NZ508257A - The semi-synthesis process for the conversion of 9-dihydro-13-acetylbaccatin III into baccatin III - Google Patents

The semi-synthesis process for the conversion of 9-dihydro-13-acetylbaccatin III into baccatin III

Info

Publication number
NZ508257A
NZ508257A NZ508257A NZ50825799A NZ508257A NZ 508257 A NZ508257 A NZ 508257A NZ 508257 A NZ508257 A NZ 508257A NZ 50825799 A NZ50825799 A NZ 50825799A NZ 508257 A NZ508257 A NZ 508257A
Authority
NZ
New Zealand
Prior art keywords
iii
dihydro
semi
conversion
synthesis process
Prior art date
Application number
NZ508257A
Inventor
Gaetan Caron
Lolita Zamir
Original Assignee
Lolita Zamir
Gaetan Caron
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lolita Zamir, Gaetan Caron filed Critical Lolita Zamir
Publication of NZ508257A publication Critical patent/NZ508257A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

The compound for use in the synthesis of Baccatin III has the structure (Y), wherein: R1 is O-acetyl or hydroxy; R2 is ketone, O-benzyl or hydroxy; R3 is O-acetyl, O-benzyl, or hydroxy; with the proviso that (i) R2 and R3 cannot both be hydroxy substituents and (ii) when R2 is ketone, then R1 and R3 cannot both be hydroxy substituents.
NZ508257A 1998-04-20 1999-04-20 The semi-synthesis process for the conversion of 9-dihydro-13-acetylbaccatin III into baccatin III NZ508257A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA2235356 1998-04-20
PCT/CA1999/000328 WO1999054322A1 (en) 1998-04-20 1999-04-20 The semi-synthesis of baccatin iii

Publications (1)

Publication Number Publication Date
NZ508257A true NZ508257A (en) 2003-04-29

Family

ID=4162351

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ508257A NZ508257A (en) 1998-04-20 1999-04-20 The semi-synthesis process for the conversion of 9-dihydro-13-acetylbaccatin III into baccatin III

Country Status (4)

Country Link
EP (1) EP1087955A1 (en)
AU (1) AU3402699A (en)
NZ (1) NZ508257A (en)
WO (1) WO1999054322A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1178979T3 (en) * 1999-05-17 2004-03-22 Bristol Myers Squibb Co New reaction conditions for cleavage of silyl ethers in the preparation of paclitaxel (Taxol (R)) and paclitaxel analogs
US6812356B2 (en) * 2002-09-26 2004-11-02 John Findlay Conversion 9-dihydro-13-acetylbaccatin III into 10-deacetylbaccatin III
TW200604153A (en) * 2004-04-23 2006-02-01 Phytogen Life Sciences Inc Semi-synthesis and isolation of taxane intermediates from a mixture of taxanes
US7893283B2 (en) 2004-06-04 2011-02-22 Chatham Biotec, Limited Semi-synthesis of taxane intermediates and their conversion to paclitaxel and docetaxel
US20050288520A1 (en) 2004-06-25 2005-12-29 Phytogen Life Sciences Inc. One pot synthesis of taxane derivatives and their conversion to paclitaxel and docetaxel
US20050288521A1 (en) 2004-06-29 2005-12-29 Phytogen Life Sciences Inc. Semi-synthetic conversion of paclitaxel to docetaxel
CA2599888C (en) * 2005-03-31 2010-06-15 Bioxel Pharma Inc. Preparation of taxanes from 9-dihydro-13-acetylbaccatin iii
CN1314675C (en) * 2005-07-01 2007-05-09 中国科学院上海有机化学研究所 Taxol derivatives
CN100417649C (en) * 2006-04-05 2008-09-10 云南思摩贝特生物科技有限公司 Preparation method of doxytasai

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2188190A1 (en) * 1996-10-18 1998-04-18 Sarala Balachandran The semi-synthesis of a protected bacatin iii compound
CA2204197A1 (en) * 1997-05-01 1998-11-01 Jian Liu Process for converting 9-dihydro-13-acetylbaccatin iii into taxol and derivatives thereof

Also Published As

Publication number Publication date
WO1999054322A1 (en) 1999-10-28
EP1087955A1 (en) 2001-04-04
AU3402699A (en) 1999-11-08
WO1999054322B1 (en) 1999-12-16

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Legal Events

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PSEA Patent sealed