IL147990A0 - Multipotent adult stem cells and methods for isolation - Google Patents

Multipotent adult stem cells and methods for isolation

Info

Publication number
IL147990A0
IL147990A0 IL14799000A IL14799000A IL147990A0 IL 147990 A0 IL147990 A0 IL 147990A0 IL 14799000 A IL14799000 A IL 14799000A IL 14799000 A IL14799000 A IL 14799000A IL 147990 A0 IL147990 A0 IL 147990A0
Authority
IL
Israel
Prior art keywords
isolation
methods
stem cells
adult stem
multipotent adult
Prior art date
Application number
IL14799000A
Other languages
English (en)
Original Assignee
Mcl Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mcl Llc filed Critical Mcl Llc
Publication of IL147990A0 publication Critical patent/IL147990A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/46432—Nervous system antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5156—Animal cells expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/105—Insulin-like growth factors [IGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/135—Platelet-derived growth factor [PDGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/235—Leukemia inhibitory factor [LIF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
IL14799000A 1999-08-05 2000-08-04 Multipotent adult stem cells and methods for isolation IL147990A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14732499P 1999-08-05 1999-08-05
US16465099P 1999-11-10 1999-11-10
PCT/US2000/021387 WO2001011011A2 (en) 1999-08-05 2000-08-04 Multipotent adult stem cells and methods for isolation

Publications (1)

Publication Number Publication Date
IL147990A0 true IL147990A0 (en) 2002-09-12

Family

ID=26844814

Family Applications (4)

Application Number Title Priority Date Filing Date
IL14799000A IL147990A0 (en) 1999-08-05 2000-08-04 Multipotent adult stem cells and methods for isolation
IL147990A IL147990A (en) 1999-08-05 2002-02-04 Population of multipotent adult stem cells expressing telomerase and being cd45-and glycophorin a-, methods for their preparation and uses
IL192762A IL192762A (en) 1999-08-05 2008-07-10 Method for identifying cell differentiation factors
IL210618A IL210618A (en) 1999-08-05 2011-01-13 Cell cultures containing isolated and multiplied human cells other than embryonic and germ cells, pharmaceutical preparations containing them, methods of preparation, and methods for identifying modulators and differentiation factors.

Family Applications After (3)

Application Number Title Priority Date Filing Date
IL147990A IL147990A (en) 1999-08-05 2002-02-04 Population of multipotent adult stem cells expressing telomerase and being cd45-and glycophorin a-, methods for their preparation and uses
IL192762A IL192762A (en) 1999-08-05 2008-07-10 Method for identifying cell differentiation factors
IL210618A IL210618A (en) 1999-08-05 2011-01-13 Cell cultures containing isolated and multiplied human cells other than embryonic and germ cells, pharmaceutical preparations containing them, methods of preparation, and methods for identifying modulators and differentiation factors.

Country Status (11)

Country Link
US (1) US10006004B2 (ja)
EP (2) EP2348104A1 (ja)
JP (9) JP5398941B2 (ja)
AT (1) ATE514772T1 (ja)
CA (2) CA2381292C (ja)
DK (1) DK1226233T3 (ja)
HK (1) HK1049350B (ja)
IL (4) IL147990A0 (ja)
NZ (1) NZ517002A (ja)
PT (1) PT1226233E (ja)
WO (1) WO2001011011A2 (ja)

Families Citing this family (146)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6787355B1 (en) * 1996-08-26 2004-09-07 Mcgill University Multipotent neural stem cells from peripheral tissues and uses thereof
US6440734B1 (en) 1998-09-25 2002-08-27 Cytomatrix, Llc Methods and devices for the long-term culture of hematopoietic progenitor cells
US6548299B1 (en) 1999-11-12 2003-04-15 Mark J. Pykett Lymphoid tissue-specific cell production from hematopoietic progenitor cells in three-dimensional devices
US7759113B2 (en) 1999-04-30 2010-07-20 The General Hospital Corporation Fabrication of tissue lamina using microfabricated two-dimensional molds
AU2003901668A0 (en) 2003-03-28 2003-05-01 Medvet Science Pty. Ltd. Non-haemopoietic precursor cells
AUPQ147799A0 (en) 1999-07-07 1999-07-29 Medvet Science Pty. Ltd. Mesenchymal precursor cell
US8062675B2 (en) 1999-07-07 2011-11-22 Angioblast Systems, Inc. Mesenchymal precursor cell
US7670628B2 (en) 1999-07-07 2010-03-02 Angioblast Systems, Inc. Mesenchymal precursor cell
US7015037B1 (en) 1999-08-05 2006-03-21 Regents Of The University Of Minnesota Multiponent adult stem cells and methods for isolation
ATE514772T1 (de) * 1999-08-05 2011-07-15 Abt Holding Co Multipotente erwachsene stammzellen und verfahren zu deren isolierung
US8147824B2 (en) 1999-08-05 2012-04-03 Athersys, Inc. Immunomodulatory properties of multipotent adult progenitor cells and uses thereof
US10638734B2 (en) 2004-01-05 2020-05-05 Abt Holding Company Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof
US8252280B1 (en) 1999-08-05 2012-08-28 Regents Of The University Of Minnesota MAPC generation of muscle
US7927587B2 (en) 1999-08-05 2011-04-19 Regents Of The University Of Minnesota MAPC administration for the treatment of lysosomal storage disorders
US20030161817A1 (en) 2001-03-28 2003-08-28 Young Henry E. Pluripotent embryonic-like stem cells, compositions, methods and uses thereof
EP1218489B1 (en) * 1999-09-24 2009-03-18 Cybios LLC Pluripotent embryonic-like stem cells, compositions, methods and uses thereof
DE60041821D1 (de) * 1999-09-24 2009-04-30 Cybios Llc Pluripotent embryonale stammzellen-ähnliche zellen, zusammensetzungen und ihre vervendungen
US7776021B2 (en) 2000-04-28 2010-08-17 The Charles Stark Draper Laboratory Micromachined bilayer unit for filtration of small molecules
EP1757681A1 (en) * 2000-11-22 2007-02-28 Geron Corporation Tolerizing allografts of pluripotent stem cells
US6921665B2 (en) * 2000-11-27 2005-07-26 Roslin Institute (Edinburgh) Selective antibody targeting of undifferentiated stem cells
US6576464B2 (en) 2000-11-27 2003-06-10 Geron Corporation Methods for providing differentiated stem cells
RU2322497C2 (ru) * 2000-11-30 2008-04-20 Стемрон Инк. Изолированная гомозиготная стволовая клетка (варианты), способ ее получения (варианты), способ получения требуемой клетки-родоначальника, дифференцированной клетки, группы дифференцированных клеток или типа ткани
WO2002053193A2 (en) 2001-01-02 2002-07-11 The Charles Stark Draper Laboratory, Inc. Tissue engineering of three-dimensional vascularized using microfabricated polymer assembly technology
JP2004529621A (ja) * 2001-02-14 2004-09-30 ティー ファークト，レオ 多能性成体幹細胞、その起源、それを得る方法および維持する方法、それを分化させる方法、その使用法、ならびにそれ由来の細胞
CA2442177A1 (en) * 2001-03-29 2002-10-10 Ixion Biotechnology, Inc. Method for transdifferentiation of non-pancreatic stem cells to the pancreatic differentiation pathway
ATE433484T1 (de) * 2001-04-24 2009-06-15 Dolores Baksh Vorläuferzellpopulationen, deren expansion und die entstehung von nicht-hämatopoetischen zelltypen daraus
