|
PA8474101A1
(es)
*
|
1998-06-19 |
2000-09-29 |
Pfizer Prod Inc |
Compuestos de pirrolo [2,3-d] pirimidina
|
|
SK286640B6
(sk)
|
1998-06-19 |
2009-03-05 |
Pfizer Products Inc. |
Pyrol [2,3-d] pyrimidínová zlúčenina, jej použitie na výrobu liečiva, farmaceutická kompozícia s jej obsahom, použitie jej kombinácie s ďalšími činidlami a súpravy s jej obsahom na výrobu liečiva
|
|
EP1510212A1
(de)
*
|
1998-08-21 |
2005-03-02 |
Parker Hughes Institute |
Verwendung von 4-substituerte Chinazolin-Derivaten zur Herstellung von therapeutischen Mitteln
|
|
KR20010089171A
(ko)
*
|
1998-08-21 |
2001-09-29 |
추후제출 |
퀴나졸린 유도체
|
|
US6080747A
(en)
*
|
1999-03-05 |
2000-06-27 |
Hughes Institute |
JAK-3 inhibitors for treating allergic disorders
|
|
CA2392554A1
(en)
*
|
1999-11-30 |
2001-06-28 |
Parker Hughes Institute |
Inhibitors of thrombin induced platelet aggregation
|
|
DE60037345T2
(de)
*
|
1999-12-10 |
2008-11-13 |
Pfizer Products Inc., Groton |
Pyrrolo(2,3-d)pyrimidin-Verbindungen
|
|
UA73993C2
(uk)
*
|
2000-06-06 |
2005-10-17 |
Астразенека Аб |
Хіназолінові похідні для лікування пухлин та фармацевтична композиція
|
|
ATE423120T1
(de)
*
|
2000-06-26 |
2009-03-15 |
Pfizer Prod Inc |
Pyrroloä2,3-düpyrimidin verbindungen als immunosuppressive wirkstoffe
|
|
ATE384121T1
(de)
*
|
2000-08-08 |
2008-02-15 |
Philadelphia Health & Educatio |
Verfahren zur kultivierung von menschlichen lungenmastzellen und deren anwendungen
|
|
WO2002016352A1
(en)
|
2000-08-21 |
2002-02-28 |
Astrazeneca Ab |
Quinazoline derivatives
|
|
EP1318985A2
(de)
*
|
2000-09-20 |
2003-06-18 |
MERCK PATENT GmbH |
4-amino chinazolinen
|
|
JP2004509876A
(ja)
*
|
2000-09-20 |
2004-04-02 |
メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング |
4−アミノ−キナゾリン
|
|
US20040034045A1
(en)
*
|
2000-11-29 |
2004-02-19 |
Parker Hughes Institute |
Inhibitors of thrombin induced platelet aggregation
|
|
PE20020958A1
(es)
*
|
2001-03-23 |
2002-11-14 |
Bayer Corp |
Inhibidores de la rho-quinasa
|
|
UY27224A1
(es)
*
|
2001-03-23 |
2002-10-31 |
Bayer Corp |
Inhibidores de la rho-quinasa
|
|
US7301023B2
(en)
*
|
2001-05-31 |
2007-11-27 |
Pfizer Inc. |
Chiral salt resolution
|
|
US7132427B2
(en)
*
|
2001-06-21 |
2006-11-07 |
Ariad Pharmaceuticals, Inc. |
Quinazolines and uses thereof
|
|
US7829566B2
(en)
*
|
2001-09-17 |
2010-11-09 |
Werner Mederski |
4-amino-quinazolines
|
|
GB0126433D0
(en)
*
|
2001-11-03 |
2002-01-02 |
Astrazeneca Ab |
Compounds
|
|
US20050043336A1
(en)
*
|
2001-11-03 |
2005-02-24 |
Hennequin Laurent Francois Andre |
Quinazoline derivatives as antitumor agents
|
|
PY0228255A
(es)
*
|
2001-12-06 |
2004-06-01 |
Pfizer Prod Inc |
Compuestos cristalinos novedosos
|
|
JP4505228B2
(ja)
*
|
2002-01-10 |
2010-07-21 |
バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト |
Rho−キナーゼ阻害剤
|
|
EP1470121B1
(de)
*
|
2002-01-23 |
2012-07-11 |
Bayer HealthCare LLC |
Pyrimidin-derivate als rho kinase inhibitoren
|
|
MXPA04007196A
(es)
*
|
2002-01-23 |
2005-06-08 |
Bayer Pharmaceuticals Corp |
Inhibidores de rho-quinasa.
|
|
TWI329105B
(en)
*
|
2002-02-01 |
2010-08-21 |
Rigel Pharmaceuticals Inc |
2,4-pyrimidinediamine compounds and their uses
|
|
US7645878B2
(en)
*
|
2002-03-22 |
2010-01-12 |
Bayer Healthcare Llc |
Process for preparing quinazoline Rho-kinase inhibitors and intermediates thereof
|
|
TWI324597B
(en)
*
|
2002-03-28 |
2010-05-11 |
Astrazeneca Ab |
Quinazoline derivatives
|
|
US6924285B2
(en)
|
2002-03-30 |
2005-08-02 |
Boehringer Ingelheim Pharma Gmbh & Co. |
Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them
|
|
RU2004135386A
(ru)
*
|
2002-05-06 |
2005-07-20 |
Вертекс Фармасьютикалз Инкорпорейтед (Us) |
Тиадиазолы или оксадиазолы и их применение в качестве ингибиторов протеинкиназы jak
|
|
US7576074B2
(en)
|
2002-07-15 |
2009-08-18 |
Rice Kenneth D |
Receptor-type kinase modulators and methods of use
|
|
HRP20050089B1
(hr)
|
2002-07-29 |
2015-06-19 |
Rigel Pharmaceuticals |
Upotreba 2,4 pirimidindiaminskog spoja za proizvodnju lijeka za lijeäśenje ili sprjeäśavanje autoimunosne bolesti
|
|
NZ539901A
(en)
*
|
2002-11-26 |
2007-09-28 |
Pfizer Prod Inc |
Method of treatment of transplant rejection
|
|
CA2506432A1
(en)
*
|
2002-12-09 |
2004-06-24 |
Robert A. Kirken |
Methods for selectively inhibiting janus tyrosine kinase 3 (jak3)
|
|
GB0309009D0
(en)
*
|
2003-04-22 |
2003-05-28 |
Astrazeneca Ab |
Quinazoline derivatives
|
|
GB0309850D0
(en)
*
|
2003-04-30 |
2003-06-04 |
Astrazeneca Ab |
Quinazoline derivatives
|
|
US8309562B2
(en)
*
|
2003-07-03 |
2012-11-13 |
Myrexis, Inc. |
Compounds and therapeutical use thereof
|
|
AU2004253967B2
(en)
*
|
2003-07-03 |
2010-02-18 |
Cytovia, Inc. |
4-arylamino-quinazolines as activators of caspases and inducers of apoptosis
|
|
WO2006074147A2
(en)
|
2005-01-03 |
2006-07-13 |
Myriad Genetics, Inc. |
Nitrogen containing bicyclic compounds and therapeutical use thereof
|
|
GB0317665D0
(en)
*
|
2003-07-29 |
2003-09-03 |
Astrazeneca Ab |
Qinazoline derivatives
|
|
UY28441A1
(es)
*
|
2003-07-29 |
2005-02-28 |
Astrazeneca Ab |
Derivados de quinazolina
|
|
WO2005012294A1
(en)
*
|
2003-07-30 |
2005-02-10 |
Rigel Pharmaceuticals, Inc. |
2,4-pyrimidinediamine compounds for use in the treatment or prevention of autoimmune diseases
|
|
ATE395346T1
(de)
*
|
2003-09-16 |
2008-05-15 |
Astrazeneca Ab |
Chinazolinderivate als tyrosinkinaseinhibitoren
|
|
EP1664028A1
(de)
*
|
2003-09-16 |
2006-06-07 |
AstraZeneca AB |
Chinazolinderivate als tyrosinkinaseinhibitoren
|
|
GB0321648D0
(en)
*
|
2003-09-16 |
2003-10-15 |
Astrazeneca Ab |
Quinazoline derivatives
|
|
ES2279441T3
(es)
*
|
2003-09-19 |
2007-08-16 |
Astrazeneca Ab |
Derivados de quinazolina.
|
|
CN1882570B
(zh)
*
|
2003-09-19 |
2010-12-08 |
阿斯利康(瑞典)有限公司 |
喹唑啉衍生物
|
|
WO2005030757A1
(en)
*
|
2003-09-25 |
2005-04-07 |
Astrazeneca Ab |
Quinazoline derivatives
|
|
EP2210607B1
(de)
*
|
2003-09-26 |
2011-08-17 |
Exelixis Inc. |
N-[3-fluoro-4-({6-(methyloxy)-7-[(3-morpholin-4-ylpropyl)oxy]quinolin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamid zur Behandlung von Krebs
|
|
US20070123537A1
(en)
*
|
2003-10-06 |
2007-05-31 |
Gpc Biotech Ag |
Quinazoline derivatives for the treatment of herpesviral infections
|
|
GB0326459D0
(en)
|
2003-11-13 |
2003-12-17 |
Astrazeneca Ab |
Quinazoline derivatives
|
|
DK1704145T3
(da)
*
|
2004-01-12 |
2012-09-24 |
Ym Biosciences Australia Pty |
Selektive kinaseinhibitorer
|
|
CA2929754A1
(en)
|
2004-04-12 |
2005-10-27 |
Sanbio Inc. |
Cells exhibiting neuronal progenitor cell characteristics
|
|
AU2005237254B2
(en)
|
2004-05-03 |
2010-02-04 |
Novartis Ag |
Combinations comprising a S1P receptor agonist and a JAK3 kinase inhibitor
|
|
US7405037B2
(en)
*
|
2004-05-07 |
2008-07-29 |
Lonza Walkersville, Inc. |
Methods and tools for detecting collagen degradation
|
|
BRPI0511741A
(pt)
*
|
2004-06-04 |
2008-01-02 |
Astrazeneca Ab |
derivado de quinazolina ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, processo para a preparação de um derivado de quinazolina ou de um sal farmaceuticamente aceitável do mesmo
|
|
US9132116B2
(en)
*
|
2004-08-02 |
2015-09-15 |
Willowcroft Pharm Inc. |
Mast cell stabilizers to prevent or treat laminitis
|
|
ATE501148T1
(de)
|
2004-12-14 |
2011-03-15 |
Astrazeneca Ab |
Pyrazolopyrimidinverbindungen als antitumormittel
|
|
AR054416A1
(es)
|
2004-12-22 |
2007-06-27 |
Incyte Corp |
Pirrolo [2,3-b]piridin-4-il-aminas y pirrolo [2,3-b]pirimidin-4-il-aminas como inhibidores de las quinasas janus. composiciones farmaceuticas.
|
|
US8258145B2
(en)
*
|
2005-01-03 |
2012-09-04 |
Myrexis, Inc. |
Method of treating brain cancer
|
|
AU2006206458B2
(en)
|
2005-01-19 |
2012-10-25 |
Rigel Pharmaceuticals, Inc. |
Prodrugs of 2,4-pyrimidinediamine compounds and their uses
|
|
KR20070107151A
(ko)
*
|
2005-02-26 |
2007-11-06 |
아스트라제네카 아베 |
티로신 키나제 억제제로서의 퀴나졸린 유도체
|
|
CA2600745A1
(en)
*
|
2005-03-03 |
2006-09-08 |
The Burnham Institute For Medical Research |
Screening methods for protein kinase b inhibitors employing virtual docking approaches and compounds and compositions discovered thereby
|
|
GB0504474D0
(en)
*
|
2005-03-04 |
2005-04-13 |
Astrazeneca Ab |
Chemical compounds
|
|
JP2008534689A
(ja)
*
|
2005-04-05 |
2008-08-28 |
ファーマコペイア, インコーポレイテッド |
免疫抑制のためのプリン及びイミダゾピリジン誘導体
|
|
US7884109B2
(en)
*
|
2005-04-05 |
2011-02-08 |
Wyeth Llc |
Purine and imidazopyridine derivatives for immunosuppression
|
|
GB0508717D0
(en)
*
|
2005-04-29 |
2005-06-08 |
Astrazeneca Ab |
Chemical compounds
|
|
GB0508715D0
(en)
*
|
2005-04-29 |
2005-06-08 |
Astrazeneca Ab |
Chemical compounds
|
|
US20070203161A1
(en)
|
2006-02-24 |
2007-08-30 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the jak pathway
|
|
BRPI0610876B8
(pt)
|
2005-06-08 |
2021-05-25 |
Rigel Pharmaceuticals Inc |
composto, formulação farmacêutica, e métodos de inibir uma atividade de uma jak cinase, e de inibir uma cascata de transdução de sinal em que jak3 cinase desempenha um papel
|
|
ATE488513T1
(de)
*
|
2005-09-20 |
2010-12-15 |
Astrazeneca Ab |
4-(1h-indazol-5-ylamino)chinazolinverbindungen als inhibitoren der erbb-rezeptortyrosinkinase zur behandlung von krebs
|
|
JP2009508917A
(ja)
*
|
2005-09-20 |
2009-03-05 |
アストラゼネカ アクチボラグ |
抗癌剤としてのキナゾリン誘導体
|
|
WO2007063293A1
(en)
*
|
2005-12-02 |
2007-06-07 |
Astrazeneca Ab |
Quinazoleine derivatives used as inhibitors of erbb tyrosine kinase
|
|
EP1957499A1
(de)
*
|
2005-12-02 |
2008-08-20 |
AstraZeneca AB |
4-anilinosubstituierte chinazolinderivate als tyrosinkinaseinhibitoren
|
|
US8409565B2
(en)
*
|
2006-02-14 |
2013-04-02 |
Francesca Levi-Schaffer |
Therapeutic target and diagnostic marker for asthma and related conditions
|
|
US7989459B2
(en)
*
|
2006-02-17 |
2011-08-02 |
Pharmacopeia, Llc |
Purinones and 1H-imidazopyridinones as PKC-theta inhibitors
|
|
US20090281075A1
(en)
*
|
2006-02-17 |
2009-11-12 |
Pharmacopeia, Inc. |
Isomeric purinones and 1h-imidazopyridinones as pkc-theta inhibitors
|
|
ES2622493T3
(es)
*
|
2006-02-24 |
2017-07-06 |
Rigel Pharmaceuticals, Inc. |
Composiciones y métodos para la inhibición de la ruta de JAK
|
|
AU2007238608A1
(en)
|
2006-04-14 |
2007-10-25 |
Massachusetts Institute Of Technology |
Identifying and modulating molecular pathways that mediate nervous system plasticity
|
|
TW200837064A
(en)
*
|
2006-10-04 |
2008-09-16 |
Pharmacopeia Inc |
8-substituted 2-(benzimidazolyl)purine derivatives for immunosuppression
|
|
US7902187B2
(en)
*
|
2006-10-04 |
2011-03-08 |
Wyeth Llc |
6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression
|
|
US7919490B2
(en)
*
|
2006-10-04 |
2011-04-05 |
Wyeth Llc |
6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression
|
|
EP1921070A1
(de)
*
|
2006-11-10 |
2008-05-14 |
Boehringer Ingelheim Pharma GmbH & Co. KG |
Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstelllung
|
|
US20080119496A1
(en)
*
|
2006-11-16 |
2008-05-22 |
Pharmacopeia Drug Discovery, Inc. |
7-Substituted Purine Derivatives for Immunosuppression
|
|
AU2008212999A1
(en)
*
|
2007-02-06 |
2008-08-14 |
Boehringer Ingelheim International Gmbh |
Bicyclic heterocycles, drugs containing said compounds, use thereof, and method for production thereof
|
|
NZ582188A
(en)
*
|
2007-07-11 |
2012-03-30 |
Pfizer |
Pharmaceutical compositions and methods of treating dry eye disorders
|
|
US8497369B2
(en)
|
2008-02-07 |
2013-07-30 |
Boehringer Ingelheim International Gmbh |
Spirocyclic heterocycles medicaments containing said compounds, use thereof and method for their production
|
|
HUE030912T2
(en)
|
2008-02-15 |
2017-06-28 |
Rigel Pharmaceuticals Inc |
Pyrimidine-2-amine compounds and their use as inhibitors of yak kinases
|
|
US8138339B2
(en)
|
2008-04-16 |
2012-03-20 |
Portola Pharmaceuticals, Inc. |
Inhibitors of protein kinases
|
|
US8063058B2
(en)
|
2008-04-16 |
2011-11-22 |
Portola Pharmaceuticals, Inc. |
Inhibitors of syk and JAK protein kinases
|
|
AU2009238590A1
(en)
*
|
2008-04-22 |
2009-10-29 |
Portola Pharmaceuticals, Inc. |
Inhibitors of protein kinases
|
|
JP5739802B2
(ja)
|
2008-05-13 |
2015-06-24 |
アストラゼネカ アクチボラグ |
4−(3−クロロ−2−フルオロアニリノ)−7−メトキシ−6−{[1−(n−メチルカルバモイルメチル)ピペリジン−4−イル]オキシ}キナゾリンのフマル酸塩
|
|
EP2313397B1
(de)
*
|
2008-08-08 |
2016-04-20 |
Boehringer Ingelheim International GmbH |
Cyclohexyloxy-substituierte heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung
|
|
KR101335843B1
(ko)
|
2008-08-20 |
2013-12-02 |
조에티스 엘엘씨 |
피롤로[2,3-d]피리미딘 화합물
|
|
US8385364B2
(en)
*
|
2008-09-24 |
2013-02-26 |
Nec Laboratories America, Inc. |
Distributed message-passing based resource allocation in wireless systems
|
|
NZ779754A
(en)
|
2009-01-16 |
2023-04-28 |
Exelixis Inc |
Malate salt of n-(4-{ [6,7-bis(methyloxy)quinolin-4-yl] oxy} phenyl)-n’-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, and crystalline forms thereof for the treatment of cancer
|
|
WO2010093808A1
(en)
*
|
2009-02-11 |
2010-08-19 |
Reaction Biology Corp. |
Selective kinase inhibitors
|
|
MY159327A
(en)
*
|
2009-02-27 |
2016-12-25 |
Ambit Biosciences Corp |
Jak kinase modulating quinazoline derivatives and methods of use thereof
|
|
CN106420756A
(zh)
*
|
2009-07-28 |
2017-02-22 |
里格尔药品股份有限公司 |
抑制jak途径的组合物和方法
|
|
UA108618C2
(uk)
|
2009-08-07 |
2015-05-25 |
|
Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку
|
|
WO2011159726A2
(en)
|
2010-06-14 |
2011-12-22 |
The Scripps Research Institute |
Reprogramming of cells to a new fate
|
|
WO2012030948A1
(en)
|
2010-09-01 |
2012-03-08 |
Ambit Biosciences Corporation |
Quinazoline compounds and methods of use thereof
|
|
EP2663553B1
(de)
*
|
2010-09-01 |
2015-08-26 |
Ambit Biosciences Corporation |
Chinolin- und isochinolinverbindungen zur verwendung als jak-modulatoren
|
|
EP2975027A1
(de)
|
2010-11-01 |
2016-01-20 |
Portola Pharmaceuticals, Inc. |
Nicotinamide als jak-kinasemodulatoren
|
|
MX363551B
(es)
|
2011-11-23 |
2019-03-27 |
Portola Pharmaceuticals Inc Star |
Compuestos derivados de pirazina como inhibidores de cinasa.
|
|
WO2014018195A1
(en)
*
|
2012-06-21 |
2014-01-30 |
Monsanto Technology Llc |
Lysis buffer and methods for extraction of dna from plant material
|
|
WO2014013014A1
(en)
|
2012-07-18 |
2014-01-23 |
Fundació Privada Centre De Regulació Genòmica (Crg) |
Jak inhibitors for activation of epidermal stem cell populations
|
|
WO2014058921A2
(en)
|
2012-10-08 |
2014-04-17 |
Portola Pharmaceuticals, Inc. |
Substituted pyrimidinyl kinase inhibitors
|
|
US20180107782A1
(en)
*
|
2014-01-20 |
2018-04-19 |
Stevan Hubbard |
Atomic model for janus kinase-2 (jak2) and uses thereof
|
|
US10045981B2
(en)
|
2015-11-24 |
2018-08-14 |
Jakpharm, Llc |
Selective kinase inhibitors
|
|
WO2018041989A1
(en)
|
2016-09-02 |
2018-03-08 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for diagnosing and treating refractory celiac disease type 2
|
|
JP7291077B2
(ja)
|
2016-12-16 |
2023-06-14 |
ヤンセン ファーマシューティカ エヌ.ベー. |
Jakファミリーのキナーゼの低分子阻害物質
|
|
JOP20190144A1
(ar)
|
2016-12-16 |
2019-06-16 |
Janssen Pharmaceutica Nv |
إيميدازو بيرولو بيريدين كمثبطات لعائلة jak الخاصة بإنزيمات الكيناز
|
|
TW202016110A
(zh)
|
2018-06-15 |
2020-05-01 |
比利時商健生藥品公司 |
Jak激酶家族之小分子抑制劑
|
|
NL2022471B1
(en)
|
2019-01-29 |
2020-08-18 |
Vationpharma B V |
Solid state forms of oclacitinib
|
|
EP3947737A2
(de)
|
2019-04-02 |
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INSERM (Institut National de la Santé et de la Recherche Médicale) |
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|
|
EP3955920A1
(de)
|
2019-04-16 |
2022-02-23 |
Institut National de la Santé et de la Recherche Médicale (INSERM) |
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|
|
MX2023010642A
(es)
|
2021-03-11 |
2023-11-28 |
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Lorpucitinib para uso en el tratamiento de trastornos mediados por jak.
|
|
WO2023222565A1
(en)
|
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Institut National de la Santé et de la Recherche Médicale |
Methods for assessing the exhaustion of hematopoietic stems cells induced by chronic inflammation
|