IL145728A0 - A topical antiandrogen for hair loss and other hyperandrogenic conditions - Google Patents

A topical antiandrogen for hair loss and other hyperandrogenic conditions

Info

Publication number
IL145728A0
IL145728A0 IL14572800A IL14572800A IL145728A0 IL 145728 A0 IL145728 A0 IL 145728A0 IL 14572800 A IL14572800 A IL 14572800A IL 14572800 A IL14572800 A IL 14572800A IL 145728 A0 IL145728 A0 IL 145728A0
Authority
IL
Israel
Prior art keywords
hair loss
hyperandrogenic conditions
androgen receptor
antiandrogen
topical
Prior art date
Application number
IL14572800A
Other languages
English (en)
Original Assignee
Biophysica Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biophysica Inc filed Critical Biophysica Inc
Publication of IL145728A0 publication Critical patent/IL145728A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/56—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and doubly-bound oxygen atoms bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/46—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/06—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms
    • C07C335/08—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/22—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
    • C07D207/408—Radicals containing only hydrogen and carbon atoms attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/86—Oxygen and sulfur atoms, e.g. thiohydantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL14572800A 2000-02-11 2000-05-25 A topical antiandrogen for hair loss and other hyperandrogenic conditions IL145728A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/502,376 US6472415B1 (en) 1998-12-18 2000-02-11 Androgen receptor suppressors in the therapy and diagnosis of prostate cancer, alopecia and other hyper-androgenic syndromes
PCT/US2000/014792 WO2001058854A1 (en) 2000-02-11 2000-05-25 A topical antiandrogen for hair loss and other hyperandrogenic conditions

Publications (1)

Publication Number Publication Date
IL145728A0 true IL145728A0 (en) 2002-07-25

Family

ID=23997526

Family Applications (2)

Application Number Title Priority Date Filing Date
IL14572800A IL145728A0 (en) 2000-02-11 2000-05-25 A topical antiandrogen for hair loss and other hyperandrogenic conditions
IL145728A IL145728A (en) 2000-02-11 2001-10-01 Derivatives of 2 - hydroxy - 2 - methyl - N - (4 - X - 3 - (trifluoromethyl) phenyl) - 3 - (perfluoroacylamino) propionamide, compounds containing them and their use in the preparation of medicinal preparations

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL145728A IL145728A (en) 2000-02-11 2001-10-01 Derivatives of 2 - hydroxy - 2 - methyl - N - (4 - X - 3 - (trifluoromethyl) phenyl) - 3 - (perfluoroacylamino) propionamide, compounds containing them and their use in the preparation of medicinal preparations

Country Status (19)

Country Link
US (1) US6472415B1 (ja)
EP (1) EP1169301B1 (ja)
JP (1) JP4806508B2 (ja)
KR (1) KR100508681B1 (ja)
CN (1) CN100402492C (ja)
AT (1) ATE259781T1 (ja)
AU (3) AU2000253026A1 (ja)
BR (1) BRPI0008439B1 (ja)
CA (1) CA2400185C (ja)
CZ (1) CZ301910B6 (ja)
DE (2) DE10084380T1 (ja)
ES (2) ES2215672T3 (ja)
HK (2) HK1043692A1 (ja)
IL (2) IL145728A0 (ja)
MX (1) MXPA01006376A (ja)
PL (1) PL201173B1 (ja)
RU (1) RU2225390C2 (ja)
WO (2) WO2001058854A1 (ja)
ZA (1) ZA200206497B (ja)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6828458B2 (en) * 2000-05-25 2004-12-07 Biophysica, Inc. Topical antiandrogen for hair loss and other hyperandrogenic conditions
FR2826263B1 (fr) * 2001-06-26 2005-02-25 Oreal Composition cosmetique ou dermatologique comprenant une association entre un compose inhibiteur de l'elastase de la famille des n-acylaminoamides et au moins un compose anti-inflammatoire
US7355081B2 (en) * 2002-04-17 2008-04-08 The University Of North Carolina At Chapel Hill Curcumin analogues and uses thereof
WO2005000795A2 (en) * 2003-06-10 2005-01-06 Smithkline Beecham Corporation Aniline derivatived androgen-, glucocorticoid-, mineralcorticoid- and progesterone- receptor modulators
US7505948B2 (en) * 2003-11-18 2009-03-17 Aureon Laboratories, Inc. Support vector regression for censored data
US7467119B2 (en) * 2003-07-21 2008-12-16 Aureon Laboratories, Inc. Systems and methods for treating, diagnosing and predicting the occurrence of a medical condition
GB0324551D0 (en) * 2003-10-21 2003-11-26 Karobio Ab Novel compounds
WO2005050563A2 (en) * 2003-11-17 2005-06-02 Aureon Biosciences Corporation Pathological tissue mapping
CA2550447A1 (en) * 2003-12-19 2005-07-07 The Regents Of The University Of California Methods and materials for assessing prostate cancer therapies
US7718684B2 (en) 2004-02-24 2010-05-18 The Regents Of The University Of California Methods and materials for assessing prostate cancer therapies and compounds
CA2557716A1 (en) * 2004-02-27 2005-09-15 Aureon Biosciences Corporation Methods and systems for predicting occurrence of an event
CA2575859A1 (en) * 2004-08-11 2006-02-23 Aureon Laboratories, Inc. Systems and methods for automated diagnosis and grading of tissue images
CN101103003A (zh) * 2004-11-16 2008-01-09 詹森药业有限公司 用作选择性雄激素受体调节剂(sarms)的新的杂环衍生物
FR2878155A1 (fr) * 2004-11-22 2006-05-26 Oreal Protection de la peau contre les alterations liees a un dysfonctionnement des mecanismes physiologiques d'apoptose
WO2006053790A1 (en) * 2004-11-22 2006-05-26 L'oreal Use of compounds of the n-acylaminoamide family as soothing or calming agents
FR2878156A1 (fr) * 2004-11-22 2006-05-26 Oreal Utilisation des composes de la famille des n-acylamino-amides comme agents apaisants
WO2006053789A1 (en) * 2004-11-22 2006-05-26 L'oreal Protection of the skin against deterioration linked to a stress-induced dysfunction of the apoptotic and immune defence processes
US7709517B2 (en) 2005-05-13 2010-05-04 The Regents Of The University Of California Diarylhydantoin compounds
US7709516B2 (en) * 2005-06-17 2010-05-04 Endorecherche, Inc. Helix 12 directed non-steroidal antiandrogens
US20070048246A1 (en) * 2005-09-01 2007-03-01 Biophysica Research, Inc. Novel skin care compositions
WO2007057909A1 (en) * 2005-11-21 2007-05-24 Hadasit Medical Research Services & Development Ltd. Androgen-receptor (ar) ligands for use in the treatment and diagnosis of ar-related pathologies
PT2656842T (pt) 2006-03-27 2016-10-04 Univ California Modulador do recetor de androgénios para o tratamento de cancro da próstata e doenças associadas ao recetor de androgénios
EP2013187B1 (en) 2006-03-29 2014-10-29 The Regents of The University of California Diarylthiohydantoin compounds
WO2008044033A1 (en) * 2006-10-11 2008-04-17 Astrazeneca Ab Amide derivatives
AR069039A1 (es) 2007-10-26 2009-12-23 Univ California Compuestos de diarilhidantoina, composicion farmaceutica, proceso de obtencion del compuesto, utiles para desordenes hiperproliferativos
GB0722088D0 (en) * 2007-11-09 2007-12-19 Spirogen Ltd Pyrrolobenzodiazepines
EP2235010A1 (en) 2007-12-21 2010-10-06 AstraZeneca AB Bicyclic derivatives for use in the treatment of androgen receptor associated conditions
TW201111378A (en) 2009-09-11 2011-04-01 Bayer Schering Pharma Ag Substituted (heteroarylmethyl) thiohydantoins
EP3357917A1 (en) 2010-02-16 2018-08-08 Aragon Pharmaceuticals, Inc. Androgen receptor modulators and uses thereof
LT3150575T (lt) * 2010-09-27 2023-12-27 Corteva Agriscience Llc 2-amino-n-(2,2,2-trifluoretil) acetamido gamybos būdas
UA124967C2 (uk) 2012-09-26 2021-12-22 Араґон Фармасьютікалз, Інк. Антиандрогени для лікування неметастатичного кастраційно-резистентного раку передміхурової залози
JOP20200097A1 (ar) 2013-01-15 2017-06-16 Aragon Pharmaceuticals Inc معدل مستقبل أندروجين واستخداماته
EP3089974B1 (en) * 2013-12-31 2019-02-20 Ipsen Pharma S.A.S. Novel imidazolidine-2,4-dione derivatives
US10654809B2 (en) 2016-06-10 2020-05-19 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US10865184B2 (en) 2015-04-21 2020-12-15 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US10093613B2 (en) 2015-04-21 2018-10-09 Gtx, Inc. Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US10441570B2 (en) 2015-04-21 2019-10-15 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) Ligands and methods of use thereof
US10314797B2 (en) * 2016-06-10 2019-06-11 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US10806720B2 (en) 2015-04-21 2020-10-20 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
TWI726969B (zh) 2016-01-11 2021-05-11 比利時商健生藥品公司 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物
US11230523B2 (en) 2016-06-10 2022-01-25 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
SG11202003402QA (en) 2017-10-16 2020-05-28 Aragon Pharmaceuticals Inc Anti-androgens for the treatment of non-metastatic castration-resistant prostate cancer
AU2019387367A1 (en) 2018-11-30 2021-06-10 Nuvation Bio Inc. Diarylhydantoin compounds and methods of use thereof
KR102417496B1 (ko) 2019-11-29 2022-07-06 (주)수파드엘릭사 안드로겐 수용체의 활성을 억제하는 폡타이드 및 이를 이용하는 화장료 조성물
WO2023011596A1 (zh) * 2021-08-05 2023-02-09 中国药科大学 酰胺类化合物及其应用
CN115919860B (zh) * 2022-12-05 2023-11-10 中国药科大学 氟班色林在制备治疗雄激素脱发药物中的用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3372965D1 (en) 1982-07-23 1987-09-17 Ici Plc Amide derivatives
GB8617652D0 (en) 1986-07-18 1986-08-28 Ici Plc Acylanilide derivatives
JPH05194204A (ja) * 1992-01-20 1993-08-03 Lion Corp 抗男性ホルモン剤
US5656651A (en) 1995-06-16 1997-08-12 Biophysica Inc. Androgenic directed compositions
BR9710988A (pt) * 1996-06-27 2002-01-15 Ligand Pharm Inc Método e compostos moduladores receptores de androgênio
JP3568325B2 (ja) * 1996-07-12 2004-09-22 株式会社ノエビア 抗アンドロゲン剤及び養毛剤並びに毛髪用化粧料
US6184249B1 (en) * 1998-12-18 2001-02-06 Biophysica, Inc. Androgen receptor suppressors in the therapy and diagnosis of prostate cancer, alopecia and other hyper-androgenic syndromes

Also Published As

Publication number Publication date
KR20020089347A (ko) 2002-11-29
US6472415B1 (en) 2002-10-29
HK1043692A1 (zh) 2002-09-20
JP2003522752A (ja) 2003-07-29
CN1416416A (zh) 2003-05-07
BR0008439A (pt) 2002-04-23
PL201173B1 (pl) 2009-03-31
KR100508681B1 (ko) 2005-08-17
ES2187390B2 (es) 2004-04-01
EP1169301B1 (en) 2004-02-18
CA2400185A1 (en) 2001-08-16
CA2400185C (en) 2011-07-05
JP4806508B2 (ja) 2011-11-02
ES2215672T3 (es) 2004-10-16
HK1051849A1 (en) 2003-08-22
BRPI0008439B1 (pt) 2016-04-19
WO2001058854A1 (en) 2001-08-16
PL350356A1 (en) 2002-12-02
MXPA01006376A (es) 2003-06-06
AU2001236856B2 (en) 2005-08-11
CZ301910B6 (cs) 2010-07-28
EP1169301A1 (en) 2002-01-09
DE60008360D1 (de) 2004-03-25
DE60008360T2 (de) 2004-12-09
RU2225390C2 (ru) 2004-03-10
WO2001058855A9 (en) 2002-10-31
AU2000253026A1 (en) 2001-08-20
CZ20012398A3 (cs) 2001-11-14
ZA200206497B (en) 2003-08-14
CN100402492C (zh) 2008-07-16
ATE259781T1 (de) 2004-03-15
IL145728A (en) 2008-04-13
AU3685601A (en) 2001-08-20
WO2001058855A1 (en) 2001-08-16
DE10084380T1 (de) 2002-06-20
ES2187390A1 (es) 2003-06-01

Similar Documents

Publication Publication Date Title
IL145728A0 (en) A topical antiandrogen for hair loss and other hyperandrogenic conditions
WO2000037430A3 (en) Use of androgen receptor suppressors
SI1165516T1 (en) Heterocyclic urea and related compounds useful as anti-inflammatory agents
AU9309898A (en) Benzimidazolinones, benzoxazolinones, benzopiperazinones, indanones, and derivatives thereof as inhibitors of factor xa
UA81603C2 (ru) ПРОИЗВОДНЫЕ МОЧЕВИНЫ КАК АНТАГОНИСТЫ б4 ИНТЕГРИНА
DK1047397T3 (da) Topiske præparater til forögelse af glutathionproduktion
BR0007864A (pt) Composto, e, uso de um composto
AR045991A2 (es) Compuesto de urea
GB9812048D0 (en) Means for combining extendible,coilable members to create compound struts
ATE318578T1 (de) Zubereitungen zur topischen applikation von antiandrogen wirksamen substanzen
HRP20090407T1 (en) Hair growth inhibition
MXPA04001249A (es) Reduccion del crecimiento del vello.
WO2000040532A3 (en) Synthesis of dihydrohonokiol compositions
AU6975600A (en) Topical urea composition
DE69930186D1 (de) Verzögerungsverriegelungsschleifennachführung für Direktsequenzspreizspektrumsignale
TR199901546A2 (xx) Pirolidinil hidroksamik asid bile�imleri i�in y�ntem.
MXPA05008464A (es) Derivados de bencilurea y benciltiourea utiles como antagonistas del receptor de androgeno.
WO2001062668A3 (en) Sulfur containing compounds
ATE268871T1 (de) Befestigerschutz
Blersch et al. Stretched-Exponential-Like Relaxation of an Impurity in a S= 1/2 XY Chain
Sheltraw et al. A New Approximation Technique for the Calculation of Pulsed Gradient NMR Signals
Jean-Paul Excitations in CuGeO3: ESR versus Neutron Inelastic Scattering
Lebedev et al. Search for Periodicity of the Space Distribution of Quasars
Leyko Specific of a rotation the solar mean magnetic field during cycle 21 and 22
UA34270A (uk) Спосіб отримання літійвміщуючих сплавів

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
KB Patent renewed