IL138221A0 - Formulations for protection of peg-interferon alpha conjugates - Google Patents

Formulations for protection of peg-interferon alpha conjugates

Info

Publication number
IL138221A0
IL138221A0 IL13822199A IL13822199A IL138221A0 IL 138221 A0 IL138221 A0 IL 138221A0 IL 13822199 A IL13822199 A IL 13822199A IL 13822199 A IL13822199 A IL 13822199A IL 138221 A0 IL138221 A0 IL 138221A0
Authority
IL
Israel
Prior art keywords
peg
formulations
protection
interferon alpha
alpha conjugates
Prior art date
Application number
IL13822199A
Other languages
English (en)
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21957085&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL138221(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of IL138221A0 publication Critical patent/IL138221A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IL13822199A 1998-03-26 1999-03-24 Formulations for protection of peg-interferon alpha conjugates IL138221A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4890798A 1998-03-26 1998-03-26
PCT/US1999/004268 WO1999048535A1 (en) 1998-03-26 1999-03-24 Formulations for protection of peg-interferon alpha conjugates

Publications (1)

Publication Number Publication Date
IL138221A0 true IL138221A0 (en) 2001-10-31

Family

ID=21957085

Family Applications (2)

Application Number Title Priority Date Filing Date
IL13822199A IL138221A0 (en) 1998-03-26 1999-03-24 Formulations for protection of peg-interferon alpha conjugates
IL138221A IL138221A (en) 1998-03-26 2000-09-03 Formulations for preserving PEG conjugates - interferon alpha

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL138221A IL138221A (en) 1998-03-26 2000-09-03 Formulations for preserving PEG conjugates - interferon alpha

Country Status (26)

Country Link
EP (1) EP1066059B1 (ko)
JP (3) JP3643034B2 (ko)
KR (1) KR100420642B1 (ko)
CN (1) CN1191863C (ko)
AR (1) AR014772A1 (ko)
AT (1) ATE297761T1 (ko)
AU (1) AU754002B2 (ko)
BR (1) BR9909087A (ko)
CA (1) CA2324467C (ko)
CO (1) CO5080738A1 (ko)
CZ (1) CZ302005B6 (ko)
DE (1) DE69925820T2 (ko)
ES (1) ES2241272T3 (ko)
HK (1) HK1029754A1 (ko)
HU (1) HU228877B1 (ko)
ID (1) ID28470A (ko)
IL (2) IL138221A0 (ko)
MY (1) MY119227A (ko)
NO (1) NO329916B1 (ko)
NZ (1) NZ506631A (ko)
PE (1) PE20000338A1 (ko)
PL (1) PL193286B1 (ko)
PT (1) PT1066059E (ko)
SK (1) SK285284B6 (ko)
TW (2) TWI250024B (ko)
WO (1) WO1999048535A1 (ko)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL138221A0 (en) * 1998-03-26 2001-10-31 Schering Corp Formulations for protection of peg-interferon alpha conjugates
NZ514629A (en) * 1999-04-08 2004-02-27 Schering Corp PEGylated interferon-alpha administered at about 4.5- 9.0 micrograms/kg/week as a renal cell carcinoma treatment
US6923966B2 (en) 1999-04-08 2005-08-02 Schering Corporation Melanoma therapy
US6362162B1 (en) 1999-04-08 2002-03-26 Schering Corporation CML Therapy
US6605273B2 (en) 1999-04-08 2003-08-12 Schering Corporation Renal cell carcinoma treatment
EP1908477A3 (en) * 2000-01-24 2008-06-11 Schering Corporation Combination of temozolomide and pegylated interferon-alpha for treating cancer
EP1251866A1 (en) * 2000-01-24 2002-10-30 Schering Corporation Combination of temozolomide and pegylated interferon-alpha for treating cancer
KR100353392B1 (ko) * 2000-03-13 2002-09-18 선바이오(주) 높은 생체 활성도를 갖는 생체 활성 단백질과 ｐｅｇ의결합체 제조방법
EP1279406A4 (en) 2000-04-03 2007-10-24 Santen Pharmaceutical Co Ltd TRANSPORTERS AND DRUG DISPENSING SYSTEMS USING THESE
EP1478339B9 (en) 2002-02-22 2009-08-19 Schering Corporation Pharmaceutical formulations of antineoplastic agents, in particular temozolomide, processes of making and using the same
AU2008201682B2 (en) * 2004-02-02 2011-02-24 Ambrx, Inc. Modified human interferon polypeptides and their uses
JP4971160B2 (ja) * 2004-08-12 2012-07-11 シェーリング コーポレイション 安定するｐｅｇ化インターフェロン処方物
PT2234645E (pt) 2007-12-20 2012-05-21 Merck Serono Sa Formulações de peg-interferão-beta
KR101303388B1 (ko) * 2010-10-26 2013-09-03 한미사이언스 주식회사 지속형 인터페론 알파 결합체의 액상 제제
SG11201502930XA (en) * 2012-10-26 2015-05-28 Lupin Ltd Stable pharmaceutical composition of peginterferon alpha-2b
KR101736870B1 (ko) 2014-08-20 2017-05-18 한국코러스 주식회사 인터페론 접합체를 포함하는 복합체 및 이의 제조방법
EP4019007A1 (en) 2016-06-01 2022-06-29 Servier IP UK Limited Formulations of polyalkylene oxide-asparaginase and methods of making and using the same
CN112358541B (zh) * 2020-11-25 2022-04-01 广州迪澳医疗科技有限公司 一种重组人γ-干扰素的冻干保护剂

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2024046A1 (en) * 1989-09-28 1991-03-29 Alberto Ferro Stabilized leukocyte-interferons
US5382657A (en) * 1992-08-26 1995-01-17 Hoffmann-La Roche Inc. Peg-interferon conjugates
ATE214940T1 (de) * 1993-11-10 2002-04-15 Enzon Inc Verbesserte interferon-polymerkonjugate
US5766582A (en) * 1994-10-11 1998-06-16 Schering Corporation Stable, aqueous alfa interferon solution formulations
US5738846A (en) * 1994-11-10 1998-04-14 Enzon, Inc. Interferon polymer conjugates and process for preparing the same
JP2000510813A (ja) * 1995-02-06 2000-08-22 ジェネテイックス・インスティテュート・インコーポレイテッド Ｉｌ−１２用処方
JP2758154B2 (ja) * 1995-04-06 1998-05-28 エフ・ホフマン−ラ ロシユ アーゲー インターフェロンを含む液体製剤
WO1997004801A1 (en) * 1995-07-27 1997-02-13 Genentech, Inc. Stabile isotonic lyophilized protein formulation
US5908621A (en) * 1995-11-02 1999-06-01 Schering Corporation Polyethylene glycol modified interferon therapy
ATE262920T1 (de) * 1995-11-02 2004-04-15 Schering Corp Kontinuierliche, niedrigdosierte zytokine- infusionstherapie
TW517067B (en) * 1996-05-31 2003-01-11 Hoffmann La Roche Interferon conjugates
IL138221A0 (en) * 1998-03-26 2001-10-31 Schering Corp Formulations for protection of peg-interferon alpha conjugates

Also Published As

Publication number Publication date
EP1066059A1 (en) 2001-01-10
CZ302005B6 (cs) 2010-09-01
CZ20003315A3 (cs) 2001-04-11
TWI250024B (en) 2006-03-01
AU754002B2 (en) 2002-10-31
SK14262000A3 (sk) 2001-04-09
CA2324467A1 (en) 1999-09-30
HU228877B1 (en) 2013-06-28
JP3643034B2 (ja) 2005-04-27
NZ506631A (en) 2003-03-28
ES2241272T3 (es) 2005-10-16
DE69925820T2 (de) 2006-05-18
CO5080738A1 (es) 2001-09-25
PE20000338A1 (es) 2000-05-16
NO329916B1 (no) 2011-01-24
CA2324467C (en) 2002-11-05
NO20004785L (no) 2000-09-25
KR20010034654A (ko) 2001-04-25
EP1066059B1 (en) 2005-06-15
ATE297761T1 (de) 2005-07-15
HK1029754A1 (en) 2001-04-12
CN1295484A (zh) 2001-05-16
MY119227A (en) 2005-04-30
DE69925820D1 (de) 2005-07-21
AU3181299A (en) 1999-10-18
CN1191863C (zh) 2005-03-09
PL345568A1 (en) 2001-12-17
SK285284B6 (sk) 2006-10-05
HUP0101749A2 (hu) 2001-11-28
JP2002507583A (ja) 2002-03-12
JP2003221345A (ja) 2003-08-05
KR100420642B1 (ko) 2004-03-02
TWI243057B (en) 2005-11-11
NO20004785D0 (no) 2000-09-25
JP4580744B2 (ja) 2010-11-17
BR9909087A (pt) 2000-12-05
WO1999048535A1 (en) 1999-09-30
AR014772A1 (es) 2001-03-28
PL193286B1 (pl) 2007-01-31
IL138221A (en) 2007-12-03
ID28470A (id) 2001-05-24
JP2005104985A (ja) 2005-04-21
PT1066059E (pt) 2005-10-31
TW200536557A (en) 2005-11-16
HUP0101749A3 (en) 2001-12-28

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