IL144976A0 - A process for the preparation of paclitaxel - Google Patents

A process for the preparation of paclitaxel

Info

Publication number
IL144976A0
IL144976A0 IL14497600A IL14497600A IL144976A0 IL 144976 A0 IL144976 A0 IL 144976A0 IL 14497600 A IL14497600 A IL 14497600A IL 14497600 A IL14497600 A IL 14497600A IL 144976 A0 IL144976 A0 IL 144976A0
Authority
IL
Israel
Prior art keywords
paclitaxel
taxane
precursor
analogues
acid
Prior art date
Application number
IL14497600A
Other languages
English (en)
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of IL144976A0 publication Critical patent/IL144976A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL14497600A 1999-05-17 2000-05-08 A process for the preparation of paclitaxel IL144976A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13446999P 1999-05-17 1999-05-17
PCT/US2000/012469 WO2000069840A1 (en) 1999-05-17 2000-05-08 Novel reaction conditions for the cleavage of silyl ethers in the preparation of paclitaxel (taxol®) and paclitaxel analogues

Publications (1)

Publication Number Publication Date
IL144976A0 true IL144976A0 (en) 2002-06-30

Family

ID=22463532

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14497600A IL144976A0 (en) 1999-05-17 2000-05-08 A process for the preparation of paclitaxel

Country Status (17)

Country Link
US (1) US6184395B1 (zh)
EP (1) EP1178979B1 (zh)
JP (1) JP2002544269A (zh)
KR (1) KR100648125B1 (zh)
AT (1) ATE256117T1 (zh)
AU (1) AU761389B2 (zh)
CA (1) CA2373819A1 (zh)
DE (1) DE60007115T2 (zh)
DK (1) DK1178979T3 (zh)
ES (1) ES2211550T3 (zh)
HK (1) HK1042302B (zh)
HU (1) HUP0201176A3 (zh)
IL (1) IL144976A0 (zh)
MX (1) MXPA01011046A (zh)
PT (1) PT1178979E (zh)
TW (1) TWI257387B (zh)
WO (1) WO2000069840A1 (zh)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6750246B1 (en) 2000-02-03 2004-06-15 Bristol-Myers Squibb Company C-4 carbonate taxanes
US6916942B2 (en) * 2000-02-03 2005-07-12 Bristol-Myers Squibb Company Process for the preparation of C-4 carbonate taxanes
RU2284328C2 (ru) * 2001-11-29 2006-09-27 Дайити Фармасьютикал Ко., Лтд. Кристаллы производных таксана и способ их получения
PL374283A1 (en) * 2001-12-20 2005-10-03 Bristol-Myers Squibb Company Pharmaceutical compositions of orally active taxane derivatives having enhanced bioavailability
CA2495476C (en) * 2002-08-04 2011-08-02 James H. Johnson Methods and compositions for converting taxane amides to paclitaxel or other taxanes
US8703982B2 (en) 2003-03-17 2014-04-22 Phyton Holdings Llc Purification of taxanes
JP4499383B2 (ja) * 2003-07-11 2010-07-07 良明 木曽 水溶性プロドラッグ
FR2859996B1 (fr) * 2003-09-19 2006-02-03 Aventis Pharma Sa Solvat acetonique du dimethoxy docetaxel et son procede de preparation
FR2882362B1 (fr) * 2005-02-23 2007-05-11 Seripharm Procede de preparation du paclitaxel
WO2009137084A2 (en) * 2008-05-07 2009-11-12 Ivax Research, Llc Processes for preparation of taxanes and intermediates thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601676B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Procede de preparation du taxol et du desacetyl-10 taxol
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
USRE34277E (en) 1988-04-06 1993-06-08 Centre National De La Recherche Scientifique Process for preparing taxol
FR2687150B1 (fr) * 1992-02-07 1995-04-28 Rhone Poulenc Rorer Sa Procede de preparation de derives du taxane.
FR2702212B1 (fr) 1993-03-02 1995-04-07 Rhone Poulenc Rorer Sa Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
TW467896B (en) 1993-03-19 2001-12-11 Bristol Myers Squibb Co Novel β-lactams, methods for the preparation of taxanes and sidechain-bearing taxanes
FR2718135B1 (fr) * 1994-04-05 1996-04-26 Rhone Poulenc Rorer Sa Procédé de préparation d'hydroxy-7 taxanes.
AU3402699A (en) * 1998-04-20 1999-11-08 Gaetan Caron The semi-synthesis of baccatin iii

Also Published As

Publication number Publication date
US6184395B1 (en) 2001-02-06
EP1178979A4 (en) 2002-06-12
MXPA01011046A (es) 2002-07-22
PT1178979E (pt) 2004-04-30
DK1178979T3 (da) 2004-03-22
AU761389B2 (en) 2003-06-05
CA2373819A1 (en) 2000-11-23
ES2211550T3 (es) 2004-07-16
DE60007115D1 (de) 2004-01-22
KR100648125B1 (ko) 2006-11-24
ATE256117T1 (de) 2003-12-15
HK1042302A1 (en) 2003-12-19
DE60007115T2 (de) 2004-09-02
JP2002544269A (ja) 2002-12-24
HUP0201176A2 (en) 2002-08-28
EP1178979B1 (en) 2003-12-10
AU4992000A (en) 2000-12-05
WO2000069840A1 (en) 2000-11-23
TWI257387B (en) 2006-07-01
HK1042302B (zh) 2004-10-08
HUP0201176A3 (en) 2005-02-28
KR20010112493A (ko) 2001-12-20
EP1178979A1 (en) 2002-02-13

Similar Documents

Publication Publication Date Title
TW410228B (en) Phosphonooxymethyl ethers of taxane derivatives
ZA200410000B (en) Method for producing C13-alcohol mixtures
IL144976A0 (en) A process for the preparation of paclitaxel
BG105547A (en) Ethanolate of azithromycin, process for manufacture, and pharmaceutical compositions thereof
EP2867202B1 (en) Method for producing stereoselective epoxyketone compound
ZA200806271B (en) Process for producing monopentaerythritol of high purity and monopentaerythritol produced by the process
EP0918764B1 (en) Method for acylating 10-deacetylbaccatin iii selectively at the c-10 position
AU747096C (en) Crystal of diuridine tetraphosphate or salt thereof and method for preparing the same, and method for producing said compound
DE60102000T2 (de) Verfahren zur herstellung von flavonoiden
KR20080093871A (ko) 3-ｏ-알킬-5,6-ｏ-(1-메틸에틸리덴)-ｌ-아스코르빈산의제조방법 및 5,6-ｏ-(1-메틸에틸리덴)-ｌ-아스코르빈산의제조방법
EP1623982B8 (en) The process for the preparation of docetaxel trihydrate
TWI712611B (zh) 泛艾黴素之製造方法及其新穎之製造中間體
CA2403227A1 (en) Simple and efficient hydrazinolysis of c-10 and c-13 ester functionalities of taxanes to obtain 10-dab iii
US20080287696A1 (en) Process for the Preparation of Synthetic Taxanes
EP2420504B1 (en) Method for producing tetrahydropyran compound and intermediate thereof
CN109535201B (zh) 一种环磷酰胺的合成方法
CN113549102A (zh) 脱除酰胺基团上的对甲氧基苯基保护基的方法
CN101260135B (zh) 一种高级脂肪酸齐多夫定酯的合成方法
CN108997454B (zh) 一种β-熊果苷的化学合成方法
US8299279B2 (en) Semi-synthetic process for the preparation of taxane derivatives
CN100488977C (zh) 化学合成法生产胞苷的工艺
AU2003290719A1 (en) Process for purifying bisphenol-a
ES8505360A1 (es) Procedimiento para la obtencion de un acido aminolactoncarboxilico.
CN114163309A (zh) 一种多拉韦林中间体的制备方法
KR20100044631A (ko) 베타-메틸 비닐 포스페이트 카바페넴의 입체 선택적 제조방법

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed