IL143811A - Apparatus and process for preparing crystalline particles - Google Patents

Apparatus and process for preparing crystalline particles

Info

Publication number
IL143811A
IL143811A IL14381199A IL14381199A IL143811A IL 143811 A IL143811 A IL 143811A IL 14381199 A IL14381199 A IL 14381199A IL 14381199 A IL14381199 A IL 14381199A IL 143811 A IL143811 A IL 143811A
Authority
IL
Israel
Prior art keywords
crystalline particles
preparing crystalline
preparing
particles
crystalline
Prior art date
Application number
IL14381199A
Other languages
English (en)
Other versions
IL143811A0 (en
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of IL143811A0 publication Critical patent/IL143811A0/xx
Publication of IL143811A publication Critical patent/IL143811A/xx

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • B01D9/0054—Use of anti-solvent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0059—General arrangements of crystallisation plant, e.g. flow sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B01F23/411—Emulsifying using electrical or magnetic fields, heat or vibrations
    • B01F23/4111—Emulsifying using electrical or magnetic fields, heat or vibrations using vibrations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/80—Mixing by means of high-frequency vibrations above one kHz, e.g. ultrasonic vibrations
    • B01F31/85—Mixing by means of high-frequency vibrations above one kHz, e.g. ultrasonic vibrations with a vibrating element inside the receptacle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers
    • B01F33/452—Magnetic mixers; Mixers with magnetically driven stirrers using independent floating stirring elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/08—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor
    • B01J19/10—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor employing sonic or ultrasonic vibrations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/18—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic using a vibrating apparatus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nozzles (AREA)
IL14381199A 1998-12-24 1999-12-22 Apparatus and process for preparing crystalline particles IL143811A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9828721.2A GB9828721D0 (en) 1998-12-24 1998-12-24 Novel apparatus and process
PCT/GB1999/004368 WO2000038811A1 (en) 1998-12-24 1999-12-22 Apparatus and process for preparing crystalline particles

Publications (2)

Publication Number Publication Date
IL143811A0 IL143811A0 (en) 2002-04-21
IL143811A true IL143811A (en) 2005-06-19

Family

ID=10845091

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14381199A IL143811A (en) 1998-12-24 1999-12-22 Apparatus and process for preparing crystalline particles

Country Status (19)

Country Link
US (1) US6482438B1 (ja)
EP (1) EP1144065A1 (ja)
JP (1) JP3588050B2 (ja)
KR (1) KR20010099933A (ja)
CN (1) CN1335787A (ja)
AU (1) AU759880B2 (ja)
BR (1) BR9916587A (ja)
CA (1) CA2356897A1 (ja)
CZ (1) CZ20012331A3 (ja)
GB (1) GB9828721D0 (ja)
HK (1) HK1038709A1 (ja)
HU (1) HUP0104855A3 (ja)
IL (1) IL143811A (ja)
NO (1) NO20013039L (ja)
NZ (1) NZ512400A (ja)
PL (1) PL349345A1 (ja)
TR (1) TR200101845T2 (ja)
WO (1) WO2000038811A1 (ja)
ZA (1) ZA200105070B (ja)

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8123130B2 (en) 1998-04-17 2012-02-28 Remote Inc. Remote ordering device
DK1169019T3 (da) 1999-04-14 2003-06-02 Glaxo Group Ltd Farmaceutisk aerosolformulering
GB0016002D0 (en) * 2000-06-29 2000-08-23 Glaxo Group Ltd Novel process for preparing crystalline particles
GB0015981D0 (en) * 2000-06-29 2000-08-23 Glaxo Group Ltd Novel process for preparing crystalline particles
GB0016040D0 (en) * 2000-06-29 2000-08-23 Glaxo Group Ltd Novel process for preparing crystalline particles
US6777399B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
GB0019172D0 (en) 2000-08-05 2000-09-27 Glaxo Group Ltd Novel compounds
US6777400B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
EA005992B1 (ru) 2000-08-05 2005-08-25 Глаксо Груп Лимитед S-ФТОРМЕТИЛОВЫЙ ЭФИР 6α,9α-ДИФТОР-17α-[(2-ФУРАНИЛКАРБОНИЛ)ОКСИ]-11β-ГИДРОКСИ-16α-МЕТИЛ-3-ОКСОАНДРОСТА-1,4-ДИЕН-17β-КАРБОТИОКИСЛОТЫ В КАЧЕСТВЕ ПРОТИВОВОСПАЛИТЕЛЬНОГО АГЕНТА
US6858596B2 (en) * 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
US6759398B2 (en) 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
US6787532B2 (en) 2000-08-05 2004-09-07 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivatives
US6858593B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6750210B2 (en) 2000-08-05 2004-06-15 Smithkline Beecham Corporation Formulation containing novel anti-inflammatory androstane derivative
FI20002215A0 (fi) * 2000-10-06 2000-10-06 Orion Yhtymae Oyj Yhdistelmäpartikkelit
UA77656C2 (en) 2001-04-07 2007-01-15 Glaxo Group Ltd S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
EP2039700A2 (en) 2001-04-30 2009-03-25 Glaxo Group Limited Novel anti-inflammatory androstane derivatives
DE60210622T2 (de) * 2001-05-05 2007-04-05 Accentus Plc Bildung kleiner Kristalle
DE10137017A1 (de) * 2001-07-30 2003-02-20 Basf Ag Kristallisationsverfahren zur Einstellung kleiner Partikel
US20030049323A1 (en) * 2001-08-29 2003-03-13 Hitt James E. Process to precipitate drug particles
GB0125604D0 (en) * 2001-10-25 2001-12-19 Glaxo Group Ltd Novel process
GB0201400D0 (en) 2002-01-22 2002-03-13 Glaxo Group Ltd Novel apparatus and process
WO2003092852A1 (en) * 2002-04-29 2003-11-13 Bristol-Myers Squibb Company Crystallization system utilizing atomization
GB0219815D0 (en) * 2002-08-24 2002-10-02 Accentus Plc Preparation of small crystals
GB0212626D0 (en) * 2002-05-31 2002-07-10 Accentus Plc Production of crystalline ingredients
GB2389530B (en) 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
GB0216700D0 (en) 2002-07-18 2002-08-28 Astrazeneca Ab Process
AU2003267433A1 (en) * 2002-10-17 2004-05-04 Boehringer Ingelheim Pharma Gmbh And Co.Kg Process and reactor for the manufacture of powders of inhalable medicaments
US20040197275A1 (en) 2002-10-17 2004-10-07 Ecole Polytechnique Federale De Lausanne Process for the manufacture of powders of inhalable medicaments
GB0302673D0 (en) 2003-02-06 2003-03-12 Astrazeneca Ab Pharmaceutical formulations
PL224720B1 (pl) * 2003-02-21 2017-01-31 Univ Bath Sposób wytwarzania cząstek krystalicznych, cząstki krystaliczne oraz kompozycja farmaceutyczna je zawierająca
WO2004073729A1 (ja) 2003-02-21 2004-09-02 Translational Research Ltd. 薬物の経鼻投与用組成物
CN100404545C (zh) * 2003-03-27 2008-07-23 尼科梅德有限责任公司 具有规定粒径的结晶环缩松的制备方法
KR100974482B1 (ko) 2003-03-27 2010-08-10 가부시키가이샤 바이오악티스 비강용 분말 약제 투약 장치
MY143936A (en) * 2003-03-27 2011-07-29 Nycomed Gmbh Process for preparing crystalline ciclesonide with defined particle size
SE0302029D0 (sv) * 2003-07-07 2003-07-07 Astrazeneca Ab Novel process
ITMI20032054A1 (it) * 2003-10-22 2005-04-23 Monteres S R L Processo per la preparazione di sospensioni farmaceutiche da inalare.
CN1878602A (zh) * 2003-11-28 2006-12-13 三菱化学株式会社 有机化合物微粒的制造方法
JP2005177746A (ja) * 2003-11-28 2005-07-07 Mitsubishi Chemicals Corp 有機化合物微粒子の製造方法
WO2006016530A1 (ja) 2004-08-10 2006-02-16 Translational Research, Ltd. 速効性でかつ高い吸収性を可能とする経鼻投与用組成物
EP1949891A1 (en) * 2004-10-12 2008-07-30 Generics (UK) Limited Process for the preparation of suspension aerosol formulations, wherein the particles are formed by precipitation inside an aerosol canister
WO2006040598A2 (en) * 2004-10-12 2006-04-20 Generics (Uk) Limited Process for the preparation of suspension aerosol formulations, wherein the particles are formed by precipitation inside an aerosol canister
US7314516B2 (en) * 2004-12-29 2008-01-01 Five Star Technologies, Inc. Hydrodynamic cavitation crystallization device and process
JP5156397B2 (ja) 2005-02-10 2013-03-06 グラクソ グループ リミテッド 予備分級技術を用いて乳糖を製造する方法及びその乳糖から形成させた医薬製剤
CN101312713A (zh) * 2005-03-18 2008-11-26 纳米材料科技有限公司 可吸入的药物
GB0507165D0 (en) * 2005-04-08 2005-05-18 Glaxo Group Ltd Novel crystalline pharmaceutical product
WO2006113309A1 (en) 2005-04-15 2006-10-26 Dr. Reddy's Laboratories Ltd. Lacidipine particles
DE102005053862A1 (de) * 2005-11-04 2007-05-10 Pharmasol Gmbh Verfahren und Vorrichtung zur Herstellung hochfeiner Partikel sowie zur Beschichtung solcher Partikel
FR2897267A1 (fr) * 2006-02-16 2007-08-17 Flamel Technologies Sa Formes pharmaceutiques multimicroparticulaires pour administration per os
GB0610090D0 (en) * 2006-05-20 2006-06-28 Price Robert Particulate drug compositions and their uses
AU2013202835B2 (en) * 2006-06-14 2015-11-12 Generics [Uk] Limited Process for the preparation of S-fluoromethyl-6,9-difluoro-11-hydroxy-16-methyl-17-propionyloxy-3-oxo-androsta-1, 4-diene-17-carbothioate and intermediates
EP2402361B1 (en) * 2006-06-14 2020-04-15 Generics [UK] Limited Process for the preparation of s-fluoromethyl-6,9-difluoro-11-hydroxy-16-methyl-17-propionyloxy-3-oxo-androsta-1,4-diene-17-carbothioate and intermediates
US7811381B2 (en) * 2006-06-14 2010-10-12 Sirkar Kamalesh K Antisolvent crystallization in porous hollow fiber devices and methods of use thereof
WO2008078730A1 (ja) 2006-12-26 2008-07-03 Translational Research, Ltd. 経鼻投与用製剤
GB0705159D0 (en) * 2007-03-19 2007-04-25 Prosonix Ltd Process for making crystals
GB0711680D0 (en) 2007-06-18 2007-07-25 Prosonix Ltd Process
JP2010111592A (ja) * 2008-11-04 2010-05-20 Aska Pharmaceutical Co Ltd プロピオン酸フルチカゾンを含む局所投与剤
GB0900080D0 (en) * 2009-01-06 2009-02-11 Prosonix Ltd An apparatus and process for producing crystals
DE102009008478A1 (de) 2009-02-11 2010-08-19 PHAST Gesellschaft für pharmazeutische Qualitätsstandards mbH Vorrichtung und Verfahren zur Herstellung pharmazeutisch hochfeiner Partikel sowie zur Beschichtung solcher Partikel in Mikroreaktoren
JP2012526726A (ja) 2009-05-15 2012-11-01 株式会社新日本科学 薬物動態が改善された鼻腔内用薬学的組成物
GB2472327B (en) 2009-07-31 2013-03-13 Shin Nippon Biomedical Lab Ltd Intranasal granisetron and nasal applicator
CA2778441C (en) 2009-10-22 2019-01-08 Api Genesis, Llc Hydrated microparticles of apigenin and/or luteolin with improved solubility
PL2550092T3 (pl) 2010-03-22 2019-01-31 Instillo Gmbh Sposób wytwarzania mikro- lub nanocząstek
CN101862633B (zh) * 2010-07-10 2012-07-11 浙江卫信生物药业有限公司 全自动无菌恒温连续流体制剂超声波匀化处理装置
US9278867B2 (en) 2010-12-30 2016-03-08 Yava Technologies Inc. Transition metal compound particles and methods of production
EP2500072A1 (en) * 2011-03-15 2012-09-19 LEK Pharmaceuticals d.d. A novel process of residual solvent removal
KR20140048237A (ko) * 2011-07-08 2014-04-23 화이자 리미티드 플루티카손 프로피오네이트 형태 1의 제조 방법
BR112014027681B8 (pt) * 2012-05-08 2023-10-31 Aciex Therapeutics Inc Nanocristais de propionato de fluticasona, composição tópica farmacêutica compreendendo os mesmos, seu uso e método de fabricação
US8765725B2 (en) 2012-05-08 2014-07-01 Aciex Therapeutics, Inc. Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
DE102012221219B4 (de) * 2012-11-20 2014-05-28 Jesalis Pharma Gmbh Verfahren zur Vergrößerung der Partikelgröße kristalliner Wirkstoff-Mikropartikel
US9815865B2 (en) 2013-01-07 2017-11-14 Nicox Ophthalmics, Inc. Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
US9452930B2 (en) * 2013-11-04 2016-09-27 New Jersey Institute Of Technology System and method for continuous polymer coating of particles
CN103977593B (zh) * 2014-05-19 2017-01-04 中国工程物理研究院化工材料研究所 制备纳米共晶含能材料的方法及装置
CN105012237B (zh) * 2015-08-10 2018-09-11 重庆华邦制药有限公司 糠酸氟替卡松鼻喷雾剂及其制备方法
US11744967B2 (en) 2017-09-26 2023-09-05 Shin Nippon Biomedical Laboratories, Ltd. Intranasal delivery devices
CN109012260B (zh) * 2018-09-06 2020-10-02 董旭 一种便于配比的麻醉药物混合器
US20210369667A1 (en) 2019-03-29 2021-12-02 Vizuri Health Sciences Consumer Healthcare, Inc. Compositions and methods for the prevention and treatment of radiation dermatitis, eczema, burns, wounds and certain cancers

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL67349C (ja) * 1946-01-16
DE1262240B (de) 1964-11-14 1968-03-07 Helmut Pelzer Dipl Chem Dr Verfahren zur Herstellung feinster Teilchen kristallisierbarer Verbindungen
DE2504347C3 (de) * 1975-02-03 1978-10-05 Dso, Pharmachim, Sofia Verfahren zur Herstellung von reinem Tetracyclinhydrochlorid
US3979269A (en) 1975-02-25 1976-09-07 DSO "Pharmachim Method for obtaining tetracyclinehydrochloride
WO1990003782A2 (en) * 1988-10-05 1990-04-19 The Upjohn Company Finely divided solid crystalline powders via precipitation into an anti-solvent
JPH02164712A (ja) 1988-12-17 1990-06-25 Tosoh Corp 重炭酸ナトリウムの製造方法
GB9005275D0 (en) 1990-03-09 1990-05-02 Atomic Energy Authority Uk Crystallization monitor
JPH0497908A (ja) 1990-08-10 1992-03-30 Lion Corp ゼオライトの製造方法
WO1994008599A1 (en) 1992-10-14 1994-04-28 The Regents Of The University Of Colorado Ion-pairing of drugs for improved efficacy and delivery
GB9307225D0 (en) 1993-04-03 1993-05-26 Atomic Energy Authority Uk Processing vessel
US5471001A (en) * 1994-12-15 1995-11-28 E. I. Du Pont De Nemours And Company Crystallization of adipic acid
SE9501384D0 (sv) * 1995-04-13 1995-04-13 Astra Ab Process for the preparation of respirable particles
US5905003A (en) 1995-06-26 1999-05-18 Energy Conversion Devices, Inc. Beta to gamma phase cycleable electrochemically active nickel hydroxide material
GB9624615D0 (en) 1996-11-26 1997-01-15 Zeneca Ltd Chrystallisation process
KR100573192B1 (ko) * 1997-02-05 2006-04-24 머크 앤드 캄파니 인코포레이티드 역-용매를 사용한 역전사효소 억제제의 결정화 방법 및 당해 역전사효소 억제제의 결정형
GB9826175D0 (en) 1998-11-28 1999-01-20 Smithkline Beecham Plc Novel process
GB9826242D0 (en) 1998-11-30 1999-01-20 Smithkline Beecham Plc Novel process
ATE313366T1 (de) 1999-01-29 2006-01-15 Bristol Myers Squibb Co Vorrichtung und verfahren zur mit ultraschall beaufschlagten strahlkristallisation

