DK0941221T3 - Substituerede dihydrobenzofuraner som PDE-inhibitorer - Google Patents
Substituerede dihydrobenzofuraner som PDE-inhibitorerInfo
- Publication number
- DK0941221T3 DK0941221T3 DK97950157T DK97950157T DK0941221T3 DK 0941221 T3 DK0941221 T3 DK 0941221T3 DK 97950157 T DK97950157 T DK 97950157T DK 97950157 T DK97950157 T DK 97950157T DK 0941221 T3 DK0941221 T3 DK 0941221T3
- Authority
- DK
- Denmark
- Prior art keywords
- pct
- pde inhibitors
- substituted dihydrobenzofurans
- dihydrobenzofurans
- substituted
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 abstract 2
- 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
- C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Pyrane Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19647881 | 1996-11-20 | ||
| EP96118743 | 1996-11-22 | ||
| PCT/EP1997/006248 WO1998022453A1 (en) | 1996-11-20 | 1997-11-11 | Substituted dihydrobenzofurans as pde inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0941221T3 true DK0941221T3 (da) | 2003-06-10 |
Family
ID=26031440
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK97950157T DK0941221T3 (da) | 1996-11-20 | 1997-11-11 | Substituerede dihydrobenzofuraner som PDE-inhibitorer |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6054475A (da) |
| EP (1) | EP0941221B1 (da) |
| JP (1) | JP2001505198A (da) |
| AT (1) | ATE233252T1 (da) |
| AU (1) | AU5320698A (da) |
| CY (1) | CY2472B1 (da) |
| DE (1) | DE69719358T2 (da) |
| DK (1) | DK0941221T3 (da) |
| ES (1) | ES2193414T3 (da) |
| PT (1) | PT941221E (da) |
| SI (1) | SI0941221T1 (da) |
| WO (1) | WO1998022453A1 (da) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001013953A2 (en) | 1999-08-21 | 2001-03-01 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Synergistic combination of pde inhibitors and beta 2 adrenoceptor agonist |
| JP2003525845A (ja) * | 1997-10-28 | 2003-09-02 | ヴィヴァス・インコーポレイテッド | 勃起機能不全の処置のためのホスホジエステラーゼインヒビターの局所投与 |
| EP1280523A2 (en) * | 2000-05-03 | 2003-02-05 | Sucampo AG | Use of benzamide derivatives for the treatment of high ocular tension and glaucoma |
| JP3940290B2 (ja) * | 2000-12-22 | 2007-07-04 | ザ・ヨルダニアン・フアーマシユーテイカル・エム・エフ・ジー・アンド・メデイカル・イクイツプメント・カンパニー・リミテツド | 新規化合物 |
| SE0004780D0 (sv) * | 2000-12-22 | 2000-12-22 | Jordanian Pharmaceutical Mfg & | Novel compunds |
| ES2254611T3 (es) * | 2001-05-11 | 2006-06-16 | Pfizer Products Inc. | Derivados de tiazol. |
| CA2469075C (en) | 2001-12-20 | 2011-09-13 | Applied Research Systems Ars Holding N.V. | Pyrrolidine derivatives as prostaglandin modulators |
| US6723755B2 (en) | 2002-06-12 | 2004-04-20 | Piotr Chomczynski | Method of treating rosacea |
| DE10348022A1 (de) * | 2003-10-15 | 2005-05-25 | Imtm Gmbh | Neue Dipeptidylpeptidase IV-Inhibitoren zur funktionellen Beeinflussung unterschiedlicher Zellen und zur Behandlung immunologischer, entzündlicher, neuronaler und anderer Erkrankungen |
| US7812057B2 (en) * | 2004-08-25 | 2010-10-12 | Molecular Research Center, Inc. | Cosmetic compositions |
| CA2620333A1 (en) | 2005-08-26 | 2007-03-01 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
| EP2258359A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation with sabcomelin |
| EP1940389A2 (en) | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
| EP1942879A1 (en) | 2005-10-31 | 2008-07-16 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| JP2009536669A (ja) | 2006-05-09 | 2009-10-15 | ブレインセルス，インコーポレイティド | アンジオテンシン調節による神経新生 |
| JP2009536667A (ja) | 2006-05-09 | 2009-10-15 | ブレインセルス，インコーポレイティド | ５ｈｔ受容体介在性の神経新生 |
| BRPI0716604A2 (pt) | 2006-09-08 | 2013-04-09 | Braincells Inc | combinaÇÕes contendo um derivado de 4-acilaminopiridina |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| EP2804603A1 (en) | 2012-01-10 | 2014-11-26 | President and Fellows of Harvard College | Beta-cell replication promoting compounds and methods of their use |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ283425B6 (cs) * | 1992-04-02 | 1998-04-15 | Smithkline Beecham Corporation | Fenylové deriváty a farmaceutické prostředky s jejich obsahem |
| PT772610E (pt) * | 1994-07-22 | 2001-03-30 | Byk Gulden Lomberg Chem Fab | Di-hidrobenzofuranos |
| DK0828728T3 (da) * | 1995-05-18 | 2003-05-19 | Altana Pharma Ag | Phenyldihydrobenzofuraner |
| EP0828727B1 (de) * | 1995-05-18 | 2003-01-02 | ALTANA Pharma AG | Cyclohexyldihydrobenzofurane |
-
1997
- 1997-11-11 PT PT97950157T patent/PT941221E/pt unknown
- 1997-11-11 WO PCT/EP1997/006248 patent/WO1998022453A1/en active IP Right Grant
- 1997-11-11 EP EP97950157A patent/EP0941221B1/en not_active Expired - Lifetime
- 1997-11-11 US US09/284,459 patent/US6054475A/en not_active Expired - Fee Related
- 1997-11-11 AU AU53206/98A patent/AU5320698A/en not_active Abandoned
- 1997-11-11 SI SI9730523T patent/SI0941221T1/xx unknown
- 1997-11-11 ES ES97950157T patent/ES2193414T3/es not_active Expired - Lifetime
- 1997-11-11 JP JP52316498A patent/JP2001505198A/ja not_active Ceased
- 1997-11-11 DE DE69719358T patent/DE69719358T2/de not_active Expired - Fee Related
- 1997-11-11 DK DK97950157T patent/DK0941221T3/da active
- 1997-11-11 AT AT97950157T patent/ATE233252T1/de not_active IP Right Cessation
-
2004
- 2004-08-11 CY CY0400063A patent/CY2472B1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT941221E (pt) | 2003-07-31 |
| DE69719358T2 (de) | 2003-12-24 |
| US6054475A (en) | 2000-04-25 |
| EP0941221B1 (en) | 2003-02-26 |
| ES2193414T3 (es) | 2003-11-01 |
| SI0941221T1 (en) | 2003-10-31 |
| DE69719358D1 (de) | 2003-04-03 |
| CY2472B1 (en) | 2005-06-03 |
| JP2001505198A (ja) | 2001-04-17 |
| EP0941221A1 (en) | 1999-09-15 |
| AU5320698A (en) | 1998-06-10 |
| ATE233252T1 (de) | 2003-03-15 |
| WO1998022453A1 (en) | 1998-05-28 |
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