IL129056A0 - Monocyclic N-heterocyclics substituted by thio acid derivatives and pharmaceutical compositions containing same - Google Patents

Monocyclic N-heterocyclics substituted by thio acid derivatives and pharmaceutical compositions containing same

Info

Publication number
IL129056A0
IL129056A0 IL12905697A IL12905697A IL129056A0 IL 129056 A0 IL129056 A0 IL 129056A0 IL 12905697 A IL12905697 A IL 12905697A IL 12905697 A IL12905697 A IL 12905697A IL 129056 A0 IL129056 A0 IL 129056A0
Authority
IL
Israel
Prior art keywords
monocyclic
pharmaceutical compositions
compositions containing
acid derivatives
containing same
Prior art date
Application number
IL12905697A
Other languages
English (en)
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of IL129056A0 publication Critical patent/IL129056A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL12905697A 1996-10-09 1997-09-24 Monocyclic N-heterocyclics substituted by thio acid derivatives and pharmaceutical compositions containing same IL129056A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/731,128 US6004985A (en) 1996-10-09 1996-10-09 Thio acid derived monocylic N-heterocyclics as anticoagulants
PCT/EP1997/005231 WO1998015547A1 (en) 1996-10-09 1997-09-24 Thio acid derived monocyclic n-heterocyclics as anticoagulants

Publications (1)

Publication Number Publication Date
IL129056A0 true IL129056A0 (en) 2000-02-17

Family

ID=24938188

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12905697A IL129056A0 (en) 1996-10-09 1997-09-24 Monocyclic N-heterocyclics substituted by thio acid derivatives and pharmaceutical compositions containing same

Country Status (21)

Country Link
US (6) US6004985A (de)
EP (1) EP0934310B1 (de)
JP (1) JP3768244B2 (de)
KR (1) KR20000048966A (de)
CN (1) CN1111159C (de)
AT (1) ATE288908T1 (de)
AU (1) AU730060B2 (de)
CA (1) CA2268172A1 (de)
CZ (1) CZ122799A3 (de)
DE (1) DE69732490T2 (de)
DK (1) DK0934310T3 (de)
ES (1) ES2236828T3 (de)
HK (1) HK1020958A1 (de)
HU (1) HUP9904180A3 (de)
IL (1) IL129056A0 (de)
NO (1) NO991594L (de)
NZ (1) NZ334758A (de)
PL (1) PL332602A1 (de)
PT (1) PT934310E (de)
SK (1) SK46499A3 (de)
WO (1) WO1998015547A1 (de)

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ATE228513T1 (de) 1996-09-12 2002-12-15 Schering Ag Durch cyclische aminosäuren oder cyclische hydroxysäuren substituierte benzamidinderivate und deren verwendung als antikoagulantien
US6004985A (en) * 1996-10-09 1999-12-21 Berlex Laboratories, Inc. Thio acid derived monocylic N-heterocyclics as anticoagulants
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US6262018B1 (en) 1997-08-06 2001-07-17 Cornell Research Foundation, Inc. Hypersensitive response elicitor from Erwinia amylovora and its use
US6228644B1 (en) 1997-08-06 2001-05-08 Cornell Research Foundation, Inc. Hypersensitive response elicitor from Erwinia amylovora, its use, and encoding gene
US6686364B2 (en) 1997-12-08 2004-02-03 Berlex Laboratories, Inc. Benzamidine derivatives and their use as anti-coagulants
US6140351A (en) * 1997-12-19 2000-10-31 Berlex Laboratories, Inc. Ortho-anthranilamide derivatives as anti-coagulants
EP1040108B1 (de) 1997-12-19 2004-02-25 Schering Aktiengesellschaft Ortho-anthranilamide derivate als antikoagulantien
US6713651B1 (en) * 1999-06-07 2004-03-30 Theravance, Inc. β2-adrenergic receptor agonists
US6960705B2 (en) 1998-10-05 2005-11-01 Eden Bioscience Corporation Nucleic acid encoding a hypersensitive response elicitor from Xanthomonas campestris
US6858707B1 (en) 1998-10-05 2005-02-22 Eden Bioscience Corporation Hypersensitive response elicitor fragments which are active but do not elicit a hypersensitive response
US6624139B1 (en) 1998-11-05 2003-09-23 Eden Bioscience Corporation Hypersensitive response elicitor-induced stress resistance
US6262088B1 (en) * 1998-11-19 2001-07-17 Berlex Laboratories, Inc. Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants
US6127376A (en) * 1998-12-04 2000-10-03 Berlex Laboratories, Inc. Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants
WO2000038683A1 (en) * 1998-12-23 2000-07-06 Du Pont Pharmaceuticals Company THROMBIN OR FACTOR Xa INHIBITORS
US6350761B1 (en) 1999-07-30 2002-02-26 Berlex Laboratories, Inc. Benzenamine derivatives as anti-coagulants
US7291616B2 (en) * 2001-10-31 2007-11-06 Cell Therapeutics, Inc. Aryl triazines as LPAAT-β inhibitors and uses thereof
TWI329105B (en) 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
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AR040456A1 (es) 2002-06-27 2005-04-06 Bristol Myers Squibb Co Piridina n-oxidos 2,4 -disubstituidos utiles como inhibidores de transcriptasa inversa del virus de inmunodeficiencia humana
ES2445208T3 (es) * 2002-07-29 2014-02-28 Rigel Pharmaceuticals, Inc. Compuestos de 2,4-pirimidindiamina para uso en métodos para tratar o prevenir enfermedades autoinmunitarias
US7419984B2 (en) * 2002-10-17 2008-09-02 Cell Therapeutics, Inc. Pyrimidines and uses thereof
KR20040042071A (ko) * 2002-11-12 2004-05-20 박영민 인터넷 홈페이지를 활용한 경조사 자동알림 및 게시판 자동등록 방법
AU2003302238A1 (en) 2002-12-03 2004-06-23 Axys Pharmaceuticals, Inc. 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors
US6875781B2 (en) * 2003-04-04 2005-04-05 Cell Therapeutics, Inc. Pyridines and uses thereof
BRPI0413018B8 (pt) * 2003-07-30 2021-05-25 Rigel Pharmaceuticals Inc composto, e, uso de um composto
EP1814878B1 (de) * 2004-11-24 2012-01-04 Rigel Pharmaceuticals, Inc. Spiro-2,4-pyrimidindiamin-verbindungen und ihre verwendungen
DE602006010979D1 (de) 2005-01-19 2010-01-21 Rigel Pharmaceuticals Inc Prodrugs aus 2,4-pyrimidindiamin-verbindungen und ihre verwendungen
EP1883302A4 (de) * 2005-05-03 2009-05-20 Rigel Pharmaceuticals Inc Jak-kinase-hemmer und deren verwendung
US20070015834A1 (en) * 2005-07-18 2007-01-18 Moshe Flashner-Barak Formulations of fenofibrate containing PEG/Poloxamer
MX2010011463A (es) 2008-04-16 2011-06-03 Portola Pharm Inc 2,6-diamino-pirimidin-5-il-carboxamidas como inhibidores de syk o jak quinasas.
US8138339B2 (en) 2008-04-16 2012-03-20 Portola Pharmaceuticals, Inc. Inhibitors of protein kinases
US9273077B2 (en) 2008-05-21 2016-03-01 Ariad Pharmaceuticals, Inc. Phosphorus derivatives as kinase inhibitors
PT2300013T (pt) 2008-05-21 2017-10-31 Ariad Pharma Inc Derivados de fósforo como inibidores de cinases
US9834518B2 (en) 2011-05-04 2017-12-05 Ariad Pharmaceuticals, Inc. Compounds for inhibiting cell proliferation in EGFR-driven cancers
CA3094793A1 (en) 2011-11-23 2013-05-30 Portola Pharmaceuticals, Inc. Pyrazine kinase inhibitors
US20150166591A1 (en) 2012-05-05 2015-06-18 Ariad Pharmaceuticals, Inc. Methods and compositions for raf kinase mediated diseases
US9611283B1 (en) 2013-04-10 2017-04-04 Ariad Pharmaceuticals, Inc. Methods for inhibiting cell proliferation in ALK-driven cancers
US10676436B2 (en) * 2018-07-05 2020-06-09 Landos Biopharma, Inc. NLRX1 ligands
US10487057B1 (en) * 2018-07-05 2019-11-26 Landos Biopharma, Inc. NLRX1 ligands
CN113527193B (zh) * 2020-04-18 2022-06-10 中国科学院精密测量科学与技术创新研究院 一种用于核磁氟谱检测的探针及其在检测巯基类化合物中的应用

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GB824908A (en) * 1958-06-03 1959-12-09 May & Baker Ltd Improvements in or relating to triazine derivatives
JPS5922697B2 (ja) * 1976-01-13 1984-05-28 エーザイ株式会社 ビス−（メタ−アミジノフエノキシ）−化合物
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US5451700A (en) * 1991-06-11 1995-09-19 Ciba-Geigy Corporation Amidino compounds, their manufacture and methods of treatment
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US5332822A (en) * 1992-12-24 1994-07-26 Bristol-Myers Squibb Company Heteroaromatic and thioheteroaromatic substituted sulfonamide thrombin inhibitors
ATE181334T1 (de) * 1993-02-12 1999-07-15 Corvas Int Inc Inhibitoren gegen thrombose
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IL115420A0 (en) * 1994-09-26 1995-12-31 Zeneca Ltd Aminoheterocyclic derivatives
ATE251141T1 (de) * 1995-03-10 2003-10-15 Berlex Lab Benzamidin-derivate, deren herstellung und deren verwendung als anti-koagulantien
US5691364A (en) * 1995-03-10 1997-11-25 Berlex Laboratories, Inc. Benzamidine derivatives and their use as anti-coagulants
US5663381A (en) * 1995-04-21 1997-09-02 Hexal Pharmaceuticals, Inc. Process for preparing form 1 ranitidine hydrochloride
US5612363A (en) * 1995-06-02 1997-03-18 Berlex Laboratories, Inc. N,N-di(aryl) cyclic urea derivatives as anti-coagulants
US5849759A (en) * 1995-12-08 1998-12-15 Berlex Laboratories, Inc. Naphthyl-substituted benzimidazole derivatives as anti-coagulants
US5994375A (en) * 1996-02-12 1999-11-30 Berlex Laboratories, Inc. Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants
US5693641A (en) * 1996-08-16 1997-12-02 Berlex Laboratories Inc. Bicyclic pyrimidine derivatives and their use as anti-coagulants
US5753635A (en) * 1996-08-16 1998-05-19 Berlex Laboratories, Inc. Purine derivatives and their use as anti-coagulants
US6008234A (en) 1996-09-12 1999-12-28 Berlex Laboratories, Inc. Benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives and their use as anti-coagulants
ATE228513T1 (de) * 1996-09-12 2002-12-15 Schering Ag Durch cyclische aminosäuren oder cyclische hydroxysäuren substituierte benzamidinderivate und deren verwendung als antikoagulantien
US6004985A (en) * 1996-10-09 1999-12-21 Berlex Laboratories, Inc. Thio acid derived monocylic N-heterocyclics as anticoagulants
EP1040108B1 (de) * 1997-12-19 2004-02-25 Schering Aktiengesellschaft Ortho-anthranilamide derivate als antikoagulantien

Also Published As

Publication number Publication date
HUP9904180A2 (hu) 2000-09-28
PL332602A1 (en) 1999-09-27
EP0934310B1 (de) 2005-02-09
NO991594D0 (no) 1999-03-31
KR20000048966A (ko) 2000-07-25
ATE288908T1 (de) 2005-02-15
US6150382A (en) 2000-11-21
DE69732490D1 (en) 2005-03-17
HK1020958A1 (en) 2004-03-19
WO1998015547A1 (en) 1998-04-16
SK46499A3 (en) 2000-04-10
US6004985A (en) 1999-12-21
NZ334758A (en) 2000-11-24
EP0934310A1 (de) 1999-08-11
CN1111159C (zh) 2003-06-11
DK0934310T3 (da) 2005-05-30
NO991594L (no) 1999-06-08
CN1233247A (zh) 1999-10-27
CA2268172A1 (en) 1998-04-16
AU4624097A (en) 1998-05-05
US6034084A (en) 2000-03-07
JP3768244B2 (ja) 2006-04-19
CZ122799A3 (cs) 1999-09-15
ES2236828T3 (es) 2005-07-16
DE69732490T2 (de) 2006-04-27
JP2001501632A (ja) 2001-02-06
US6166014A (en) 2000-12-26
HUP9904180A3 (en) 2000-11-28
US6162807A (en) 2000-12-19
AU730060B2 (en) 2001-02-22
PT934310E (pt) 2005-06-30
US6221886B1 (en) 2001-04-24

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