US20040203146A1 (en) 2001-04-30 2004-10-14 Dan Gazit Composite scaffolds and methods using same for generating complex tissue grafts
WO2003010305A1 (en) * 2001-07-27 2003-02-06 Arhus Amt Immortilized stem cells
WO2003025160A2 (de) * 2001-09-14 2003-03-27 Max-Delbrück-Centrum für Molekulare Medizin Nervenzellkulturmedium und verwendung von cholesterin zur kultivierung, differenzierung oder proliferation von nervenzellen
US9969980B2 (en) * 2001-09-21 2018-05-15 Garnet Biotherapeutics Cell populations which co-express CD49c and CD90
US20030082153A1 (en) 2001-10-22 2003-05-01 The Government Of The United States Of America Stem cells that transform to beating cardiomyocytes
GB2399823B (en) 2001-12-07 2006-02-15 Geron Corp Islet cells from primate pluripotent stem cells
US7687505B2 (en) 2002-01-14 2010-03-30 Board Of Trustees Of The University Of Illinois Use of modified pyrimidine compounds to promote stem cell migration and proliferation
AU2003208580A1 (en) * 2002-02-05 2003-09-02 Technion Research And Development Foundation Ltd Lineage committed stem cells selected for telomerase promoter activity
WO2003074684A1 (fr) * 2002-03-07 2003-09-12 Takeda Chemical Industries, Ltd. Cellules capables de se differencier en cellules de type myocarde
WO2003089592A2 (en) * 2002-04-16 2003-10-30 Oregon Health And Science University Enhancement of hematopoietic stem cell survival
WO2003104442A1 (en) 2002-06-07 2003-12-18 Es Cell International Pte Ltd Methods of regulating differentiation in stem cells
AU2003240281A1 (en) 2002-06-14 2003-12-31 Case Western Reserve University Cell targeting methods and compositions
EP1541674B9 (en) 2002-06-18 2011-09-14 Eisai R&D Management Co., Ltd. Primary cultured adipocytes for gene therapy
CA2493871A1 (en) * 2002-07-16 2004-01-22 Hadi Aslan Methods of implanting mesenchymal stem cells for tissue repair and formation
US7422736B2 (en) * 2002-07-26 2008-09-09 Food Industry Research And Development Institute Somatic pluripotent cells
US7527968B2 (en) 2002-07-29 2009-05-05 Robarts Research Institute Regeneration initiating cells
CA2493532C (fr) * 2002-07-31 2014-05-27 Yves Saint-Laurent Parfums Cellules souches issues de tissu adipeux et cellules differenciees issues de ces cellules
FR2843123B1 (fr) * 2002-07-31 2007-11-02 Saint Laurent Parfums Cellules souches issues de tissu adipeux humain
EP1527162A1 (de) * 2002-08-09 2005-05-04 Dr. H. Zech GmbH Verfahren zur erzeugung von zellinien sowie organen mithilfe differenzierfähiger zellen
EP1400587A1 (en) * 2002-09-19 2004-03-24 MainGen Biotechnologie GmbH Use of a fusion polypeptide for obtaining pluripotent non-embryonic stem cells
US9969977B2 (en) 2002-09-20 2018-05-15 Garnet Biotherapeutics Cell populations which co-express CD49c and CD90
EP1563061B1 (en) 2002-11-14 2012-06-20 Aderans Research Institute, Inc. Cultivation of hair inductive cells
AU2003298016A1 (en) * 2002-11-27 2004-06-23 Regents Of The University Of Minnesota Homologous recombination in multipotent adult progenitor cells
DE602004022508D1 (de) 2003-01-16 2009-09-24 Gen Hospital Corp Verwendung von dreidimensionalen, mikrogefertigten, mittels gewebetechnologie hergestellten systemen für pharmakologische anwendungen
CA2515469C (en) 2003-02-11 2013-12-17 John E. Davies Progenitor cells from wharton's jelly of human umbilical cord
JPWO2004101775A1 (ja) * 2003-05-16 2006-07-13 協和醗酵工業株式会社 新規な成体組織由来の幹細胞およびその用途
ES2265199B1 (es) * 2003-06-12 2008-02-01 Cellerix, S.L. Celulas madre adultas multipotentes procedentes de condrocitos desdiferenciados y sus aplicaciones.
DE10362002B4 (de) * 2003-06-23 2006-10-12 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Adulte pluripotente Stammzellen
WO2005001080A2 (en) 2003-06-27 2005-01-06 Ethicon, Incorporated Postpartum-derived cells for use in treatment of disease of the heart and circulatory system
US9572840B2 (en) 2003-06-27 2017-02-21 DePuy Synthes Products, Inc. Regeneration and repair of neural tissue using postpartum-derived cells
US9592258B2 (en) 2003-06-27 2017-03-14 DePuy Synthes Products, Inc. Treatment of neurological injury by administration of human umbilical cord tissue-derived cells
US7875272B2 (en) 2003-06-27 2011-01-25 Ethicon, Incorporated Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells
US8790637B2 (en) 2003-06-27 2014-07-29 DePuy Synthes Products, LLC Repair and regeneration of ocular tissue using postpartum-derived cells
WO2005047491A2 (en) * 2003-11-10 2005-05-26 Amgen Inc. Methods of using g-csf mobilized c-kit+cells in the production of embryoid body-like cell clusters for tissue repair and in the treatment of cardiac myopathy
EP1694345A1 (en) * 2003-12-04 2006-08-30 Regents Of The University Of Minnesota Compositions and methods for the treatment of lysosomal storage disorders
WO2005080598A1 (ja) 2004-02-19 2005-09-01 Dainippon Sumitomo Pharma Co., Ltd. 体細胞核初期化物質のスクリーニング方法
EP1753439A2 (en) 2004-05-17 2007-02-21 Regents Of The University Of Minnesota Use of umbilical cord blood stem cells to treat ischemic event
US20080254002A1 (en) * 2004-09-03 2008-10-16 Edelberg Jay M Bone Marrow Derived Oct3/4+ Stem Cells
US20090104158A1 (en) * 2004-09-03 2009-04-23 Moraga Biotechnology Corporation Non-Embryonic Totipotent Blastomere-Like Stem Cells And Methods Therefor
KR20160028498A (ko) 2004-09-24 2016-03-11 메소블라스트, 아이엔씨. 간엽 전구세포의 증식 및/또는 생존성 증강 방법
CA2589063C (en) 2004-12-23 2016-08-09 Ethicon Incorporated Treatment of parkinson's disease and related disorders using postpartum derived cells
US20090104159A1 (en) * 2005-02-10 2009-04-23 Felipe Prosper Vascular/Lymphatic Endothelial Cells
CA2607213A1 (en) * 2005-05-05 2006-11-16 Regents Of The University Of Minnesota Use of nk cell inhibition to facilitate persistence of engrafted mhc- i negative cells
JP2009509911A (ja) * 2005-05-05 2009-03-12 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ リンパ造血組織を定着させるためのｍａｐｃまたはそれらの子孫の使用
WO2006121454A2 (en) * 2005-05-05 2006-11-16 Regents Of The University Of Minnesota Use of mapc or progeny therefrom to populate lymphohematopoietic tissues
CN101243178A (zh) 2005-06-16 2008-08-13 特拉维夫大学拉莫特有限公司 用于治疗cns疾病的分离细胞和包含这种细胞的细胞群
US20080194024A1 (en) * 2005-07-29 2008-08-14 Mays Robert W Culture of Non-Embryonic Cells at High Cell Density
WO2007047509A2 (en) * 2005-10-14 2007-04-26 Regents Of The University Of Minnesota Differentiation of non-embryonic stem cells to cells having a pancreatic phenotype
JPWO2007046398A1 (ja) * 2005-10-18 2009-04-23 学校法人慶應義塾 幹細胞特異的プロモーター
US10117900B2 (en) 2005-11-09 2018-11-06 Athersys, Inc. MAPC treatment of brain injuries and diseases
US11000546B2 (en) 2005-11-09 2021-05-11 Athersys, Inc. Immunomodulatory properties of MAPCs and uses thereof
AU2016203976B2 (en) * 2005-11-09 2018-02-01 Abt Holding Company Immunomodulatory properties of multipotent adult progenitor cells and uses thereof
CN101573441A (zh) * 2005-12-08 2009-11-04 路易斯维尔大学研究基金会有限公司 非常小的胚胎样（vsel）干细胞及分离和利用其的方法
US9155762B2 (en) 2005-12-08 2015-10-13 University Of Louisville Research Foundation, Inc. Uses and isolation of stem cells from bone marrow
CN101374946B (zh) 2005-12-16 2017-07-18 伊西康公司 用于在组织相容性不匹配的移植中抑制有害的免疫反应的组合物和方法
US8278102B2 (en) 2005-12-22 2012-10-02 Jane Ennis Viable cells from frozen umbilical cord tissue
US9125906B2 (en) 2005-12-28 2015-09-08 DePuy Synthes Products, Inc. Treatment of peripheral vascular disease using umbilical cord tissue-derived cells
NZ595786A (en) 2005-12-29 2013-05-31 Anthrogenesis Corp Placental stem cell populations
US20070253931A1 (en) * 2006-01-12 2007-11-01 Osiris Therapeutics, Inc. Use of mesenchymal stem cells for treating genetic diseases and disorders
NZ727755A (en) * 2006-01-23 2023-01-27 Abt Holding Co Mapc therapeutics without adjunctive immunosuppressive treatment
CA2871219C (en) 2006-05-05 2020-06-30 John E. Davies Immune privileged and modulatory progenitor cells
WO2007149182A2 (en) 2006-06-19 2007-12-27 Geron Corporation Differentiation and enrichment of islet-like cells from human pluripotent stem cells
KR101475303B1 (ko) * 2006-07-12 2014-12-23 메소블라스트, 아이엔씨. 과다 혈관신생의 치료 방법
JP5543778B2 (ja) * 2006-07-24 2014-07-09 ザ・ユニバーシティ・オブ・クイーンズランド 細胞集団を産生する方法
EP1900810A1 (fr) * 2006-09-15 2008-03-19 Celogos Methode d'extraction et de selection de cellules
WO2008063675A2 (en) 2006-11-24 2008-05-29 Regents Of The University Of Minnesota Endodermal progenitor cells
US7922688B2 (en) 2007-01-08 2011-04-12 Restoration Robotics, Inc. Automated delivery of a therapeutic or cosmetic substance to cutaneous, subcutaneous and intramuscular tissue regions
WO2008137115A1 (en) 2007-05-03 2008-11-13 The Brigham And Women's Hospital, Inc. Multipotent stem cells and uses thereof
US8574567B2 (en) 2007-05-03 2013-11-05 The Brigham And Women's Hospital, Inc. Multipotent stem cells and uses thereof
JP2010529987A (ja) 2007-06-15 2010-09-02 ガーネット バイオセラピューティクス インコーポレイテッド ｉｎｖｉｔｒｏで培養および増殖させた自己複製性コロニー形成細胞を用いる疾患および障害の治療
AU2009205886B2 (en) * 2008-01-18 2015-08-27 Katholieke Universiteit Leuven Stem cell aggregates and methods for making and using
US9005599B2 (en) 2008-04-21 2015-04-14 Tissue Regeneration Therapeutics Inc. Genetically modified human umbilical cord perivascular cells for prophylaxis against or treatment of biological or chemical agents
EP3514229A1 (en) 2008-05-28 2019-07-24 Ramot at Tel-Aviv University Ltd. Mesenchymal stem cells for the treatment of cns diseases
US8268620B2 (en) * 2008-10-24 2012-09-18 Wisconsin Alumni Research Foundation OCT4 and SOX2 with SV40 T antigen produce pluripotent stem cells from primate somatic cells
US10179900B2 (en) 2008-12-19 2019-01-15 DePuy Synthes Products, Inc. Conditioned media and methods of making a conditioned media
PL2379088T3 (pl) 2008-12-19 2018-07-31 DePuy Synthes Products, Inc. Leczenie płuca oraz chorób i zaburzeń płucnych
AU2010229651B2 (en) 2009-03-26 2014-05-08 Advanced Technologies And Regenerative Medicine, Llc Human umbilical cord tissue cells as therapy for Alzheimer' s disease
US9399758B2 (en) 2009-07-15 2016-07-26 Mari Dezawa SSEA3(+) pluripotent stem cell that can be isolated from body tissue
US9550975B2 (en) 2009-07-15 2017-01-24 Mari Dezawa SSEA-3 pluripotent stem cell isolated from body tissue
ES2690199T3 (es) * 2009-07-21 2018-11-19 Abt Holding Company Uso de células madre para reducir la extravasación de leucocitos
AU2013231210B2 (en) * 2009-07-21 2014-11-20 Abt Holding Company Use of stem cells to reduce leukocyte extravasation
AU2013237687B2 (en) * 2009-07-21 2014-11-20 Abt Holding Company Use of stem cells to reduce leukocyte extravasation
AU2011205674A1 (en) * 2010-01-14 2012-08-09 Organogenesis, Inc. Bioengineered tissue constructs and methods for producing and using thereof
ES2703428T3 (es) * 2010-02-25 2019-03-08 Abt Holding Co Modulación de la angiogénesis
WO2011133889A2 (en) 2010-04-23 2011-10-27 Cold Spring Harbor Laboratory NOVEL STRUCTURALLY DESIGNED shRNAs
WO2011143415A1 (en) 2010-05-12 2011-11-17 Abt Holding Company Modulation of splenocytes in cell therapy
SG188306A1 (en) 2010-08-27 2013-04-30 Univ Health Network Methods for enriching pluripotent stem cell-derived cardiomyocyte progenitor cells and cardiomyocyte cells based on sirpa expression
WO2012048275A2 (en) 2010-10-08 2012-04-12 Caridianbct, Inc. Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
AR093183A1 (es) 2010-12-31 2015-05-27 Anthrogenesis Corp Aumento de la potencia de celulas madre de placenta usando moleculas de arn moduladoras
MX357749B (es) 2011-06-01 2018-07-23 Anthrogenesis Corp Tratamiento contra el dolor utilizando células madre placentarias.
ES2763331T3 (es) * 2011-06-06 2020-05-28 ReGenesys BVBA Expansión de células madre en biorreactores de fibra hueca
JP6607675B2 (ja) 2011-07-06 2019-11-20 セル セラピー リミテッド 中胚葉系列の前駆細胞
WO2013007284A1 (en) * 2011-07-08 2013-01-17 Mikael Sigvardsson A method for enriching mesenchymal stem cells and applications thereof
CN103958665A (zh) 2011-11-11 2014-07-30 基本药品有限责任公司 包含血清替代物和不稳定因子的试剂盒
WO2013078286A1 (en) * 2011-11-22 2013-05-30 Cornell University Methods for stimulating hematopoietic recovery by inhibiting tgf beta signaling
ES2827207T3 (es) * 2011-12-01 2021-05-20 R Bio Co Ltd Composición de medio de cultivo de rejuvenecimiento de células madre
EP2794854B1 (en) 2011-12-23 2018-06-20 DePuy Synthes Products, Inc. Detection of human umbilical cord tissue-derived cells
US8940294B2 (en) 2012-03-02 2015-01-27 Tissuetech, Inc. Methods of isolating and culturing stem cells
CN105338989B (zh) * 2013-04-12 2022-04-08 赛维里奥·拉弗朗切西卡 改进用于移植的器官
US10100283B2 (en) * 2013-11-01 2018-10-16 Kyoto University Efficient chondrocyte induction method
EP3068867B1 (en) 2013-11-16 2018-04-18 Terumo BCT, Inc. Expanding cells in a bioreactor
CN106062205A (zh) 2013-12-20 2016-10-26 基本药品有限责任公司 细胞培养基
EP3122866B1 (en) 2014-03-25 2019-11-20 Terumo BCT, Inc. Passive replacement of media
CN106715676A (zh) 2014-09-26 2017-05-24 泰尔茂比司特公司 按计划供养
WO2016118780A1 (en) 2015-01-21 2016-07-28 Fred Hutchinson Cancer Research Center Point-of-care and/or portable platform for gene therapy
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
US11312940B2 (en) 2015-08-31 2022-04-26 University Of Louisville Research Foundation, Inc. Progenitor cells and methods for preparing and using the same
WO2017127123A1 (en) 2016-01-21 2017-07-27 Abt Holding Company Stem cells for wound healing
US11072777B2 (en) 2016-03-04 2021-07-27 University Of Louisville Research Foundation, Inc. Methods and compositions for ex vivo expansion of very small embryonic-like stem cells (VSELs)
EP3464565A4 (en) 2016-05-25 2020-01-01 Terumo BCT, Inc. CELL EXPANSION
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
CN117247899A (zh) 2017-03-31 2023-12-19 泰尔茂比司特公司 细胞扩增
US20210380950A1 (en) 2018-11-28 2021-12-09 Milica Radisic Methods for tissue generation
US20200246390A1 (en) * 2019-02-01 2020-08-06 Abt Holding Company Multipotent adult projenitor cells for treatment of ich
EP3983542A2 (en) 2019-06-17 2022-04-20 CRISPR Therapeutics AG Methods and compositions for improved homology directed repair
CA3205138A1 (en) 2020-12-17 2022-06-23 Vertex Pharmaceuticals Incorporated Compositions and methods for editing beta-globin for treatment of hemaglobinopathies
US20230377685A1 (en) 2022-04-15 2023-11-23 Aspen Neuroscience, Inc. Methods of classifying the differentiation state of cells and related compositions of differentiated cells

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US759793A (en) 1903-05-20 1904-05-10 Standard Piano Hammer And Felt Company Pressure mechanism.
US5635386A (en) * 1989-06-15 1997-06-03 The Regents Of The University Of Michigan Methods for regulating the specific lineages of cells produced in a human hematopoietic cell culture
US5061620A (en) 1990-03-30 1991-10-29 Systemix, Inc. Human hematopoietic stem cell
US5635387A (en) 1990-04-23 1997-06-03 Cellpro, Inc. Methods and device for culturing human hematopoietic cells and their precursors
US5811094A (en) 1990-11-16 1998-09-22 Osiris Therapeutics, Inc. Connective tissue regeneration using human mesenchymal stem cell preparations
US5837539A (en) 1990-11-16 1998-11-17 Osiris Therapeutics, Inc. Monoclonal antibodies for human mesenchymal stem cells
US5486359A (en) 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US5460964A (en) 1992-04-03 1995-10-24 Regents Of The University Of Minnesota Method for culturing hematopoietic cells
WO1994000484A1 (en) 1992-06-22 1994-01-06 Young Henry E Scar inhibitory factor and use thereof
CZ307995A3 (en) * 1993-05-24 1996-10-16 Immunex Corp Ligands for flt3 receptors
AU7404494A (en) * 1993-07-21 1995-02-20 Cellpro, Incorporated Methods and compositions for preventing immune rejection of solid organ grafts
DK0802800T3 (da) 1993-08-12 2002-10-07 Neurotech Sa Biokompatible immunoisolatoriske kapsler indeholdende genetisk ændrede celler for levering af biologisk aktive molekyler
US6015686A (en) 1993-09-15 2000-01-18 Chiron Viagene, Inc. Eukaryotic layered vector initiation systems
US5409813A (en) 1993-09-30 1995-04-25 Systemix, Inc. Method for mammalian cell separation from a mixture of cell populations
WO1995010599A1 (en) * 1993-10-15 1995-04-20 The University Of Melbourne Embryonic stem cell-like cells
ATE247933T1 (de) 1994-06-06 2003-09-15 Univ Case Western Reserve Biomatrix für geweberegenaration
US5677136A (en) 1994-11-14 1997-10-14 Systemix, Inc. Methods of obtaining compositions enriched for hematopoietic stem cells, compositions derived therefrom and methods of use thereof
US5736396A (en) 1995-01-24 1998-04-07 Case Western Reserve University Lineage-directed induction of human mesenchymal stem cell differentiation
GB9502022D0 (en) 1995-02-02 1995-03-22 Abuljadayel Ilham M S A method for preparing lymphohaematopoietic progenitor cells
US6653134B2 (en) * 1995-03-28 2003-11-25 Cp Hahnemann University Isolated stromal cells for use in the treatment of diseases of the central nervous system
US5837670A (en) 1995-04-18 1998-11-17 Hartshorn; Richard Timothy Detergent compositions having suds suppressing properties
US5855610A (en) 1995-05-19 1999-01-05 Children's Medical Center Corporation Engineering of strong, pliable tissues
CA2191655C (en) * 1995-12-01 2010-01-12 Terry E. Thomas Novel antibody compositions for preparing enriched human hematopoietic and tumor cell preparations
US5827740A (en) 1996-07-30 1998-10-27 Osiris Therapeutics, Inc. Adipogenic differentiation of human mesenchymal stem cells
WO1998040468A1 (en) 1997-03-13 1998-09-17 Vanderbilt University Methods of constructing a gene mutation library and compounds and compositions thereof
WO1998042838A1 (en) 1997-03-25 1998-10-01 Morphogenesis, Inc. Universal stem cells
US6331406B1 (en) 1997-03-31 2001-12-18 The John Hopkins University School Of Medicine Human enbryonic germ cell and methods of use
US5968829A (en) * 1997-09-05 1999-10-19 Cytotherapeutics, Inc. Human CNS neural stem cells
US6093531A (en) 1997-09-29 2000-07-25 Neurospheres Holdings Ltd. Generation of hematopoietic cells from multipotent neural stem cells
WO1999027076A1 (en) * 1997-11-25 1999-06-03 Arc Genomic Research Pluripotent embryonic stem cells and methods of obtaining them
WO1999035243A2 (en) * 1998-01-12 1999-07-15 Cold Spring Harbor Laboratory Extension of cellular lifespan, methods and reagents
US6777231B1 (en) * 1999-03-10 2004-08-17 The Regents Of The University Of California Adipose-derived stem cells and lattices
US20050169896A1 (en) * 1999-05-14 2005-08-04 Henry Ford Health System Bone marrow transplantation for treatment of stroke
AUPQ147799A0 (en) 1999-07-07 1999-07-29 Medvet Science Pty. Ltd. Mesenchymal precursor cell
AU782396B2 (en) 1999-07-29 2005-07-21 Steven Baranowitz Methods for transdifferentiation of body tissues
ATE514772T1 (de) * 1999-08-05 2011-07-15 Abt Holding Co Multipotente erwachsene stammzellen und verfahren zu deren isolierung
WO2001021766A2 (en) 1999-09-23 2001-03-29 Cell Science Therapeutics Methods and devices for obtaining non-hematopoietic lineage cells from hematopoietic progenitor cells
EP1218489B1 (en) 1999-09-24 2009-03-18 Cybios LLC Pluripotent embryonic-like stem cells, compositions, methods and uses thereof
IL149933A0 (en) * 1999-12-06 2002-11-10 Gen Hospital Corp Pancreatic stem cells and their use in transplantation
PT1261694E (pt) * 2000-02-26 2008-04-03 Artecel Inc Células estaminais pluripotentes produzidas a partir de células estromais derivadas de tecido adiposo e suas utilizações.
EP1176189A1 (en) 2000-07-21 2002-01-30 Fornix Biosciences N.V. Stem cell-like cells
US20020098167A1 (en) * 2000-07-31 2002-07-25 Piero Anversa Methods and compositions for the repair and/or regeneration of damaged myocardium
GB0026252D0 (en) 2000-10-26 2000-12-13 Univ Edinburgh Pluripotential stem cells
US7560280B2 (en) * 2000-11-03 2009-07-14 Kourion Therapeutics Gmbh Human cord blood derived unrestricted somatic stem cells (USSC)
US7056738B2 (en) * 2001-03-23 2006-06-06 Tulane University Early stage multipotential stem cells in colonies of bone marrow stromal cells
KR100449141B1 (ko) * 2001-04-19 2004-09-21 (주)라이프코드 간엽 간세포를 신경세포로 분화시키는 방법
US20030003090A1 (en) * 2001-05-31 2003-01-02 Prockop Darwin J. Directed in vitro differentiation of marrow stromal cells into neural cell progenitors
US9969980B2 (en) * 2001-09-21 2018-05-15 Garnet Biotherapeutics Cell populations which co-express CD49c and CD90
US20040235165A1 (en) * 2003-05-19 2004-11-25 Darwin Prockop In vitro differentiation of adult stem cells
CN1845987A (zh) * 2003-08-29 2006-10-11 明尼苏达大学董事会 肾来源的干细胞及其分离、分化和使用方法

Also Published As

Publication number Publication date
AU6621800A (en) 2001-03-05
JP2016054745A (ja) 2016-04-21
JP2012107035A (ja) 2012-06-07
EP1226233A2 (en) 2002-07-31
JP5398941B2 (ja) 2014-01-29
DK1226233T3 (da) 2011-10-03
JP2018075016A (ja) 2018-05-17
HK1049350B (zh) 2012-01-27
JP6227390B2 (ja) 2017-11-08
JP6227221B2 (ja) 2017-11-08
US10006004B2 (en) 2018-06-26
AU784163B2 (en) 2006-02-16
JP2014054264A (ja) 2014-03-27
JP2008044965A (ja) 2008-02-28
IL210618A (en) 2015-06-30
CA2852534A1 (en) 2001-02-15
NZ517002A (en) 2004-06-25
US20090203130A1 (en) 2009-08-13
IL192762A0 (en) 2009-02-11
JP2014087354A (ja) 2014-05-15
EP2348104A1 (en) 2011-07-27
JP2003506075A (ja) 2003-02-18
HK1049350A1 (en) 2003-05-09
JP6272628B2 (ja) 2018-01-31
IL147990A (en) 2011-02-28
JP2020072702A (ja) 2020-05-14
EP1226233B1 (en) 2011-06-29
IL192762A (en) 2012-03-29
WO2001011011A9 (en) 2002-07-25
JP2016127859A (ja) 2016-07-14
PT1226233E (pt) 2011-10-04
IL210618A0 (en) 2011-03-31
CA2381292A1 (en) 2001-02-15
WO2001011011A3 (en) 2001-05-10
WO2001011011A2 (en) 2001-02-15
CA2381292C (en) 2016-05-24
ATE514772T1 (de) 2011-07-15

Similar Documents

Publication Publication Date Title
IL147990A0 (en) Multipotent adult stem cells and methods for isolation
WO2002064748A3 (en) Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof
WO2006047743A8 (en) Swine multipotent adult progenitor cells
DE60120151D1 (de) Isolierung von mesenchymalen stammzellen und deren verwendung
DK1082410T3 (da) Humane CD45 - og/eller fibroblast mesenchymale stamceller
WO2004055155A3 (en) Methods of preparing feeder cells-free, xeno-free human embryonic stem cells and stem cell cultures prepared using same
AU2821601A (en) Multipotent neural stem cells from peripheral tissues and uses thereof
WO2006044204A3 (en) Neuronal progenitors from feeder-free human embryonic stem cell culture
WO2003014313A3 (en) Alternative compositions and methods for the culture of stem cells
ATE534728T1 (de) Nestinexprimierende haarfollikelstammzellen
WO1999064566A8 (en) In vitro maintenance of hematopoietic stem cells
WO2003010243A3 (en) Multipotent stem cells from peripheral tissues and uses thereof
WO2003104443A3 (de) Mesenchymale stammzellen des haarfollikels und deren verwendung
BR0312764A (pt) Cardiomiócitos funcionais originados de células-tronco embrionárias humanas
WO2002034890A3 (en) Pluripotential stem cells
ATE473273T1 (de) Angereicherte zellpopulationen des zentralen nervensystems
AU2002364302A8 (en) Bag3 nucleotide and protein sequences to be used in research, diagnostics and therapy for cell death-involving diseases
WO2000066732A3 (en) Laminin 8 and methods for its use
HK1047294A1 (en) Surface for cell culture
WO2003029432A3 (en) Human mesenchymal progenitor cell
WO2004015091A3 (en) Preparation of type ii pneumocytes from stem cells
WO2001028574A3 (en) Methods for inducing in vivo proliferation and migration of transplanted progenitor cells in the brain
WO2001025398A3 (en) Process for inducing functional tolerance to gene transfer products
AU2002239306A1 (en) Immunocompetent animals including xenogeneic implants of mesenchymal stem cells
WO2000022097A3 (en) Periferal blood mensenchymal precursor cells

Legal Events

Date Code Title Description
FF Patent granted