DE60007115D1 - Neue umsetzungsbedingungen für die spaltung von silylethern bei der herstellung von paclitaxel (taxol(r)) und paclitaxel -analogen - Google Patents

Neue umsetzungsbedingungen für die spaltung von silylethern bei der herstellung von paclitaxel (taxol(r)) und paclitaxel -analogen

Info

Publication number
DE60007115D1
DE60007115D1 DE60007115T DE60007115T DE60007115D1 DE 60007115 D1 DE60007115 D1 DE 60007115D1 DE 60007115 T DE60007115 T DE 60007115T DE 60007115 T DE60007115 T DE 60007115T DE 60007115 D1 DE60007115 D1 DE 60007115D1
Authority
DE
Germany
Prior art keywords
paclitaxel
cleavage
taxane
silylethers
taxol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60007115T
Other languages
English (en)
Other versions
DE60007115T2 (de
Inventor
Ambarish Singh
E Weaver
L Powers
W Rosso
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of DE60007115D1 publication Critical patent/DE60007115D1/de
Application granted granted Critical
Publication of DE60007115T2 publication Critical patent/DE60007115T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
DE60007115T 1999-05-17 2000-05-08 Neue Umsetzungsbedingungen für die Spaltung von Silylethern bei der Herstellung von Paclitaxel (Taxol) und Paclitaxelanaloga Expired - Fee Related DE60007115T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13446999P 1999-05-17 1999-05-17
US134469P 1999-05-17
PCT/US2000/012469 WO2000069840A1 (en) 1999-05-17 2000-05-08 Novel reaction conditions for the cleavage of silyl ethers in the preparation of paclitaxel (taxol®) and paclitaxel analogues

Publications (2)

Publication Number Publication Date
DE60007115D1 true DE60007115D1 (de) 2004-01-22
DE60007115T2 DE60007115T2 (de) 2004-09-02

Family

ID=22463532

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60007115T Expired - Fee Related DE60007115T2 (de) 1999-05-17 2000-05-08 Neue Umsetzungsbedingungen für die Spaltung von Silylethern bei der Herstellung von Paclitaxel (Taxol) und Paclitaxelanaloga

Country Status (17)

Country Link
US (1) US6184395B1 (de)
EP (1) EP1178979B1 (de)
JP (1) JP2002544269A (de)
KR (1) KR100648125B1 (de)
AT (1) ATE256117T1 (de)
AU (1) AU761389B2 (de)
CA (1) CA2373819A1 (de)
DE (1) DE60007115T2 (de)
DK (1) DK1178979T3 (de)
ES (1) ES2211550T3 (de)
HK (1) HK1042302B (de)
HU (1) HUP0201176A3 (de)
IL (1) IL144976A0 (de)
MX (1) MXPA01011046A (de)
PT (1) PT1178979E (de)
TW (1) TWI257387B (de)
WO (1) WO2000069840A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6750246B1 (en) 2000-02-03 2004-06-15 Bristol-Myers Squibb Company C-4 carbonate taxanes
US6916942B2 (en) * 2000-02-03 2005-07-12 Bristol-Myers Squibb Company Process for the preparation of C-4 carbonate taxanes
CA2468953C (en) * 2001-11-29 2010-05-11 Daiichi Pharmaceutical Co., Ltd. Taxane derivative crystal and method for preparing the same
EP1465618A2 (de) * 2001-12-20 2004-10-13 Bristol-Myers Squibb Company Pharmazeutische zusammensetzungen oral aktiver taxanderivate mit verbesserter bioverfügbarkeit
ES2503265T3 (es) 2002-08-04 2014-10-06 Phyton Holdings, Llc Métodos para convertir amidas de taxano en paclitaxel u otros taxanos
US8703982B2 (en) 2003-03-17 2014-04-22 Phyton Holdings Llc Purification of taxanes
JP4499383B2 (ja) * 2003-07-11 2010-07-07 良明 木曽 水溶性プロドラッグ
FR2859996B1 (fr) * 2003-09-19 2006-02-03 Aventis Pharma Sa Solvat acetonique du dimethoxy docetaxel et son procede de preparation
FR2882362B1 (fr) * 2005-02-23 2007-05-11 Seripharm Procede de preparation du paclitaxel
WO2009137084A2 (en) * 2008-05-07 2009-11-12 Ivax Research, Llc Processes for preparation of taxanes and intermediates thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601676B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Procede de preparation du taxol et du desacetyl-10 taxol
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
USRE34277E (en) 1988-04-06 1993-06-08 Centre National De La Recherche Scientifique Process for preparing taxol
FR2687150B1 (fr) * 1992-02-07 1995-04-28 Rhone Poulenc Rorer Sa Procede de preparation de derives du taxane.
FR2702212B1 (fr) 1993-03-02 1995-04-07 Rhone Poulenc Rorer Sa Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
TW467896B (en) 1993-03-19 2001-12-11 Bristol Myers Squibb Co Novel β-lactams, methods for the preparation of taxanes and sidechain-bearing taxanes
FR2718135B1 (fr) * 1994-04-05 1996-04-26 Rhone Poulenc Rorer Sa Procédé de préparation d'hydroxy-7 taxanes.
AU3402699A (en) * 1998-04-20 1999-11-08 Gaetan Caron The semi-synthesis of baccatin iii

Also Published As

Publication number Publication date
AU761389B2 (en) 2003-06-05
JP2002544269A (ja) 2002-12-24
EP1178979A4 (de) 2002-06-12
KR100648125B1 (ko) 2006-11-24
HK1042302A1 (en) 2003-12-19
EP1178979B1 (de) 2003-12-10
HUP0201176A2 (en) 2002-08-28
WO2000069840A1 (en) 2000-11-23
AU4992000A (en) 2000-12-05
KR20010112493A (ko) 2001-12-20
HK1042302B (en) 2004-10-08
TWI257387B (en) 2006-07-01
CA2373819A1 (en) 2000-11-23
EP1178979A1 (de) 2002-02-13
IL144976A0 (en) 2002-06-30
HUP0201176A3 (en) 2005-02-28
US6184395B1 (en) 2001-02-06
ES2211550T3 (es) 2004-07-16
DE60007115T2 (de) 2004-09-02
MXPA01011046A (es) 2002-07-22
ATE256117T1 (de) 2003-12-15
DK1178979T3 (da) 2004-03-22
PT1178979E (pt) 2004-04-30

Similar Documents

Publication Publication Date Title
DE60007115D1 (de) Neue umsetzungsbedingungen für die spaltung von silylethern bei der herstellung von paclitaxel (taxol(r)) und paclitaxel -analogen
EP2867202B1 (de) Verfahren zur herstellung einer stereoselektiven epoxyketonverbindung
EP1785416A3 (de) 9, 10-Alpha, Alpha-OH-Taxan-Analogen und Herstellungsverfahren dafür
IL166985A (en) Method for the purification of lansoprazole
KR20080093871A (ko) 3-ｏ-알킬-5,6-ｏ-(1-메틸에틸리덴)-ｌ-아스코르빈산의제조방법 및 5,6-ｏ-(1-메틸에틸리덴)-ｌ-아스코르빈산의제조방법
DE60102000T2 (de) Verfahren zur herstellung von flavonoiden
EP0918764B1 (de) Methoden zur selektiven acylierung von 10-deacetylbaccatin iii in der c-10 position
NO20011634L (no) Krystall av diuridintetrafosfat eller salter derav, og fremgangsmåte for fremstilling av samme og fremgangsmåte forfremstilling av nevnte forbindelse
TW200633977A (en) Novel process for the manufacture of 3-pyrrolidin-2-yl-propionic acid derivatives
MX2007004157A (es) Procedimiento de semisintesis para la preparacion de 10-desacetil-n-debenzoil-paclitaxel.
TW200640853A (en) Process for production of aromatic carbonate
DE69502772T2 (de) Baccatinderivate und Verfahren zu ihrer Herstellung
CN113549102B (zh) 脱除酰胺基团上的对甲氧基苯基保护基的方法
US8299279B2 (en) Semi-synthetic process for the preparation of taxane derivatives
CN106957323A (zh) 一种合成芝麻素前体的简易方法
EP1810968A3 (de) 9, 10-a, a-OH-Taxan-Analoge und Herstellungsverfahren dafür
ES8405375A1 (es) Un metodo para preparar espiro-(mono- y difluorofluoren-9,4-imidazolidin)-2,5'-dionas.
CN115572317B (zh) 一种莫那比拉韦中间体的制备方法
EP2468702B1 (de) Verfahren zur herstellung von aryl-, heteroaryl- oder alkenyl-substituiertem ungesättigtem kohlenwasserstoff
CN116789559B (zh) 一种曲霉明a及其类似物的合成方法
CN103709194A (zh) 光学活性的羟基保护的脂肪族磷酸酯的制备方法
CN104356156B (zh) 一种四元环紫杉烷侧链化合物的制备方法
US20140039209A1 (en) Process for preparing docetaxel and its hydrate
JP2002121195A (ja) １３位置換ミルベマイシン誘導体の製造法
CN105503686A (zh) 一种依替米贝的合成方法

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee