PA8474101A1
(es)
|
1998-06-19 |
2000-09-29 |
Pfizer Prod Inc |
Compuestos de pirrolo [2,3-d] pirimidina
|
RS50087B
(sr)
|
1998-06-19 |
2009-01-22 |
Pfizer Products Inc., |
Pirolo (2,3-d) pirimidin jedinjenja
|
JP2002523403A
(ja)
*
|
1998-08-21 |
2002-07-30 |
パーカー ヒューズ インスティテュート |
キナゾリン誘導体
|
EP1510212A1
(de)
*
|
1998-08-21 |
2005-03-02 |
Parker Hughes Institute |
Verwendung von 4-substituerte Chinazolin-Derivaten zur Herstellung von therapeutischen Mitteln
|
US6080747A
(en)
*
|
1999-03-05 |
2000-06-27 |
Hughes Institute |
JAK-3 inhibitors for treating allergic disorders
|
WO2001045641A2
(en)
*
|
1999-11-30 |
2001-06-28 |
Parker Hughes Institute |
Inhibitors of thrombin induced platelet aggregation
|
PT1382339E
(pt)
*
|
1999-12-10 |
2008-02-06 |
Pfizer Prod Inc |
Composições que contêm derivados de pirrolo[2,3-d]- pirimidina
|
UA73993C2
(uk)
*
|
2000-06-06 |
2005-10-17 |
Астразенека Аб |
Хіназолінові похідні для лікування пухлин та фармацевтична композиція
|
OA12292A
(en)
|
2000-06-26 |
2003-11-11 |
Pfizer Prod Inc |
PyrroloÄ2,3-dÜpyrimidine compounds as immunosuppressive agents.
|
AU2001284786B2
(en)
*
|
2000-08-08 |
2006-04-27 |
Philadelphia Health And Education Corporation |
Methods for culturing human lung mast cells and uses thereof
|
PL202812B1
(pl)
|
2000-08-21 |
2009-07-31 |
Astrazeneca Ab |
Pochodna chinazoliny, jej kompozycja famaceutyczna oraz jej zastosowanie
|
BR0114021A
(pt)
*
|
2000-09-20 |
2003-08-19 |
Merck Patent Gmbh |
4-amino-quinazolinas
|
MXPA03002410A
(es)
*
|
2000-09-20 |
2003-06-19 |
Merck Patent Gmbh |
4-amino-quinazolinas.
|
US20040034045A1
(en)
*
|
2000-11-29 |
2004-02-19 |
Parker Hughes Institute |
Inhibitors of thrombin induced platelet aggregation
|
AR035792A1
(es)
*
|
2001-03-23 |
2004-07-14 |
Bayer Corp |
Compuestos de n-(4-quinazolinil)-n-(1h-indazol-5-il) amina, inhibidor de la rho-quinasa, su uso para la fabricacion de un medicamento y metodo para prepararlo
|
US20030125344A1
(en)
*
|
2001-03-23 |
2003-07-03 |
Bayer Corporation |
Rho-kinase inhibitors
|
US7301023B2
(en)
*
|
2001-05-31 |
2007-11-27 |
Pfizer Inc. |
Chiral salt resolution
|
EP1408980A4
(de)
*
|
2001-06-21 |
2004-10-20 |
Ariad Pharma Inc |
Neue chinazoline und ihre verwendungszwecke
|
US7829566B2
(en)
*
|
2001-09-17 |
2010-11-09 |
Werner Mederski |
4-amino-quinazolines
|
CN100343238C
(zh)
*
|
2001-11-03 |
2007-10-17 |
阿斯特拉曾尼卡有限公司 |
用作抗肿瘤药物的喹唑啉衍生物
|
GB0126433D0
(en)
*
|
2001-11-03 |
2002-01-02 |
Astrazeneca Ab |
Compounds
|
GT200200234A
(es)
*
|
2001-12-06 |
2003-06-27 |
|
Compuestos cristalinos novedosos
|
WO2003059913A1
(en)
*
|
2002-01-10 |
2003-07-24 |
Bayer Healthcare Ag |
Roh-kinase inhibitors
|
MXPA04007191A
(es)
*
|
2002-01-23 |
2005-03-31 |
Bayer Pharmaceuticals Corp |
Derivados de pirimidina como inhibidores de rho-quinasa.
|
ATE381557T1
(de)
*
|
2002-01-23 |
2008-01-15 |
Bayer Pharmaceuticals Corp |
Rho-kinase inhibitoren
|
TWI329105B
(en)
|
2002-02-01 |
2010-08-21 |
Rigel Pharmaceuticals Inc |
2,4-pyrimidinediamine compounds and their uses
|
US7645878B2
(en)
*
|
2002-03-22 |
2010-01-12 |
Bayer Healthcare Llc |
Process for preparing quinazoline Rho-kinase inhibitors and intermediates thereof
|
TWI324597B
(en)
*
|
2002-03-28 |
2010-05-11 |
Astrazeneca Ab |
Quinazoline derivatives
|
US6924285B2
(en)
|
2002-03-30 |
2005-08-02 |
Boehringer Ingelheim Pharma Gmbh & Co. |
Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them
|
JP4681302B2
(ja)
|
2002-05-06 |
2011-05-11 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
チアジアゾールまたはオキサジアゾール、およびこれらの、jakプロテインキナーゼのインヒビターとしての使用
|
EP2277867B1
(de)
|
2002-07-15 |
2012-12-05 |
Symphony Evolution, Inc. |
Verbindungen, pharmazeutische Zusammensetzungen die diese enthalten und ihre Verwendung zur Behandlung von Krebs
|
DK1534286T3
(da)
*
|
2002-07-29 |
2010-04-26 |
Rigel Pharmaceuticals Inc |
Fremgangsmåder til behandling eller forebyggelse af autoimmune sygdomme med 2,4-pyrimidindiamin-forbindelser
|
KR20050086784A
(ko)
*
|
2002-11-26 |
2005-08-30 |
화이자 프로덕츠 인크. |
이식 거부반응의 치료 방법
|
AU2003297740B2
(en)
*
|
2002-12-09 |
2008-09-11 |
The Board Of Regents Of The University Of Texas System |
Methods for selectively inhibiting Janus tyrosine kinase 3 (Jak3)
|
GB0309009D0
(en)
*
|
2003-04-22 |
2003-05-28 |
Astrazeneca Ab |
Quinazoline derivatives
|
GB0309850D0
(en)
*
|
2003-04-30 |
2003-06-04 |
Astrazeneca Ab |
Quinazoline derivatives
|
WO2006074147A2
(en)
|
2005-01-03 |
2006-07-13 |
Myriad Genetics, Inc. |
Nitrogen containing bicyclic compounds and therapeutical use thereof
|
US8309562B2
(en)
*
|
2003-07-03 |
2012-11-13 |
Myrexis, Inc. |
Compounds and therapeutical use thereof
|
CA2531327A1
(en)
*
|
2003-07-03 |
2005-01-13 |
Myriad Genetics, Inc. |
Compounds and therapeutical use thereof
|
GB0317665D0
(en)
*
|
2003-07-29 |
2003-09-03 |
Astrazeneca Ab |
Qinazoline derivatives
|
CA2533345A1
(en)
*
|
2003-07-29 |
2005-02-10 |
Astrazeneca Ab |
Piperidyl-quinazoline derivatives as tyrosine kinase inhibitors
|
PT1656372E
(pt)
*
|
2003-07-30 |
2013-06-27 |
Rigel Pharmaceuticals Inc |
Métodos para o tratamento ou prevenção de doenças autoimunes com compostos de 2,4-pirimidinadiamina
|
GB0321648D0
(en)
*
|
2003-09-16 |
2003-10-15 |
Astrazeneca Ab |
Quinazoline derivatives
|
WO2005026151A1
(en)
*
|
2003-09-16 |
2005-03-24 |
Astrazeneca Ab |
Quinazoline derivatives as tyrosine kinase inhibitors
|
ATE395346T1
(de)
*
|
2003-09-16 |
2008-05-15 |
Astrazeneca Ab |
Chinazolinderivate als tyrosinkinaseinhibitoren
|
AU2004274227B2
(en)
*
|
2003-09-19 |
2008-04-24 |
Astrazeneca Ab |
Quinazoline derivatives
|
JP2007505878A
(ja)
*
|
2003-09-19 |
2007-03-15 |
アストラゼネカ アクチボラグ |
キナゾリン誘導体
|
US20070043010A1
(en)
*
|
2003-09-25 |
2007-02-22 |
Astrazeneca Uk Limited |
Quinazoline derivatives
|
EP2609919A3
(de)
*
|
2003-09-26 |
2014-02-26 |
Exelixis, Inc. |
c-Met-Modulatoren und Verwendungsverfahren
|
US20070123537A1
(en)
*
|
2003-10-06 |
2007-05-31 |
Gpc Biotech Ag |
Quinazoline derivatives for the treatment of herpesviral infections
|
GB0326459D0
(en)
*
|
2003-11-13 |
2003-12-17 |
Astrazeneca Ab |
Quinazoline derivatives
|
CA2545427C
(en)
*
|
2004-01-12 |
2012-08-21 |
Cytopia Research Pty Ltd |
Selective kinase inhibitors
|
EP2314674A1
(de)
|
2004-04-12 |
2011-04-27 |
SanBio, Inc. |
Zellen mit neuronalen Vorläuferzelleigenschaften
|
EP1755680A1
(de)
*
|
2004-05-03 |
2007-02-28 |
Novartis AG |
Kombinationen mit einem s1p-rezeptoragonist und einem jak3-kinaseinhibitor
|
US7405037B2
(en)
*
|
2004-05-07 |
2008-07-29 |
Lonza Walkersville, Inc. |
Methods and tools for detecting collagen degradation
|
MXPA06014125A
(es)
*
|
2004-06-04 |
2007-01-31 |
Astrazeneca Ab |
Derivados de quinazolina en la forma de cinasas de tirosina de receptor erbb.
|
US9132116B2
(en)
*
|
2004-08-02 |
2015-09-15 |
Willowcroft Pharm Inc. |
Mast cell stabilizers to prevent or treat laminitis
|
CN101124228B
(zh)
|
2004-12-14 |
2011-06-15 |
阿斯利康(瑞典)有限公司 |
用作抗肿瘤药物的吡唑并嘧啶化合物
|
AR054416A1
(es)
|
2004-12-22 |
2007-06-27 |
Incyte Corp |
Pirrolo [2,3-b]piridin-4-il-aminas y pirrolo [2,3-b]pirimidin-4-il-aminas como inhibidores de las quinasas janus. composiciones farmaceuticas.
|
US8258145B2
(en)
*
|
2005-01-03 |
2012-09-04 |
Myrexis, Inc. |
Method of treating brain cancer
|
AU2006206458B2
(en)
|
2005-01-19 |
2012-10-25 |
Rigel Pharmaceuticals, Inc. |
Prodrugs of 2,4-pyrimidinediamine compounds and their uses
|
CA2599210A1
(en)
*
|
2005-02-26 |
2006-08-31 |
Astrazeneca Ab |
Quinazoline derivatives as tyrosine kinase inhibitors
|
EP1866822A4
(de)
*
|
2005-03-03 |
2010-09-01 |
Burnham Inst Medical Research |
Screeningverfahren für hemmer der proteinkinase b unter verwendung virtueller dockingansätze sowie damit entdeckte verbindungen und zusammensetzungen
|
GB0504474D0
(en)
*
|
2005-03-04 |
2005-04-13 |
Astrazeneca Ab |
Chemical compounds
|
US7884109B2
(en)
*
|
2005-04-05 |
2011-02-08 |
Wyeth Llc |
Purine and imidazopyridine derivatives for immunosuppression
|
BRPI0610514A2
(pt)
*
|
2005-04-05 |
2016-11-16 |
Pharmacopeia Inc |
composto, composição farmacêutica, e, método de tratamento de um distúrbio
|
GB0508717D0
(en)
*
|
2005-04-29 |
2005-06-08 |
Astrazeneca Ab |
Chemical compounds
|
GB0508715D0
(en)
*
|
2005-04-29 |
2005-06-08 |
Astrazeneca Ab |
Chemical compounds
|
US20070203161A1
(en)
|
2006-02-24 |
2007-08-30 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the jak pathway
|
NZ563454A
(en)
*
|
2005-06-08 |
2011-03-31 |
Rigel Pharmaceuticals Inc |
2,4-diaminopyrimidine derivatives for inhibition of the JAK pathway
|
US20090239861A1
(en)
*
|
2005-09-20 |
2009-09-24 |
Robert Hugh Bradbury |
Quinazoline derivatives as anticancer agents
|
DE602006018331D1
(de)
*
|
2005-09-20 |
2010-12-30 |
Astrazeneca Ab |
4-(1h-indazol-5-ylamino)chinazolinverbindungen als inhibitoren der erbb-rezeptortyrosinkinase zur behandlung von krebs
|
CN101321739A
(zh)
*
|
2005-12-02 |
2008-12-10 |
阿斯利康(瑞典)有限公司 |
用作erbB酪氨酸激酶抑制剂的喹唑啉衍生物
|
JP2009517450A
(ja)
*
|
2005-12-02 |
2009-04-30 |
アストラゼネカ アクチボラグ |
チロシンキナーゼ阻害薬としての4−アニリノ置換キナゾリン誘導体
|
US8409565B2
(en)
*
|
2006-02-14 |
2013-04-02 |
Francesca Levi-Schaffer |
Therapeutic target and diagnostic marker for asthma and related conditions
|
US20090281075A1
(en)
*
|
2006-02-17 |
2009-11-12 |
Pharmacopeia, Inc. |
Isomeric purinones and 1h-imidazopyridinones as pkc-theta inhibitors
|
US7989459B2
(en)
*
|
2006-02-17 |
2011-08-02 |
Pharmacopeia, Llc |
Purinones and 1H-imidazopyridinones as PKC-theta inhibitors
|
ES2622493T3
(es)
*
|
2006-02-24 |
2017-07-06 |
Rigel Pharmaceuticals, Inc. |
Composiciones y métodos para la inhibición de la ruta de JAK
|
AU2007238608A1
(en)
|
2006-04-14 |
2007-10-25 |
Massachusetts Institute Of Technology |
Identifying and modulating molecular pathways that mediate nervous system plasticity
|
AR063141A1
(es)
*
|
2006-10-04 |
2008-12-30 |
Pharmacopeia Inc |
Derivados de 2- ( benzimidazolil ) purina 8- sustituida para inmunosupresion
|
US7902187B2
(en)
*
|
2006-10-04 |
2011-03-08 |
Wyeth Llc |
6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression
|
TW200831104A
(en)
*
|
2006-10-04 |
2008-08-01 |
Pharmacopeia Inc |
6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression
|
EP1921070A1
(de)
*
|
2006-11-10 |
2008-05-14 |
Boehringer Ingelheim Pharma GmbH & Co. KG |
Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstelllung
|
US20080119496A1
(en)
*
|
2006-11-16 |
2008-05-22 |
Pharmacopeia Drug Discovery, Inc. |
7-Substituted Purine Derivatives for Immunosuppression
|
AU2008212999A1
(en)
*
|
2007-02-06 |
2008-08-14 |
Boehringer Ingelheim International Gmbh |
Bicyclic heterocycles, drugs containing said compounds, use thereof, and method for production thereof
|
KR101258316B1
(ko)
*
|
2007-07-11 |
2013-04-30 |
화이자 인코포레이티드 |
안구 건조증 치료용 약학 조성물 및 방법
|
CA2711582A1
(en)
|
2008-02-07 |
2009-08-13 |
Boehringer Ingelheim International Gmbh |
Spirocyclic heterocycles, formulations containing said compounds, use thereof and processes for the preparation thereof
|
WO2009103032A1
(en)
|
2008-02-15 |
2009-08-20 |
Rigel Pharmaceuticals, Inc. |
Pyrimidine-2-amine compounds and their use as inhibitors of jak kinases
|
US8138339B2
(en)
|
2008-04-16 |
2012-03-20 |
Portola Pharmaceuticals, Inc. |
Inhibitors of protein kinases
|
MX2010011463A
(es)
|
2008-04-16 |
2011-06-03 |
Portola Pharm Inc |
2,6-diamino-pirimidin-5-il-carboxamidas como inhibidores de syk o jak quinasas.
|
EP2271631B1
(de)
|
2008-04-22 |
2018-07-04 |
Portola Pharmaceuticals, Inc. |
Inhibitoren von proteinkinasen
|
JP5739802B2
(ja)
*
|
2008-05-13 |
2015-06-24 |
アストラゼネカ アクチボラグ |
4−(3−クロロ−2−フルオロアニリノ)−7−メトキシ−6−{[1−(n−メチルカルバモイルメチル)ピペリジン−4−イル]オキシ}キナゾリンのフマル酸塩
|
JP5539351B2
(ja)
*
|
2008-08-08 |
2014-07-02 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
シクロヘキシルオキシ置換ヘテロ環、これらの化合物を含有する医薬、およびそれらを生成するための方法
|
ME01269B
(me)
*
|
2008-08-20 |
2013-06-20 |
Zoetis Services Llc |
Jedinjenja pirolo (2,3-d) pirimidina
|
US8385364B2
(en)
*
|
2008-09-24 |
2013-02-26 |
Nec Laboratories America, Inc. |
Distributed message-passing based resource allocation in wireless systems
|
TWI577664B
(zh)
|
2009-01-16 |
2017-04-11 |
艾克塞里克斯公司 |
N-(4-{〔6,7-雙(甲氧基)喹啉-4-基〕氧基}苯基)-n’-(4-氟苯基)環丙烷-1,1-二甲醯胺蘋果酸鹽、包含其之醫藥組合物及其用途
|
WO2010093808A1
(en)
*
|
2009-02-11 |
2010-08-19 |
Reaction Biology Corp. |
Selective kinase inhibitors
|
JP5746981B2
(ja)
|
2009-02-27 |
2015-07-08 |
アムビト ビオスシエンセス コルポラチオン |
Jakキナーゼ調節キナゾリン誘導体、及びその使用方法
|
MX337849B
(es)
*
|
2009-07-28 |
2016-03-09 |
Rigel Pharmaceuticals Inc |
Composiciones y metodos para inhibicion de la via jak.
|
UA108618C2
(uk)
|
2009-08-07 |
2015-05-25 |
|
Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку
|
US9376664B2
(en)
|
2010-06-14 |
2016-06-28 |
The Scripps Research Institute |
Reprogramming of cells to a new fate
|
EP2663553B1
(de)
*
|
2010-09-01 |
2015-08-26 |
Ambit Biosciences Corporation |
Chinolin- und isochinolinverbindungen zur verwendung als jak-modulatoren
|
EP2611789A1
(de)
|
2010-09-01 |
2013-07-10 |
Ambit Biosciences Corporation |
Chinazolinverbindungen und anwendungsverfahren dafür
|
TW201300360A
(zh)
|
2010-11-01 |
2013-01-01 |
Portola Pharm Inc |
做為jak激酶調節劑之菸鹼醯胺
|
AU2012340555B2
(en)
|
2011-11-23 |
2016-10-20 |
Portola Pharmaceuticals, Inc. |
Pyrazine kinase inhibitors
|
WO2014018195A1
(en)
*
|
2012-06-21 |
2014-01-30 |
Monsanto Technology Llc |
Lysis buffer and methods for extraction of dna from plant material
|
WO2014013014A1
(en)
|
2012-07-18 |
2014-01-23 |
Fundació Privada Centre De Regulació Genòmica (Crg) |
Jak inhibitors for activation of epidermal stem cell populations
|
EP2903970A4
(de)
|
2012-10-08 |
2016-11-30 |
Portola Pharm Inc |
Substituierte pyrimidinylkinasehemmer
|
US20180107782A1
(en)
*
|
2014-01-20 |
2018-04-19 |
Stevan Hubbard |
Atomic model for janus kinase-2 (jak2) and uses thereof
|
US10045981B2
(en)
|
2015-11-24 |
2018-08-14 |
Jakpharm, Llc |
Selective kinase inhibitors
|
WO2018041989A1
(en)
|
2016-09-02 |
2018-03-08 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for diagnosing and treating refractory celiac disease type 2
|
JOP20190144A1
(ar)
|
2016-12-16 |
2019-06-16 |
Janssen Pharmaceutica Nv |
إيميدازو بيرولو بيريدين كمثبطات لعائلة jak الخاصة بإنزيمات الكيناز
|
EP4086256A1
(de)
|
2016-12-16 |
2022-11-09 |
Janssen Pharmaceutica NV |
Kleinmolekülige inhibitoren der jak-familie von kinasen
|
TW202016110A
(zh)
|
2018-06-15 |
2020-05-01 |
比利時商健生藥品公司 |
Jak激酶家族之小分子抑制劑
|
EP3947737A2
(de)
|
2019-04-02 |
2022-02-09 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Verfahren zur vorhersage und vorbeugung von krebs bei patienten mit prämalignen läsionen
|
WO2020212395A1
(en)
|
2019-04-16 |
2020-10-22 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Use of jak inhibitors for the treatment of painful conditions involving nav1.7 channels
|
WO2023222565A1
(en)
|
2022-05-16 |
2023-11-23 |
Institut National de la Santé et de la Recherche Médicale |
Methods for assessing the exhaustion of hematopoietic stems cells induced by chronic inflammation
|