DE69709933T2 - Aromatische amidinderivate als selektive thrombininhibitoren - Google Patents
Aromatische amidinderivate als selektive thrombininhibitorenInfo
- Publication number
- DE69709933T2 DE69709933T2 DE69709933T DE69709933T DE69709933T2 DE 69709933 T2 DE69709933 T2 DE 69709933T2 DE 69709933 T DE69709933 T DE 69709933T DE 69709933 T DE69709933 T DE 69709933T DE 69709933 T2 DE69709933 T2 DE 69709933T2
- Authority
- DE
- Germany
- Prior art keywords
- selective
- aromatic amidine
- amidine derivatives
- thrombine
- inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR19960019282 | 1996-05-31 | ||
PCT/KR1997/000100 WO1997045424A1 (en) | 1996-05-31 | 1997-05-31 | Aromatic amidine derivatives useful as selective thrombin inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69709933D1 DE69709933D1 (en) | 2002-02-28 |
DE69709933T2 true DE69709933T2 (de) | 2002-08-29 |
Family
ID=19460481
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69709933T Expired - Fee Related DE69709933T2 (de) | 1996-05-31 | 1997-05-31 | Aromatische amidinderivate als selektive thrombininhibitoren |
Country Status (11)
Country | Link |
---|---|
US (1) | US6201006B1 (de) |
EP (1) | EP0918768B1 (de) |
JP (1) | JP3202994B2 (de) |
KR (1) | KR100469028B1 (de) |
CN (1) | CN1079396C (de) |
AT (1) | ATE211741T1 (de) |
AU (1) | AU3049497A (de) |
CA (1) | CA2256438C (de) |
DE (1) | DE69709933T2 (de) |
ES (1) | ES2171945T3 (de) |
WO (1) | WO1997045424A1 (de) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6602864B1 (en) * | 1996-12-13 | 2003-08-05 | Aventis Pharma Deutschland Gmbh | Sulfonic acid or sulfonylamino N-(heteroaralkyl)-azaheterocyclylamide compounds |
KR19990043605A (ko) * | 1997-11-29 | 1999-06-15 | 이경하 | 선택적 트롬빈 억제제로 유용한 방향족 아미딘유도체 |
SK15072000A3 (sk) | 1998-04-10 | 2001-08-06 | Japan Tobacco Inc. | Amidové zlúčeniny |
WO2000073269A2 (en) * | 1999-06-02 | 2000-12-07 | Regents Of The University Of Minnesota | Nicotine receptor ligands |
WO2001014358A2 (en) * | 1999-08-26 | 2001-03-01 | Aventis Pharmaceuticals Inc. | Substituted (aminoiminomethyl or aminomethyl) dihydrobenzofurans and benozopyrans |
GB9924155D0 (en) * | 1999-10-12 | 1999-12-15 | Rhone Poulenc Rorer Pharma | Chemical compounds |
US7361663B2 (en) * | 1999-11-10 | 2008-04-22 | Aventis Pharmaceuticals Inc. | N-acylpyrrolidin-2-ylalkylbenzamidine derivatives as inhibitors of factor Xa |
IL149544A0 (en) * | 1999-11-10 | 2002-11-10 | Aventis Pharma Gmbh | N-ACYLPYRROLIDIN-2-YLALKYLBENZAMIDINE DERIVATIVES AS INHIBITORS OF FACTOR Xa |
WO2004103993A1 (en) * | 2003-05-14 | 2004-12-02 | Syrrx, Inc. | Dipeptidyl peptidase inhibitors |
JP2005350417A (ja) * | 2004-06-11 | 2005-12-22 | Dai Ichi Seiyaku Co Ltd | 還元的エーテル化法を用いたピロリジン誘導体の製造法 |
WO2006038119A1 (en) * | 2004-10-08 | 2006-04-13 | Warner-Lambert Company Llc | Stereoselective synthesis of n-protected alkoxy prolines |
GB0507577D0 (en) | 2005-04-14 | 2005-05-18 | Novartis Ag | Organic compounds |
WO2007143211A2 (en) * | 2006-06-02 | 2007-12-13 | Bioseek, Inc. | Methods for identifying agents and their use for the prevention of restenosis |
EP2085397A1 (de) * | 2008-01-21 | 2009-08-05 | Esteve Quimica, S.A. | Kristalline Form von Abacavir |
SG194901A1 (en) | 2011-05-09 | 2013-12-30 | Univ Glasgow | Methods of modulating micrornas in the treatment of pulmonary arterial hypertension |
CN113956192A (zh) * | 2021-11-16 | 2022-01-21 | 上海延安药业(湖北)有限公司 | 一种阿维巴坦中间体的合成方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4258192A (en) * | 1977-12-16 | 1981-03-24 | Mitsubishi Chemical Industries Limited | N2 -Arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof |
JPS5813549A (ja) * | 1981-07-15 | 1983-01-26 | Kowa Co | 新規フエニルエステル類 |
ZA928276B (en) * | 1991-10-31 | 1993-05-06 | Daiichi Seiyaku Co | Aromatic amidine derivates and salts thereof. |
JPH0820532A (ja) * | 1994-07-05 | 1996-01-23 | Dai Ichi Seiyaku Co Ltd | 抗膵炎剤 |
-
1997
- 1997-05-31 CA CA002256438A patent/CA2256438C/en not_active Expired - Fee Related
- 1997-05-31 AT AT97925316T patent/ATE211741T1/de not_active IP Right Cessation
- 1997-05-31 JP JP54206597A patent/JP3202994B2/ja not_active Expired - Fee Related
- 1997-05-31 DE DE69709933T patent/DE69709933T2/de not_active Expired - Fee Related
- 1997-05-31 CN CN97195005A patent/CN1079396C/zh not_active Expired - Fee Related
- 1997-05-31 KR KR1019970022566A patent/KR100469028B1/ko not_active IP Right Cessation
- 1997-05-31 EP EP97925316A patent/EP0918768B1/de not_active Expired - Lifetime
- 1997-05-31 AU AU30494/97A patent/AU3049497A/en not_active Abandoned
- 1997-05-31 US US09/180,675 patent/US6201006B1/en not_active Expired - Fee Related
- 1997-05-31 WO PCT/KR1997/000100 patent/WO1997045424A1/en active IP Right Grant
- 1997-05-31 ES ES97925316T patent/ES2171945T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE69709933D1 (en) | 2002-02-28 |
CA2256438A1 (en) | 1997-12-04 |
JP2000504030A (ja) | 2000-04-04 |
CA2256438C (en) | 2002-10-15 |
US6201006B1 (en) | 2001-03-13 |
EP0918768A1 (de) | 1999-06-02 |
ES2171945T3 (es) | 2002-09-16 |
WO1997045424A1 (en) | 1997-12-04 |
KR970074779A (ko) | 1997-12-10 |
CN1219932A (zh) | 1999-06-16 |
CN1079396C (zh) | 2002-02-20 |
EP0918768B1 (de) | 2002-01-09 |
ATE211741T1 (de) | 2002-01-15 |
AU3049497A (en) | 1998-01-05 |
JP3202994B2 (ja) | 2001-08-27 |
KR100469028B1 (ko) | 2005-07-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8339 | Ceased/non-payment of the annual fee |