AU2000253026A1 - A topical antiandrogen for hair loss and other hyperandrogenic conditions - Google Patents
A topical antiandrogen for hair loss and other hyperandrogenic conditionsInfo
- Publication number
- AU2000253026A1 AU2000253026A1 AU2000253026A AU5302600A AU2000253026A1 AU 2000253026 A1 AU2000253026 A1 AU 2000253026A1 AU 2000253026 A AU2000253026 A AU 2000253026A AU 5302600 A AU5302600 A AU 5302600A AU 2000253026 A1 AU2000253026 A1 AU 2000253026A1
- Authority
- AU
- Australia
- Prior art keywords
- hair loss
- hyperandrogenic conditions
- androgen receptor
- antiandrogen
- topical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/56—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and doubly-bound oxygen atoms bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
- C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C07C317/46—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/06—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms
- C07C335/08—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of a saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/22—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
- C07D207/408—Radicals containing only hydrogen and carbon atoms attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/86—Oxygen and sulfur atoms, e.g. thiohydantoin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/88—Nitrogen atoms, e.g. allantoin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Abstract
Substituted phenylalanines are provided comprising an hydantoin, urea or 2-hydroxyl, 2-methylpropionyl group, dimers thereof and alkyl, polyfluoroamido and haloarylamino derivatives thereof, as well as radiolabeled derivatives thereof. The compounds bind specifically to the androgen receptor and find use in indications associated with the androgen receptor, such as cell hyperplasia dependent on androgens, hirsutism, acne and androgenetic alopecia.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09502376 | 2000-02-11 | ||
US09/502,376 US6472415B1 (en) | 1998-12-18 | 2000-02-11 | Androgen receptor suppressors in the therapy and diagnosis of prostate cancer, alopecia and other hyper-androgenic syndromes |
PCT/US2000/014792 WO2001058854A1 (en) | 2000-02-11 | 2000-05-25 | A topical antiandrogen for hair loss and other hyperandrogenic conditions |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2000253026A1 true AU2000253026A1 (en) | 2001-08-20 |
Family
ID=23997526
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2000253026A Abandoned AU2000253026A1 (en) | 2000-02-11 | 2000-05-25 | A topical antiandrogen for hair loss and other hyperandrogenic conditions |
AU2001236856A Ceased AU2001236856B2 (en) | 2000-02-11 | 2001-02-09 | Androgen receptor suppressors in the therapy and diagnosis of prostate cancer, alopecia and other hyper-androgenic syndromes |
AU3685601A Pending AU3685601A (en) | 2000-02-11 | 2001-02-09 | Androgen receptor suppressors in the therapy and diagnosis of prostate cancer, alopecia and other hyper-androgenic syndromes |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001236856A Ceased AU2001236856B2 (en) | 2000-02-11 | 2001-02-09 | Androgen receptor suppressors in the therapy and diagnosis of prostate cancer, alopecia and other hyper-androgenic syndromes |
AU3685601A Pending AU3685601A (en) | 2000-02-11 | 2001-02-09 | Androgen receptor suppressors in the therapy and diagnosis of prostate cancer, alopecia and other hyper-androgenic syndromes |
Country Status (19)
Country | Link |
---|---|
US (1) | US6472415B1 (en) |
EP (1) | EP1169301B1 (en) |
JP (1) | JP4806508B2 (en) |
KR (1) | KR100508681B1 (en) |
CN (1) | CN100402492C (en) |
AT (1) | ATE259781T1 (en) |
AU (3) | AU2000253026A1 (en) |
BR (1) | BRPI0008439B1 (en) |
CA (1) | CA2400185C (en) |
CZ (1) | CZ301910B6 (en) |
DE (2) | DE10084380T1 (en) |
ES (2) | ES2187390B2 (en) |
HK (2) | HK1043692A1 (en) |
IL (2) | IL145728A0 (en) |
MX (1) | MXPA01006376A (en) |
PL (1) | PL201173B1 (en) |
RU (1) | RU2225390C2 (en) |
WO (2) | WO2001058854A1 (en) |
ZA (1) | ZA200206497B (en) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6828458B2 (en) * | 2000-05-25 | 2004-12-07 | Biophysica, Inc. | Topical antiandrogen for hair loss and other hyperandrogenic conditions |
FR2826263B1 (en) * | 2001-06-26 | 2005-02-25 | Oreal | COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING AN ASSOCIATION BETWEEN AN ELASTIC INHIBITOR COMPOUND OF THE N-ACYLAMINOAMIDE FAMILY AND AT LEAST ONE ANTI-INFLAMMATORY COMPOUND |
US7355081B2 (en) * | 2002-04-17 | 2008-04-08 | The University Of North Carolina At Chapel Hill | Curcumin analogues and uses thereof |
EP1654221A2 (en) * | 2003-06-10 | 2006-05-10 | Smithkline Beecham Corporation | Aniline derivatived androgen-, glucocorticoid-, mineralcorticoid- and progesterone- receptor modulators |
US7321881B2 (en) * | 2004-02-27 | 2008-01-22 | Aureon Laboratories, Inc. | Methods and systems for predicting occurrence of an event |
US7505948B2 (en) * | 2003-11-18 | 2009-03-17 | Aureon Laboratories, Inc. | Support vector regression for censored data |
US7467119B2 (en) * | 2003-07-21 | 2008-12-16 | Aureon Laboratories, Inc. | Systems and methods for treating, diagnosing and predicting the occurrence of a medical condition |
GB0324551D0 (en) * | 2003-10-21 | 2003-11-26 | Karobio Ab | Novel compounds |
WO2005050563A2 (en) * | 2003-11-17 | 2005-06-02 | Aureon Biosciences Corporation | Pathological tissue mapping |
US8034548B2 (en) * | 2003-12-19 | 2011-10-11 | The Regents Of The University Of California | Methods and materials for assessing prostate cancer therapies |
AU2005232526B2 (en) | 2004-02-24 | 2011-06-23 | The Regents Of The University Of California | Methods and materials for assessing prostate cancer therapies and compounds |
CA2575859A1 (en) * | 2004-08-11 | 2006-02-23 | Aureon Laboratories, Inc. | Systems and methods for automated diagnosis and grading of tissue images |
WO2006055184A2 (en) * | 2004-11-16 | 2006-05-26 | Janssen Pharmaceutica N.V. | Novel heterocycle derivatives useful as selective androgen receptor modulators (sarms) |
WO2006053790A1 (en) * | 2004-11-22 | 2006-05-26 | L'oreal | Use of compounds of the n-acylaminoamide family as soothing or calming agents |
FR2878156A1 (en) * | 2004-11-22 | 2006-05-26 | Oreal | Use of compound of N-acylamino-amides family in a composition containing medium e.g. as alleviating agent, to prevent and/or decrease cutaneous reaction induced by a stress and dermatological effects e.g. acne and atopic dermatitis |
WO2006053789A1 (en) * | 2004-11-22 | 2006-05-26 | L'oreal | Protection of the skin against deterioration linked to a stress-induced dysfunction of the apoptotic and immune defence processes |
FR2878155A1 (en) * | 2004-11-22 | 2006-05-26 | Oreal | Use of a compound of the family of N-acylamino-amides in a composition (containing a medium), as an agent to protect skin and/or its phanera from skin changes related to dysfunction of the physiological mechanisms of apoptosis |
US7709517B2 (en) | 2005-05-13 | 2010-05-04 | The Regents Of The University Of California | Diarylhydantoin compounds |
US7709516B2 (en) * | 2005-06-17 | 2010-05-04 | Endorecherche, Inc. | Helix 12 directed non-steroidal antiandrogens |
US20070048246A1 (en) * | 2005-09-01 | 2007-03-01 | Biophysica Research, Inc. | Novel skin care compositions |
WO2007057909A1 (en) * | 2005-11-21 | 2007-05-24 | Hadasit Medical Research Services & Development Ltd. | Androgen-receptor (ar) ligands for use in the treatment and diagnosis of ar-related pathologies |
HUE027894T2 (en) * | 2006-03-27 | 2016-11-28 | Univ California | Androgen receptor modulator for the treatment of prostate cancer and androgen receptor-associated diseases |
KR101456722B1 (en) * | 2006-03-29 | 2014-10-31 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | Diarylthiohydantoin compounds |
WO2008044033A1 (en) * | 2006-10-11 | 2008-04-17 | Astrazeneca Ab | Amide derivatives |
PE20121470A1 (en) | 2007-10-26 | 2012-11-18 | Univ California | DIARYLHIDANTOIN COMPOUNDS AS ANDROGEN RECEPTOR ANTAGONISTS |
GB0722088D0 (en) * | 2007-11-09 | 2007-12-19 | Spirogen Ltd | Pyrrolobenzodiazepines |
BRPI0821676A2 (en) | 2007-12-21 | 2015-06-16 | Astrazeneca Ab | Compound, pharmaceutical composition, and process for preparing the compounds. |
TW201111378A (en) | 2009-09-11 | 2011-04-01 | Bayer Schering Pharma Ag | Substituted (heteroarylmethyl) thiohydantoins |
EA028869B1 (en) | 2010-02-16 | 2018-01-31 | Арагон Фармасьютикалс, Инк. | Androgen receptor modulators and use thereof |
LT2621894T (en) * | 2010-09-27 | 2017-01-25 | E. I. Du Pont De Nemours And Company | Method for preparing 2-amino-n-(2,2,2-trifluoroethyl) acetamide |
CN104661658A (en) | 2012-09-26 | 2015-05-27 | 阿拉贡药品公司 | Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer |
JOP20200097A1 (en) | 2013-01-15 | 2017-06-16 | Aragon Pharmaceuticals Inc | Androgen receptor modulator and uses thereof |
US9975880B2 (en) | 2013-12-31 | 2018-05-22 | Ipsen Pharma S.A.S. | Imidazolidine-2,4-dione dervatives |
US10654809B2 (en) | 2016-06-10 | 2020-05-19 | University Of Tennessee Research Foundation | Selective androgen receptor degrader (SARD) ligands and methods of use thereof |
US10093613B2 (en) | 2015-04-21 | 2018-10-09 | Gtx, Inc. | Selective androgen receptor degrader (SARD) ligands and methods of use thereof |
US10865184B2 (en) | 2015-04-21 | 2020-12-15 | University Of Tennessee Research Foundation | Selective androgen receptor degrader (SARD) ligands and methods of use thereof |
US10806720B2 (en) | 2015-04-21 | 2020-10-20 | University Of Tennessee Research Foundation | Selective androgen receptor degrader (SARD) ligands and methods of use thereof |
TWI726969B (en) | 2016-01-11 | 2021-05-11 | 比利時商健生藥品公司 | Substituted thiohydantoin derivatives as androgen receptor antagonists |
US11230523B2 (en) | 2016-06-10 | 2022-01-25 | University Of Tennessee Research Foundation | Selective androgen receptor degrader (SARD) ligands and methods of use thereof |
MX2018015179A (en) * | 2016-06-10 | 2019-10-14 | Univ Tennessee Res Found | Selective androgen receptor degrader (sard) ligands and methods of use thereof. |
CN111479560A (en) | 2017-10-16 | 2020-07-31 | 阿拉贡药品公司 | Antiandrogen for treating non-metastatic castration-resistant prostate cancer |
US11292782B2 (en) | 2018-11-30 | 2022-04-05 | Nuvation Bio Inc. | Diarylhydantoin compounds and methods of use thereof |
KR102417496B1 (en) | 2019-11-29 | 2022-07-06 | (주)수파드엘릭사 | Peptide for inhibiting activity of androgen receptor and Cosmetic composition using the same |
CN117751099A (en) * | 2021-08-05 | 2024-03-22 | 中国药科大学 | Amide compound and application thereof |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE28864T1 (en) | 1982-07-23 | 1987-08-15 | Ici Plc | AMIDE DERIVATIVES. |
GB8617652D0 (en) | 1986-07-18 | 1986-08-28 | Ici Plc | Acylanilide derivatives |
JPH05194204A (en) * | 1992-01-20 | 1993-08-03 | Lion Corp | Anti-male sex hormone preparation |
US5656651A (en) * | 1995-06-16 | 1997-08-12 | Biophysica Inc. | Androgenic directed compositions |
DE69709752T2 (en) * | 1996-06-27 | 2002-07-18 | Ligand Pharm Inc | ANDROGEN RECEPTOR MODULATOR CONNECTIONS AND METHOD |
JP3568325B2 (en) * | 1996-07-12 | 2004-09-22 | 株式会社ノエビア | Anti-androgen agent, hair restorer, and hair cosmetic |
US6184249B1 (en) * | 1998-12-18 | 2001-02-06 | Biophysica, Inc. | Androgen receptor suppressors in the therapy and diagnosis of prostate cancer, alopecia and other hyper-androgenic syndromes |
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2000
- 2000-02-11 US US09/502,376 patent/US6472415B1/en not_active Expired - Lifetime
- 2000-05-25 ES ES200150040A patent/ES2187390B2/en not_active Expired - Fee Related
- 2000-05-25 EP EP00937913A patent/EP1169301B1/en not_active Expired - Lifetime
- 2000-05-25 WO PCT/US2000/014792 patent/WO2001058854A1/en not_active IP Right Cessation
- 2000-05-25 AU AU2000253026A patent/AU2000253026A1/en not_active Abandoned
- 2000-05-25 MX MXPA01006376A patent/MXPA01006376A/en active IP Right Grant
- 2000-05-25 DE DE10084380T patent/DE10084380T1/en not_active Withdrawn
- 2000-05-25 CZ CZ20012398A patent/CZ301910B6/en not_active IP Right Cessation
- 2000-05-25 ES ES00937913T patent/ES2215672T3/en not_active Expired - Lifetime
- 2000-05-25 PL PL350356A patent/PL201173B1/en unknown
- 2000-05-25 IL IL14572800A patent/IL145728A0/en active IP Right Grant
- 2000-05-25 AT AT00937913T patent/ATE259781T1/en active
- 2000-05-25 DE DE60008360T patent/DE60008360T2/en not_active Expired - Lifetime
- 2000-05-25 BR BRPI0008439A patent/BRPI0008439B1/en not_active IP Right Cessation
- 2000-05-25 RU RU2001130354/04A patent/RU2225390C2/en active
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2001
- 2001-02-09 WO PCT/US2001/004290 patent/WO2001058855A1/en active IP Right Grant
- 2001-02-09 AU AU2001236856A patent/AU2001236856B2/en not_active Ceased
- 2001-02-09 AU AU3685601A patent/AU3685601A/en active Pending
- 2001-02-09 JP JP2001558407A patent/JP4806508B2/en not_active Expired - Fee Related
- 2001-02-09 KR KR10-2002-7010447A patent/KR100508681B1/en not_active IP Right Cessation
- 2001-02-09 CA CA2400185A patent/CA2400185C/en not_active Expired - Fee Related
- 2001-02-09 CN CNB018064450A patent/CN100402492C/en not_active Expired - Fee Related
- 2001-10-01 IL IL145728A patent/IL145728A/en not_active IP Right Cessation
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2002
- 2002-07-09 HK HK02105114.8A patent/HK1043692A1/en unknown
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2003
- 2003-06-10 HK HK03104064A patent/HK1051849A1/en not_active IP Right Cessation
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