IL131140A0 - Improved method for preparing and purifying an n-alkylated aspartame derivative - Google Patents

Improved method for preparing and purifying an n-alkylated aspartame derivative

Info

Publication number
IL131140A0
IL131140A0 IL13114098A IL13114098A IL131140A0 IL 131140 A0 IL131140 A0 IL 131140A0 IL 13114098 A IL13114098 A IL 13114098A IL 13114098 A IL13114098 A IL 13114098A IL 131140 A0 IL131140 A0 IL 131140A0
Authority
IL
Israel
Prior art keywords
purifying
preparing
improved method
aspartame derivative
alkylated aspartame
Prior art date
Application number
IL13114098A
Other languages
English (en)
Original Assignee
Nutrasweet Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nutrasweet Co filed Critical Nutrasweet Co
Publication of IL131140A0 publication Critical patent/IL131140A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Seasonings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Arrangements For Transmission Of Measured Signals (AREA)
IL13114098A 1997-01-29 1998-01-29 Improved method for preparing and purifying an n-alkylated aspartame derivative IL131140A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/790,113 US5728862A (en) 1997-01-29 1997-01-29 Method for preparing and purifying an N-alkylated aspartame derivative
PCT/US1998/001734 WO1998032767A1 (en) 1997-01-29 1998-01-29 Method for preparing and purifying an n-alkylated aspartame derivative

Publications (1)

Publication Number Publication Date
IL131140A0 true IL131140A0 (en) 2001-01-28

Family

ID=25149681

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13114098A IL131140A0 (en) 1997-01-29 1998-01-29 Improved method for preparing and purifying an n-alkylated aspartame derivative

Country Status (29)

Country Link
US (1) US5728862A (es)
EP (1) EP0973796B1 (es)
CN (1) CN1136227C (es)
AR (1) AR011782A1 (es)
AT (1) ATE313555T1 (es)
AU (1) AU723479B2 (es)
BG (1) BG64562B1 (es)
BR (1) BR9807020B1 (es)
CA (1) CA2278608C (es)
CO (1) CO5040054A1 (es)
CZ (1) CZ296888B6 (es)
DE (1) DE69832870T2 (es)
DK (1) DK0973796T3 (es)
EA (1) EA001948B1 (es)
EE (1) EE03928B1 (es)
ES (1) ES2251765T3 (es)
HU (1) HU228676B1 (es)
ID (1) ID22966A (es)
IL (1) IL131140A0 (es)
NO (1) NO326212B1 (es)
NZ (1) NZ336893A (es)
PE (1) PE71999A1 (es)
PL (1) PL191750B1 (es)
SK (1) SK285451B6 (es)
TR (1) TR199901811T2 (es)
TW (1) TW432074B (es)
UA (1) UA57605C2 (es)
UY (1) UY24864A1 (es)
WO (1) WO1998032767A1 (es)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6146680A (en) * 1997-09-11 2000-11-14 The Nutrasweet Company Metal complexes of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester
US6180156B1 (en) 1997-09-11 2001-01-30 The Nutrasweet Company Acid salts of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester
US6129942A (en) * 1997-09-11 2000-10-10 The Nutrasweet Company Sweetener salts of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester
US6291004B1 (en) 1997-09-11 2001-09-18 The Nutrasweet Company Basic salts of n-[n-(3,3-dimethylbutyl)-l-α-aspartyl]-l-phenylalanine 1-methyl ester
JPH1180108A (ja) 1997-09-12 1999-03-26 Ajinomoto Co Inc 甘味料の精製法
JPH11130794A (ja) * 1997-10-23 1999-05-18 Ajinomoto Co Inc アスパルテーム誘導体の精製方法
JPH11171895A (ja) 1997-12-11 1999-06-29 Ajinomoto Co Inc アスパルテームとアスパルテーム誘導体の分離精製方法
JPH11169132A (ja) * 1997-12-15 1999-06-29 Ajinomoto Co Inc アスパルテームとアスパルテーム誘導体の混晶及びその製造方法
US6692778B2 (en) * 1998-06-05 2004-02-17 Wm. Wrigley Jr. Company Method of controlling release of N-substituted derivatives of aspartame in chewing gum
BR9815887A (pt) * 1998-06-05 2001-10-23 Wrigley W M Jun Co Método de controle de liberação de derivados de aspartame n-substituìdos em goma de mascar e goma assim produzida
US5977415A (en) * 1998-08-20 1999-11-02 The Nutrasweet Company Preparation of 3, 3-dimethylbutyraldehyde from a tert-butyl cation precursor, vinyl chloride and an acidic catalyst
NL1010063C2 (nl) * 1998-09-10 2000-03-13 Holland Sweetener Co Werkwijze voor de bereiding van neotaam.
US5994593A (en) * 1998-09-17 1999-11-30 The Nutrasweet Company Synthesis and purification of 3,3-dimethylbutyraldehyde via hydrolysis of 1,1-dichloro-3,3-dimethylbutane or 1-bromo-1-chloro-3,3-dimethylbutane
US6214402B1 (en) 1998-09-17 2001-04-10 The Nutrasweet Company Co-crystallization of sugar and n-[n-(3,3-dimethylbutyl)-l αaspartyl]-l-phenylalanine 1-methyl ester
US6914151B1 (en) 1998-10-30 2005-07-05 Ajinomoto Co., Inc. Crystallization processes for the formation of stable crystals of aspartame derivative
US6844465B2 (en) * 1998-10-30 2005-01-18 Ajinomoto Co., Inc. Method for preparing highly stable crystals of aspartame derivative
US6465677B1 (en) * 1998-11-19 2002-10-15 The Nutrasweet Company Method for the preparation of N-neohexyl-α-aspartyl-L-phenylalanine methyl ester from imidazolidin-4-one intermediates
AU1628700A (en) 1998-11-20 2000-06-13 Nutrasweet Company, The Amorphous N-(N-(3,3-dimethylbutyl)-l-alpha-aspartyl)-l-phenylalanine 1-methyl ester
AU1832500A (en) 1998-11-25 2000-06-19 Nutrasweet Company, The Purification of N-(N-(3,3-dimethylbutyl)-l-alpha-aspartyl)-l-phenylalanine 1-methyl ester via crystallization
US20030008046A1 (en) * 1998-12-18 2003-01-09 Paula A. Gerlat Use of n-neohexyl-a-aspartyl-l-phenylalanine methyl ester as a flavor modifier
US6077962A (en) * 1998-12-24 2000-06-20 The Nutrasweet Company N-3, 3-dimethylbutyl-L-aspartic acid and esters thereof, the process of preparing the same, and the process for preparing N-(N-(3,3-dimethylbutyl) -α L-aspartyl)-L- phenylalanine 1-methyl ester therefrom
US6048999A (en) * 1999-01-25 2000-04-11 The Nutrasweet Company N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester synergistic sweetener blends
US6180157B1 (en) 1999-02-18 2001-01-30 The Nutrasweet Company Process for preparing an N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester agglomerate
AU4449100A (en) * 1999-03-03 2000-09-21 Nutrasweet Company, The Novel crystallization products of neotame and methods for producing same
WO2000057725A1 (en) 1999-03-26 2000-10-05 The Nutrasweet Company PARTICLES OF N-[N-(3,3-DIMETHYLBUTYL)-L-α-ASPARTYL]-L-PHENYLALANINE 1-METHYL ESTER
US6573409B1 (en) 1999-07-02 2003-06-03 The Nutrasweet Company Process for the preparation of 3,3-dimethylbutanal
AU4459400A (en) * 1999-07-28 2001-02-19 Nutrasweet Company, The A method for the purification of n-[n-(3,3-dimethylbutyl)-l-alpha-aspartyl]-l-phenylalanine 1-methyl ester
US6506434B1 (en) 1999-08-06 2003-01-14 The Nutrasweet Company Process for coating N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester onto a carrier
KR20020038795A (ko) * 1999-10-07 2002-05-23 에가시라 구니오 아스파르틸디펩타이드 에스테르 유도체의 제조방법과 이를위한 신규한 제조 중간체 및 이의 제조방법
US20040176472A1 (en) * 1999-10-07 2004-09-09 Ajinomoto Co., Inc. Process for production of aspartyl dipeptide ester derivative, novel production intermediate therefor, and process for production thereof
KR20020038797A (ko) * 1999-10-08 2002-05-23 에가시라 구니오 아스파탐 유도체의 제조방법, 이의 결정, 이를 위한신규한 제조 중간체 및 당해 중간체의 제조방법
US6627431B1 (en) 2000-05-12 2003-09-30 The Nutrasweet Company Chemoenzymatic synthesis of neotame
WO2001087927A2 (en) 2000-05-18 2001-11-22 The Nutrasweet Company gYNTHESIS OF N-[N-(3,3-DIMETHYLBUTYL)-L-α-ASPARTYL]-L-PHENYLALANINE 1-METHYL ESTER USING L-α-ASPARTYL-L-PHENYLALANINE 1-METHYL ESTER PRECURSORS
US6281380B1 (en) * 2000-05-18 2001-08-28 The Nutra Sweet Company Synthesis of N-(N-(3,3-dimethylbutyl)-L-α-aspartyl)L-phenylalanine1-methyl ester by reductive alkylation and crystallization/ isolation in aqueous methanol
US6852875B2 (en) 2000-05-19 2005-02-08 The Nutrasweet Co. Synthesis of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester using oxazolidinone derivatives
US7326430B2 (en) * 2000-07-18 2008-02-05 The Nutrasweet Company Method of preparing liquid compositions for delivery of N-[N- (3,3-dimethylbutyl-L-α-aspartyl]-L-phenylalanine 1-methyl ester in food and beverage systems
US6225493B1 (en) * 2000-08-21 2001-05-01 The Nutrasweet Company Metal ion assisted N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester isomer resolution
EP1349829A4 (en) * 2000-11-06 2005-11-09 Nutrasweet Co MODIFICATION OF A CATALYST TO ENHANCE NEOTAME PRODUCTION
US6720446B2 (en) * 2001-11-05 2004-04-13 The Nutrasweet Company Catalyst modification to enhance neotame production
US6782048B2 (en) * 2002-06-21 2004-08-24 Pulse-Link, Inc. Ultra-wideband communication through a wired network
KR20110060969A (ko) 2003-05-06 2011-06-08 뉴트라스위트 프라퍼티 홀딩스 인코포레이티드 3,3-디메틸부티르알데히드 전구체를 이용한 Ｎ-(Ｎ-(3,3-디메틸부틸)-Ｌ-α-아스파르틸)-Ｌ-페닐알라닌 1-메틸 에스테르의 합성
CA2558683A1 (en) * 2004-03-05 2005-09-22 Sunil Srivastava High-intensity sweetener-polyol compositions
US20060188629A1 (en) * 2005-01-21 2006-08-24 Greg Liesen Method for the purification of sucralose
CN101270092B (zh) * 2008-04-30 2010-12-08 厦门大学 一种合成纽甜的方法
FR3102041A1 (fr) 2019-10-22 2021-04-23 Aroma Sens Edulcorant pour liquides de cigarette électronique

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59227849A (ja) * 1983-06-08 1984-12-21 Ajinomoto Co Inc Ｌ―α―アスパルチル―Ｌ―フェニルアラニンメチルエステル束状晶の晶析分離法
FR2697844B1 (fr) * 1992-11-12 1995-01-27 Claude Nofre Nouveaux composés dérivés de dipeptides ou d'analogues dipeptidiques utiles comme agents édulcorants, leur procédé de préparation.
FR2719590B1 (fr) * 1994-05-09 1996-07-26 Claude Nofre Procédé perfectionné de préparation d'un composé dérivé de l'aspartame utile comme agent édulcorant.
US5480688A (en) * 1994-06-13 1996-01-02 The Auld Company Shaped flexible decorative articles and method for making same
US5510805A (en) * 1994-08-08 1996-04-23 Prime View International Co. Scanning circuit
ATE214397T1 (de) * 1995-06-30 2002-03-15 Holland Sweetener Co Kristallisierung von alpha-l-aspartyl-l- phenylalaninmethylester aus wässerigen lösungen

Also Published As

Publication number Publication date
US5728862A (en) 1998-03-17
BR9807020A (pt) 2000-03-14
EE9900329A (et) 2000-02-15
AR011782A1 (es) 2000-09-13
WO1998032767A1 (en) 1998-07-30
CN1251107A (zh) 2000-04-19
EE03928B1 (et) 2002-12-16
NO326212B1 (no) 2008-10-20
BG64562B1 (bg) 2005-07-29
UY24864A1 (es) 1998-02-10
DE69832870D1 (de) 2006-01-26
PL334882A1 (en) 2000-03-27
SK285451B6 (sk) 2007-01-04
BG103694A (en) 2000-07-31
NZ336893A (en) 2001-04-27
AU6137598A (en) 1998-08-18
DK0973796T3 (da) 2006-04-18
UA57605C2 (uk) 2003-06-16
CA2278608C (en) 2002-03-12
SK101099A3 (en) 2000-06-12
HUP0001453A3 (en) 2002-02-28
EA199900690A1 (ru) 2000-04-24
NO993676L (no) 1999-09-28
NO993676D0 (no) 1999-07-28
CO5040054A1 (es) 2001-05-29
AU723479B2 (en) 2000-08-24
TR199901811T2 (xx) 1999-12-21
DE69832870T2 (de) 2006-08-10
ATE313555T1 (de) 2006-01-15
EA001948B1 (ru) 2001-10-22
ID22966A (id) 1999-12-23
CZ261299A3 (cs) 2000-06-14
HU228676B1 (en) 2013-05-28
CA2278608A1 (en) 1998-07-30
BR9807020B1 (pt) 2011-04-19
ES2251765T3 (es) 2006-05-01
HUP0001453A2 (hu) 2000-08-28
PE71999A1 (es) 1999-08-19
EP0973796B1 (en) 2005-12-21
PL191750B1 (pl) 2006-06-30
TW432074B (en) 2001-05-01
CN1136227C (zh) 2004-01-28
EP0973796A1 (en) 2000-01-26
CZ296888B6 (cs) 2006-07-12

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Legal Events

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