WO2001062668A3 - Sulfur containing compounds - Google Patents

Sulfur containing compounds Download PDF

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Publication number
WO2001062668A3
WO2001062668A3 PCT/CA2001/000234 CA0100234W WO0162668A3 WO 2001062668 A3 WO2001062668 A3 WO 2001062668A3 CA 0100234 W CA0100234 W CA 0100234W WO 0162668 A3 WO0162668 A3 WO 0162668A3
Authority
WO
WIPO (PCT)
Prior art keywords
containing compounds
sulfur containing
cells
antifungals
efficient
Prior art date
Application number
PCT/CA2001/000234
Other languages
French (fr)
Other versions
WO2001062668A2 (en
Inventor
Richard Francis Langler
Felix J Baerlocker
Linda Z Penn
Original Assignee
Univ Health Network
Richard Francis Langler
Felix J Baerlocker
Linda Z Penn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CA002299247A external-priority patent/CA2299247A1/en
Application filed by Univ Health Network, Richard Francis Langler, Felix J Baerlocker, Linda Z Penn filed Critical Univ Health Network
Priority to CA002402114A priority Critical patent/CA2402114A1/en
Priority to JP2001561685A priority patent/JP2003523983A/en
Priority to AU2001237173A priority patent/AU2001237173A1/en
Priority to EP01909377A priority patent/EP1259482A2/en
Priority to US10/204,944 priority patent/US20030220524A1/en
Publication of WO2001062668A2 publication Critical patent/WO2001062668A2/en
Publication of WO2001062668A3 publication Critical patent/WO2001062668A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/12—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C313/02—Sulfinic acids; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
    • C07C323/65—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfone or sulfoxide groups bound to the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

This invention is directed to novel and known sulfur containing compounds and pharmaceutically acceptable salts thereof that have utility as antifungals and as antiproliferative agents against mammalian cells, in particular cancer cells and most particularly leukemia-derived cells. The invention provides a method for synthesizing certain of the sulfur containing compounds that is more efficient than previously known methods.
PCT/CA2001/000234 2000-02-25 2001-02-26 Sulfur containing compounds WO2001062668A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA002402114A CA2402114A1 (en) 2000-02-25 2001-02-26 Sulfur containing compounds
JP2001561685A JP2003523983A (en) 2000-02-25 2001-02-26 Sulfur-containing compounds
AU2001237173A AU2001237173A1 (en) 2000-02-25 2001-02-26 Sulfur containing compounds
EP01909377A EP1259482A2 (en) 2000-02-25 2001-02-26 Sulfur containing compounds
US10/204,944 US20030220524A1 (en) 2000-02-25 2001-02-26 Sulfur containing compounds

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US18518900P 2000-02-25 2000-02-25
US60/185,189 2000-02-25
CA002299247A CA2299247A1 (en) 2000-02-25 2000-02-25 Sulfur containing compounds
CA2,299,247 2000-02-25

Publications (2)

Publication Number Publication Date
WO2001062668A2 WO2001062668A2 (en) 2001-08-30
WO2001062668A3 true WO2001062668A3 (en) 2002-05-16

Family

ID=25681563

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2001/000234 WO2001062668A2 (en) 2000-02-25 2001-02-26 Sulfur containing compounds

Country Status (4)

Country Link
EP (1) EP1259482A2 (en)
JP (1) JP2003523983A (en)
AU (1) AU2001237173A1 (en)
WO (1) WO2001062668A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2571800A1 (en) * 2005-12-23 2007-06-23 Canadian Blood Services Nitrophenyls and related compounds and thimerosal for the inhibition of immune related cell or tissue destruction
WO2013124441A1 (en) * 2012-02-23 2013-08-29 Pancosma S.A. Use of dialkyl-thiosulfinate and/or thiosulfonate to improve the resistance of an animal infected by a pathogen
US20150238579A1 (en) * 2014-02-26 2015-08-27 Investfood, LLC Methods for assembling a product for modulating an immunomodulatory response in humans
EP4412457A1 (en) * 2021-10-08 2024-08-14 Crop Health Vision B.V. Organosulfur compounds as plant biostimulants

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4643994A (en) * 1984-12-17 1987-02-17 The Research Foundation Of State University Of New York Novel organic trithio oxides and method for the preparation thereof
US5583235A (en) * 1994-03-11 1996-12-10 Shaman Pharmaceuticals, Inc. Preparation of symmetrical and unsymmetrical 3,6-disubstituted-1,2-dithiins having antifungal activity

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4643994A (en) * 1984-12-17 1987-02-17 The Research Foundation Of State University Of New York Novel organic trithio oxides and method for the preparation thereof
US5583235A (en) * 1994-03-11 1996-12-10 Shaman Pharmaceuticals, Inc. Preparation of symmetrical and unsymmetrical 3,6-disubstituted-1,2-dithiins having antifungal activity

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BAERLOCHER F J ET AL: "STRUCTURE-ACTIVITY RELATIONSHIPS FOR SELECTED SULFUR-RICH ANTIFUNGAL COMPOUNDS", AUSTRALIAN JOURNAL OF CHEMISTRY, XX, XX, vol. 52, 1999, pages 167 - 172, XP001028517, ISSN: 0004-9425 *
BECKWITH, A L J ET AL, TETRAHEDRON., vol. 39, no. 23, 1983, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM., NL, pages 3995 - 4002, ISSN: 0040-4020 *
BLOCK ET AL, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY., vol. 95, 1973, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC., US, pages 5048, ISSN: 0002-7863 *
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002180002, Database accession no. 4988442 *
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002180003, Database accession no. 2041820 *
F J BAERLOCHER ET AL: "New and more potent antifungal disulfides", AUSTRALIAN JOURNAL OF CHEMISTRY., vol. 53, 2000, pages 1 - 5, XP001030010, ISSN: 0004-9425 *

Also Published As

Publication number Publication date
EP1259482A2 (en) 2002-11-27
JP2003523983A (en) 2003-08-12
AU2001237173A1 (en) 2001-09-03
WO2001062668A2 (en) 2001-08-30

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