IL135313A0 - 1-substituted-1-aminomethylcycloalkane derivatives (gabapentin analogues), their preparation and their use in the treatment of neurological disorders - Google Patents
1-substituted-1-aminomethylcycloalkane derivatives (gabapentin analogues), their preparation and their use in the treatment of neurological disordersInfo
- Publication number
- IL135313A0 IL135313A0 IL13531398A IL13531398A IL135313A0 IL 135313 A0 IL135313 A0 IL 135313A0 IL 13531398 A IL13531398 A IL 13531398A IL 13531398 A IL13531398 A IL 13531398A IL 135313 A0 IL135313 A0 IL 135313A0
- Authority
- IL
- Israel
- Prior art keywords
- integer
- disorders
- treatment
- aminomethylcycloalkane
- derivatives
- Prior art date
Links
- UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical class OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 title 2
- 208000012902 Nervous system disease Diseases 0.000 title 1
- 208000025966 Neurological disease Diseases 0.000 title 1
- 229960002870 gabapentin Drugs 0.000 title 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical group OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical group C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 208000006083 Hypokinesia Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001408 amides Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 208000002173 dizziness Diseases 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000003483 hypokinetic effect Effects 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 230000002981 neuropathic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940124530 sulfonamide Drugs 0.000 abstract 1
- 150000003456 sulfonamides Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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- C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/36—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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- C07C239/14—Hydroxylamino compounds or their ethers or esters having nitrogen atoms of hydroxylamino groups further bound to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
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- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
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- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
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- C07C311/33—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings
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- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
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- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6977397P | 1997-12-16 | 1997-12-16 | |
US10500598P | 1998-10-20 | 1998-10-20 | |
PCT/US1998/023918 WO1999031075A1 (en) | 1997-12-16 | 1998-11-10 | 1-substituted-1-aminomethyl-cycloalkane derivatives (=gabapentin analogues), their preparation and their use in the treatment of neurological disorders |
Publications (1)
Publication Number | Publication Date |
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IL135313A0 true IL135313A0 (en) | 2001-05-20 |
Family
ID=26750409
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL13531398A IL135313A0 (en) | 1997-12-16 | 1998-11-10 | 1-substituted-1-aminomethylcycloalkane derivatives (gabapentin analogues), their preparation and their use in the treatment of neurological disorders |
Country Status (22)
Country | Link |
---|---|
US (1) | US6518289B1 (de) |
EP (2) | EP1047678B1 (de) |
JP (1) | JP2002508362A (de) |
KR (1) | KR20010033158A (de) |
CN (2) | CN1495160A (de) |
AT (1) | ATE275552T1 (de) |
AU (1) | AU765802B2 (de) |
BR (1) | BR9814286A (de) |
CA (1) | CA2304974C (de) |
DE (1) | DE69826151T2 (de) |
ES (1) | ES2227896T3 (de) |
HK (1) | HK1032966A1 (de) |
HU (1) | HUP0004439A3 (de) |
IL (1) | IL135313A0 (de) |
IS (1) | IS5435A (de) |
NO (2) | NO317252B1 (de) |
NZ (1) | NZ503963A (de) |
PL (1) | PL341291A1 (de) |
PT (1) | PT1047678E (de) |
SI (1) | SI1047678T1 (de) |
TR (1) | TR200001795T2 (de) |
WO (1) | WO1999031075A1 (de) |
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GB2362646A (en) * | 2000-05-26 | 2001-11-28 | Warner Lambert Co | Cyclic amino acid derivatives useful as pharmaceutical agents |
GB0018272D0 (en) * | 2000-07-25 | 2000-09-13 | Vernalis Research Limited | Chemical compounds IV |
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US6620829B2 (en) * | 2000-10-17 | 2003-09-16 | Warner-Lambert Company | Method of treating noninflammatory cartilage damage |
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EP2192916A4 (de) * | 2007-08-23 | 2012-04-04 | Univ Leland Stanford Junior | Modulation der synaptogenese |
US8119658B2 (en) | 2007-10-01 | 2012-02-21 | Bristol-Myers Squibb Company | Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors |
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WO2009105887A1 (en) * | 2008-02-26 | 2009-09-03 | Ernest Puil | Cyclic amino acids for the treatment of pain |
EP2116539A1 (de) | 2008-04-25 | 2009-11-11 | Laboratorios Del. Dr. Esteve, S.A. | 1-Aryl-3-Amino-alkoxy-pyrazole als Sigma-Liganden zur Verbesserung der analgetischen Wirkung von Opioiden und zur Schwächung der Abhängigkeit davon |
ES2589915T3 (es) | 2008-10-08 | 2016-11-17 | Xgene Pharmaceutical Inc | Conjugados de GABA y métodos de utilización de los mismos |
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HUE047629T2 (hu) | 2013-01-28 | 2020-05-28 | Lopez Hector L | Eljárások ß-alanin tolerancia, farmakodinamika és hatékonyság javítására és azok alkalmazása |
AU2014364647A1 (en) | 2013-12-17 | 2016-06-23 | Laboratorios Del Dr. Esteve, S.A. | Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs) and Sigma receptor ligands combinations |
US20160310501A1 (en) | 2013-12-17 | 2016-10-27 | Laboratorios Del Dr. Esteve, S.A. | Gabapentinoids and sigma receptor ligands combinations |
CN109721562A (zh) * | 2013-12-18 | 2019-05-07 | 诺瓦色生物公司 | 用于治疗疼痛和其它病症的γ-氨基丁酸(GABA)类似物 |
CN106132406B (zh) | 2014-02-03 | 2020-03-27 | 夸德里加生物科学公司 | 作为化疗剂的β-取代的γ-氨基酸和类似物 |
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TWI665178B (zh) | 2015-08-03 | 2019-07-11 | 夸德里加生物科學公司 | 作為化療劑的β-取代的β-氨基酸和類似物及其應用 |
BR112020022885A2 (pt) | 2018-05-14 | 2021-03-23 | Xgene Pharmaceutical Inc. | formas cristalinas de conjugados de fármacos de carbamato de 1-(aciloxi)-alquila de naproxeno e pregabalina |
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DE3300774A1 (de) * | 1983-01-12 | 1984-07-12 | Hoechst Ag, 6230 Frankfurt | Neue spirocyclische aminosaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue spirocyclische aminosaeuren als zwischenprodukte und verfahren zu deren herstellung |
DE3327318C1 (de) * | 1983-07-29 | 1985-03-14 | Gödecke AG, 1000 Berlin | 1-Aminomethylcyclohexylmethan-sulfonsaeure,Verfahren zu deren Herstellung und deren Verwendung |
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DE3634066A1 (de) * | 1986-10-07 | 1988-04-21 | Boehringer Mannheim Gmbh | Neue 5-alkylbenzimidazole, verfahren zu ihrer herstellung sowie arzneimittel |
US5015644A (en) * | 1987-06-02 | 1991-05-14 | Warner-Lambert Company | Antihyperlipidemic and antiatherosclerotic urea and carbamate compounds |
US6197819B1 (en) | 1990-11-27 | 2001-03-06 | Northwestern University | Gamma amino butyric acid analogs and optical isomers |
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FR2687402B1 (fr) * | 1992-02-14 | 1995-06-30 | Lipha | Nouveaux azaindoles, procedes de preparation et medicaments les contenant. |
CA2123728A1 (en) * | 1993-05-21 | 1994-11-22 | Noriyoshi Sueda | Urea derivatives and their use as acat inhibitors |
JPH07101929A (ja) * | 1993-10-01 | 1995-04-18 | Fujisawa Pharmaceut Co Ltd | 尿素誘導体およびその製造法 |
ES2169848T3 (es) * | 1996-03-14 | 2002-07-16 | Warner Lambert Co | Nuevos aminoacidos ciclicos coronados como agentes farmaceuticos. |
DK0888285T3 (da) * | 1996-03-14 | 2002-04-08 | Warner Lambert Co | Nye broforbundne cycliske aminosyrer som farmaceutiske midler |
IL127194A0 (en) * | 1996-08-22 | 1999-09-22 | Warner Lambert Co | Non-peptide bombesin receptor antagonists |
-
1998
- 1998-11-10 JP JP2000539002A patent/JP2002508362A/ja active Pending
- 1998-11-10 BR BR9814286-0A patent/BR9814286A/pt not_active Application Discontinuation
- 1998-11-10 WO PCT/US1998/023918 patent/WO1999031075A1/en not_active Application Discontinuation
- 1998-11-10 EP EP98957745A patent/EP1047678B1/de not_active Expired - Lifetime
- 1998-11-10 AT AT98957745T patent/ATE275552T1/de not_active IP Right Cessation
- 1998-11-10 AU AU13929/99A patent/AU765802B2/en not_active Ceased
- 1998-11-10 PL PL98341291A patent/PL341291A1/xx unknown
- 1998-11-10 KR KR1020007006535A patent/KR20010033158A/ko not_active Application Discontinuation
- 1998-11-10 CN CNA2003101142270A patent/CN1495160A/zh active Pending
- 1998-11-10 DE DE69826151T patent/DE69826151T2/de not_active Expired - Fee Related
- 1998-11-10 ES ES98957745T patent/ES2227896T3/es not_active Expired - Lifetime
- 1998-11-10 TR TR2000/01795T patent/TR200001795T2/xx unknown
- 1998-11-10 EP EP04006036A patent/EP1475371A1/de not_active Withdrawn
- 1998-11-10 NZ NZ503963A patent/NZ503963A/xx unknown
- 1998-11-10 IL IL13531398A patent/IL135313A0/xx unknown
- 1998-11-10 US US09/509,905 patent/US6518289B1/en not_active Expired - Fee Related
- 1998-11-10 CN CN98811481XA patent/CN1131855C/zh not_active Expired - Fee Related
- 1998-11-10 SI SI9830690T patent/SI1047678T1/xx unknown
- 1998-11-10 HU HU0004439A patent/HUP0004439A3/hu unknown
- 1998-11-10 CA CA002304974A patent/CA2304974C/en not_active Expired - Fee Related
- 1998-11-10 PT PT98957745T patent/PT1047678E/pt unknown
-
2000
- 2000-04-07 IS IS5435A patent/IS5435A/is unknown
- 2000-06-14 NO NO20003039A patent/NO317252B1/no not_active IP Right Cessation
-
2001
- 2001-05-23 HK HK01103570A patent/HK1032966A1/xx not_active IP Right Cessation
-
2004
- 2004-03-17 NO NO20041112A patent/NO20041112L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP1047678A1 (de) | 2000-11-02 |
NZ503963A (en) | 2002-09-27 |
CN1279674A (zh) | 2001-01-10 |
JP2002508362A (ja) | 2002-03-19 |
EP1047678B1 (de) | 2004-09-08 |
AU765802B2 (en) | 2003-10-02 |
DE69826151T2 (de) | 2005-01-27 |
DE69826151D1 (de) | 2004-10-14 |
CA2304974A1 (en) | 1999-06-24 |
ES2227896T3 (es) | 2005-04-01 |
US6518289B1 (en) | 2003-02-11 |
CA2304974C (en) | 2005-10-25 |
BR9814286A (pt) | 2000-10-03 |
HUP0004439A3 (en) | 2001-12-28 |
KR20010033158A (ko) | 2001-04-25 |
NO317252B1 (no) | 2004-09-27 |
AU1392999A (en) | 1999-07-05 |
CN1495160A (zh) | 2004-05-12 |
HUP0004439A2 (hu) | 2001-10-28 |
CN1131855C (zh) | 2003-12-24 |
ATE275552T1 (de) | 2004-09-15 |
NO20003039D0 (no) | 2000-06-14 |
SI1047678T1 (en) | 2005-02-28 |
WO1999031075A1 (en) | 1999-06-24 |
HK1032966A1 (en) | 2001-08-10 |
NO20041112L (no) | 2000-06-14 |
IS5435A (is) | 2000-04-07 |
PT1047678E (pt) | 2004-12-31 |
TR200001795T2 (tr) | 2000-11-21 |
NO20003039L (no) | 2000-06-14 |
PL341291A1 (en) | 2001-04-09 |
EP1475371A1 (de) | 2004-11-10 |
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