IL126951A0 - Carboline derivatives - Google Patents

Carboline derivatives

Info

Publication number
IL126951A0
IL126951A0 IL12695197A IL12695197A IL126951A0 IL 126951 A0 IL126951 A0 IL 126951A0 IL 12695197 A IL12695197 A IL 12695197A IL 12695197 A IL12695197 A IL 12695197A IL 126951 A0 IL126951 A0 IL 126951A0
Authority
IL
Israel
Prior art keywords
carboline derivatives
carboline
derivatives
Prior art date
Application number
IL12695197A
Other languages
English (en)
Original Assignee
Icos Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9609777.9A external-priority patent/GB9609777D0/en
Priority claimed from GBGB9609820.7A external-priority patent/GB9609820D0/en
Application filed by Icos Corp filed Critical Icos Corp
Publication of IL126951A0 publication Critical patent/IL126951A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL12695197A 1996-05-10 1997-05-05 Carboline derivatives IL126951A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9609777.9A GB9609777D0 (en) 1996-05-10 1996-05-10 Chemical compounds
GBGB9609820.7A GB9609820D0 (en) 1996-05-10 1996-05-10 Chemical compounds
PCT/EP1997/002277 WO1997043287A1 (en) 1996-05-10 1997-05-05 Carboline derivatives

Publications (1)

Publication Number Publication Date
IL126951A0 true IL126951A0 (en) 1999-09-22

Family

ID=26309303

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12695197A IL126951A0 (en) 1996-05-10 1997-05-05 Carboline derivatives

Country Status (26)

Country Link
US (2) US6117881A (hu)
EP (1) EP0912567B1 (hu)
JP (1) JP3418405B2 (hu)
KR (1) KR20000010918A (hu)
CN (1) CN1067071C (hu)
AP (1) AP9801365A0 (hu)
AT (1) ATE215950T1 (hu)
AU (1) AU711885B2 (hu)
BG (1) BG102879A (hu)
BR (1) BR9709230A (hu)
CA (1) CA2253948C (hu)
CZ (1) CZ358598A3 (hu)
DE (1) DE69711882T2 (hu)
EA (1) EA199800907A1 (hu)
EE (1) EE9800390A (hu)
ES (1) ES2175404T3 (hu)
HU (1) HUP9901478A3 (hu)
IL (1) IL126951A0 (hu)
IS (1) IS4864A (hu)
NO (1) NO985222L (hu)
OA (1) OA10920A (hu)
PL (1) PL329875A1 (hu)
SK (1) SK154498A3 (hu)
TR (1) TR199802282T2 (hu)
WO (1) WO1997043287A1 (hu)
YU (1) YU49898A (hu)

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US6331543B1 (en) 1996-11-01 2001-12-18 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
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JP2002539247A (ja) 1999-03-24 2002-11-19 ハーバー ブランチ オーシャノグラフィック インスティテューション インク． マンズアミンの抗炎症作用の使用
US6451807B1 (en) 1999-04-30 2002-09-17 Lilly Icos, Llc. Methods of treating sexual dysfunction in an individual suffering from a retinal disease, class 1 congestive heart failure, or myocardial infarction using a PDE5 inhibitor
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US6821978B2 (en) 2000-09-19 2004-11-23 Schering Corporation Xanthine phosphodiesterase V inhibitors
EP1360186B1 (en) * 2001-02-12 2006-11-22 Lilly Icos LLC Carboline derivatives
EP1360185B1 (en) * 2001-02-12 2005-08-24 Lilly Icos LLC Carboline derivatives
ES2278956T3 (es) * 2001-04-25 2007-08-16 Lilly Icos Llc Derivados de carbolina como inhibidores de fosfodiesterasa 5 (pde5) para el tratamiento de enfermedades cardiovasculares y de la disfuncion erectil.
US6992192B2 (en) 2001-06-05 2006-01-31 Lilly Icos Llc. Carboline derivatives as PDE5 inhibitors
WO2003000691A1 (en) * 2001-06-21 2003-01-03 Lilly Icos Llc Carboline derivatives as pdev inhibitors
MXPA04004370A (es) 2001-11-09 2004-08-11 Schering Corp Derivados policiclicos de guanina inhibidores de fosfodiesterasa v.
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TWI329111B (en) 2002-05-24 2010-08-21 X Ceptor Therapeutics Inc Azepinoindole and pyridoindole derivatives as pharmaceutical agents
US7595311B2 (en) 2002-05-24 2009-09-29 Exelixis, Inc. Azepinoindole derivatives as pharmaceutical agents
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US8076352B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Administration of carboline derivatives useful in the treatment of cancer and other diseases
CN1972916B (zh) * 2004-05-26 2013-03-27 卫材R&D管理有限公司 肉桂酰胺类化合物
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KR20070083781A (ko) 2004-10-26 2007-08-24 에자이 알앤드디 매니지먼트 가부시키가이샤 신나미드 화합물의 비정질체
PT1829874E (pt) 2004-12-22 2014-04-10 Ono Pharmaceutical Co Composto tricíclico e sua utilização
US8506934B2 (en) 2005-04-29 2013-08-13 Robert I. Henkin Methods for detection of biological substances
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
EP2275095A3 (en) 2005-08-26 2011-08-17 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
JP2009512711A (ja) 2005-10-21 2009-03-26 ブレインセルス，インコーポレイティド Ｐｄｅ阻害による神経新生の調節
CA2625210A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
EP2218442A1 (en) 2005-11-09 2010-08-18 CombinatoRx, Inc. Methods, compositions, and kits for the treatment of ophthalmic disorders
US20090048448A1 (en) * 2005-11-18 2009-02-19 Ikuo Kushida Salts of cynnamide compound or solvates thereof
CA2628047A1 (en) * 2005-11-18 2007-05-24 Eisai R & D Management Co., Ltd. Process for production of cinnamide derivative
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US7935815B2 (en) * 2007-08-31 2011-05-03 Eisai R&D Management Co., Ltd. Imidazoyl pyridine compounds and salts thereof
AU2009210070A1 (en) * 2008-01-28 2009-08-06 Eisai R & D Management Co., Ltd. Crystalline cinnamide compounds or salts thereof
US8580801B2 (en) 2008-07-23 2013-11-12 Robert I. Henkin Phosphodiesterase inhibitor treatment
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US20150119399A1 (en) 2012-01-10 2015-04-30 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
WO2014055801A1 (en) 2012-10-05 2014-04-10 Henkin Robert I Phosphodiesterase inhibitors for treating taste and smell disorders
WO2015126944A1 (en) 2014-02-18 2015-08-27 Henkin Robert I Methods and compositions for diagnosing and treating loss and/or distortion of taste or smell
CA2999503A1 (en) * 2015-09-23 2017-03-30 Minerva Biotechnologies Corporation Method of screening for agents for differentiating stem cells

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Also Published As

Publication number Publication date
CZ358598A3 (cs) 1999-03-17
EE9800390A (et) 1999-06-15
EP0912567A1 (en) 1999-05-06
BR9709230A (pt) 1999-08-10
NO985222D0 (no) 1998-11-09
TR199802282T2 (xx) 1999-03-22
AU2891097A (en) 1997-12-05
ATE215950T1 (de) 2002-04-15
IS4864A (is) 1998-10-13
JP2000513717A (ja) 2000-10-17
YU49898A (sh) 2000-03-21
US6117881A (en) 2000-09-12
SK154498A3 (en) 2000-01-18
KR20000010918A (ko) 2000-02-25
HUP9901478A2 (hu) 1999-08-30
NO985222L (no) 1999-01-11
EP0912567B1 (en) 2002-04-10
AP9801365A0 (en) 1998-12-31
BG102879A (en) 1999-09-30
CN1218471A (zh) 1999-06-02
WO1997043287A1 (en) 1997-11-20
OA10920A (en) 2003-02-21
DE69711882D1 (en) 2002-05-16
HUP9901478A3 (en) 1999-11-29
ES2175404T3 (es) 2002-11-16
EA199800907A1 (ru) 1999-04-29
PL329875A1 (en) 1999-04-12
US6306870B1 (en) 2001-10-23
JP3418405B2 (ja) 2003-06-23
CA2253948C (en) 2005-07-26
AU711885B2 (en) 1999-10-21
DE69711882T2 (de) 2002-10-31
CA2253948A1 (en) 1997-11-20
CN1067071C (zh) 2001-06-13

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