DE69919149D1 - Amidin-verbindungen - Google Patents

Amidin-verbindungen

Info

Publication number
DE69919149D1
DE69919149D1 DE69919149T DE69919149T DE69919149D1 DE 69919149 D1 DE69919149 D1 DE 69919149D1 DE 69919149 T DE69919149 T DE 69919149T DE 69919149 T DE69919149 T DE 69919149T DE 69919149 D1 DE69919149 D1 DE 69919149D1
Authority
DE
Germany
Prior art keywords
amidine
connections
amidine connections
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69919149T
Other languages
English (en)
Inventor
Susumu Katoh
Katsuyuki Yokota
Mikio Hayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Japan Tobacco Inc
Original Assignee
Japan Tobacco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Tobacco Inc filed Critical Japan Tobacco Inc
Application granted granted Critical
Publication of DE69919149D1 publication Critical patent/DE69919149D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
DE69919149T 1998-04-10 1999-04-09 Amidin-verbindungen Expired - Lifetime DE69919149D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP11623398 1998-04-10
JP23786998 1998-08-25
PCT/JP1999/001900 WO1999052895A1 (en) 1998-04-10 1999-04-09 Amidine compounds

Publications (1)

Publication Number Publication Date
DE69919149D1 true DE69919149D1 (de) 2004-09-09

Family

ID=26454606

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69919149T Expired - Lifetime DE69919149D1 (de) 1998-04-10 1999-04-09 Amidin-verbindungen

Country Status (23)

Country Link
US (2) US6562828B1 (de)
EP (1) EP1070714B1 (de)
KR (1) KR100416111B1 (de)
CN (1) CN1305470A (de)
AR (1) AR015269A1 (de)
AT (1) ATE272630T1 (de)
AU (1) AU752588B2 (de)
BR (1) BR9910122A (de)
CA (1) CA2327488A1 (de)
CO (1) CO5021130A1 (de)
DE (1) DE69919149D1 (de)
HU (1) HUP0101137A3 (de)
ID (1) ID28266A (de)
IL (1) IL138899A0 (de)
NO (1) NO20005083L (de)
NZ (1) NZ508101A (de)
PE (1) PE20000422A1 (de)
PL (1) PL343424A1 (de)
RU (1) RU2201927C2 (de)
SG (1) SG74717A1 (de)
SK (1) SK15072000A3 (de)
TR (1) TR200002904T2 (de)
WO (1) WO1999052895A1 (de)

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AU6123699A (en) * 1998-10-16 2000-05-08 Takeda Chemical Industries Ltd. Nitrogenous fused heterocycle compounds, process for the preparation thereof andagents containing the same
US6262088B1 (en) 1998-11-19 2001-07-17 Berlex Laboratories, Inc. Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants
US6350761B1 (en) * 1999-07-30 2002-02-26 Berlex Laboratories, Inc. Benzenamine derivatives as anti-coagulants
WO2001056989A2 (en) * 2000-02-01 2001-08-09 Cor Therapeutics, Inc. Inhibitors of factor xa
AU2001249398A1 (en) * 2000-03-24 2001-10-08 Cor Therapeutics, Inc. Bicyclic sulfonyl amino inhibitors of factor xa
US6469026B2 (en) 2000-03-24 2002-10-22 Millennium Pharmaceuticals, Inc. Isoquinolone inhibitors of factor Xa
US7393652B2 (en) * 2000-05-10 2008-07-01 The Trustees Of Columbia University In The City Of New York Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2)
US20060293266A1 (en) * 2000-05-10 2006-12-28 The Trustees Of Columbia Phosphodiesterase 4D in the ryanodine receptor complex protects against heart failure
US6489125B1 (en) * 2000-05-10 2002-12-03 The Trustees Of Columbia University In The City Of New York Methods for identifying chemical compounds that inhibit dissociation of FKBP12.6 binding protein from type 2 ryanodine receptor
US8022058B2 (en) 2000-05-10 2011-09-20 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US7879840B2 (en) * 2005-08-25 2011-02-01 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US20040229781A1 (en) * 2000-05-10 2004-11-18 Marks Andrew Robert Compounds and methods for treating and preventing exercise-induced cardiac arrhythmias
US7718644B2 (en) * 2004-01-22 2010-05-18 The Trustees Of Columbia University In The City Of New York Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof
US20040048780A1 (en) * 2000-05-10 2004-03-11 The Trustees Of Columbia University In The City Of New York Method for treating and preventing cardiac arrhythmia
US20030187023A1 (en) * 2000-07-17 2003-10-02 Keiji Kubo Sulfone derivatives, process for their production and use thereof
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EP1465635A4 (de) 2002-01-10 2005-04-13 Neurogen Corp Melanin-konzentrierende hormonrezeptor-liganden: substituierte 2-(4-benzyl-piperazin-1-ylmethyl)- und 2-(4-benzyl-diazepan-1-ylmethyl)-1h-benzoimidazol-analoga
JPWO2003095446A1 (ja) * 2002-05-09 2005-09-15 持田製薬株式会社 １−（４−ピリジル）−４−ピペリドンの製造方法
US7544678B2 (en) * 2002-11-05 2009-06-09 The Trustees Of Columbia University In The City Of New York Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2)
CA2507026A1 (en) * 2002-11-22 2004-06-10 Takeda Pharmaceutical Company Limited Imidazole derivatives, their production and use
DK1569912T3 (en) 2002-12-03 2015-06-29 Pharmacyclics Inc 2- (2-hydroxybiphenyl-3-yl) -1h-benzoimidazole-5-carboxamidine derivatives as factor VIIa inhibitors.
JP2007525165A (ja) 2003-03-07 2007-09-06 トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク タイプ１ライアノジン受容体に基づく方法
US7741341B2 (en) * 2003-05-19 2010-06-22 Sanofi-Aventis Deutschland Gmbh Benzimidazole-derivatives as factor Xa inhibitors
EP1479676A1 (de) * 2003-05-19 2004-11-24 Aventis Pharma Deutschland GmbH Benzimidazolderivate als Faktor Xa-Inhibitoren
US7378409B2 (en) 2003-08-21 2008-05-27 Bristol-Myers Squibb Company Substituted cycloalkylamine derivatives as modulators of chemokine receptor activity
JP4355917B2 (ja) 2003-10-29 2009-11-04 信越化学工業株式会社 含窒素有機化合物、レジスト材料及びパターン形成方法
US8710045B2 (en) * 2004-01-22 2014-04-29 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the ryanodine receptors
DE102004016605A1 (de) * 2004-04-03 2005-10-20 Merck Patent Gmbh Thiocarbamoylproline
TWI396686B (zh) * 2004-05-21 2013-05-21 Takeda Pharmaceutical 環狀醯胺衍生物、以及其製品和用法
FR2870846B1 (fr) 2004-05-25 2006-08-04 Sanofi Synthelabo Derives de tetrahydroisoquinolylsulfonamides, leur preparation et leur utilisation en therapeutique
EP1780210A4 (de) * 2004-08-11 2009-06-10 Kyorin Seiyaku Kk Neues zyklisches aminobenzoesäurederivat
WO2006083003A1 (ja) 2005-02-02 2006-08-10 Ajinomoto Co., Inc. 新規ベンズアミジン化合物
CN101189231B (zh) * 2005-03-23 2011-05-18 杏林制药株式会社 环状氨基苯基链烷酸衍生物
US7709516B2 (en) 2005-06-17 2010-05-04 Endorecherche, Inc. Helix 12 directed non-steroidal antiandrogens
US7704990B2 (en) * 2005-08-25 2010-04-27 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
EP1790646A1 (de) * 2005-11-24 2007-05-30 Sanofi-Aventis Isoquinolin- und Benzo[h]isoquinolinderivate, deren Herstellung und deren therapeutischen Verwendung als Antagonisten des Histamin-H3-Rezeptors .
US20080186971A1 (en) * 2007-02-02 2008-08-07 Tarari, Inc. Systems and methods for processing access control lists (acls) in network switches using regular expression matching logic
KR20110036833A (ko) * 2008-07-11 2011-04-11 아지노모토 가부시키가이샤 아미딘 유도체
AR080375A1 (es) 2010-03-05 2012-04-04 Sanofi Aventis Procedimiento para la preparacion de 2-(cicloheximetil)-n-{2-[(2s)-1-metilpirrolidin-2-il] etil}-1,2,3,4-tetrahidroisoquinolina- 7-sulfonamida
KR101499696B1 (ko) * 2013-10-16 2015-03-09 한국식품연구원 젓갈 유래 엔테로코쿠스속 미생물 및 이를 이용하여 s-아데노실-l-메티오닌을 대량 생산하는 방법
CN103965113A (zh) * 2014-05-06 2014-08-06 四川大学 1-羟乙基-2-取代苯氧甲基苯并咪唑类化合物及其制备方法
CN111148735B (zh) * 2017-10-04 2023-08-08 日本烟草产业株式会社 含氮杂芳基化合物及其药物用途

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Also Published As

Publication number Publication date
PE20000422A1 (es) 2000-05-19
IL138899A0 (en) 2001-11-25
HUP0101137A3 (en) 2003-03-28
AU752588B2 (en) 2002-09-26
SK15072000A3 (sk) 2001-08-06
EP1070714B1 (de) 2004-08-04
CA2327488A1 (en) 1999-10-21
US6562828B1 (en) 2003-05-13
ID28266A (id) 2001-05-10
ATE272630T1 (de) 2004-08-15
TR200002904T2 (tr) 2001-02-21
HUP0101137A2 (hu) 2001-10-28
AR015269A1 (es) 2001-04-18
NO20005083D0 (no) 2000-10-09
NO20005083L (no) 2000-12-08
RU2201927C2 (ru) 2003-04-10
EP1070714A4 (de) 2002-10-30
KR20010042606A (ko) 2001-05-25
SG74717A1 (en) 2000-08-22
WO1999052895A1 (en) 1999-10-21
AU3167799A (en) 1999-11-01
KR100416111B1 (ko) 2004-01-31
NZ508101A (en) 2002-12-20
EP1070714A9 (de) 2005-10-19
EP1070714A1 (de) 2001-01-24
BR9910122A (pt) 2001-10-16
PL343424A1 (en) 2001-08-13
CO5021130A1 (es) 2001-03-27
CN1305470A (zh) 2001-07-25
US20040006099A1 (en) 2004-01-08

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Legal Events

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8332 No legal effect for de