Also Published As

Publication number Publication date
GB9828721D0 (en) 1999-02-17
NO20013039L (no) 2001-08-22
HK1038709A1 (zh) 2002-03-28
AU1877100A (en) 2000-07-31
EP1144065A1 (en) 2001-10-17
US6482438B1 (en) 2002-11-19
AU759880B2 (en) 2003-05-01
JP2002533205A (ja) 2002-10-08
IL143811A0 (en) 2002-04-21
HUP0104855A2 (hu) 2002-04-29
CZ20012331A3 (cs) 2002-03-13
WO2000038811A1 (en) 2000-07-06
TR200101845T2 (tr) 2001-10-22
KR20010099933A (ko) 2001-11-09
JP3588050B2 (ja) 2004-11-10
ZA200105070B (en) 2002-09-20
NZ512400A (en) 2003-02-28
BR9916587A (pt) 2001-09-25
CA2356897A1 (en) 2000-07-06
CN1335787A (zh) 2002-02-13
HUP0104855A3 (en) 2005-12-28
NO20013039D0 (no) 2001-06-19
PL349345A1 (en) 2002-07-15

Similar Documents

Publication Publication Date Title
HUP0104855A3 (en) Apparatus and process for preparing crystalline particles
HUP0203278A3 (en) Apparatus and process for preparing crystalline particles
GB9919230D0 (en) Process and apparatus for producing (large) packs
GB2346133B (en) Method and apparatus for preparing infant formula from powder
HUP9800208A3 (en) Omega-cycloalkyl-prostaglandin e2-derivatives and process for preparing them
CZ20012118A3 (cs) Způsob výroby 3-alkanoylindolu a 3-alkylindolu
HUP9902419A3 (en) Process for preparing nitrobiphenylene
PL372897A1 (en) Apparatus and process for preparing crystalline particles
AU5730500A (en) Method and apparatus for forming polycrystalline particles
HUP0101779A3 (en) Process for de-chlorinating and de-fouling waste-oil
GB2351928B (en) Process and apparatus for seperating particles
GB9808470D0 (en) Novel process and apparatus
EP0916636A4 (en) METHOD AND DEVICE FOR PRODUCING A COMPOST
EP1089978A4 (en) METHOD FOR PRODUCING OXIMIDAZOLES
EG22139A (en) Process for preparing 4- substituted-1H-indole -3- glyoxamides
GB2317178B (en) Process for preparing 1-chloromethylsilatrane
EP1173751A4 (en) X-RAY GRADOMETERS AND METHODS
GB9811225D0 (en) Methods and apparatus for making appliquÚ items
HK1023559A1 (en) Process for producing dichloroacetoxypropane and derivatives thereof
EP0943689A4 (en) METHOD FOR PRODUCING FR900482 AND ANALOG CONNECTIONS
HUP0101730A3 (en) Method for preparing and using b-starch
HUP9701594A3 (en) Process for producing amines
GB0025692D0 (en) Method and apparatus for adjusting filter
GB2339165B (en) Methods and apparatus for particle formation
EP1119549A4 (en) PROCESS FOR THE PREPARATION OF SUBSTITUTED 4-1H-INDOLE-3-GLYOXAMIDES

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees