NO20020457D0 - Benzenaminderivater som antikoagulanter - Google Patents

Benzenaminderivater som antikoagulanter

Info

Publication number
NO20020457D0
NO20020457D0 NO20020457A NO20020457A NO20020457D0 NO 20020457 D0 NO20020457 D0 NO 20020457D0 NO 20020457 A NO20020457 A NO 20020457A NO 20020457 A NO20020457 A NO 20020457A NO 20020457 D0 NO20020457 D0 NO 20020457D0
Authority
NO
Norway
Prior art keywords
anticoagulants
benzamine derivatives
benzamine
derivatives
Prior art date
Application number
NO20020457A
Other languages
English (en)
Other versions
NO20020457L (no
Inventor
William J Guilford
Steven T Sakata
Kenneth J Shaw
Shung Wu
Wei Xu
Zuchun Zhao
Original Assignee
Berlex Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Berlex Lab filed Critical Berlex Lab
Publication of NO20020457D0 publication Critical patent/NO20020457D0/no
Publication of NO20020457L publication Critical patent/NO20020457L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40Oxygen atoms
    • C07D211/44Oxygen atoms attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40Oxygen atoms
    • C07D211/44Oxygen atoms attached in position 4
    • C07D211/46Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56Nitrogen atoms
    • C07D211/58Nitrogen atoms attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10Oxygen atoms
    • C07D309/12Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D335/00Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/02Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Separation Of Suspended Particles By Flocculating Agents (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyrane Compounds (AREA)
NO20020457A 1999-07-30 2002-01-29 Benzenaminderivater som antikoagulanter NO20020457L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14657299P 1999-07-30 1999-07-30
US09/624,519 US6350761B1 (en) 1999-07-30 2000-07-24 Benzenamine derivatives as anti-coagulants
PCT/US2000/020390 WO2001009093A1 (en) 1999-07-30 2000-07-27 Benzenamine derivatives as anti-coagulants

Publications (2)

Publication Number Publication Date
NO20020457D0 true NO20020457D0 (no) 2002-01-29
NO20020457L NO20020457L (no) 2002-03-27

Family

ID=26844067

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20020457A NO20020457L (no) 1999-07-30 2002-01-29 Benzenaminderivater som antikoagulanter

Country Status (23)

Country Link
US (1) US6350761B1 (no)
EP (1) EP1200405A1 (no)
JP (1) JP2003506353A (no)
KR (1) KR20020068494A (no)
CN (1) CN1367777A (no)
AU (1) AU766820B2 (no)
BR (1) BR0013292A (no)
CA (1) CA2380029A1 (no)
CZ (1) CZ2002346A3 (no)
EE (1) EE200200050A (no)
HK (1) HK1049482A1 (no)
HR (1) HRP20020185A2 (no)
HU (1) HUP0202234A3 (no)
IL (2) IL147746A0 (no)
LT (1) LT4972B (no)
LV (1) LV12844B (no)
MX (1) MXPA02001065A (no)
NO (1) NO20020457L (no)
NZ (1) NZ516804A (no)
PL (1) PL357871A1 (no)
SI (1) SI20815A (no)
SK (1) SK1252002A3 (no)
WO (1) WO2001009093A1 (no)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2208737T3 (es) 1995-03-10 2004-06-16 Berlex Laboratories, Inc. Derivados de benzamidina, su preparacion y su utilizacion como anticoagulantes.
US6686364B2 (en) 1997-12-08 2004-02-03 Berlex Laboratories, Inc. Benzamidine derivatives and their use as anti-coagulants
US6262088B1 (en) 1998-11-19 2001-07-17 Berlex Laboratories, Inc. Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants
HUP0203161A3 (en) * 1999-10-28 2003-12-29 Sankyo Company Ltd Chuo Ku Benzamidine derivatives, process for their preparation and pharmaceutical compositions containing them and their use
AU2004203154B2 (en) * 1999-10-28 2006-06-01 Sankyo Company, Limited Benzamidine derivatives
AU2001234689A1 (en) * 2000-02-01 2001-08-14 Cor Therapeutics, Inc. Bivalent phenylene inhibitors of factor xa
DE10110325A1 (de) * 2001-03-03 2002-09-05 Merck Patent Gmbh Phenylderivate 2
MXPA03009097A (es) * 2001-04-05 2004-02-12 Sankyo Co Derivados de benzamidina.
WO2004050637A2 (en) 2002-12-03 2004-06-17 Axys Pharmaceuticals, Inc. 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors
JP5468900B2 (ja) * 2006-07-24 2014-04-09 ユセベ ファルマ ソシエテ アノニム 置換されたアニリン誘導体
JP2011506441A (ja) * 2007-12-12 2011-03-03 アムジエン・インコーポレーテツド グリシン輸送体−1阻害薬
EP2602248A1 (en) * 2011-12-05 2013-06-12 University Of Leicester Novel pyrrole compounds
US11596612B1 (en) 2022-03-08 2023-03-07 PTC Innovations, LLC Topical anesthetics

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Publication number Priority date Publication date Assignee Title
GB824908A (en) 1958-06-03 1959-12-09 May & Baker Ltd Improvements in or relating to triazine derivatives
JPS5922697B2 (ja) 1976-01-13 1984-05-28 エーザイ株式会社 ビス−(メタ−アミジノフエノキシ)−化合物
JPS58150559A (ja) * 1982-03-04 1983-09-07 Sumitomo Chem Co Ltd オキシムエ−テル誘導体、その製造法およびそれを有効成分として含有する殺虫剤
US4594092A (en) * 1982-12-20 1986-06-10 American Cyanamid Company Substituted nitro and cyanoguanidines and their use of increasing crop yields
JP3280040B2 (ja) 1990-03-26 2002-04-30 武田薬品工業株式会社 アミノベンゼン化合物
US5451700A (en) 1991-06-11 1995-09-19 Ciba-Geigy Corporation Amidino compounds, their manufacture and methods of treatment
EP0518818A3 (en) 1991-06-11 1993-04-28 Ciba-Geigy Ag Arylethers, their manufacture and use as medicament
ZA928276B (en) 1991-10-31 1993-05-06 Daiichi Seiyaku Co Aromatic amidine derivates and salts thereof.
WO1993015756A1 (en) 1992-02-14 1993-08-19 Corvas International, Inc. Inhibitors of thrombosis
DE4213919A1 (de) 1992-04-28 1993-11-04 Thomae Gmbh Dr K Cyclische iminoderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
TW234077B (no) 1992-07-17 1994-11-11 Shell Internat Res Schappej B V
AU675981B2 (en) 1992-12-02 1997-02-27 Bristol-Myers Squibb Company Guanidinyl-substituted heterocyclic thrombin inhibitors
WO1994013693A1 (en) 1992-12-15 1994-06-23 Corvas International, Inc. NOVEL INHIBITORS OF FACTOR Xa
US5332822A (en) 1992-12-24 1994-07-26 Bristol-Myers Squibb Company Heteroaromatic and thioheteroaromatic substituted sulfonamide thrombin inhibitors
EP0684830B1 (en) 1993-02-12 1999-06-16 Corvas International, Inc. Inhibitors of thrombosis
US5633381A (en) 1994-07-05 1997-05-27 Berlex Laboratories, Inc. (Z,Z), (Z,E) and (E,Z) isomers of substituted bis(phenylmethylene)cycloketones
IL115420A0 (en) 1994-09-26 1995-12-31 Zeneca Ltd Aminoheterocyclic derivatives
JP3004362B2 (ja) 1994-12-02 2000-01-31 山之内製薬株式会社 新規なアミジノナフチル誘導体又はその塩
US5691364A (en) 1995-03-10 1997-11-25 Berlex Laboratories, Inc. Benzamidine derivatives and their use as anti-coagulants
US6004981A (en) 1996-03-08 1999-12-21 Berlex Laboratories, Inc. Benzamidine derivatives and their use as anti-coagulants
ES2208737T3 (es) 1995-03-10 2004-06-16 Berlex Laboratories, Inc. Derivados de benzamidina, su preparacion y su utilizacion como anticoagulantes.
US5612363A (en) 1995-06-02 1997-03-18 Berlex Laboratories, Inc. N,N-di(aryl) cyclic urea derivatives as anti-coagulants
US5721214A (en) 1995-06-07 1998-02-24 Cor Therapeutics, Inc. Inhibitors of factor Xa
US5849759A (en) * 1995-12-08 1998-12-15 Berlex Laboratories, Inc. Naphthyl-substituted benzimidazole derivatives as anti-coagulants
US5994375A (en) 1996-02-12 1999-11-30 Berlex Laboratories, Inc. Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants
US5753635A (en) 1996-08-16 1998-05-19 Berlex Laboratories, Inc. Purine derivatives and their use as anti-coagulants
US5693641A (en) 1996-08-16 1997-12-02 Berlex Laboratories Inc. Bicyclic pyrimidine derivatives and their use as anti-coagulants
US6008234A (en) 1996-09-12 1999-12-28 Berlex Laboratories, Inc. Benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives and their use as anti-coagulants
US6004985A (en) 1996-10-09 1999-12-21 Berlex Laboratories, Inc. Thio acid derived monocylic N-heterocyclics as anticoagulants
JP2002510313A (ja) 1997-06-26 2002-04-02 イーライ・リリー・アンド・カンパニー 抗血栓物質
ES2241151T3 (es) 1997-06-26 2005-10-16 Eli Lilly And Company Agentes antitromboticos.
US6140351A (en) 1997-12-19 2000-10-31 Berlex Laboratories, Inc. Ortho-anthranilamide derivatives as anti-coagulants
AU2074699A (en) 1998-01-26 1999-08-09 Yamanouchi Pharmaceutical Co., Ltd. Novel benzene-fused heterocyclic derivatives or salts thereof
RU2201927C2 (ru) 1998-04-10 2003-04-10 Джапан Тобакко Инк. Амидиновые соединения и фармацевтическая композиция, обладающая фактор ха ингибирующим действием
US6127376A (en) 1998-12-04 2000-10-03 Berlex Laboratories, Inc. Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants

Also Published As

Publication number Publication date
LT4972B (lt) 2002-11-25
IL147746A0 (en) 2002-08-14
CN1367777A (zh) 2002-09-04
HUP0202234A2 (en) 2002-10-28
NO20020457L (no) 2002-03-27
CA2380029A1 (en) 2001-02-08
WO2001009093A1 (en) 2001-02-08
HUP0202234A3 (en) 2005-02-28
CZ2002346A3 (cs) 2002-06-12
IL147746A (en) 2007-02-11
SI20815A (sl) 2002-08-31
LT2002009A (en) 2002-07-25
HK1049482A1 (zh) 2003-05-16
JP2003506353A (ja) 2003-02-18
AU766820B2 (en) 2003-10-23
AU6380500A (en) 2001-02-19
MXPA02001065A (es) 2002-10-31
PL357871A1 (en) 2004-07-26
EE200200050A (et) 2003-04-15
EP1200405A1 (en) 2002-05-02
KR20020068494A (ko) 2002-08-27
WO2001009093A8 (en) 2005-11-10
SK1252002A3 (en) 2002-08-06
NZ516804A (en) 2003-08-29
HRP20020185A2 (en) 2004-02-29
LV12844B (en) 2002-11-20
BR0013292A (pt) 2002-04-02
US6350761B1 (en) 2002-02-26

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application