IL128043A

IL128043A - Multi-layered osmotic device for controlled delivery of active agents

Multi-layered osmotic device for controlled delivery of active agents

Info

Publication number: IL128043A
Authority: IL; Israel
Prior art keywords: active agent; osmotic device; agent; core; coat
Prior art date: 1997-05-30

Application number

IL12804398A

Other languages

English (en)

Other versions

IL128043A0 (en

Original Assignee

Osmotica Corp

Priority date

1997-05-30

Filing date

1998-05-29

Publication date

2004-08-31

1997-05-30 Priority claimed from ARP970102351A external-priority patent/AR007358A1/es

1998-05-29 Application filed by Osmotica Corp filed Critical Osmotica Corp

1999-11-30 Publication of IL128043A0 publication Critical patent/IL128043A0/xx

2004-08-31 Publication of IL128043A publication Critical patent/IL128043A/en

Links

239000013543 active substance Substances 0.000 title claims abstract description 154
230000003204 osmotic effect Effects 0.000 title claims abstract description 140
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229920001577 copolymer Polymers 0.000 claims abstract description 24
239000003814 drug Substances 0.000 claims description 36
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239000012530 fluid Substances 0.000 claims description 25
239000003795 chemical substances by application Substances 0.000 claims description 20
229920002301 cellulose acetate Polymers 0.000 claims description 19
229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 19
235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 19
239000002357 osmotic agent Substances 0.000 claims description 15
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229920002678 cellulose Polymers 0.000 claims description 14
239000000796 flavoring agent Substances 0.000 claims description 13
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239000000454 talc Substances 0.000 claims description 10
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KWGRBVOPPLSCSI-WCBMZHEXSA-N pseudoephedrine Chemical compound CN[C@@H](C)[C@@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WCBMZHEXSA-N 0.000 claims description 9
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JCCNYMKQOSZNPW-UHFFFAOYSA-N loratadine Chemical group C1CN(C(=O)OCC)CCC1=C1C2=NC=CC=C2CCC2=CC(Cl)=CC=C21 JCCNYMKQOSZNPW-UHFFFAOYSA-N 0.000 claims description 4
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GXDALQBWZGODGZ-UHFFFAOYSA-N astemizole Chemical group C1=CC(OC)=CC=C1CCN1CCC(NC=2N(C3=CC=CC=C3N=2)CC=2C=CC(F)=CC=2)CC1 GXDALQBWZGODGZ-UHFFFAOYSA-N 0.000 claims description 3
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VMXUWOKSQNHOCA-LCYFTJDESA-N ranitidine Chemical group [O-][N+](=O)/C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 VMXUWOKSQNHOCA-LCYFTJDESA-N 0.000 claims 4
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DCSUBABJRXZOMT-IRLDBZIGSA-N cisapride Chemical compound C([C@@H]([C@@H](CC1)NC(=O)C=2C(=CC(N)=C(Cl)C=2)OC)OC)N1CCCOC1=CC=C(F)C=C1 DCSUBABJRXZOMT-IRLDBZIGSA-N 0.000 claims 2
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DCSUBABJRXZOMT-UHFFFAOYSA-N cisapride Natural products C1CC(NC(=O)C=2C(=CC(N)=C(Cl)C=2)OC)C(OC)CN1CCCOC1=CC=C(F)C=C1 DCSUBABJRXZOMT-UHFFFAOYSA-N 0.000 claims 2
HSUGRBWQSSZJOP-RTWAWAEBSA-N diltiazem Chemical group C1=CC(OC)=CC=C1[C@H]1[C@@H](OC(C)=O)C(=O)N(CCN(C)C)C2=CC=CC=C2S1 HSUGRBWQSSZJOP-RTWAWAEBSA-N 0.000 claims 2
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