DK1178979T3 - Hidtil ukendte reaktionsbetingelser til spaltning af silylethere ved fremstillingen af paclitaxel (Taxol(R)) og paclitaxelanaloge - Google Patents

Hidtil ukendte reaktionsbetingelser til spaltning af silylethere ved fremstillingen af paclitaxel (Taxol(R)) og paclitaxelanaloge

Info

Publication number
DK1178979T3
DK1178979T3 DK00932151T DK00932151T DK1178979T3 DK 1178979 T3 DK1178979 T3 DK 1178979T3 DK 00932151 T DK00932151 T DK 00932151T DK 00932151 T DK00932151 T DK 00932151T DK 1178979 T3 DK1178979 T3 DK 1178979T3
Authority
DK
Denmark
Prior art keywords
paclitaxel
cleavage
reaction conditions
taxane
silyl ethers
Prior art date
Application number
DK00932151T
Other languages
English (en)
Inventor
Ambarish Singh
Raymond E Weaver Jr
Gerald L Powers
Victor W Rosso
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of DK1178979T3 publication Critical patent/DK1178979T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK00932151T 1999-05-17 2000-05-08 Hidtil ukendte reaktionsbetingelser til spaltning af silylethere ved fremstillingen af paclitaxel (Taxol(R)) og paclitaxelanaloge DK1178979T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13446999P 1999-05-17 1999-05-17
PCT/US2000/012469 WO2000069840A1 (en) 1999-05-17 2000-05-08 Novel reaction conditions for the cleavage of silyl ethers in the preparation of paclitaxel (taxol®) and paclitaxel analogues

Publications (1)

Publication Number Publication Date
DK1178979T3 true DK1178979T3 (da) 2004-03-22

Family

ID=22463532

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00932151T DK1178979T3 (da) 1999-05-17 2000-05-08 Hidtil ukendte reaktionsbetingelser til spaltning af silylethere ved fremstillingen af paclitaxel (Taxol(R)) og paclitaxelanaloge

Country Status (17)

Country Link
US (1) US6184395B1 (da)
EP (1) EP1178979B1 (da)
JP (1) JP2002544269A (da)
KR (1) KR100648125B1 (da)
AT (1) ATE256117T1 (da)
AU (1) AU761389B2 (da)
CA (1) CA2373819A1 (da)
DE (1) DE60007115T2 (da)
DK (1) DK1178979T3 (da)
ES (1) ES2211550T3 (da)
HK (1) HK1042302B (da)
HU (1) HUP0201176A3 (da)
IL (1) IL144976A0 (da)
MX (1) MXPA01011046A (da)
PT (1) PT1178979E (da)
TW (1) TWI257387B (da)
WO (1) WO2000069840A1 (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6750246B1 (en) 2000-02-03 2004-06-15 Bristol-Myers Squibb Company C-4 carbonate taxanes
US6916942B2 (en) * 2000-02-03 2005-07-12 Bristol-Myers Squibb Company Process for the preparation of C-4 carbonate taxanes
CN1295229C (zh) * 2001-11-29 2007-01-17 第一制药株式会社 紫杉烷衍生物的结晶及其制备方法
BR0215184A (pt) * 2001-12-20 2006-06-06 Bristol Myers Squibb Co composições farmacêuticas de derivados de taxano oralmente ativos tendo biodisponibilidade aumentada
ES2503265T3 (es) 2002-08-04 2014-10-06 Phyton Holdings, Llc Métodos para convertir amidas de taxano en paclitaxel u otros taxanos
US8703982B2 (en) * 2003-03-17 2014-04-22 Phyton Holdings Llc Purification of taxanes
JP4499383B2 (ja) * 2003-07-11 2010-07-07 良明 木曽 水溶性プロドラッグ
FR2859996B1 (fr) * 2003-09-19 2006-02-03 Aventis Pharma Sa Solvat acetonique du dimethoxy docetaxel et son procede de preparation
FR2882362B1 (fr) 2005-02-23 2007-05-11 Seripharm Procede de preparation du paclitaxel
EP2285792A2 (en) * 2008-05-07 2011-02-23 Ivax Research, Llc Processes for preparation of taxanes and intermediates thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601676B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Procede de preparation du taxol et du desacetyl-10 taxol
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
USRE34277E (en) 1988-04-06 1993-06-08 Centre National De La Recherche Scientifique Process for preparing taxol
FR2687150B1 (fr) * 1992-02-07 1995-04-28 Rhone Poulenc Rorer Sa Procede de preparation de derives du taxane.
FR2702212B1 (fr) 1993-03-02 1995-04-07 Rhone Poulenc Rorer Sa Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
TW467896B (en) 1993-03-19 2001-12-11 Bristol Myers Squibb Co Novel β-lactams, methods for the preparation of taxanes and sidechain-bearing taxanes
FR2718135B1 (fr) * 1994-04-05 1996-04-26 Rhone Poulenc Rorer Sa Procédé de préparation d'hydroxy-7 taxanes.
NZ508257A (en) * 1998-04-20 2003-04-29 Lolita Zamir The semi-synthesis process for the conversion of 9-dihydro-13-acetylbaccatin III into baccatin III

Also Published As

Publication number Publication date
ES2211550T3 (es) 2004-07-16
HK1042302A1 (en) 2003-12-19
CA2373819A1 (en) 2000-11-23
HUP0201176A2 (en) 2002-08-28
MXPA01011046A (es) 2002-07-22
DE60007115T2 (de) 2004-09-02
DE60007115D1 (de) 2004-01-22
ATE256117T1 (de) 2003-12-15
IL144976A0 (en) 2002-06-30
US6184395B1 (en) 2001-02-06
HUP0201176A3 (en) 2005-02-28
EP1178979A1 (en) 2002-02-13
PT1178979E (pt) 2004-04-30
KR100648125B1 (ko) 2006-11-24
WO2000069840A1 (en) 2000-11-23
KR20010112493A (ko) 2001-12-20
AU761389B2 (en) 2003-06-05
HK1042302B (zh) 2004-10-08
TWI257387B (en) 2006-07-01
EP1178979B1 (en) 2003-12-10
JP2002544269A (ja) 2002-12-24
EP1178979A4 (en) 2002-06-12
AU4992000A (en) 2000-12-05

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