ES8405375A1 - Un metodo para preparar espiro-(mono- y difluorofluoren-9,4-imidazolidin)-2,5'-dionas. - Google Patents

Un metodo para preparar espiro-(mono- y difluorofluoren-9,4-imidazolidin)-2,5'-dionas.

Info

Publication number
ES8405375A1
ES8405375A1 ES521444A ES521444A ES8405375A1 ES 8405375 A1 ES8405375 A1 ES 8405375A1 ES 521444 A ES521444 A ES 521444A ES 521444 A ES521444 A ES 521444A ES 8405375 A1 ES8405375 A1 ES 8405375A1
Authority
ES
Spain
Prior art keywords
aldose reductase
reductase activity
fluoren
compounds
hydantoin derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES521444A
Other languages
English (en)
Other versions
ES521444A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Vision LLC
Original Assignee
Alcon Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/368,630 external-priority patent/US4436745A/en
Priority claimed from US06/368,631 external-priority patent/US4438272A/en
Application filed by Alcon Laboratories Inc filed Critical Alcon Laboratories Inc
Publication of ES521444A0 publication Critical patent/ES521444A0/es
Publication of ES8405375A1 publication Critical patent/ES8405375A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

METODO PARA PREPARAR ESPIRO-(MONO- Y DIFLUOROFLUOREN-9,4-IMIDAZOLIDIN)-2,5-DIONAS.COMPRENDE: A) HACER REACCIONAR UN COMPUESTO DE FORMULA (I) CON UN HIDROXIDO DE TETRAALCOHIL- O ARILALCOHIL-TRIALCOHIL-AMONIO Y UN EXCESO DE OXIGENO EN UN DISOLVENTE BASICO APROTIDO; B) PURIFICAR EL PRODUCTO DE LA REACCION POR FILTRACION Y DESTILACION; C) HACER REACCIONAR EL PRODUCTO DE LA REACCION CON CARBONATO DE AMONIO Y CIANURO DE POTASIO; Y D) RECUPERAR DE LA MEZCLA DE REACCION UN PRODUCTO DE FORMULA (II).PRESENTA APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE COMPLICACIONES SURGIDAS A CONSECUENCIADE LA DIABETES MELLITUS, TALES COMO CATARATAS Y NEUROPATIAS.
ES521444A 1982-04-15 1983-04-14 Un metodo para preparar espiro-(mono- y difluorofluoren-9,4-imidazolidin)-2,5'-dionas. Expired ES8405375A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36863282A 1982-04-15 1982-04-15
US06/368,630 US4436745A (en) 1982-04-15 1982-04-15 Method of inhibiting aldose reductase activity
US06/368,631 US4438272A (en) 1982-04-15 1982-04-15 Spiro-(fluoren-9,4'-imidazolidine)-2',5'-diones

Publications (2)

Publication Number Publication Date
ES521444A0 ES521444A0 (es) 1984-06-01
ES8405375A1 true ES8405375A1 (es) 1984-06-01

Family

ID=27408873

Family Applications (1)

Application Number Title Priority Date Filing Date
ES521444A Expired ES8405375A1 (es) 1982-04-15 1983-04-14 Un metodo para preparar espiro-(mono- y difluorofluoren-9,4-imidazolidin)-2,5'-dionas.

Country Status (12)

Country Link
EP (1) EP0092385B1 (es)
KR (1) KR900003392B1 (es)
AU (1) AU561264B2 (es)
CA (1) CA1200247A (es)
DE (1) DE3382308D1 (es)
ES (1) ES8405375A1 (es)
GR (1) GR78557B (es)
IE (1) IE56955B1 (es)
IL (1) IL68314A0 (es)
NZ (1) NZ203876A (es)
PT (1) PT76552B (es)
WO (1) WO1983003543A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5153211A (en) * 1983-09-14 1992-10-06 Alcon Laboratories, Inc. Spiro-tricyclicaromatic succinimide derivatives as inhibitors of aldose reductase
US4537892A (en) * 1983-09-14 1985-08-27 Alcon Laboratories, Inc. Spiro-tricyclicaromatic succinimide derivatives as inhibitors of aldose reductase
US5070100A (en) * 1983-09-14 1991-12-03 Alcon Laboratories, Inc. Spiro-tricyclicaromatic succinimide derivatives
US4864028A (en) * 1983-09-14 1989-09-05 Alcon Laboratories, Inc. Spiro-tricyclicaromatic succinimide derivatives
CN113651757B (zh) * 2021-09-16 2023-09-08 河北工业大学 一种含螺[芴-杂环]结构的空穴传输材料及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4117230A (en) * 1976-10-18 1978-09-26 Pfizer Inc. Hydantoin derivatives as therapeutic agents
US4181728A (en) * 1978-11-16 1980-01-01 Pfizer Inc. Spiro-polycyclicimidazolidinedione derivatives
US4181729A (en) * 1979-03-21 1980-01-01 Pfizer Inc. Phenyl or phenoxy substituted spiro-imidazolidinedione derivatives

Also Published As

Publication number Publication date
IL68314A0 (en) 1983-07-31
EP0092385B1 (en) 1991-06-12
GR78557B (es) 1984-09-27
AU561264B2 (en) 1987-05-07
PT76552A (en) 1983-05-01
PT76552B (en) 1986-01-21
KR900003392B1 (ko) 1990-05-18
ES521444A0 (es) 1984-06-01
EP0092385A2 (en) 1983-10-26
IE56955B1 (en) 1992-02-12
DE3382308D1 (de) 1991-07-18
AU1325983A (en) 1983-10-20
IE830837L (en) 1983-10-15
NZ203876A (en) 1985-11-08
EP0092385A3 (en) 1985-01-09
CA1200247A (en) 1986-02-04
KR840004408A (ko) 1984-10-15
WO1983003543A1 (en) 1983-10-27

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19991007