IL133176A0 - Pharmaceutical compositions of peptides having low solubility in physiological medium - Google Patents

Pharmaceutical compositions of peptides having low solubility in physiological medium

Info

Publication number
IL133176A0
IL133176A0 IL13317698A IL13317698A IL133176A0 IL 133176 A0 IL133176 A0 IL 133176A0 IL 13317698 A IL13317698 A IL 13317698A IL 13317698 A IL13317698 A IL 13317698A IL 133176 A0 IL133176 A0 IL 133176A0
Authority
IL
Israel
Prior art keywords
peptides
pharmaceutical compositions
low solubility
physiological medium
physiological
Prior art date
Application number
IL13317698A
Other languages
English (en)
Original Assignee
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP97108593A external-priority patent/EP0880968A1/fr
Application filed by Applied Research Systems filed Critical Applied Research Systems
Publication of IL133176A0 publication Critical patent/IL133176A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/25—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
IL13317698A 1997-05-28 1998-05-26 Pharmaceutical compositions of peptides having low solubility in physiological medium IL133176A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP97108593A EP0880968A1 (fr) 1997-05-28 1997-05-28 Compositions pharmaceutiques de peptides de faible solubilité dans un milieu physiologique
EP97121246A EP0880969A1 (fr) 1997-05-28 1997-12-03 Compositions pharmaceutiques de peptides de faible solubilité dans un milieu physioloqique
PCT/EP1998/003079 WO1998053844A1 (fr) 1997-05-28 1998-05-26 Composition pharmaceutique de peptides presentant une faible solubilite dans un milieu physiologique

Publications (1)

Publication Number Publication Date
IL133176A0 true IL133176A0 (en) 2001-03-19

Family

ID=26145485

Family Applications (2)

Application Number Title Priority Date Filing Date
IL13317698A IL133176A0 (en) 1997-05-28 1998-05-26 Pharmaceutical compositions of peptides having low solubility in physiological medium
IL133176A IL133176A (en) 1997-05-28 1999-11-28 Pharmaceutical preparations containing peptides in a low solubility vessel in a physiological medium

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL133176A IL133176A (en) 1997-05-28 1999-11-28 Pharmaceutical preparations containing peptides in a low solubility vessel in a physiological medium

Country Status (27)

Country Link
US (1) US6331520B1 (fr)
EP (2) EP0880969A1 (fr)
JP (1) JP2002502384A (fr)
KR (1) KR100552546B1 (fr)
CN (1) CN1159062C (fr)
AR (1) AR012868A1 (fr)
AT (1) ATE252909T1 (fr)
AU (1) AU743152B2 (fr)
BG (1) BG64668B1 (fr)
BR (1) BR9809708A (fr)
CA (1) CA2291765A1 (fr)
CZ (1) CZ298825B6 (fr)
DE (1) DE69819322T2 (fr)
DK (1) DK0984788T3 (fr)
EA (1) EA002227B1 (fr)
EE (1) EE04001B1 (fr)
ES (1) ES2210772T3 (fr)
HK (1) HK1029928A1 (fr)
IL (2) IL133176A0 (fr)
NO (1) NO323697B1 (fr)
NZ (1) NZ500777A (fr)
PL (1) PL192647B1 (fr)
PT (1) PT984788E (fr)
SI (1) SI0984788T1 (fr)
SK (1) SK284640B6 (fr)
TR (1) TR199902865T2 (fr)
WO (1) WO1998053844A1 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8343186B2 (en) 2004-04-06 2013-01-01 Arthrex, Inc. Fully threaded suture anchor with transverse anchor pin
EP1064934A1 (fr) * 1999-06-30 2001-01-03 Applied Research Systems ARS Holding N.V. Compositions lyophilisées contenant du GRF
WO2001087322A2 (fr) * 2000-05-17 2001-11-22 Bionebraska, Inc. Preparations pharmaceutiques peptidiques
US20040229334A1 (en) * 2003-05-15 2004-11-18 Mendoza Christine B. Process for manufacture of nematode-extracted anticoagulant protein (NAP)
JP2010523501A (ja) * 2007-04-04 2010-07-15 セラテクノロジーズ インコーポレイティド Ｇｈｒｈ分子の医薬製剤
EP2873422A4 (fr) 2012-07-10 2015-12-30 Takeda Pharmaceutical Préparation pharmaceutique pour l'injection
CN104918927B (zh) * 2012-10-12 2018-09-07 莱雅公司 含有至少一种水溶助长剂和至少一种活性化合物的化妆品组合物
US9018177B2 (en) 2012-10-12 2015-04-28 L'oreal S.A. Cosmetic compositions for increasing bioavailability of the active compounds baicalin and/or vitamin C
US9023826B2 (en) 2012-10-12 2015-05-05 L'oreal S.A. Compositions containing adenosine and the hydrotropes caffeine and nicotinamide for cosmetic use
US9072919B2 (en) 2012-10-12 2015-07-07 L'oreal S.A. Synergistic antioxidant cosmetic compositions containing at least one of baicalin and taxifolin, at least one of caffeine and nicotinamide, at least one of vitamin C and resveratrol and ferulic acid
US9107853B2 (en) 2012-10-12 2015-08-18 L'oreal S.A. Compositions containing phenolic compounds and hydrotropes for cosmetic use
US9669242B2 (en) * 2013-07-01 2017-06-06 L'oreal Compositions containing at least two phenolic compounds, a lipid-soluble antioxidant and at least one hydrotrope for cosmetic use
JP6634758B2 (ja) * 2015-09-25 2020-01-22 ニプロ株式会社 液体組成物及び凍結乾燥製剤
CA3014406A1 (fr) 2016-02-16 2017-08-24 Strongbridge Biopharma plc Veldoreotide de faible solubilite dans des conditions physiologiques destine a etre utilise dans le traitement d'une acromegalie, d'un cancer associe a une acromegalie, de tumeurs exprimant le sst-r5, du diabete de type 2, d'une hyperglycemie, et de tumeurs associees aux hormones
KR20210062638A (ko) 2018-09-20 2021-05-31 레보 테라퓨틱스 인코포레이티드 카르베토신의 안정한 비강내 제형

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4563352A (en) * 1982-10-04 1986-01-07 The Salk Institute For Biological Studies Human pancreatic GRF
US4935491A (en) * 1987-08-24 1990-06-19 Board Of Regents, The University Of Texas System Effective antagonists of the luteinizing hormone releasing hormone which release negligible histamine
EP0374120A3 (fr) * 1988-12-13 1991-07-31 Monsanto Company Composition pour la libération contrôlée des polypeptides
AU641721B2 (en) * 1989-12-21 1993-09-30 Novo Nordisk A/S Insulin preparations containing nicotinic acid or nicotinamide
CA2070061C (fr) * 1991-06-07 2004-02-10 Shigeyuki Takama Composition pharmaceutique renfermant des polypeptides physiologiquement actives
DE69231536T2 (de) * 1991-08-26 2001-06-13 Abbott Laboratories, Abbott Park Verbindungen und methoden zur sublingualen oder buccalen verabreichung von therapeutischen agentien
US5487898A (en) * 1991-08-26 1996-01-30 Abbott Laboratories Compositions and method for the sublingual or buccal administration therapeutic agents
US5446025A (en) * 1992-06-12 1995-08-29 Abbott Laboratories Formulations and method of the percutaneous administration of leuprolide
EP0626170A3 (fr) * 1993-05-10 1996-03-27 Sandoz Ltd Stabilisation de composés pharmacoligiquement actifs dans des compositions à libération contrÔlée.
TW280770B (fr) * 1993-10-15 1996-07-11 Takeda Pharm Industry Co Ltd
AU3562195A (en) * 1994-10-04 1996-04-26 Novo Nordisk A/S Preparations containing aspb28 human insulin and nicotinamide
KR100236393B1 (ko) * 1996-02-02 1999-12-15 나까니시 히로유끼 사람성장호르몬을 함유하는 의약제제

Also Published As

Publication number Publication date
SK284640B6 (sk) 2005-08-04
AU743152B2 (en) 2002-01-17
KR20010012253A (ko) 2001-02-15
EP0984788B1 (fr) 2003-10-29
JP2002502384A (ja) 2002-01-22
EE04001B1 (et) 2003-04-15
CA2291765A1 (fr) 1998-12-03
SK159799A3 (en) 2000-07-11
NO995763D0 (no) 1999-11-24
BR9809708A (pt) 2000-07-11
DK0984788T3 (da) 2004-03-08
NZ500777A (en) 2001-09-28
NO323697B1 (no) 2007-06-25
EP0984788A1 (fr) 2000-03-15
EE9900545A (et) 2000-06-15
ATE252909T1 (de) 2003-11-15
PL336982A1 (en) 2000-07-31
BG64668B1 (bg) 2005-11-30
DE69819322D1 (de) 2003-12-04
HK1029928A1 (en) 2001-04-20
CN1263469A (zh) 2000-08-16
KR100552546B1 (ko) 2006-02-14
CZ423199A3 (cs) 2000-05-17
BG103884A (en) 2000-07-31
WO1998053844A1 (fr) 1998-12-03
CZ298825B6 (cs) 2008-02-20
IL133176A (en) 2006-08-01
EA002227B1 (ru) 2002-02-28
AR012868A1 (es) 2000-11-22
NO995763L (no) 1999-11-24
CN1159062C (zh) 2004-07-28
DE69819322T2 (de) 2004-07-29
EP0880969A1 (fr) 1998-12-02
PT984788E (pt) 2004-01-30
ES2210772T3 (es) 2004-07-01
SI0984788T1 (en) 2004-02-29
AU8106298A (en) 1998-12-30
US6331520B1 (en) 2001-12-18
PL192647B1 (pl) 2006-11-30
EA199901089A1 (ru) 2000-06-26
TR199902865T2 (xx) 2000-05-22

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees