IL147746A0 - Benzenamine derivatives as anti-coagulants - Google Patents

Benzenamine derivatives as anti-coagulants

Info

Publication number
IL147746A0
IL147746A0 IL14774600A IL14774600A IL147746A0 IL 147746 A0 IL147746 A0 IL 147746A0 IL 14774600 A IL14774600 A IL 14774600A IL 14774600 A IL14774600 A IL 14774600A IL 147746 A0 IL147746 A0 IL 147746A0
Authority
IL
Israel
Prior art keywords
coagulants
benzenamine
derivatives
benzenamine derivatives
Prior art date
Application number
IL14774600A
Other languages
English (en)
Original Assignee
Berlex Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Berlex Lab filed Critical Berlex Lab
Publication of IL147746A0 publication Critical patent/IL147746A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Separation Of Suspended Particles By Flocculating Agents (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyrane Compounds (AREA)
IL14774600A 1999-07-30 2000-07-27 Benzenamine derivatives as anti-coagulants IL147746A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14657299P 1999-07-30 1999-07-30
US09/624,519 US6350761B1 (en) 1999-07-30 2000-07-24 Benzenamine derivatives as anti-coagulants
PCT/US2000/020390 WO2001009093A1 (en) 1999-07-30 2000-07-27 Benzenamine derivatives as anti-coagulants

Publications (1)

Publication Number Publication Date
IL147746A0 true IL147746A0 (en) 2002-08-14

Family

ID=26844067

Family Applications (2)

Application Number Title Priority Date Filing Date
IL14774600A IL147746A0 (en) 1999-07-30 2000-07-27 Benzenamine derivatives as anti-coagulants
IL147746A IL147746A (en) 1999-07-30 2002-01-21 History of benzamine used as anticoagulants

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL147746A IL147746A (en) 1999-07-30 2002-01-21 History of benzamine used as anticoagulants

Country Status (23)

Country Link
US (1) US6350761B1 (no)
EP (1) EP1200405A1 (no)
JP (1) JP2003506353A (no)
KR (1) KR20020068494A (no)
CN (1) CN1367777A (no)
AU (1) AU766820B2 (no)
BR (1) BR0013292A (no)
CA (1) CA2380029A1 (no)
CZ (1) CZ2002346A3 (no)
EE (1) EE200200050A (no)
HK (1) HK1049482A1 (no)
HR (1) HRP20020185A2 (no)
HU (1) HUP0202234A3 (no)
IL (2) IL147746A0 (no)
LT (1) LT4972B (no)
LV (1) LV12844B (no)
MX (1) MXPA02001065A (no)
NO (1) NO20020457L (no)
NZ (1) NZ516804A (no)
PL (1) PL357871A1 (no)
SI (1) SI20815A (no)
SK (1) SK1252002A3 (no)
WO (1) WO2001009093A1 (no)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0813525B9 (en) 1995-03-10 2004-02-04 Berlex Laboratories, Inc. Benzamidine derivatives their preparation and their use as anti-coagulants
US6686364B2 (en) 1997-12-08 2004-02-03 Berlex Laboratories, Inc. Benzamidine derivatives and their use as anti-coagulants
US6262088B1 (en) 1998-11-19 2001-07-17 Berlex Laboratories, Inc. Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants
PL354619A1 (en) * 1999-10-28 2004-02-09 Sankyo Company, Limited Benzamidine derivatives
AU2004203154B2 (en) * 1999-10-28 2006-06-01 Sankyo Company, Limited Benzamidine derivatives
US20020065303A1 (en) * 2000-02-01 2002-05-30 Bing-Yan Zhu Bivalent phenylene inhibitors of factor Xa
DE10110325A1 (de) * 2001-03-03 2002-09-05 Merck Patent Gmbh Phenylderivate 2
AU2002246336B2 (en) * 2001-04-05 2005-05-19 Sankyo Company, Limited Benzamidine derivative
DK1569912T3 (en) 2002-12-03 2015-06-29 Pharmacyclics Inc 2- (2-hydroxybiphenyl-3-yl) -1h-benzoimidazole-5-carboxamidine derivatives as factor VIIa inhibitors.
CA2658913C (en) 2006-07-24 2015-07-21 Ucb Pharma S.A. Substituted aniline derivatives
MX2010006045A (es) * 2007-12-12 2010-06-23 Amgen Inc Inhibidores de transportador de glicina-1.
EP2602248A1 (en) * 2011-12-05 2013-06-12 University Of Leicester Novel pyrrole compounds
US11596612B1 (en) 2022-03-08 2023-03-07 PTC Innovations, LLC Topical anesthetics

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB824908A (en) 1958-06-03 1959-12-09 May & Baker Ltd Improvements in or relating to triazine derivatives
JPS5922697B2 (ja) 1976-01-13 1984-05-28 エーザイ株式会社 ビス−（メタ−アミジノフエノキシ）−化合物
JPS58150559A (ja) * 1982-03-04 1983-09-07 Sumitomo Chem Co Ltd オキシムエ−テル誘導体、その製造法およびそれを有効成分として含有する殺虫剤
US4594092A (en) * 1982-12-20 1986-06-10 American Cyanamid Company Substituted nitro and cyanoguanidines and their use of increasing crop yields
JP3280040B2 (ja) 1990-03-26 2002-04-30 武田薬品工業株式会社 アミノベンゼン化合物
EP0518818A3 (en) 1991-06-11 1993-04-28 Ciba-Geigy Ag Arylethers, their manufacture and use as medicament
US5451700A (en) 1991-06-11 1995-09-19 Ciba-Geigy Corporation Amidino compounds, their manufacture and methods of treatment
ZA928276B (en) 1991-10-31 1993-05-06 Daiichi Seiyaku Co Aromatic amidine derivates and salts thereof.
JP3194953B2 (ja) 1992-02-14 2001-08-06 コルバス・インターナショナル、インコーポレイテッド 血栓症抑制剤
DE4213919A1 (de) 1992-04-28 1993-11-04 Thomae Gmbh Dr K Cyclische iminoderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
IL106324A (en) 1992-07-17 1998-09-24 Shell Int Research Transformed pyrimidine compounds, their preparation and use as pesticides
AU675981B2 (en) 1992-12-02 1997-02-27 Bristol-Myers Squibb Company Guanidinyl-substituted heterocyclic thrombin inhibitors
ATE177752T1 (de) 1992-12-15 1999-04-15 Corvas Int Inc Neue inhibitoren von faktor xa
US5332822A (en) 1992-12-24 1994-07-26 Bristol-Myers Squibb Company Heteroaromatic and thioheteroaromatic substituted sulfonamide thrombin inhibitors
EP0684830B1 (en) 1993-02-12 1999-06-16 Corvas International, Inc. Inhibitors of thrombosis
US5633381A (en) 1994-07-05 1997-05-27 Berlex Laboratories, Inc. (Z,Z), (Z,E) and (E,Z) isomers of substituted bis(phenylmethylene)cycloketones
IL115420A0 (en) 1994-09-26 1995-12-31 Zeneca Ltd Aminoheterocyclic derivatives
WO1996016940A1 (fr) * 1994-12-02 1996-06-06 Yamanouchi Pharmaceutical Co., Ltd. Nouveau derive d'amidinonaphtyle ou sel de celui-ci
US5691364A (en) 1995-03-10 1997-11-25 Berlex Laboratories, Inc. Benzamidine derivatives and their use as anti-coagulants
US6004981A (en) 1996-03-08 1999-12-21 Berlex Laboratories, Inc. Benzamidine derivatives and their use as anti-coagulants
EP0813525B9 (en) 1995-03-10 2004-02-04 Berlex Laboratories, Inc. Benzamidine derivatives their preparation and their use as anti-coagulants
US5612363A (en) 1995-06-02 1997-03-18 Berlex Laboratories, Inc. N,N-di(aryl) cyclic urea derivatives as anti-coagulants
US5721214A (en) 1995-06-07 1998-02-24 Cor Therapeutics, Inc. Inhibitors of factor Xa
US5849759A (en) * 1995-12-08 1998-12-15 Berlex Laboratories, Inc. Naphthyl-substituted benzimidazole derivatives as anti-coagulants
US5994375A (en) * 1996-02-12 1999-11-30 Berlex Laboratories, Inc. Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants
US5753635A (en) 1996-08-16 1998-05-19 Berlex Laboratories, Inc. Purine derivatives and their use as anti-coagulants
US5693641A (en) 1996-08-16 1997-12-02 Berlex Laboratories Inc. Bicyclic pyrimidine derivatives and their use as anti-coagulants
US6008234A (en) 1996-09-12 1999-12-28 Berlex Laboratories, Inc. Benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives and their use as anti-coagulants
US6004985A (en) 1996-10-09 1999-12-21 Berlex Laboratories, Inc. Thio acid derived monocylic N-heterocyclics as anticoagulants
WO1999000128A1 (en) 1997-06-26 1999-01-07 Eli Lilly And Company Antithrombotic agents
JP2002510313A (ja) 1997-06-26 2002-04-02 イーライ・リリー・アンド・カンパニー 抗血栓物質
US6140351A (en) 1997-12-19 2000-10-31 Berlex Laboratories, Inc. Ortho-anthranilamide derivatives as anti-coagulants
AU2074699A (en) 1998-01-26 1999-08-09 Yamanouchi Pharmaceutical Co., Ltd. Novel benzene-fused heterocyclic derivatives or salts thereof
DE69919149D1 (de) 1998-04-10 2004-09-09 Japan Tobacco Inc Amidin-verbindungen
US6127376A (en) 1998-12-04 2000-10-03 Berlex Laboratories, Inc. Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants

Also Published As

Publication number Publication date
NO20020457L (no) 2002-03-27
EE200200050A (et) 2003-04-15
CN1367777A (zh) 2002-09-04
HUP0202234A2 (en) 2002-10-28
IL147746A (en) 2007-02-11
EP1200405A1 (en) 2002-05-02
LT2002009A (en) 2002-07-25
AU6380500A (en) 2001-02-19
LV12844B (en) 2002-11-20
US6350761B1 (en) 2002-02-26
CA2380029A1 (en) 2001-02-08
SK1252002A3 (en) 2002-08-06
BR0013292A (pt) 2002-04-02
CZ2002346A3 (cs) 2002-06-12
NZ516804A (en) 2003-08-29
HUP0202234A3 (en) 2005-02-28
AU766820B2 (en) 2003-10-23
HRP20020185A2 (en) 2004-02-29
HK1049482A1 (zh) 2003-05-16
LT4972B (lt) 2002-11-25
WO2001009093A1 (en) 2001-02-08
KR20020068494A (ko) 2002-08-27
WO2001009093A8 (en) 2005-11-10
SI20815A (sl) 2002-08-31
NO20020457D0 (no) 2002-01-29
JP2003506353A (ja) 2003-02-18
MXPA02001065A (es) 2002-10-31
PL357871A1 (en) 2004-07-26

Similar Documents

Publication Publication Date Title
ZA9811599B (en) Ortho-anthranilamide derivatives as anti-coagulants.
EG23817A (en) 4-Phenyl-pyridine derivatives
HUP0201535A2 (en) 5-cyano-2-aminopyrimidine derivatives
IL148167A0 (en) Amino-triazolopyridine derivatives
GC0000183A (en) 3-Phenyl-pyridine derivatives
IL145739A0 (en) 13-methyl-erythromycin derivatives
GC0000338A (en) 5-Phenyl-pyrimidine derivatives
HK1046400A1 (en) Substituted 2-dialkylaminoalkylbiphenyl derivatives
EG23070A (en) Novel propargylether derivatives
IL148837A0 (en) Isoxazolecarboxamide derivatives
IL147746A0 (en) Benzenamine derivatives as anti-coagulants
GC0000191A (en) 4-Phenyl-pyrimidine derivatives
GB9925880D0 (en) B-Carboline derivatives
GC0000256A (en) Ethanesulfonyl-piperidine derivatives
HUP0204217A3 (en) Novel a-500359 derivatives
IL147636A0 (en) 3-amino-2-benzyl-1-phenyl-propane derivatives
IL150132A0 (en) Cyclopenteneone derivatives
AP2001002327A0 (en) 1-Trifluoromethyl-4-hydroxy-7- piperidinylaminomethy lchroman derivatives
IL146282A0 (en) Thio-oxindole derivatives
GB9907134D0 (en) Antimor napthylcombretastatin derivatives
HK1043987A1 (zh) 硫-羥吲衍生物

Legal Events

Date Code Title Description
FF Patent granted
MM9K Patent not in force due to non-payment of renewal fees