IL134043A0 - Cellular vesicle called "exosome", its preparation and use thereof in immune stimulation - Google Patents

Cellular vesicle called "exosome", its preparation and use thereof in immune stimulation

Info

Publication number
IL134043A0
IL134043A0 IL13404398A IL13404398A IL134043A0 IL 134043 A0 IL134043 A0 IL 134043A0 IL 13404398 A IL13404398 A IL 13404398A IL 13404398 A IL13404398 A IL 13404398A IL 134043 A0 IL134043 A0 IL 134043A0
Authority
IL
Israel
Prior art keywords
dexosomes
molecules
class
exosome
preparation
Prior art date
Application number
IL13404398A
Other languages
English (en)
Original Assignee
Inst Nat Sante Rech Med
Roussy Inst Gustave
Centre Nat Rech Scient
Inst Curie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Nat Sante Rech Med, Roussy Inst Gustave, Centre Nat Rech Scient, Inst Curie filed Critical Inst Nat Sante Rech Med
Publication of IL134043A0 publication Critical patent/IL134043A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4615—Dendritic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
    • A61K39/4622—Antigen presenting cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/46449—Melanoma antigens
    • A61K39/464491—Melan-A/MART
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/46449—Melanoma antigens
    • A61K39/464492—Glycoprotein 100 [Gp100]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5152—Tumor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55588—Adjuvants of undefined constitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
    • A61K9/5068—Cell membranes or bacterial membranes enclosing drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
IL13404398A 1997-07-16 1998-07-03 Cellular vesicle called "exosome", its preparation and use thereof in immune stimulation IL134043A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9709007A FR2766205B1 (fr) 1997-07-16 1997-07-16 Nouveau procede de sensibilisation de cellules presentatrices d'antigene et nouveaux moyens pour la mise en oeuvre du procede
FR9801437A FR2774697B1 (fr) 1997-07-16 1998-02-06 Procede de sensibilisation de cellules presentatrices d'antigene et moyens pour la mise en oeuvre du procede
PCT/FR1998/001431 WO1999003499A1 (fr) 1997-07-16 1998-07-03 Vesicule cellulaire denommee ''exosome'', leur preparation et utilisation dans la stimulation d'une reponse immunitaire

Publications (1)

Publication Number Publication Date
IL134043A0 true IL134043A0 (en) 2001-04-30

Family

ID=26233678

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13404398A IL134043A0 (en) 1997-07-16 1998-07-03 Cellular vesicle called "exosome", its preparation and use thereof in immune stimulation

Country Status (16)

Country Link
US (2) US6685911B1 (xx)
EP (2) EP1001806B1 (xx)
JP (2) JP3484201B2 (xx)
CN (1) CN1250285C (xx)
AT (2) ATE442160T1 (xx)
AU (1) AU743296B2 (xx)
CA (1) CA2296750C (xx)
DE (2) DE69826288T2 (xx)
DK (1) DK1001806T3 (xx)
EA (2) EA002827B1 (xx)
ES (2) ES2227863T3 (xx)
FR (2) FR2766205B1 (xx)
IL (1) IL134043A0 (xx)
PT (1) PT1001806E (xx)
TW (1) TW592708B (xx)
WO (1) WO1999003499A1 (xx)

Families Citing this family (114)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997005900A1 (en) * 1995-08-03 1997-02-20 Rijksuniversiteit Te Leiden Cell derived antigen presenting vesicles
US5763445A (en) 1996-03-08 1998-06-09 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US6849452B1 (en) * 1998-03-03 2005-02-01 Institut Gustave Roussy Methods for activating natural killer (NK) cells and means for carrying out said methods
FR2788780B1 (fr) * 1999-01-27 2001-03-30 Ap Cells Inc Procede de preparation de vesicules membranaires
GB9927320D0 (en) * 1999-11-18 2000-01-12 Chiron Spa Exosome separation
US20040241176A1 (en) * 2000-04-27 2004-12-02 Ap Cells. Inc. Method of producing membrane vesicles
EP1280889B1 (en) * 2000-05-11 2007-08-29 Baylor Research Institute Compositions and methods for producing antigen-presenting cells
US20030165483A1 (en) * 2000-07-10 2003-09-04 Ulrich Zimmermann Method for the modification of biological cells
FR2827872A1 (fr) * 2001-07-30 2003-01-31 Roussy Inst Gustave Vesicules membranaires de fluide biologique preleve in vivo, leur preparation et utilisation dans la stimulation d'une reponse immunitaire
US7704964B2 (en) 2001-08-17 2010-04-27 Exothera L.L.C. Methods and compounds for the targeting of protein to exosomes
EP1308167A1 (de) * 2001-11-06 2003-05-07 Pickl, Winfried, Ao. Univ. Prof. Dr. Antigenpräsentierende Vesikel
KR20030085659A (ko) * 2002-04-30 2003-11-07 동부한농화학 주식회사 암 치료용 엑소좀 및 그를 이용한 암 백신
US20040022813A1 (en) * 2002-08-05 2004-02-05 Jean-Claude Bystryn Shed antigen vaccine with dendritic cells adjuvant
KR100519384B1 (ko) * 2002-08-13 2005-10-06 (주)누백스 유전자 이입을 이용한 엑소좀의 제조방법 및 상기 엑소좀의 용도
DK2261249T3 (en) 2002-09-12 2015-02-16 Oncotherapy Science Inc KDR peptides and vaccines comprising the same
US8021847B2 (en) * 2004-06-02 2011-09-20 Proxy Life Science Holdings, Inc. Microvesicle-based compositions and methods
EP1766053A4 (en) * 2004-06-02 2007-12-12 Sourcepharm Inc MICROVESICLES CONTAINING RNA AND METHODS
KR20070058441A (ko) * 2004-07-01 2007-06-08 유니버시티 오브 피츠버그 오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 면역억제성 엑소솜
PT2325306E (pt) 2005-02-25 2014-04-29 Oncotherapy Science Inc Vacinas peptídicas para cancros do pulmão que expressam polipéptidos ttk, urlc10 ou koc1
ES2435650T3 (es) 2005-02-28 2013-12-20 Oncotherapy Science, Inc. Péptidos epítopos derivados del receptor 1 del factor de crecimiento endotelial vascular y vacunas que contienen estos péptidos
EP1712238A1 (en) * 2005-04-11 2006-10-18 Institut Gustave Roussy Anthracyclin induced immunogenic dead or dying cells composition
CA2504279A1 (en) * 2005-04-15 2006-10-15 University Of Saskatchewan Materials and method of modulating the immune response using t helper-antigen presenting cells
CN1322115C (zh) * 2005-07-06 2007-06-20 清华大学 载有外源配体分子的胞外体及其制备方法与应用
EP1910839B1 (en) 2005-07-27 2016-04-27 Oncotherapy Science, Inc. Colon cancer related gene tom34
WO2007016340A2 (en) 2005-07-29 2007-02-08 Providence Health System Defective ribosomal products in blebs (dribbles) and methods of use to stimulate an immune response
WO2007127848A1 (en) 2006-04-26 2007-11-08 University Of Louisville Research Foundation, Inc Isolation of membrane vesicles from biological fluids and methods of using same
US9085778B2 (en) * 2006-05-03 2015-07-21 VL27, Inc. Exosome transfer of nucleic acids to cells
CN101085349B (zh) * 2006-06-09 2011-05-25 项雯华 囊泡导向的免疫细胞及其在制备抗肿瘤药物上的应用
WO2008108808A2 (en) * 2006-08-24 2008-09-12 Trustees Of Boston University Complexes derived from heterohybrid cells and uses thereof
CN101568550B (zh) 2006-10-17 2012-12-26 肿瘤疗法科学股份有限公司 用于表达mphosph1或depdc1多肽的癌症的肽疫苗
US8455188B2 (en) * 2007-01-26 2013-06-04 University Of Louisville Research Foundation, Inc. Modification of exosomal components for use as a vaccine
TWI610939B (zh) 2007-02-21 2018-01-11 腫瘤療法 科學股份有限公司 表現腫瘤相關抗原之癌症的胜肽疫苗
TWI434853B (zh) 2007-04-11 2014-04-21 Oncotherapy Science Inc 腫瘤血管內皮標誌８胜肽及包含此胜肽之疫苗
CN101129405B (zh) * 2007-07-31 2011-05-11 崔澂 一种治疗习惯性流产的生物学制剂
WO2009020604A2 (en) 2007-08-06 2009-02-12 Southern Connecticut State University Tissue organizing structure and therapeutic methods
EP2176665B1 (en) 2007-08-16 2016-03-02 The Royal Institution for the Advancement of Learning / McGill University Tumor cell-derived microvesicles
US20100255514A1 (en) * 2007-08-16 2010-10-07 The Royal Institution For The Advancement Of Learning/Mcgill University Tumor cell-derived microvesicles
BRPI0815578B8 (pt) 2007-08-20 2023-01-03 Oncotherapy Science Inc Peptídeo de cdca1, seu uso e composição imunogênica compreendendo o mesmo para induzir imunidade, tratar e/ou prevenir o câncer, bem como método in vitro para induzir uma célula apresentadora de antígeno e uma célula t citotóxica (killer)
KR101543624B1 (ko) 2007-08-20 2015-08-11 온코세라피 사이언스 가부시키가이샤 Ｆｏｘｍ１ 펩티드 및 이를 포함하는 약학적 조성물
EP2072617A1 (en) 2007-12-12 2009-06-24 Trimed Biotech GmbH Method for producing dendritic cells
TWI526219B (zh) 2008-06-19 2016-03-21 腫瘤療法 科學股份有限公司 Ｃｄｃａ１抗原決定位胜肽及含此胜肽的疫苗
EP2358912B1 (en) 2008-10-30 2016-10-12 Caris Life Sciences Switzerland Holdings GmbH Methods for assessing rna patterns
EP2730662A1 (en) * 2008-11-12 2014-05-14 Caris Life Sciences Luxembourg Holdings Methods and systems of using exosomes for determining phenotypes
TWI539160B (zh) 2008-12-05 2016-06-21 腫瘤療法 科學股份有限公司 Ｗｄｒｐｕｈ抗原決定位胜肽以及含此胜肽之疫苗
TWI469791B (zh) 2009-02-18 2015-01-21 Oncotherapy Science Inc Ｆｏｘｍ１胜肽以及含此胜肽之疫苗
CN105601725B (zh) 2009-03-18 2019-08-09 肿瘤疗法科学股份有限公司 Neil3肽及包含它的疫苗
PT2419144T (pt) 2009-04-17 2019-09-16 Univ Oxford Innovation Ltd Composição para a administração de material genético
TWI507204B (zh) 2009-05-26 2015-11-11 Oncotherapy Science Inc Ｃｄｃ４５ｌ胜肽與含此胜肽之疫苗
US8431530B2 (en) 2009-06-12 2013-04-30 Morehouse School Of Medicine Compositions and methods for treating aids or cancer by inhibiting the secretion of microparticles
WO2011002239A2 (ko) 2009-07-01 2011-01-06 주식회사이언메딕스 포유류의 유핵세포에서 유래된 마이크로베시클 및 이의 용도
TW201136604A (en) 2009-12-14 2011-11-01 Oncotherapy Science Inc TMEM22 peptides and vaccines including the same
ES2362589B1 (es) 2009-12-28 2012-05-16 Centre De Recerca En Salut Internacional De Barcelona Exosomas derivados de reticulocitos infectados con plasmodium sp., método para su obtención y su uso.
US20120315324A1 (en) * 2010-02-05 2012-12-13 University Of Louisville Research Foundation, Inc. Exosomal compositions and methods for the treatment of disease
RU2451292C2 (ru) * 2010-02-09 2012-05-20 Федеральное государственное унитарное предприятие "Антидопинговый центр" Способ определения эндогенных стероидов в плазме крови человека
CN103237901B (zh) 2010-03-01 2016-08-03 卡里斯生命科学瑞士控股有限责任公司 用于治疗诊断的生物标志物
US8933014B2 (en) 2010-03-11 2015-01-13 Oncotherapy Science, Inc. HJURP peptides and vaccines including the same
TWI538685B (zh) 2010-04-02 2016-06-21 腫瘤療法 科學股份有限公司 Ｅｃｔ２胜肽及含此胜肽之疫苗
AU2011237669B2 (en) 2010-04-06 2016-09-08 Caris Life Sciences Switzerland Holdings Gmbh Circulating biomarkers for disease
WO2011127129A1 (en) * 2010-04-06 2011-10-13 Holaday John W Methods of treating cancer
WO2012125471A1 (en) * 2011-03-11 2012-09-20 Children's Medical Center Corporation Methods and compositions relating to mesenchymal stem cell exosomes
US9816998B2 (en) 2011-04-01 2017-11-14 Cornell University Circulating exosomes as diagnostic/prognostic indicators and therapeutic targets of melanoma and other cancers
JP5564730B2 (ja) 2011-08-12 2014-08-06 オンコセラピー・サイエンス株式会社 Ｍｐｈｏｓｐｈ１ペプチドおよびそれを含むワクチン
CN102302784B (zh) * 2011-08-22 2012-12-05 湖北盛齐安生物科技有限公司 一种肿瘤化疗药物制剂及其制备方法
BR112014009176B1 (pt) 2011-10-28 2022-08-30 Oncotherapy Science, Inc Composição para indução de linfócito t citotóxico (ctl), uso no tratamento e profilaxia de câncer e indução de resposta imune contra câncer e métodos in vitro para indução de ctl
WO2013079701A2 (en) 2011-11-30 2013-06-06 University Of Bremen Expression of mirnas in placental tissue
GB201121070D0 (en) 2011-12-07 2012-01-18 Isis Innovation composition for delivery of biotherapeutics
CN103446580B (zh) * 2012-05-31 2016-08-03 湖北盛齐安生物科技有限公司 一种肿瘤疫苗及其制备方法
US10231997B2 (en) 2012-08-15 2019-03-19 The University Of Chicago Exosome-based therapeutics against neurodegenerative disorders
TWI658049B (zh) 2013-03-12 2019-05-01 腫瘤療法 科學股份有限公司 Ｋｎｔｃ２胜肽及含此胜肽之疫苗
EP3527670B1 (en) 2013-03-15 2023-10-18 Beth Israel Deaconess Medical Center, Inc. Mirna biogenesis in exosomes for diagnosis and therapy
EP3003290B1 (en) 2013-06-05 2021-03-10 AgeX Therapeutics, Inc. Compositions for use in the treatment of wounds in mammalian species
US10987432B2 (en) 2013-09-05 2021-04-27 The University Of Hong Kong Therapeutic delivery and expression system, methods and uses thereof
EP3052616A4 (en) * 2013-10-02 2017-03-29 Paradigm Biopharmaceuticals Limited A method of producing exosomes
HUE046489T2 (hu) * 2013-12-04 2020-03-30 Univ Texas Eljárás ráksejtekbõl származó exoszómák izolálására
US11078462B2 (en) 2014-02-18 2021-08-03 ReCyte Therapeutics, Inc. Perivascular stromal cells from primate pluripotent stem cells
EP3145493B1 (en) 2014-05-18 2022-07-27 Children's Medical Center Corporation Methods and compositions relating to exosomes
US10240127B2 (en) 2014-07-03 2019-03-26 ReCyte Therapeutics, Inc. Exosomes from clonal progenitor cells
WO2016021508A1 (ja) 2014-08-04 2016-02-11 オンコセラピー・サイエンス株式会社 Ｃｄｃａ１由来ペプチドおよびそれを含むワクチン
EP3590954A3 (en) 2014-08-04 2020-03-25 OncoTherapy Science, Inc. Koc1-derived peptide and vaccine including same
ES2856834T3 (es) 2014-08-04 2021-09-28 Oncotherapy Science Inc Péptido derivado de URLC10 y vacuna que contiene el mismo
KR101726488B1 (ko) * 2015-02-23 2017-04-13 이화여자대학교 산학협력단 바실러스 속 세균 유래 세포밖 소포체를 포함하는 임신관련 질환 치료용 조성물
CN105031661A (zh) * 2015-05-28 2015-11-11 杭州优玛达生物科技有限公司 生物膜、具有生物膜性的闭合结构或细胞区室作为基因转染试剂或者基因治疗试剂的应用
CN104984359A (zh) * 2015-05-28 2015-10-21 杭州优玛达生物科技有限公司 生物膜、具有生物膜性的闭合结构或细胞区室作为疫苗载体或免疫调节剂的应用
KR102706532B1 (ko) 2015-06-10 2024-09-19 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 질환의 치료를 위한 엑소좀의 용도
EP3115058A1 (fr) 2015-07-09 2017-01-11 Institut Gustave Roussy Peptides immunogenes de preprocalcitonine
RU2765574C2 (ru) 2015-08-12 2022-02-01 Онкотерапи Сайенс, Инк. Пептид, полученный из depdc1, и содержащая его вакцина
MX2018004308A (es) 2015-10-08 2018-05-01 Oncotherapy Science Inc Peptido derivado de foxm1 y vacuna que lo incluye.
SG10201913531PA (en) 2015-10-08 2020-03-30 Oncotherapy Science Inc Mphosph1-derived peptide, and vaccine including same
EP3393511A1 (en) * 2015-12-21 2018-10-31 La Jolla Institute for Allergy and Immunology Leveraging immune memory from common childhood vaccines to fight disease
EP3402901A1 (en) * 2016-01-11 2018-11-21 Dixon, Janette Methods for determining tumour phenotypes
US20190091307A1 (en) * 2016-03-03 2019-03-28 Institut Gustave Roussy Ptps-based vaccines against cancer
WO2017177204A1 (en) * 2016-04-09 2017-10-12 La Jolla Institute For Allergy And Immunology Leveraging immune memory from common childhood vaccines to fight disease
WO2017194170A1 (en) * 2016-05-13 2017-11-16 Biontech Rna Pharmaceuticals Gmbh Methods for predicting the usefulness of proteins or protein fragments for immunotherapy
CA3029813A1 (en) 2016-06-13 2017-12-21 Torque Therapeutics, Inc. Methods and compositions for promoting immune cell function
US10294454B2 (en) 2016-08-24 2019-05-21 General Electric Company Methods and kits for cell activation
WO2018071682A1 (en) 2016-10-13 2018-04-19 Vbc Holdings Llc Anti-inflammatory exosomes from inflamed cells or tissues
EP3525802B1 (en) 2016-10-13 2021-05-26 VBC Holdings LLC Cancer stem cell exosomes
WO2018071677A1 (en) 2016-10-13 2018-04-19 Vbc Holdings Llc Medical uses of exosomes
WO2018118015A1 (en) 2016-12-19 2018-06-28 Morehouse School Of Medicine Compositions and methods for treating diseases by inhibiting exosome release
US10800817B2 (en) 2016-12-19 2020-10-13 Morehouse School Of Medicine Compositions and methods for treating diseases by inhibiting exosome release
KR101862502B1 (ko) * 2017-01-02 2018-05-29 성균관대학교산학협력단 재구성 인공 암세포, 이의 제조 방법, 및 이를 포함하는 항암 조성물
JP6923875B2 (ja) * 2017-01-27 2021-08-25 東亞合成株式会社 腫瘍細胞のｃｄ４７発現を抑制するための薬剤組成物およびその利用
JP6914553B2 (ja) * 2017-02-24 2021-08-04 エムディー ヘルスケア インコーポレイテッドＭｄ Ｈｅａｌｔｈｃａｒｅ Ｉｎｃ． 細菌メタゲノム分析を通した慢性閉塞性気道疾患の診断方法
US10815520B2 (en) 2017-04-07 2020-10-27 University Of Louisville Research Foundation, Inc. Nanovesicles, methods, and systems for diagnosis and prognosis of cancer
KR101999818B1 (ko) * 2017-07-26 2019-07-12 ㈜로제타엑소좀 소수성 상호작용을 이용한 세포밖 소포체의 분리방법
JP7285828B2 (ja) 2017-09-05 2023-06-02 トルク セラピューティクス， インコーポレイテッド 治療用タンパク質組成物ならびにその作製および使用方法
CN109576219A (zh) * 2017-09-29 2019-04-05 河南省肿瘤医院 一种用于扩增t淋巴细胞的纳米级膜性囊泡的制备方法
JP7542257B2 (ja) * 2018-01-25 2024-08-30 エイシーエム バイオラブズ プライベート リミテッド 可溶化された封入抗原を含むポリマーソーム、ならびにその作製および使用方法
CN110123842B (zh) * 2018-02-09 2022-03-15 上海市第六人民医院 一种外泌体缓释体系及其构建方法与应用
TW202023581A (zh) 2018-08-02 2020-07-01 日商腫瘤療法 科學股份有限公司 來自cdca1的胜肽及含有此的疫苗
CN110876734A (zh) * 2018-09-06 2020-03-13 杨昆德 包含胞外囊泡的制剂、用以制备该制剂的方法及其用途
IT201800009235A1 (it) 2018-10-08 2020-04-08 Universita' Degli Studi Di Palermo Procedimento per la sintesi di esosomi contenenti proteine da shock termico e loro uso per il trattamento della atrofia muscolare e della cachessia
CA3125697A1 (en) 2019-01-29 2020-08-06 Helmholtz Zentrum Munchen - Deutsches Forschungszentrum Fur Gesundheit Und Umwelt (Gmbh) Treating the causative agent in adhesiogenesis
CN116785416A (zh) * 2023-06-14 2023-09-22 首都医科大学附属北京佑安医院 一种树突状细胞外泌体肝癌疫苗制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997005900A1 (en) * 1995-08-03 1997-02-20 Rijksuniversiteit Te Leiden Cell derived antigen presenting vesicles
US5962318A (en) * 1996-11-15 1999-10-05 St. Jude Children's Research Hospital Cytotoxic T lymphocyte-mediated immunotherapy
WO1998053048A1 (en) * 1997-05-21 1998-11-26 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Methods and compositions for making dendritic cells from expanded populations of monocytes and for activating t cells
DE69840739D1 (de) * 1997-10-27 2009-05-28 Merix Bioscience Inc Methode und Zusammensetzung zur Herstellung von reifen dendritischen Zellen
US6080399A (en) * 1998-04-23 2000-06-27 Arch Development Corporation Vaccine adjuvants for immunotherapy of melanoma

Also Published As

Publication number Publication date
TW592708B (en) 2004-06-21
ATE275969T1 (de) 2004-10-15
JP2000512161A (ja) 2000-09-19
FR2774697B1 (fr) 2004-04-30
CA2296750A1 (fr) 1999-01-28
DE69826288T2 (de) 2005-11-03
DE69826288D1 (de) 2004-10-21
FR2766205B1 (fr) 2002-08-30
US6685911B1 (en) 2004-02-03
JP2003125762A (ja) 2003-05-07
EA004300B1 (ru) 2004-02-26
JP3691468B2 (ja) 2005-09-07
EP1001806B1 (fr) 2004-09-15
DK1001806T3 (da) 2005-01-24
EP1001806A1 (fr) 2000-05-24
EP1523990A1 (fr) 2005-04-20
WO1999003499A1 (fr) 1999-01-28
US20040028692A1 (en) 2004-02-12
ES2227863T3 (es) 2005-04-01
EA200200517A1 (ru) 2002-10-31
FR2766205A1 (fr) 1999-01-22
US7625573B2 (en) 2009-12-01
JP3484201B2 (ja) 2004-01-06
CA2296750C (fr) 2012-09-18
FR2774697A1 (fr) 1999-08-13
AU8446498A (en) 1999-02-10
EA002827B1 (ru) 2002-10-31
ES2331838T3 (es) 2010-01-18
CN1250285C (zh) 2006-04-12
ATE442160T1 (de) 2009-09-15
PT1001806E (pt) 2004-12-31
EP1523990B1 (fr) 2009-09-09
DE69841146D1 (de) 2009-10-22
CN1265038A (zh) 2000-08-30
EA200000130A1 (ru) 2000-08-28
AU743296B2 (en) 2002-01-24

Similar Documents

Publication Publication Date Title
IL134043A0 (en) Cellular vesicle called "exosome", its preparation and use thereof in immune stimulation
AU6632496A (en) Cell derived antigen presenting vesicles
AU3188297A (en) Liposomal influenza vaccine composition and method
AU6597998A (en) HLA-A2.1 binding peptides and their uses
EP2341072A3 (en) Method for Generating Activated T-Cells and Antigen-Pulsed Antigen-Presenting Cells
HK1041433A1 (zh) 人工抗原特異性細胞和相關方法
EP2298927A3 (en) Methods for treating cancers and pathogen infections using antigen-presenting cells loaded with RNA
BR9610802A (pt) Método para melhoria da resposta imunológica método de preparo de células t de antígeno específico método para induzir tolerância de tecido de enxerto auxiliar de vacina meio de expansão e preparação de células dentríticas população de células dentríticas e respectivo método de preparo método para direcionar células-tronco hematopoiéticas ou células progenitoras a uma linhagem de células dentríticas
AU7478394A (en) Methods for (ex vivo) therapy using peptide-loaded antigen presenting cells for the activation of ctl
AU5836586A (en) Influenza vaccine
EP1917970A3 (en) Hla binding peptides and their uses
CA2214649A1 (en) Antigen presenting system and methods for activation of t-cells
AU1955997A (en) Method and compositions for obtaining mature dendritic cells
AU7158398A (en) Use of lentiviral vectors for antigen presentation in dendritic cells
EP0907370A4 (en) HLA-A2.1 BINDING PEPTIDES AND USES THEREOF
EP1911461A3 (en) HLA class I and II binding peptides and their uses
CA2182889A1 (en) Peptides recognized by melanoma-specific cytotoxic lymphocytes, and uses therefor
WO1998033527A3 (en) Cancer immunotherapy with semi-allogeneic cells
NO20024571L (no) Immunoterapeutiske fremgangsmåter og blandinger
EP0531401A4 (en) Enhancing the association of exogenous peptides with class i mhc molecules on immune system cells
EP0202642A3 (en) Process for the in vitro immunization of human splenocytes against tumor associated antigens
EP0918539A4 (en) VACCINE AGAINST MALIGNANCIES AFFECTING B LYMPHOCYTES
AU4577899A (en) Hla binding peptides and their uses
WO1999047102A3 (en) Methods for enhanced antigen presentation on antigen-presenting cells and compositions produced thereby
Herrmann et al. Lymphocyte recognition of H‐2 antigen in liposomes