WO2001025398A3 - Process for inducing functional tolerance to gene transfer products - Google Patents

Process for inducing functional tolerance to gene transfer products Download PDF

Info

Publication number
WO2001025398A3
WO2001025398A3 PCT/US2000/026946 US0026946W WO0125398A3 WO 2001025398 A3 WO2001025398 A3 WO 2001025398A3 US 0026946 W US0026946 W US 0026946W WO 0125398 A3 WO0125398 A3 WO 0125398A3
Authority
WO
WIPO (PCT)
Prior art keywords
gene transfer
inducing functional
tolerance
methods
transfer products
Prior art date
Application number
PCT/US2000/026946
Other languages
French (fr)
Other versions
WO2001025398A2 (en
Inventor
Goran K Andersson
Original Assignee
Biotransplant Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotransplant Inc filed Critical Biotransplant Inc
Priority to AU77406/00A priority Critical patent/AU7740600A/en
Priority to CA002385750A priority patent/CA2385750A1/en
Priority to JP2001528553A priority patent/JP2003531816A/en
Priority to EP00967159A priority patent/EP1578897A2/en
Publication of WO2001025398A2 publication Critical patent/WO2001025398A2/en
Publication of WO2001025398A3 publication Critical patent/WO2001025398A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
    • A61K39/4621—Cellular immunotherapy characterized by the effect or the function of the cells immunosuppressive or immunotolerising
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/46433—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/46434—Antigens related to induction of tolerance to non-self
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
    • A61K2239/59—Reproductive system, e.g. uterus, ovaries, cervix or testes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Methods of inducing functional tolerance for the expression products of transgenes in somatic cells are disclosed, which methods comprise the introduction into the recipient of stem cells, such as hematopoietic stem cells, transgenically modified so as to express one or more neoantigens, such procedure optionally preceded by a myeloreductive procedure. The purpose of the disclosed methods is to induce tolerance to these same antigens when later expressed by cells or vectors to be introduced as part of a gene therapy treatment.
PCT/US2000/026946 1999-10-01 2000-09-29 Process for inducing functional tolerance to gene transfer products WO2001025398A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU77406/00A AU7740600A (en) 1999-10-01 2000-09-29 Process for inducing functional tolerance to gene transfer products
CA002385750A CA2385750A1 (en) 1999-10-01 2000-09-29 Process for inducing functional tolerance to gene transfer products
JP2001528553A JP2003531816A (en) 1999-10-01 2000-09-29 Methods for inducing functional tolerance in transgenic products
EP00967159A EP1578897A2 (en) 1999-10-01 2000-09-29 Process for inducing functional tolerance to gene transfer products

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15723399P 1999-10-01 1999-10-01
US60/157,233 1999-10-01

Publications (2)

Publication Number Publication Date
WO2001025398A2 WO2001025398A2 (en) 2001-04-12
WO2001025398A3 true WO2001025398A3 (en) 2008-03-20

Family

ID=22562877

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/026946 WO2001025398A2 (en) 1999-10-01 2000-09-29 Process for inducing functional tolerance to gene transfer products

Country Status (5)

Country Link
EP (1) EP1578897A2 (en)
JP (1) JP2003531816A (en)
AU (1) AU7740600A (en)
CA (1) CA2385750A1 (en)
WO (1) WO2001025398A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004002425A2 (en) * 2002-06-28 2004-01-08 Bio Transplant, Inc. Process for promoting graft acceptance by depletion of hematopoietic stem cells
AU2002952834A0 (en) * 2002-09-16 2002-12-05 The Walter And Eliza Hall Institute Of Medical Research A method of treating an autoimmune disease
SG177944A1 (en) 2005-07-11 2012-02-28 Macrogenics Inc Methods for the treatment of autoimmune disorders using immunosuppressive monoclonal antibodies with reduced toxicity
WO2007147090A2 (en) 2006-06-14 2007-12-21 Macrogenics, Inc. Methods for the treatment of autoimmune disorders using monoclonal antibodies with reduced toxicity
WO2009058012A1 (en) * 2007-11-01 2009-05-07 Deltacell B.V. Means and methods for eliciting an immune response
SG10202101481YA (en) 2013-09-23 2021-03-30 Wilson Wolf Mfg Corporation Improved methods of genetically modifying animal cells

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5876708A (en) * 1992-02-19 1999-03-02 The General Hospital Corporation Allogeneic and xenogeneic transplantation
US5928638A (en) * 1996-06-17 1999-07-27 Systemix, Inc. Methods for gene transfer
US6096537A (en) * 1994-03-31 2000-08-01 Diacrin, Inc. Cells with multiple altered epitopes on a surface antigen for use in transplantation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5876708A (en) * 1992-02-19 1999-03-02 The General Hospital Corporation Allogeneic and xenogeneic transplantation
US6096537A (en) * 1994-03-31 2000-08-01 Diacrin, Inc. Cells with multiple altered epitopes on a surface antigen for use in transplantation
US5928638A (en) * 1996-06-17 1999-07-27 Systemix, Inc. Methods for gene transfer

Also Published As

Publication number Publication date
EP1578897A2 (en) 2005-09-28
CA2385750A1 (en) 2001-04-12
AU7740600A (en) 2001-05-10
JP2003531816A (en) 2003-10-28
WO2001025398A2 (en) 2001-04-12

Similar Documents

Publication Publication Date Title
HK1049350A1 (en) Multipotent adult stem cells and methods for isolation
EP0752874A4 (en) Enhanced virus-mediated dna transfer
MX2009005038A (en) Microorganisms as carriers of nucleotide sequences coding for antigens and protein toxins, process of manufacturing and uses thereof.
HK1086750A1 (en) Pharmaceutical composition for inducing an immune response in a human or animal
ATE169061T1 (en) METHOD OF GENE TRANSFER USING RETROTRANSPOSON
HK1019233A1 (en) Animal cells and processes for the replication of influenza viruses
EP1483281A4 (en) Methods for producing interfering rna molecules in mammalian cells and therapeutic uses for such molecules
ES8700320A1 (en) Recombinant DNA means and method.
WO2001021766A3 (en) Methods and devices for obtaining non-hematopoietic lineage cells from hematopoietic progenitor cells
MXPA02006145A (en) Method for isolation of rna from formalinfixed paraffinembedded tissue specimens.
EP1474507A4 (en) Methods and materials for the production of organic products in cells of candida species
WO2003025570A1 (en) Method of examining (-) strand rna virus vector having lowered ability to form grains and method of constructing the same
AU2002214596A1 (en) Methods and compositions for nucleic acid delivery
WO2002010337A3 (en) Method of cloning porcine animals
WO2001068828A3 (en) Compositions and methods for regulated protein expression in gut
WO2001025398A3 (en) Process for inducing functional tolerance to gene transfer products
AU5318496A (en) Adenovirus vectors for gene therapy
WO2003072789A3 (en) Microorganisms as carriers of nucleotide sequences coding for cell antigens used for the treatment of tumors
Matsunaga et al. Single-step generation of gene knockout-rescue system in pluripotent stem cells by promoter insertion with CRISPR/Cas9
WO2004090094A3 (en) L-carnitin dehydrogenases, their derivatives and method for producing substituted (s) alkanols
WO2001075116A3 (en) ISOLATED NUCLEIC ACIDS FROM MICROMONOSPORA ROSARIA PLASMID pMR2 AND VECTORS MADE THEREFROM
WO2007018744A3 (en) Cell-free biosynthesis of nucleic acid
WO2001094604A3 (en) Method of using dna episomes to suppress gene expression in plants
MXPA02002444A (en) Method for generating immune compatible cells and tissues using nuclear transfer techniques.
EP0220714A3 (en) Dna fragment containing the cyclodextrin-glycosyl-transferase gene, expression vector, microorganisms for expression and preparation process

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 77406/00

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2385750

Country of ref document: CA

ENP Entry into the national phase

Ref country code: JP

Ref document number: 2001 528553

Kind code of ref document: A

Format of ref document f/p: F

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2000967159

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWW Wipo information: withdrawn in national office

Ref document number: 2000967159

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2000967159

Country of ref document: EP