HRP20020185A2 - Benzenamine derivatives as anti-coagulants - Google Patents

Benzenamine derivatives as anti-coagulants Download PDF

Info

Publication number
HRP20020185A2
HRP20020185A2 HR20020185A HRP20020185A HRP20020185A2 HR P20020185 A2 HRP20020185 A2 HR P20020185A2 HR 20020185 A HR20020185 A HR 20020185A HR P20020185 A HRP20020185 A HR P20020185A HR P20020185 A2 HRP20020185 A2 HR P20020185A2
Authority
HR
Croatia
Prior art keywords
amidinophenyl
oxy
piperidin
benzenamine
prop
Prior art date
Application number
HR20020185A
Other languages
English (en)
Croatian (hr)
Inventor
William J Guilford
Steven T Sakata
Kenneth J Shaw
Shung Wu
Wei Xu
Zuchun Zhao
Original Assignee
Berlex Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Berlex Lab filed Critical Berlex Lab
Publication of HRP20020185A2 publication Critical patent/HRP20020185A2/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Separation Of Suspended Particles By Flocculating Agents (AREA)
HR20020185A 1999-07-30 2002-02-28 Benzenamine derivatives as anti-coagulants HRP20020185A2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14657299P 1999-07-30 1999-07-30
US09/624,519 US6350761B1 (en) 1999-07-30 2000-07-24 Benzenamine derivatives as anti-coagulants
PCT/US2000/020390 WO2001009093A1 (en) 1999-07-30 2000-07-27 Benzenamine derivatives as anti-coagulants

Publications (1)

Publication Number Publication Date
HRP20020185A2 true HRP20020185A2 (en) 2004-02-29

Family

ID=26844067

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20020185A HRP20020185A2 (en) 1999-07-30 2002-02-28 Benzenamine derivatives as anti-coagulants

Country Status (23)

Country Link
US (1) US6350761B1 (no)
EP (1) EP1200405A1 (no)
JP (1) JP2003506353A (no)
KR (1) KR20020068494A (no)
CN (1) CN1367777A (no)
AU (1) AU766820B2 (no)
BR (1) BR0013292A (no)
CA (1) CA2380029A1 (no)
CZ (1) CZ2002346A3 (no)
EE (1) EE200200050A (no)
HK (1) HK1049482A1 (no)
HR (1) HRP20020185A2 (no)
HU (1) HUP0202234A3 (no)
IL (2) IL147746A0 (no)
LT (1) LT4972B (no)
LV (1) LV12844B (no)
MX (1) MXPA02001065A (no)
NO (1) NO20020457L (no)
NZ (1) NZ516804A (no)
PL (1) PL357871A1 (no)
SI (1) SI20815A (no)
SK (1) SK1252002A3 (no)
WO (1) WO2001009093A1 (no)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2208737T3 (es) 1995-03-10 2004-06-16 Berlex Laboratories, Inc. Derivados de benzamidina, su preparacion y su utilizacion como anticoagulantes.
US6686364B2 (en) 1997-12-08 2004-02-03 Berlex Laboratories, Inc. Benzamidine derivatives and their use as anti-coagulants
US6262088B1 (en) 1998-11-19 2001-07-17 Berlex Laboratories, Inc. Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants
AU2004203154B2 (en) * 1999-10-28 2006-06-01 Sankyo Company, Limited Benzamidine derivatives
AU776193B2 (en) * 1999-10-28 2004-09-02 Sankyo Company Limited Benzamidine derivatives
US20020065303A1 (en) * 2000-02-01 2002-05-30 Bing-Yan Zhu Bivalent phenylene inhibitors of factor Xa
DE10110325A1 (de) * 2001-03-03 2002-09-05 Merck Patent Gmbh Phenylderivate 2
WO2002081448A1 (fr) * 2001-04-05 2002-10-17 Sankyo Company, Limited Derive benzamidine
ES2543588T3 (es) 2002-12-03 2015-08-20 Pharmacyclics Llc Derivados de 2-(2-hidroxibifenil-3-il)-1H-benzoimidazol-5-carboxamidina como inhibidores del factor VIIa
AU2007279092B2 (en) * 2006-07-24 2012-12-13 Ucb Pharma S.A. Substituted aniline derivatives
US8258306B2 (en) * 2007-12-12 2012-09-04 Amgen Inc. Glycine transporter-1 inhibitors
EP2602248A1 (en) * 2011-12-05 2013-06-12 University Of Leicester Novel pyrrole compounds
US11596612B1 (en) 2022-03-08 2023-03-07 PTC Innovations, LLC Topical anesthetics

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB824908A (en) 1958-06-03 1959-12-09 May & Baker Ltd Improvements in or relating to triazine derivatives
JPS5922697B2 (ja) 1976-01-13 1984-05-28 エーザイ株式会社 ビス−（メタ−アミジノフエノキシ）−化合物
JPS58150559A (ja) * 1982-03-04 1983-09-07 Sumitomo Chem Co Ltd オキシムエ−テル誘導体、その製造法およびそれを有効成分として含有する殺虫剤
US4594092A (en) * 1982-12-20 1986-06-10 American Cyanamid Company Substituted nitro and cyanoguanidines and their use of increasing crop yields
JP3280040B2 (ja) 1990-03-26 2002-04-30 武田薬品工業株式会社 アミノベンゼン化合物
US5451700A (en) 1991-06-11 1995-09-19 Ciba-Geigy Corporation Amidino compounds, their manufacture and methods of treatment
EP0518818A3 (en) 1991-06-11 1993-04-28 Ciba-Geigy Ag Arylethers, their manufacture and use as medicament
ZA928276B (en) 1991-10-31 1993-05-06 Daiichi Seiyaku Co Aromatic amidine derivates and salts thereof.
CA2129339C (en) 1992-02-14 2002-09-10 George P. Vlasuk Inhibitors of thrombosis
DE4213919A1 (de) 1992-04-28 1993-11-04 Thomae Gmbh Dr K Cyclische iminoderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
TW234077B (no) 1992-07-17 1994-11-11 Shell Internat Res Schappej B V
AU675981B2 (en) 1992-12-02 1997-02-27 Bristol-Myers Squibb Company Guanidinyl-substituted heterocyclic thrombin inhibitors
JPH08504769A (ja) 1992-12-15 1996-05-21 コルバス・インターナショナル、インコーポレイテッド 因子Ｘａの新規インヒビター
US5332822A (en) 1992-12-24 1994-07-26 Bristol-Myers Squibb Company Heteroaromatic and thioheteroaromatic substituted sulfonamide thrombin inhibitors
CA2155931C (en) 1993-02-12 2002-11-19 George Phillip Vlasuk Inhibitors of thrombosis
US5633381A (en) 1994-07-05 1997-05-27 Berlex Laboratories, Inc. (Z,Z), (Z,E) and (E,Z) isomers of substituted bis(phenylmethylene)cycloketones
IL115420A0 (en) 1994-09-26 1995-12-31 Zeneca Ltd Aminoheterocyclic derivatives
AU688628B2 (en) 1994-12-02 1998-03-12 Yamanouchi Pharmaceutical Co., Ltd. Novel amidinonaphthyl derivative or salt thereof
US6004981A (en) 1996-03-08 1999-12-21 Berlex Laboratories, Inc. Benzamidine derivatives and their use as anti-coagulants
ES2208737T3 (es) * 1995-03-10 2004-06-16 Berlex Laboratories, Inc. Derivados de benzamidina, su preparacion y su utilizacion como anticoagulantes.
US5691364A (en) 1995-03-10 1997-11-25 Berlex Laboratories, Inc. Benzamidine derivatives and their use as anti-coagulants
US5612363A (en) 1995-06-02 1997-03-18 Berlex Laboratories, Inc. N,N-di(aryl) cyclic urea derivatives as anti-coagulants
US5721214A (en) 1995-06-07 1998-02-24 Cor Therapeutics, Inc. Inhibitors of factor Xa
US5849759A (en) 1995-12-08 1998-12-15 Berlex Laboratories, Inc. Naphthyl-substituted benzimidazole derivatives as anti-coagulants
US5994375A (en) 1996-02-12 1999-11-30 Berlex Laboratories, Inc. Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants
US5693641A (en) 1996-08-16 1997-12-02 Berlex Laboratories Inc. Bicyclic pyrimidine derivatives and their use as anti-coagulants
US5753635A (en) 1996-08-16 1998-05-19 Berlex Laboratories, Inc. Purine derivatives and their use as anti-coagulants
US6008234A (en) 1996-09-12 1999-12-28 Berlex Laboratories, Inc. Benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives and their use as anti-coagulants
US6004985A (en) 1996-10-09 1999-12-21 Berlex Laboratories, Inc. Thio acid derived monocylic N-heterocyclics as anticoagulants
US6372759B1 (en) 1997-06-26 2002-04-16 Eli Lilly And Company Antithrombotic agents
EP1007037A4 (en) 1997-06-26 2004-10-06 Lilly Co Eli ANTITHROMBOTIC AGENTS
US6140351A (en) 1997-12-19 2000-10-31 Berlex Laboratories, Inc. Ortho-anthranilamide derivatives as anti-coagulants
WO1999037643A1 (fr) 1998-01-26 1999-07-29 Yamanouchi Pharmaceutical Co., Ltd. Nouveaux derives heterocycliques a fusion benzenique ou sels de ceux-ci
IL138899A0 (en) 1998-04-10 2001-11-25 Japan Tobacco Inc Amidene derivatives and pharmaceutical compositions containing the same
US6127376A (en) 1998-12-04 2000-10-03 Berlex Laboratories, Inc. Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants

Also Published As

Publication number Publication date
SI20815A (sl) 2002-08-31
US6350761B1 (en) 2002-02-26
EE200200050A (et) 2003-04-15
BR0013292A (pt) 2002-04-02
HUP0202234A3 (en) 2005-02-28
NZ516804A (en) 2003-08-29
AU6380500A (en) 2001-02-19
CZ2002346A3 (cs) 2002-06-12
KR20020068494A (ko) 2002-08-27
WO2001009093A8 (en) 2005-11-10
LT2002009A (en) 2002-07-25
SK1252002A3 (en) 2002-08-06
LT4972B (lt) 2002-11-25
JP2003506353A (ja) 2003-02-18
IL147746A0 (en) 2002-08-14
AU766820B2 (en) 2003-10-23
HK1049482A1 (zh) 2003-05-16
LV12844B (en) 2002-11-20
CA2380029A1 (en) 2001-02-08
NO20020457L (no) 2002-03-27
HUP0202234A2 (en) 2002-10-28
WO2001009093A1 (en) 2001-02-08
IL147746A (en) 2007-02-11
EP1200405A1 (en) 2002-05-02
CN1367777A (zh) 2002-09-04
PL357871A1 (en) 2004-07-26
NO20020457D0 (no) 2002-01-29
MXPA02001065A (es) 2002-10-31

Similar Documents

Publication Publication Date Title
US5849759A (en) Naphthyl-substituted benzimidazole derivatives as anti-coagulants
US6495574B2 (en) Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants
US6008234A (en) Benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives and their use as anti-coagulants
EP0929547B1 (en) Benzamidine derivatives substituted by cyclic amino acid or cycl ic hydroxy acid derivatives and their use as anti-coagulants
RO120971B1 (ro) Derivaţi de pirimidină aril şi heterociclil, substituiţi ca anticoagulanţi
IL125285A (en) History of benzamidine converted by history of amino acid and hydroxy acid and pharmaceutical preparations containing them
HRP20020185A2 (en) Benzenamine derivatives as anti-coagulants
AU700894C (en) Naphthyl-substituted benzimidazole derivatives as anticoagulants
BG106363A (bg) Бензенаминови производни като анти-коагуланти

Legal Events

Date Code Title Description
ODRP Renewal fee for the maintenance of a patent

Payment date: 20030728

Year of fee payment: 4

A1OB Publication of a patent application
OBST Application withdrawn