IL129555A - Pharmaceutical compositions containing n-(oxoacetyl)-amino acid amide derivatives for stimulating neurite growth - Google Patents

Pharmaceutical compositions containing n-(oxoacetyl)-amino acid amide derivatives for stimulating neurite growth

Info

Publication number
IL129555A
IL129555A IL12955597A IL12955597A IL129555A IL 129555 A IL129555 A IL 129555A IL 12955597 A IL12955597 A IL 12955597A IL 12955597 A IL12955597 A IL 12955597A IL 129555 A IL129555 A IL 129555A
Authority
IL
Israel
Prior art keywords
oxoacetyl
amino acid
pharmaceutical compositions
acid amide
compositions containing
Prior art date
Application number
IL12955597A
Other languages
English (en)
Other versions
IL129555A0 (en
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25009484&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL129555(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of IL129555A0 publication Critical patent/IL129555A0/xx
Publication of IL129555A publication Critical patent/IL129555A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Psychology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
IL12955597A 1996-11-13 1997-11-13 Pharmaceutical compositions containing n-(oxoacetyl)-amino acid amide derivatives for stimulating neurite growth IL129555A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/748,447 US5840736A (en) 1996-11-13 1996-11-13 Methods and compositions for stimulating neurite growth
PCT/US1997/020866 WO1998020891A1 (en) 1996-11-13 1997-11-13 Methods and compositions for stimulating neurite growth using compounds with affinity for fkbp12 in combination with neurotrophic factors

Publications (2)

Publication Number Publication Date
IL129555A0 IL129555A0 (en) 2000-02-29
IL129555A true IL129555A (en) 2005-08-31

Family

ID=25009484

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12955597A IL129555A (en) 1996-11-13 1997-11-13 Pharmaceutical compositions containing n-(oxoacetyl)-amino acid amide derivatives for stimulating neurite growth

Country Status (32)

Country Link
US (3) US5840736A (cs)
EP (1) EP0946190B1 (cs)
JP (1) JP2001504470A (cs)
KR (1) KR100544451B1 (cs)
CN (1) CN1168442C (cs)
AP (1) AP9901518A0 (cs)
AR (1) AR011278A1 (cs)
AT (1) ATE250424T1 (cs)
AU (1) AU724833B2 (cs)
BG (1) BG64670B1 (cs)
BR (1) BR9712765A (cs)
CA (1) CA2270634A1 (cs)
CO (1) CO4930260A1 (cs)
CZ (1) CZ296058B6 (cs)
DE (1) DE69725169T2 (cs)
DK (1) DK0946190T3 (cs)
EA (1) EA004247B1 (cs)
ES (1) ES2206753T3 (cs)
HU (1) HU226728B1 (cs)
IL (1) IL129555A (cs)
IN (1) IN183740B (cs)
IS (1) IS2057B (cs)
NO (1) NO328030B1 (cs)
NZ (1) NZ335394A (cs)
PL (1) PL190903B1 (cs)
PT (1) PT946190E (cs)
SK (1) SK284535B6 (cs)
TR (1) TR199901034T2 (cs)
TW (1) TW513302B (cs)
UA (1) UA63926C2 (cs)
WO (1) WO1998020891A1 (cs)
ZA (1) ZA9710256B (cs)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5859031A (en) 1995-06-07 1999-01-12 Gpi Nil Holdings, Inc. Small molecule inhibitors of rotamase enzyme activity
US5780484A (en) * 1996-11-13 1998-07-14 Vertex Pharmaceuticals Incorporated Methods for stimulating neurite growth with piperidine compounds
US6242468B1 (en) 1997-02-27 2001-06-05 Jia-He Li Carbamate and urea compositions and neurotrophic uses
US6514686B2 (en) 1997-04-28 2003-02-04 The University Of British Columbia Method and composition for modulating amyloidosis
US5945441A (en) 1997-06-04 1999-08-31 Gpi Nil Holdings, Inc. Pyrrolidine carboxylate hair revitalizing agents
US20010049381A1 (en) 1997-06-04 2001-12-06 Gpl Nil Holdings, Inc., Pyrrolidine derivative hair growth compositions and uses
US6852496B1 (en) * 1997-08-12 2005-02-08 Oregon Health And Science University Methods of screening for agents that promote nerve cell growth
US5968921A (en) * 1997-10-24 1999-10-19 Orgegon Health Sciences University Compositions and methods for promoting nerve regeneration
US6331537B1 (en) 1998-06-03 2001-12-18 Gpi Nil Holdings, Inc. Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds
BR9815882A (pt) 1998-06-03 2002-09-17 Gpi Nil Holding Inc Sulfonamidas ligadas por n de ácido carboxìlicos n-heterocìclicos ouou de isósteros de ácidos carboxìlicos
JP2002520413A (ja) 1998-07-17 2002-07-09 アグロン ファ−マシュ−テイカルズ インコ−ポレイテッド ニューロンの成長および伸長を刺激するための化合物、組成物、および方法
GB9815880D0 (en) 1998-07-21 1998-09-16 Pfizer Ltd Heterocycles
US6395758B1 (en) 1998-08-14 2002-05-28 Gpi Nil Holdings, Inc. Small molecule carbamates or ureas for vision and memory disorders
US6218423B1 (en) 1998-08-14 2001-04-17 Gpi Nil Holdings, Inc. Pyrrolidine derivatives for vision and memory disorders
US7338976B1 (en) 1998-08-14 2008-03-04 Gpi Nil Holdings, Inc. Heterocyclic esters or amides for vision and memory disorders
US6462072B1 (en) 1998-09-21 2002-10-08 Gpi Nil Holdings, Inc. Cyclic ester or amide derivatives
US6300341B1 (en) 1998-09-30 2001-10-09 The Procter & Gamble Co. 2-substituted heterocyclic sulfonamides
US6307049B1 (en) 1998-09-30 2001-10-23 The Procter & Gamble Co. Heterocyclic 2-substituted ketoamides
US6228872B1 (en) * 1998-11-12 2001-05-08 Bristol-Myers Squibb Company Neurotrophic diamide and carbamate agents
AU2173400A (en) * 1998-12-09 2000-06-26 Chiron Corporation Method for administering agents to the central nervous system
AU2407400A (en) * 1999-01-08 2000-07-24 Vertex Pharmaceuticals Incorporated Process for the formation of intermediates useful for the preparation of pharmaceuticals
JP2003503480A (ja) 1999-07-06 2003-01-28 バーテックス ファーマシューティカルズ インコーポレイテッド ニューロン活性を有するｎ−ヘテロ環誘導体
US6734211B1 (en) 1999-07-09 2004-05-11 Oregon Health & Sciences University Compositions and methods for promoting nerve regeneration
WO2001008685A1 (en) * 1999-07-30 2001-02-08 Vertex Pharmaceuticals Incorporated Acyclic and cyclic amine derivatives
EP1227859B1 (en) * 1999-11-12 2006-08-09 Alcon, Inc Neurophilin ligands for treating ocular conditions
US7253169B2 (en) 1999-11-12 2007-08-07 Gliamed, Inc. Aza compounds, pharmaceutical compositions and methods of use
US6417189B1 (en) 1999-11-12 2002-07-09 Gpi Nil Holdings, Inc. AZA compounds, pharmaceutical compositions and methods of use
US6818643B1 (en) 1999-12-08 2004-11-16 Bristol-Myers Squibb Company Neurotrophic bicyclic diamides
US7060676B2 (en) * 1999-12-20 2006-06-13 Trustees Of Tufts College T. cruzi-derived neurotrophic agents and methods of use therefor
MXPA02006134A (es) 1999-12-21 2002-12-13 Guilford Pharm Inc Compuestos derivados de hidantoina, composiciones farmaceuticas y metodos de uso de los mismos.
US6555573B2 (en) 2000-12-21 2003-04-29 The Quigley Corporation Method and composition for the topical treatment of diabetic neuropathy
AU2002259305A1 (en) * 2001-05-25 2002-12-09 Cornell Research Foundation, Inc. High affinity ligand for p75 neurotrophin receptor
EP1404325A2 (en) * 2001-05-29 2004-04-07 Guilford Pharmaceuticals Inc. Method for treating nerve injury caused by surgery
FR2825273B1 (fr) * 2001-05-29 2006-11-24 Oreal Composition pour le traitement des signes cutanes du vieillissement
US7435725B2 (en) * 2001-11-06 2008-10-14 The Quigly Corporation Oral compositions and methods for prevention, reduction and treatment of radiation injury
US20030105027A1 (en) * 2001-11-06 2003-06-05 Rosenbloom Richard A. Nutritional supplements and methods for prevention, reduction and treatment of radiation injury
US20030118536A1 (en) * 2001-11-06 2003-06-26 Rosenbloom Richard A. Topical compositions and methods for treatment of adverse effects of ionizing radiation
US20100247483A1 (en) * 2001-11-13 2010-09-30 Tran Loi H Therapeutic agent composition and method of use
US7232798B2 (en) 2001-11-13 2007-06-19 Tran Loi H Neuroprotection and neuroegenisis by administering cyclic prolyl glycine
WO2003041655A2 (en) * 2001-11-13 2003-05-22 Loi Tran Therapeutic agent composition and method of use
US7083813B2 (en) * 2002-11-06 2006-08-01 The Quigley Corporation Methods for the treatment of peripheral neural and vascular ailments
US8841326B2 (en) 2004-02-12 2014-09-23 Stc.Unm Therapeutic curcumin derivatives
US20070248611A1 (en) * 2006-02-02 2007-10-25 Pfizer Inc Methods wanted for treating unwanted weight loss or eating disorders by administering a trkb agonist
US7935342B2 (en) * 2006-02-02 2011-05-03 Rinat Neuroscience Corp. Methods for treating obesity by administering a trkB antagonist
KR20090091181A (ko) * 2006-12-20 2009-08-26 리나트 뉴로사이언스 코퍼레이션 자가면역 장애의 치료를 위한 티로신 수용체 키나아제 ｂ 작용제
US20090018151A1 (en) * 2007-02-23 2009-01-15 Ezekiel Fink Topical Treatment of Peripheral diabetic complications
BR112020023252A2 (pt) 2018-05-15 2021-02-23 Lloyd Hung Loi Tran composição do agente terapêutico e método de uso para tratamento de deficiência cognitiva leve, depressão e distúrbios psicológicos.

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5798355A (en) 1995-06-07 1998-08-25 Gpi Nil Holdings, Inc. Inhibitors of rotamase enzyme activity
US5543423A (en) * 1994-11-16 1996-08-06 Vertex Pharmaceuticals, Incorporated Amino acid derivatives with improved multi-drug resistance activity
IL115685A (en) * 1994-11-16 2000-08-31 Vertex Pharma Amino acid derivatives pharmaceutical compositions containing the same and processes for the preparation thereof
US5614547A (en) * 1995-06-07 1997-03-25 Guilford Pharmaceuticals Inc. Small molecule inhibitors of rotamase enzyme
US5696135A (en) * 1995-06-07 1997-12-09 Gpi Nil Holdings, Inc. Inhibitors of rotamase enzyme activity effective at stimulating neuronal growth
US5859031A (en) * 1995-06-07 1999-01-12 Gpi Nil Holdings, Inc. Small molecule inhibitors of rotamase enzyme activity
US6037370A (en) 1995-06-08 2000-03-14 Vertex Pharmaceuticals Incorporated Methods and compositions for stimulating neurite growth
US5801197A (en) * 1995-10-31 1998-09-01 Gpi Nil Holdings, Inc. Rotamase enzyme activity inhibitors
US5811434A (en) * 1996-11-13 1998-09-22 Vertex Pharmacueticals Incorporated Methods and compositions for stimulating neurite growth
JP5720848B2 (ja) * 2012-09-28 2015-05-20 Dic株式会社 多面体形状のα−アルミナ微粒子の製造方法

Also Published As

Publication number Publication date
HK1022851A1 (en) 2000-08-25
UA63926C2 (uk) 2004-02-16
CO4930260A1 (es) 2000-06-27
AP9901518A0 (en) 1999-06-30
IS2057B (is) 2005-10-14
BG103429A (en) 2000-04-28
NO992138L (no) 1999-07-13
IS5032A (is) 1999-04-21
CN1239433A (zh) 1999-12-22
SK62899A3 (en) 2000-04-10
PL190903B1 (pl) 2006-02-28
NZ335394A (en) 2000-06-23
SK284535B6 (sk) 2005-06-02
HUP0001219A2 (hu) 2000-11-28
DK0946190T3 (da) 2003-12-08
AU724833B2 (en) 2000-09-28
CZ168399A3 (cs) 1999-08-11
BR9712765A (pt) 1999-10-26
US6284778B1 (en) 2001-09-04
EA199900464A1 (ru) 2000-02-28
BG64670B1 (bg) 2005-11-30
EP0946190A1 (en) 1999-10-06
NO992138D0 (no) 1999-05-03
WO1998020891A1 (en) 1998-05-22
US5840736A (en) 1998-11-24
ES2206753T3 (es) 2004-05-16
TR199901034T2 (xx) 1999-07-21
TW513302B (en) 2002-12-11
AU5258998A (en) 1998-06-03
HUP0001219A3 (en) 2001-12-28
ZA9710256B (en) 1998-05-28
PL333270A1 (en) 1999-11-22
JP2001504470A (ja) 2001-04-03
DE69725169T2 (de) 2004-07-15
CZ296058B6 (cs) 2006-01-11
NO328030B1 (no) 2009-11-16
DE69725169D1 (de) 2003-10-30
CA2270634A1 (en) 1998-05-22
CN1168442C (zh) 2004-09-29
KR20000068962A (ko) 2000-11-25
US6172086B1 (en) 2001-01-09
EP0946190B1 (en) 2003-09-24
IN183740B (cs) 2000-04-01
AR011278A1 (es) 2000-08-16
KR100544451B1 (ko) 2006-01-24
HU226728B1 (en) 2009-08-28
IL129555A0 (en) 2000-02-29
PT946190E (pt) 2004-02-27
ATE250424T1 (de) 2003-10-15
EA004247B1 (ru) 2004-02-26

Similar Documents

Publication Publication Date Title
IL129555A (en) Pharmaceutical compositions containing n-(oxoacetyl)-amino acid amide derivatives for stimulating neurite growth
HUP9902136A3 (en) Novel substituted cyclic amino acid derivatives use as pharmaceutical agents
IL113625A0 (en) Amino acid derivatives processes for their preparation and pharmaceutical compositions containing them and their use
HUP9601285A3 (en) Substituted n-(indole-2-carbonyl)-beta-alaninamides and derivatives and pharmaceutical compositions containing them
IL134732A0 (en) Cyclic amino acids and derivatives thereof useful as pharmaceutical agents
IL115685A0 (en) Amino acid derivatives pharmaceutical compositions containing the same and processes for the preparation thereof
HUP0001383A3 (en) N-(aryl/heteroaryl) amino acid derivatives, pharmaceutical compositions comprising same and their use
HUP0000492A3 (en) N-(aryl/heteroarylacetyl) amino acid esters, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
HUP9802417A3 (en) Amide derivatives containing heteroaryl group and pharmaceutical compositions containing them
HUP0201787A2 (en) Amide derivatives substituted by heterocyclic group useful as growth hormone secretagogues, pharmaceutical compositions containing them
HUP0002404A3 (en) Amino acid derivatives, pharmaceutical compositions comprising thereof, process for preparation them and their use
HUP0105108A3 (en) Amide compounds, process for their preparation and pharmaceutical compositions containing them
PL339211A1 (en) Basic salts of n-[n-(3,3-dimethylbutyl)-l-alpha-aspartil]-l-phenylamine 1-methyl ester
IL113329A (en) Pharmaceutical compositions containing n-substituted benzamides
HUP0000960A3 (en) Spray-dried paroxetine hydrochloride, process for it's preparation,use of the compound and pharmaceutical compositions containing the same
PL339207A1 (en) Acid salts of n-[n-(3,3-dimethylbutyl)-l-alpha-aspartil]-l-phenylamine 1-methyl ester
HUP0104122A3 (en) N-arylsulfonyl amino acid omega amides, process for preparation of the compounds and pharmaceutical compositions containing them
HUP0200116A3 (en) Amide compounds for the potentiation of cholinergic activity and pharmaceutical compositions containing them and process for the preparation of the compounds
HUP9904705A3 (en) N-substituted azaheterocyclic carboxylic acid derivatives and pharmaceutical compositions containing them
HUP0204080A3 (en) Novel branched substituted amino derivatives of 3-amino-1-phenyl-1h[1,2,4]triazol, methods for producing them and pharmaceutical compositions containing them
HUP0202988A3 (en) Substituted 3-phenyl-5-alkoxi-1,3,4-oxdiazol-2-one derivatives and their use as lipase inhibitors, process for their preparation and pharmaceutical compositions containing them
FI963440A7 (fi) Uudet aminohappojohdannaiset, näiden valmistusmenetelmä ja näitä yhdis teitä sisältävät farmaseuttiset seokset
FR2766188B1 (fr) Nouveau procede de preparation de derives amines d'alkyloxy furanone, composes issus de ce procede et utilisation de ces composes
AU6843498A (en) Process for the preparation of n-(3-hydroxy-succinyl)-amino acid derivatives
IL130223A (en) Heterocyclic substituted pyrrolidine amide derivatives, process for their preparation and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees