007-05-24
JP4584840B2 (ja) 2010-11-24
AU781103B2 (en) 2005-05-05
CN1416467A (zh) 2003-05-07
JP2006149395A (ja) 2006-06-15
EP1259597A2 (de) 2002-11-27

Similar Documents

Publication Publication Date Title
IL151149A0 (en) Zinc finger domains and methods of identifying same
MY136095A (en) Use of human anti-ctla-4 antibodies for treatment of cancer
MXPA05005398A (es) Meta para terapia de deterioro cognitivo.
WO2003089457A3 (en) Peptide inhibitors of protein kinase c ϝ for pain management
DE60026452D1 (de) Verfahren zur Identifizierung von Peptidensequenzen und Proteinensequenzen mittels Massenspektromterie
IL152637A0 (en) Automatic, real time and complete identification of vehicles
EP1319178A4 (de) Verfahren zum identifizieren von krebsmarkierungen und verwendungen dafür bei der krebsdiagnose
DE60018907D1 (de) Verfahren und zusammensetzung zur zementierung von bohrlöchern
WO2004000094A3 (en) Predictive markers in cancer therapy
EP1034188A4 (de) Verfahren zum entwerfen von agonisten und antagonisten des igf-rezeptors
WO2003103581A3 (en) COMPOSITIONS AND METHODS FOR LIVER GROWTH AND PROTECTION
DE60124666D1 (de) Verfahren zur hydrierung von conjugierten dienpolymeren und copolymeren
MXPA03003682A (es) Metodo para determinar la coagulabilidad y el potencial hemostatico globales.
ATE331841T1 (de) Verfahren zum einbauen von weichen in geleisse sowie weiche zur durchführung dieses verfahrens
ATE513040T1 (de) Zinkfingerdomänenbibliotheken
PL360638A1 (en) Method of target tracing and target tracing system
DE50006521D1 (de) Verfahren zur aktivierung von passiviertem eisen
DE60044350D1 (de) Prostata-spezifisches gen pcgem1 und methoden zu dessen verwendung zur erkennung, behandlung und prävention von prostatakrebs
AU2002323374A1 (en) Phenylalanine ammonia lyase polypeptide and polynucleotide sequences and methods of obtaining and using same
ATE309370T1 (de) Retinoid-metabolisierendes protein
EP1385993B8 (de) Verfahren zur bestimmung und behandlung von tuberöse-sklerose komplex assoziierten erkrankungen
MXPA02011558A (es) Inhibidores de mmp-2/mp-9 novedosos.
IL139144A0 (en) Mycobacterial inhibitors
WO2002044417A3 (en) Expression analysis of inhibitor of differentiation nucleic acids and polypeptides useful in the diagnosis and treatment of prostate cancer
WO2003066639A3 (en) Methods for identifying targeting domains and methods and compositions comprising the same