IL126544A - Test for component detection using detectable particles in diffused light - Google Patents

Test for component detection using detectable particles in diffused light

Info

Publication number
IL126544A
IL126544A IL12654497A IL12654497A IL126544A IL 126544 A IL126544 A IL 126544A IL 12654497 A IL12654497 A IL 12654497A IL 12654497 A IL12654497 A IL 12654497A IL 126544 A IL126544 A IL 126544A
Authority
IL
Israel
Prior art keywords
particles
light
particle
scattered
analytes
Prior art date
Application number
IL12654497A
Other languages
English (en)
Hebrew (he)
Other versions
IL126544A0 (en
Original Assignee
Genicon Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genicon Sciences Inc filed Critical Genicon Sciences Inc
Publication of IL126544A0 publication Critical patent/IL126544A0/xx
Publication of IL126544A publication Critical patent/IL126544A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N2015/0038Investigating nanoparticles
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1493Particle size

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
IL12654497A 1996-04-25 1997-04-17 Test for component detection using detectable particles in diffused light IL126544A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1638396P 1996-04-25 1996-04-25
PCT/US1997/006584 WO1997040181A1 (en) 1996-04-25 1997-04-17 Analyte assay using particulate labels

Publications (2)

Publication Number Publication Date
IL126544A0 IL126544A0 (en) 1999-08-17
IL126544A true IL126544A (en) 2004-08-31

Family

ID=21776844

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12654497A IL126544A (en) 1996-04-25 1997-04-17 Test for component detection using detectable particles in diffused light

Country Status (12)

Country Link
US (1) US6214560B1 (de)
EP (1) EP1021554B1 (de)
JP (3) JP2000510582A (de)
CN (1) CN1262667C (de)
AT (1) ATE357663T1 (de)
AU (1) AU736340B2 (de)
BR (1) BR9710836A (de)
CA (1) CA2253710A1 (de)
DE (1) DE69737513T2 (de)
IL (1) IL126544A (de)
RU (1) RU2251572C2 (de)
WO (1) WO1997040181A1 (de)

Families Citing this family (310)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE43097E1 (en) 1994-10-13 2012-01-10 Illumina, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
US6586193B2 (en) * 1996-04-25 2003-07-01 Genicon Sciences Corporation Analyte assay using particulate labels
EP0918885B1 (de) * 1996-07-29 2007-04-11 Nanosphere LLC Nanopartikel mit daran angehefteten oligonukleotiden sowie deren verwendungen
US6750016B2 (en) 1996-07-29 2004-06-15 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6361944B1 (en) 1996-07-29 2002-03-26 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US20020172953A1 (en) * 1996-07-29 2002-11-21 Mirkin Chad A. Movement of biomolecule-coated nanoparticles in an electric field
US6767702B2 (en) 1996-07-29 2004-07-27 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US7098320B1 (en) 1996-07-29 2006-08-29 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6582921B2 (en) 1996-07-29 2003-06-24 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses thereof
US7169556B2 (en) 1996-07-29 2007-01-30 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6984491B2 (en) * 1996-07-29 2006-01-10 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6506564B1 (en) 1996-07-29 2003-01-14 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
GB9618897D0 (en) 1996-09-10 1996-10-23 Bio Rad Micromeasurements Ltd Micro defects in silicon wafers
EP1017987B1 (de) 1997-01-31 2005-06-15 The Horticulture And Food Research Institute Of New Zealand Limited Optische vorrichtung und methode
DE69836734D1 (de) 1997-02-20 2007-02-08 Univ California Plasmon-schwingteilchen, methode und vorrichtung
US6852252B2 (en) 1997-03-12 2005-02-08 William Marsh Rice University Use of metalnanoshells to impede the photo-oxidation of conjugated polymer
US6344272B1 (en) 1997-03-12 2002-02-05 Wm. Marsh Rice University Metal nanoshells
EP0985142A4 (de) 1997-05-23 2006-09-13 Lynx Therapeutics Inc System und gerät zur sequentiellen behandlung von analyten
US20050037397A1 (en) * 2001-03-28 2005-02-17 Nanosphere, Inc. Bio-barcode based detection of target analytes
US6974669B2 (en) 2000-03-28 2005-12-13 Nanosphere, Inc. Bio-barcodes based on oligonucleotide-modified nanoparticles
US6149867A (en) 1997-12-31 2000-11-21 Xy, Inc. Sheath fluids and collection systems for sex-specific cytometer sorting of sperm
US6428811B1 (en) 1998-03-11 2002-08-06 Wm. Marsh Rice University Temperature-sensitive polymer/nanoshell composites for photothermally modulated drug delivery
US6699724B1 (en) 1998-03-11 2004-03-02 Wm. Marsh Rice University Metal nanoshells for biosensing applications
US20030153023A1 (en) * 1999-05-13 2003-08-14 Starzl Timothy W. Enumeration method of analyte detection
EP1135682B1 (de) 1998-11-30 2007-07-11 Nanosphere, Inc. Nanopartikel mit polymerschalen
WO2000036450A1 (de) * 1998-12-17 2000-06-22 Leica Microsystems Heidelberg Gmbh Verfahren zur differenzierten untersuchung unterschiedlicher strukturen in vorzugsweise biologischen präparaten
EP1039291A1 (de) * 1999-03-26 2000-09-27 Sony International (Europe) GmbH Optochemischer Fühler and Herstellungsmethode
US20050100943A1 (en) * 2000-04-11 2005-05-12 Hideki Kambara Method of producing probe arrays for biological materials using fine particles
AU4245900A (en) * 1999-04-15 2000-11-02 Virtual Arrays, Inc. Combinatorial chemical library supports having indicia at coding positions and methods of use
US7253435B2 (en) * 1999-04-15 2007-08-07 Millipore Corporation Particles with light-polarizing codes
US20030134330A1 (en) * 1999-04-15 2003-07-17 Ilya Ravkin Chemical-library composition and method
US20030129654A1 (en) * 1999-04-15 2003-07-10 Ilya Ravkin Coded particles for multiplexed analysis of biological samples
US6908737B2 (en) * 1999-04-15 2005-06-21 Vitra Bioscience, Inc. Systems and methods of conducting multiplexed experiments
US20030166015A1 (en) * 1999-04-15 2003-09-04 Zarowitz Michael A. Multiplexed analysis of cell-substrate interactions
US20030207249A1 (en) * 1999-04-15 2003-11-06 Beske Oren E. Connection of cells to substrates using association pairs
US6868371B1 (en) * 1999-05-03 2005-03-15 General Electric Company System and method to quantify appearance defects in molded plastic parts
US6608716B1 (en) 1999-05-17 2003-08-19 New Mexico State University Technology Transfer Corporation Optical enhancement with nanoparticles and microcavities
US20030096321A1 (en) * 1999-05-19 2003-05-22 Jose Remacle Method for the identification and/or the quantification of a target compound obtained from a biological sample upon chips
US6606566B1 (en) * 1999-11-01 2003-08-12 Steven A. Sunshine Computer code for portable sensing
US7033840B1 (en) 1999-11-09 2006-04-25 Sri International Reaction calorimeter and differential scanning calorimeter for the high-throughput synthesis, screening and characterization of combinatorial libraries
US6602714B1 (en) 1999-11-09 2003-08-05 Sri International Viscosity and mass sensor for the high-throughput synthesis, screening and characterization of combinatorial libraries
US7208265B1 (en) 1999-11-24 2007-04-24 Xy, Inc. Method of cryopreserving selected sperm cells
WO2001096604A2 (en) * 2000-06-12 2001-12-20 Genicon Sciences Corporation Assay for genetic polymorphisms using scattered light detectable labels
US6602669B2 (en) 2000-07-11 2003-08-05 Northwestern University Method of detection by enhancement of silver staining
JP2004537712A (ja) 2000-10-18 2004-12-16 バーチャル・アレイズ・インコーポレーテッド 多重細胞分析システム
CA2468774C (en) 2000-11-29 2015-06-30 George E. Seidel System for in-vitro fertilization with spermatozoa separated into x-chromosome and y-chromosome bearing populations
US7713687B2 (en) 2000-11-29 2010-05-11 Xy, Inc. System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
US6726847B2 (en) 2000-12-06 2004-04-27 Northwestern University Silver stain removal by chemical etching and sonication
US7811768B2 (en) * 2001-01-26 2010-10-12 Aviva Biosciences Corporation Microdevice containing photorecognizable coding patterns and methods of using and producing the same
US7015047B2 (en) * 2001-01-26 2006-03-21 Aviva Biosciences Corporation Microdevices having a preferential axis of magnetization and uses thereof
EP1488208A4 (de) * 2001-02-23 2008-05-28 Invitrogen Corp Verfahren zur bereitstellung eines erweiterten dynamikbereichs in analytentests
US20040166502A1 (en) * 2001-03-13 2004-08-26 Yaming Lai Microelectromagnetic dispenser heads and uses thereof
US20060040286A1 (en) * 2001-03-28 2006-02-23 Nanosphere, Inc. Bio-barcode based detection of target analytes
JP4146239B2 (ja) * 2001-03-28 2008-09-10 ナノスフェアー インコーポレイテッド オリゴヌクレオチド修飾粒子をベースとするバイオバーコード
US7354733B2 (en) * 2001-03-29 2008-04-08 Cellect Technologies Corp. Method for sorting and separating living cells
US7713705B2 (en) * 2002-12-24 2010-05-11 Biosite, Inc. Markers for differential diagnosis and methods of use thereof
US20040203083A1 (en) * 2001-04-13 2004-10-14 Biosite, Inc. Use of thrombus precursor protein and monocyte chemoattractant protein as diagnostic and prognostic indicators in vascular diseases
US20040253637A1 (en) * 2001-04-13 2004-12-16 Biosite Incorporated Markers for differential diagnosis and methods of use thereof
US20040121350A1 (en) * 2002-12-24 2004-06-24 Biosite Incorporated System and method for identifying a panel of indicators
US20040126767A1 (en) * 2002-12-27 2004-07-01 Biosite Incorporated Method and system for disease detection using marker combinations
US20030113740A1 (en) * 2001-04-26 2003-06-19 Mirkin Chad A. Oligonucleotide-modified ROMP polymers and co-polymers
US7147687B2 (en) * 2001-05-25 2006-12-12 Nanosphere, Inc. Non-alloying core shell nanoparticles
US7238472B2 (en) * 2001-05-25 2007-07-03 Nanosphere, Inc. Non-alloying core shell nanoparticles
US20030092029A1 (en) 2001-06-06 2003-05-15 Lee Josephson Magneitc-nanoparticle conjugates and methods of use
AU2002310343A1 (en) * 2001-06-07 2002-12-16 University Of Pennsylvania-Center For Technology Transfer Multiplexing method
US6714299B2 (en) 2001-07-13 2004-03-30 Genicon Sciences Corporation Use of light scattering particles in design, manufacture, and quality control of small volume instruments, devices, and processes
US7110585B2 (en) * 2001-08-03 2006-09-19 Nanosphere, Inc. Nanoparticle imaging system and method
US20040146917A1 (en) * 2001-08-03 2004-07-29 Nanosphere, Inc. Nanoparticle imaging system and method
US20030049866A1 (en) * 2001-09-05 2003-03-13 Genicon Sciences Corporation Sample device preservation
WO2003021231A2 (en) * 2001-09-05 2003-03-13 Genicon Sciences Corporation Method and apparatus for normalization and deconvolution of assay data
EP2311934B1 (de) * 2001-09-06 2013-06-05 Rapid Micro Biosystems, Inc. Schnellnachweis replizierender Zellen
KR101204188B1 (ko) 2001-09-20 2012-11-23 안티캔서, 인코포레이티드 네스틴 발현 모낭 줄기 세포
US6754414B2 (en) * 2001-09-27 2004-06-22 Bio-Rad Laboratories, Inc. Imaging of microarrays using fiber optic exciter
US8148171B2 (en) * 2001-10-09 2012-04-03 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
AU2002363062B2 (en) * 2001-10-09 2007-03-22 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US20030219800A1 (en) * 2001-10-18 2003-11-27 Beske Oren E. Multiplexed cell transfection using coded carriers
EP1466015B1 (de) * 2001-11-09 2008-08-06 Nanosphere, Inc. Biokonjugat-nanopartikelsonden
US7083975B2 (en) * 2002-02-01 2006-08-01 Roland Green Microarray synthesis instrument and method
US7214427B2 (en) * 2002-03-21 2007-05-08 Aviva Biosciences Corporation Composite beads comprising magnetizable substance and electro-conductive substance
US7029631B2 (en) * 2002-04-19 2006-04-18 Agilent Technologies, Inc. Apparatus for improved light collection
US20030211488A1 (en) * 2002-05-07 2003-11-13 Northwestern University Nanoparticle probs with Raman spectrocopic fingerprints for analyte detection
US7438854B2 (en) * 2002-05-08 2008-10-21 Matsushita Electric Industrial Co., Ltd. Biomolecule substrate, and test and diagnosis methods and apparatuses using the same
US20040126773A1 (en) * 2002-05-23 2004-07-01 Beske Oren E. Assays with coded sensor particles to sense assay conditions
DE10223706A1 (de) 2002-05-28 2003-12-18 Nat Taiwan University Taipeh T Lichtemissionsdiode
ATE420357T1 (de) 2002-07-02 2009-01-15 Nanosphere Inc Nanopartikel-polyanion-konjugate sowie verfahren zur verwendung davon beim nachweis von analyten
AU2003259205B2 (en) * 2002-07-22 2009-10-08 Xy, Llc. Sperm cell process system
US20040018495A1 (en) * 2002-07-24 2004-01-29 Xing-Xiang Li Microparticle based signal amplification for the detection of analytes
US8486618B2 (en) 2002-08-01 2013-07-16 Xy, Llc Heterogeneous inseminate system
JP4595067B2 (ja) * 2002-08-01 2010-12-08 エックスワイ,エルエルシー 低圧精子細胞分離システム
MXPA05001654A (es) 2002-08-15 2005-10-18 Xy Inc Citometro de flujo de alta resolucion.
US7872804B2 (en) 2002-08-20 2011-01-18 Illumina, Inc. Encoded particle having a grating with variations in the refractive index
US7900836B2 (en) 2002-08-20 2011-03-08 Illumina, Inc. Optical reader system for substrates having an optically readable code
US7164533B2 (en) 2003-01-22 2007-01-16 Cyvera Corporation Hybrid random bead/chip based microarray
US7901630B2 (en) 2002-08-20 2011-03-08 Illumina, Inc. Diffraction grating-based encoded microparticle assay stick
US7349158B2 (en) * 2002-09-12 2008-03-25 Cyvera Corporation Diffraction grating-based encoded micro-particles for multiplexed experiments
US7126755B2 (en) * 2002-09-12 2006-10-24 Moon John A Method and apparatus for labeling using diffraction grating-based encoded optical identification elements
CA2496287A1 (en) * 2002-08-20 2004-03-04 Cyvera Corporation Diffraction grating-based optical identification element
US7923260B2 (en) 2002-08-20 2011-04-12 Illumina, Inc. Method of reading encoded particles
CA2496296A1 (en) * 2002-08-20 2004-03-04 Cyvera Corporation Diffraction grating-based encoded micro-particles for multiplexed experiments
US7508608B2 (en) 2004-11-17 2009-03-24 Illumina, Inc. Lithographically fabricated holographic optical identification element
US20040043385A1 (en) * 2002-09-03 2004-03-04 Yo-Hsin Su Microarray biochip
WO2004025561A1 (en) * 2002-09-12 2004-03-25 Cyvera Corporation Chemical synthesis using diffraction grating-based encoded optical elements
AU2003267192A1 (en) * 2002-09-12 2004-04-30 Cyvera Corporation Method and apparatus for aligning elongated microbeads in order to interrogate the same
US7092160B2 (en) 2002-09-12 2006-08-15 Illumina, Inc. Method of manufacturing of diffraction grating-based optical identification element
US20100255603A9 (en) * 2002-09-12 2010-10-07 Putnam Martin A Method and apparatus for aligning microbeads in order to interrogate the same
US7169548B2 (en) 2002-09-13 2007-01-30 Xy, Inc. Sperm cell processing and preservation systems
EP1552025A4 (de) * 2002-10-18 2006-12-13 Cylene Pharmaceuticals Inc Verfahren zur identifizierung von mittels einer quadruplexstruktur erkannten antiviralen molekülen
AU2003289853A1 (en) * 2002-11-04 2004-06-07 Ludwig-Maximilian-Uni Versitat Munchen Methods, device and instrument for detection of analytes
US7122384B2 (en) * 2002-11-06 2006-10-17 E. I. Du Pont De Nemours And Company Resonant light scattering microparticle methods
EP1587955A4 (de) * 2002-12-24 2007-03-14 Biosite Inc Differenzialdiagnose-marker und verfahren zu ihrer verwendung
EP1583473A2 (de) * 2003-01-16 2005-10-12 St. Johns University New York Stabilisierung von ir-fluoreszenten farbstoffen auf nanopartikel-basis
EP1597399A2 (de) * 2003-02-27 2005-11-23 Nanosphere, Inc. Markierungsfreie erstellung von genexpressionsprofilen mittels universeller nanopartikelsonden im mikroarray-testformat
ES2546658T3 (es) * 2003-03-27 2015-09-25 The General Hospital Corporation Método para tratamiento dermatológico cosmético y renovación fraccionada de la piel
EP2308417B1 (de) 2003-03-28 2016-03-23 Inguran, LLC Vorrichtung und Verfahren zur Bereitstellung von sortierten Partikeln
US7354916B2 (en) * 2003-04-07 2008-04-08 Cylene Pharmaceuticals Substituted quinobenzoxazine analogs
NZ543006A (en) * 2003-04-07 2009-03-31 Cylene Pharmaceuticals Inc Substituted quinobenzoxazine analogs
US7507727B2 (en) * 2003-04-07 2009-03-24 Cylene Pharmaceuticals, Inc. Substituted quinobenzoxazine analogs and methods of using thereof
EP1610795A4 (de) * 2003-04-07 2007-10-24 Cylene Pharmaceuticals Inc Heterocyclische substituierte 1,4-dihydro-4-oxo-1,8-naphthpyridin-analoga
GB0308182D0 (en) * 2003-04-09 2003-05-14 Aoti Operating Co Inc Detection method and apparatus
US7177487B2 (en) * 2003-04-21 2007-02-13 Baxter International Inc. Determination of particle size by image analysis
EP1625203B1 (de) * 2003-05-15 2015-04-08 Xy, Llc Effiziente sortierung haploider zellen für durchflusszytometer-systeme
US20050250094A1 (en) * 2003-05-30 2005-11-10 Nanosphere, Inc. Method for detecting analytes based on evanescent illumination and scatter-based detection of nanoparticle probe complexes
US7341841B2 (en) * 2003-07-12 2008-03-11 Accelr8 Technology Corporation Rapid microbial detection and antimicrobial susceptibility testing
US20120077206A1 (en) 2003-07-12 2012-03-29 Accelr8 Technology Corporation Rapid Microbial Detection and Antimicrobial Susceptibility Testing
CA2532414C (en) * 2003-07-12 2017-03-14 Accelr8 Technology Corporation Sensitive and rapid biodetection
US7641971B2 (en) * 2003-08-13 2010-01-05 Crane Company Metal-treated particles for remediation
WO2005074417A2 (en) * 2003-09-03 2005-08-18 Salk Institute For Biological Studies Multiple antigen detection assays and reagents
US7488451B2 (en) * 2003-09-15 2009-02-10 Millipore Corporation Systems for particle manipulation
US20050208468A1 (en) * 2003-09-15 2005-09-22 Beske Oren E Assays with primary cells
US7413868B2 (en) * 2003-11-05 2008-08-19 Trellis Bioscience, Inc. Use of particulate labels in bioanalyte detection methods
US7553625B2 (en) * 2003-12-22 2009-06-30 John Wayne Cancer Institute Method and apparatus for in vivo collection of circulating biological components
WO2005062940A2 (en) 2003-12-22 2005-07-14 John Wayne Cancer Institute Method and apparatus for in vivo collection and surveillance of circulating biological components
US20050153309A1 (en) 2003-12-22 2005-07-14 David Hoon Method and apparatus for in vivo surveillance of circulating biological components
WO2005066613A1 (en) * 2003-12-31 2005-07-21 President And Fellows Of Harvard College Assay device and method
US20050141843A1 (en) * 2003-12-31 2005-06-30 Invitrogen Corporation Waveguide comprising scattered light detectable particles
US8030057B2 (en) * 2004-01-26 2011-10-04 President And Fellows Of Harvard College Fluid delivery system and method
CA2564211C (en) 2004-01-26 2010-08-03 President And Fellows Of Harvard College Fluid delivery system and method
DE102004006470B4 (de) * 2004-02-06 2006-06-01 Senova Gesellschaft für Biowissenschaft und Technik mbH Absorptionsphotometrisches Verfahren zur quantitativen Stoffanalyse
US20060023310A1 (en) * 2004-02-19 2006-02-02 Putnam Martin A Optical identification element using separate or partially overlapped diffraction gratings
US7433123B2 (en) * 2004-02-19 2008-10-07 Illumina, Inc. Optical identification element having non-waveguide photosensitive substrate with diffraction grating therein
US20050270603A1 (en) * 2004-02-19 2005-12-08 Cyuera Corporation Optical identification element using separate or partially overlapped diffraction gratings
WO2005079545A2 (en) * 2004-02-19 2005-09-01 Illumina, Inc. Optical identification element using separate or partially overlapped diffraction gratings
CN104974983A (zh) 2004-03-29 2015-10-14 英格朗公司 用于授精的精子悬浮液
US7407816B2 (en) * 2004-05-07 2008-08-05 Gentius, Inc Isoelectric particles and uses thereof
US20090054255A1 (en) * 2004-07-01 2009-02-26 The Regents Of The University Of California Microfluidic devices and methods
DE102004034486B4 (de) * 2004-07-16 2007-08-23 Infineon Technologies Ag Verfahren zum Nachweis von Lumineszenzlicht aus einer porösen Trägerstruktur
WO2006020363A2 (en) 2004-07-21 2006-02-23 Illumina, Inc. Method and apparatus for drug product tracking using encoded optical identification elements
BRPI0513685A (pt) 2004-07-22 2008-05-13 Monsanto Technology Llc processo para enriquecimento de uma população de células de esperma
EP1771583A2 (de) * 2004-07-26 2007-04-11 Nanosphere, Inc. Verfahren zur unterscheidung von methicillin-resistentem s. aureus von methicillin-sensitivem s. aureus in einer mischkultur
US20060024815A1 (en) * 2004-07-30 2006-02-02 Allman Steve L High sensitivity array-based detection system
US9494581B2 (en) 2004-08-24 2016-11-15 University Of Wyoming System and method for Raman spectroscopy assay using paramagnetic particles
US7288134B2 (en) * 2004-09-10 2007-10-30 International Business Machines Corporation Dumbbell-like nanoparticles and a process of forming the same
EP1813946B1 (de) * 2004-09-14 2012-01-25 Mitsubishi Chemical Corporation Biomaterialkonstrukt, verfahren zu dessen herstellung und dessen verwendungen
US7612769B2 (en) * 2004-09-14 2009-11-03 E.I. Du Pont De Nemours And Company Computer-implemented methods for organizing image data produced by resonant Mie scattering of light from microparticles and resulting data structures
CN101031659A (zh) * 2004-09-24 2007-09-05 英詹尼斯公司 基因组分析
WO2006055736A1 (en) 2004-11-16 2006-05-26 Illumina, Inc. And methods and apparatus for reading coded microbeads
US7602952B2 (en) * 2004-11-16 2009-10-13 Illumina, Inc. Scanner having spatial light modulator
JP2008537146A (ja) 2005-04-19 2008-09-11 プレジデント・アンド・フエローズ・オブ・ハーバード・カレツジ 蛇行する幅の広いチャネルを備える流体構造
EP1880228B1 (de) 2005-05-09 2011-07-06 The General Hospital Corporation Sensoren auf wasserrelaxationsbasis
US8597576B2 (en) * 2005-06-23 2013-12-03 National Institute Of Advanced Industrial Science And Technology Analyzer for glycan or complex carbohydrate
US20070154903A1 (en) * 2005-06-23 2007-07-05 Nanosphere, Inc. Selective isolation and concentration of nucleic acids from complex samples
TWI391645B (zh) * 2005-07-06 2013-04-01 Nanometrics Inc 晶圓或其他工作表面下污染物及缺陷非接觸測量之差分波長光致發光
TWI439684B (zh) * 2005-07-06 2014-06-01 Nanometrics Inc 具自晶圓或其他工件特定材料層所發射光致發光信號優先偵測之光致發光成像
US8987004B2 (en) 2005-08-02 2015-03-24 University Of Maryland, Baltimore County Nanostructures for polarized imaging and receptor/ligan quantization: breaking the diffraction limit for imaging
JP2009505106A (ja) * 2005-08-19 2009-02-05 ナノスフェアー インコーポレイテッド Dna及び抗体を含むハイブリッド基板を調製するための方法及びその使用
CA2620861C (en) 2005-08-31 2016-07-05 T2 Biosystems, Inc. Nmr device for detection of analytes
US20070134685A1 (en) * 2005-09-06 2007-06-14 Invitrogen Corporation Control of chemical modification
CN101528912B (zh) 2005-09-26 2014-08-27 快速微型生物系统公司 包含生长培养基的盒
US8133741B2 (en) 2005-10-26 2012-03-13 General Electric Company Methods and systems for delivery of fluidic samples to sensor arrays
US7723120B2 (en) 2005-10-26 2010-05-25 General Electric Company Optical sensor array system and method for parallel processing of chemical and biochemical information
WO2007056113A2 (en) * 2005-11-02 2007-05-18 Cylene Pharmaceuticals, Inc. Methods for targeting quadruplex sequences
US7623624B2 (en) * 2005-11-22 2009-11-24 Illumina, Inc. Method and apparatus for labeling using optical identification elements characterized by X-ray diffraction
WO2007087582A1 (en) 2006-01-24 2007-08-02 Invitrogen Corporation Device and methods for quantifying analytes
US7830575B2 (en) 2006-04-10 2010-11-09 Illumina, Inc. Optical scanner with improved scan time
CN101438163B (zh) * 2006-05-09 2013-05-29 皇家飞利浦电子股份有限公司 利用磁场检测样品中的靶分子
KR20090027643A (ko) * 2006-05-17 2009-03-17 루미넥스 코포레이션 형광성 표지가 부착된 입자를 분석하기 위해 칩에 기초한 유세포분석기 시스템
EP2029777B1 (de) 2006-05-31 2017-03-08 Sequenom, Inc. Verfahren und zusammensetzungen zur nukleinsäureextraktion aus einer probe
US8207509B2 (en) 2006-09-01 2012-06-26 Pacific Biosciences Of California, Inc. Substrates, systems and methods for analyzing materials
JP5151097B2 (ja) * 2006-09-01 2013-02-27 株式会社リコー 複合金属ナノ粒子、複合金属ナノ粒子を含む多光子吸収反応材料と反応生成物、複合金属ナノ粒子を含む多光子吸収反応助剤
US8124598B2 (en) 2006-09-14 2012-02-28 Sharon Sageman 7-keto DHEA for psychiatric use
US7902345B2 (en) 2006-12-05 2011-03-08 Sequenom, Inc. Detection and quantification of biomolecules using mass spectrometry
US20120321759A1 (en) * 2007-01-05 2012-12-20 Myskin, Inc. Characterization of food materials by optomagnetic fingerprinting
ES2662027T3 (es) * 2007-01-19 2018-04-05 Tudor Arvinte Procedimiento y aparato para la determinación de parámetros de contaminantes en una solución líquida
WO2008137008A2 (en) 2007-05-04 2008-11-13 Claros Diagnostics, Inc. Fluidic connectors and microfluidic systems
US7883898B2 (en) 2007-05-07 2011-02-08 General Electric Company Method and apparatus for measuring pH of low alkalinity solutions
US8097422B2 (en) 2007-06-20 2012-01-17 Salk Institute For Biological Studies Kir channel modulators
US9097644B2 (en) 2007-08-17 2015-08-04 Massachusetts Institute Of Technology Magnetic resonance-based viscometers and methods
EP2195452B1 (de) 2007-08-29 2012-03-14 Sequenom, Inc. Verfahren und zusammensetzungen für die universelle grössenspezifische polymerasekettenreaktion
US20100160274A1 (en) * 2007-09-07 2010-06-24 Sharon Sageman 7-KETO DHEA for Psychiatric Use
US8278057B2 (en) * 2007-09-14 2012-10-02 Nestec S.A. Addressable antibody arrays and methods of use
JP4597175B2 (ja) * 2007-09-21 2010-12-15 株式会社日立ハイテクノロジーズ 標的物質を検出するための分析装置、又は分析方法、若しくはこれら分析装置及び分析方法に用いるデバイス
WO2009053902A2 (en) * 2007-10-25 2009-04-30 Koninklijke Philips Electronics N. V. Sensor device for target particles in a sample
JP4975599B2 (ja) * 2007-12-17 2012-07-11 シスメックス株式会社 標本作製装置および標本作製方法
JP2009150799A (ja) * 2007-12-21 2009-07-09 Sysmex Corp 分析装置、コンピュータプログラムおよび分析方法
US20090181361A1 (en) * 2008-01-14 2009-07-16 Weidong Xu Rapid test for detecting infection
US8852864B2 (en) 2008-01-17 2014-10-07 Sequenom Inc. Methods and compositions for the analysis of nucleic acids
CA2717320A1 (en) 2008-03-11 2009-09-17 Sequenom, Inc. Nucleic acid-based tests for prenatal gender determination
JP2009229103A (ja) * 2008-03-19 2009-10-08 Toshiba Corp 金属コロイドの定量方法
RU2472221C2 (ru) * 2008-03-21 2013-01-10 Закрытое акционерное общество "СЕЛЬМАШПРОЕКТ" Система для моделирования генетической и лингвистической информации
WO2009131677A1 (en) 2008-04-25 2009-10-29 Claros Diagnostics, Inc. Flow control in microfluidic systems
MY162695A (en) * 2008-06-10 2017-07-14 Xtralis Technologies Ltd Particle detection
TW201017149A (en) * 2008-08-06 2010-05-01 Invitrox Inc Use of focused light scattering techniques in biological applications
DK3629011T3 (da) 2008-09-16 2024-01-29 Pacific Biosciences California Inc Integreret optisk indretning
US8962247B2 (en) * 2008-09-16 2015-02-24 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
US8476013B2 (en) * 2008-09-16 2013-07-02 Sequenom, Inc. Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
EP2344679B1 (de) 2008-09-24 2018-05-23 First Light Biosciences, Inc. Kits und vorrichtungen zur erkennung von analyten
RU2494375C2 (ru) * 2008-09-25 2013-09-27 Конинклейке Филипс Электроникс Н.В. Система и способ детектирования
AU2009308841B2 (en) 2008-10-29 2014-07-17 T2 Biosystems, Inc. NMR detection of coagulation time
US9316578B2 (en) 2008-10-30 2016-04-19 New York University Automated real-time particle characterization and three-dimensional velocimetry with holographic video microscopy
CN102224259B (zh) 2008-11-24 2014-08-27 塞昆纳姆股份有限公司 核酸定量的产品和方法
EP2376226B1 (de) 2008-12-18 2018-09-12 Opko Diagnostics, LLC Verbesserte reagentienlagerung in mikrofluidsystemen und verwandte artikel und verfahren
WO2010087999A1 (en) 2009-02-02 2010-08-05 Claros Diagnostics, Inc. Structures for controlling light interaction with microfluidic devices
US20110171124A1 (en) 2009-02-26 2011-07-14 Osi Pharmaceuticals, Inc. In situ methods for monitoring the EMT status of tumor cells in vivo
CA2755615A1 (en) * 2009-03-18 2010-09-23 Sequenom, Inc. Use of thermostable endonucleases for generating reporter molecules
WO2010115016A2 (en) 2009-04-03 2010-10-07 Sequenom, Inc. Nucleic acid preparation compositions and methods
WO2011026030A1 (en) * 2009-08-31 2011-03-03 Mbio Diagnostics Corporation Integrated sample preparation and analyte detection
US20110143378A1 (en) * 2009-11-12 2011-06-16 CyVek LLC. Microfluidic method and apparatus for high performance biological assays
US9500645B2 (en) 2009-11-23 2016-11-22 Cyvek, Inc. Micro-tube particles for microfluidic assays and methods of manufacture
US9855735B2 (en) 2009-11-23 2018-01-02 Cyvek, Inc. Portable microfluidic assay devices and methods of manufacture and use
US10022696B2 (en) 2009-11-23 2018-07-17 Cyvek, Inc. Microfluidic assay systems employing micro-particles and methods of manufacture
US10065403B2 (en) 2009-11-23 2018-09-04 Cyvek, Inc. Microfluidic assay assemblies and methods of manufacture
JP5701894B2 (ja) 2009-11-23 2015-04-15 サイヴェク・インコーポレイテッド アッセイを行う方法及び装置
US9759718B2 (en) 2009-11-23 2017-09-12 Cyvek, Inc. PDMS membrane-confined nucleic acid and antibody/antigen-functionalized microlength tube capture elements, and systems employing them, and methods of their use
US9700889B2 (en) 2009-11-23 2017-07-11 Cyvek, Inc. Methods and systems for manufacture of microarray assay systems, conducting microfluidic assays, and monitoring and scanning to obtain microfluidic assay results
WO2013134742A2 (en) 2012-03-08 2013-09-12 Cyvek, Inc Micro-tube particles for microfluidic assays and methods of manufacture
HUE053571T2 (hu) 2009-11-24 2021-07-28 Opko Diagnostics Llc Folyadékkeverés és szállítás mikrofluid rendszerekben
US9339813B2 (en) 2009-12-18 2016-05-17 Koninklijke Philips N.V. Substance determining apparatus
ES2577017T3 (es) 2009-12-22 2016-07-12 Sequenom, Inc. Procedimientos y kits para identificar la aneuploidia
WO2011130629A1 (en) 2010-04-16 2011-10-20 Claros Diagnostics, Inc. Systems and devices for analysis of samples
USD645971S1 (en) 2010-05-11 2011-09-27 Claros Diagnostics, Inc. Sample cassette
WO2012037667A1 (en) * 2010-09-24 2012-03-29 The Governing Council Of The University Of Toronto Synthesis of fluorescent noble metal nanoparticles
US8409807B2 (en) 2010-10-22 2013-04-02 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
EP3974831A1 (de) 2010-10-22 2022-03-30 T2 Biosystems, Inc. Verfahren zum nachweis eines bakteriums in einer vollblutprobe
HUE040734T2 (hu) 2011-02-08 2019-03-28 Medimmune Llc Antitestek, amelyek specifikusan kötik staphylococcus aureus alfatoxinját és alkalmazási eljárások
JP5681517B2 (ja) * 2011-02-15 2015-03-11 新日本空調株式会社 粒子導電性判別装置及び粒子導電性判別方法
EP2683831B1 (de) 2011-03-07 2015-09-23 Accelerate Diagnostics, Inc. Schnelle zellreinigungssysteme
US10254204B2 (en) 2011-03-07 2019-04-09 Accelerate Diagnostics, Inc. Membrane-assisted purification
WO2012129455A2 (en) 2011-03-22 2012-09-27 Cyvek, Inc Microfluidic devices and methods of manufacture and use
EP2702168B1 (de) 2011-04-29 2018-01-17 Sequenom, Inc. Quantifizierung einer minderheitsvariante einer nukleinsäure
WO2012177792A2 (en) 2011-06-24 2012-12-27 Sequenom, Inc. Methods and processes for non-invasive assessment of a genetic variation
EP2732046B1 (de) 2011-07-13 2017-09-06 T2 Biosystems, Inc. Kernspinresonanzverfahren zur überwachung der bildung von blutgerinnseln
JP5762225B2 (ja) * 2011-09-08 2015-08-12 新留 康郎 銀シェル金ナノロッドを用いる分析方法
WO2013043858A1 (en) 2011-09-21 2013-03-28 T2 Biosystems, Inc. Nmr methods for endotoxin analysis
US10196681B2 (en) 2011-10-06 2019-02-05 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9367663B2 (en) 2011-10-06 2016-06-14 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9984198B2 (en) 2011-10-06 2018-05-29 Sequenom, Inc. Reducing sequence read count error in assessment of complex genetic variations
US10424394B2 (en) 2011-10-06 2019-09-24 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US20140242588A1 (en) 2011-10-06 2014-08-28 Sequenom, Inc Methods and processes for non-invasive assessment of genetic variations
US8688388B2 (en) 2011-10-11 2014-04-01 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
ES2659165T3 (es) 2011-11-07 2018-03-14 Rapid Micro Biosystems, Inc. Casete para ensayos de esterilidad
DE102011087679B3 (de) * 2011-12-02 2013-04-18 Schildtec GmbH Meßkammer für einen optisch arbeitenden Sensor zum Bestimmen einer Konzentration eines Stoffes
AU2013209499B2 (en) 2012-01-20 2018-05-10 Sequenom, Inc. Diagnostic processes that factor experimental conditions
EP4155401A1 (de) 2012-03-02 2023-03-29 Sequenom, Inc. Verfahren und prozesse zur nichtinvasiven beurteilung genetischer variationen
JP2013181935A (ja) * 2012-03-05 2013-09-12 Fujifilm Corp クロマトグラフ方法
EA030682B1 (ru) 2012-03-05 2018-09-28 Ой Арктик Партнерс Аб Способы и аппараты для прогнозирования риска рака предстательной железы и объема предстательной железы
IN2014DN08564A (de) 2012-04-16 2015-05-22 Rapid Micro Biosystems Inc
WO2013158281A1 (en) 2012-04-20 2013-10-24 T2 Biosystems, Inc. Compositions and methods for detection of candida species
US10504613B2 (en) 2012-12-20 2019-12-10 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
US10497461B2 (en) 2012-06-22 2019-12-03 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US20140004105A1 (en) 2012-06-29 2014-01-02 Sequenom, Inc. Age-related macular degeneration diagnostics
AU2013290102B2 (en) 2012-07-13 2018-11-15 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
US10482994B2 (en) 2012-10-04 2019-11-19 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US20140146157A1 (en) * 2012-11-29 2014-05-29 Fluid Imaging Technologies, Inc. System and method for sample dilution and particle imaging
JP2016500443A (ja) 2012-12-07 2016-01-12 ティー2 バイオシステムズ,インコーポレーテッド 強固な血餅形成をモニタリングするための方法
US20130309666A1 (en) 2013-01-25 2013-11-21 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
EP2969156B1 (de) 2013-03-13 2019-04-10 Opko Diagnostics, LLC Mischen von fluiden in fluidiksystemen
EP3597774A1 (de) 2013-03-13 2020-01-22 Sequenom, Inc. Primer zur analyse der dna-methylierung
US9677109B2 (en) 2013-03-15 2017-06-13 Accelerate Diagnostics, Inc. Rapid determination of microbial growth and antimicrobial susceptibility
LT2981921T (lt) 2013-04-03 2023-02-27 Sequenom, Inc. Neinvazinio genetinių variacijų vertinimo būdai ir procesai
US10699800B2 (en) 2013-05-24 2020-06-30 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
AU2014284180B2 (en) 2013-06-21 2020-03-19 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
EP2827130A1 (de) * 2013-07-15 2015-01-21 F. Hoffmann-La Roche AG Vorrichtung zur Verwendung bei der Bindeaffinitätserkennung
CA3205430A1 (en) 2013-10-04 2015-04-09 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10438691B2 (en) 2013-10-07 2019-10-08 Sequenom, Inc. Non-invasive assessment of chromosome alterations using change in subsequence mappability
KR102425768B1 (ko) 2014-02-12 2022-07-26 뉴욕 유니버시티 콜로이드 입자의 홀로그래픽 추적 및 특징화를 위한 고속 특징부 식별
US11365447B2 (en) 2014-03-13 2022-06-21 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
EP3175000B1 (de) 2014-07-30 2020-07-29 Sequenom, Inc. Verfahren und prozesse zur nicht-invasiven beurteilung genetischer variationen
US11085864B2 (en) 2014-11-12 2021-08-10 New York University Colloidal fingerprints for soft materials using total holographic characterization
CN107206376B (zh) 2014-12-12 2021-07-09 欧普科诊断有限责任公司 包括通过模塑形成之流控系统的包含孵育通道的流控系统
US10253355B2 (en) 2015-03-30 2019-04-09 Accelerate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
KR20170132856A (ko) 2015-03-30 2017-12-04 액셀러레이트 다이어그노스틱스, 아이엔씨. 신속한 미생물 동정 및 항균제 감수성 시험을 위한 기기 및 시스템
EP3091347A1 (de) * 2015-05-04 2016-11-09 The European Union, represented by the European Commission Screening von nanopartikeleigenschaften
USD804682S1 (en) 2015-08-10 2017-12-05 Opko Diagnostics, Llc Multi-layered sample cassette
KR102579248B1 (ko) 2015-09-18 2023-09-15 뉴욕 유니버시티 정밀 슬러리 내 대형 불순물 입자의 홀로그래픽 검출 및 특성화
US9983115B2 (en) 2015-09-21 2018-05-29 Fluid Imaging Technologies, Inc. System and method for monitoring particles in a fluid using ratiometric cytometry
US10228367B2 (en) 2015-12-01 2019-03-12 ProteinSimple Segmented multi-use automated assay cartridge
US20170160187A1 (en) * 2015-12-08 2017-06-08 Tdk Corporation Laser Scanner Particle Counter and Imager
CA3005084A1 (en) 2015-12-11 2017-06-15 Opko Diagnostics, Llc Fluidic systems involving incubation of samples and/or reagents
AU2017210033B2 (en) 2016-01-21 2022-09-29 T2 Biosystems, Inc. NMR methods and systems for the rapid detection of bacteria
TWI731030B (zh) 2016-02-08 2021-06-21 紐約大學 蛋白質聚集體之全像特性化技術
RU2631237C2 (ru) * 2016-02-26 2017-09-19 Государственное Научное Учреждение "Институт Физики Имени Б.И. Степанова Национальной Академии Наук Беларуси" Способ контроля структурного качества тонких плёнок для светопоглощающих слоёв солнечных элементов и устройство для его реализации
US10670677B2 (en) 2016-04-22 2020-06-02 New York University Multi-slice acceleration for magnetic resonance fingerprinting
EP3468477B1 (de) 2016-06-09 2023-08-23 Haimachek, Inc. Kollektor zum nachweis und reversiblen einfangen von zellen aus körperflüssigkeiten in vivo
RU169521U1 (ru) * 2016-06-28 2017-03-21 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт глазных болезней" Устройство для оценки интенсивности светорассеивающей способности биологической ткани
CA3030890A1 (en) 2016-07-27 2018-02-01 Sequenom, Inc. Genetic copy number alteration classifications
EP3574424A1 (de) 2017-01-24 2019-12-04 Sequenom, Inc. Verfahren und prozesse zur beurteilung genetischer variationen
JP7347849B2 (ja) 2018-04-19 2023-09-20 ファースト ライト ダイアグノスティクス, インコーポレイテッド 標的の検出
US11459604B2 (en) 2018-07-12 2022-10-04 Luminex Corporation Systems and methods for performing variable sample preparation and analysis processes
CN109254022B (zh) * 2018-10-24 2021-07-20 首钢智新迁安电磁材料有限公司 一种测量晶粒尺寸的方法
CN109540855B (zh) * 2018-11-07 2021-03-23 沈阳化工大学 一种荧光金壳磁性椭球的制备方法
FI129722B (en) * 2018-12-28 2022-07-29 Kemira Oyj Monitoring and regulation of hydrophobic components in a pulping process
KR20210121107A (ko) * 2019-01-30 2021-10-07 리제너론 파아마슈티컬스, 인크. 생물제제내 가시성 및/또는 현미경-가시성 입자의 특성규명 방법
IL265914B (en) * 2019-04-08 2020-11-30 Convergent R N R Ltd System and method for optimization of radiotherapy treatments
US11543338B2 (en) 2019-10-25 2023-01-03 New York University Holographic characterization of irregular particles
US11948302B2 (en) 2020-03-09 2024-04-02 New York University Automated holographic video microscopy assay
CN112014369B (zh) * 2020-08-25 2024-02-09 上海市皮肤病医院 超灵敏数字层析快速检测分析物的系统及方法
CN112229769B (zh) * 2020-10-22 2023-03-14 山东长信化学科技股份有限公司 一种n-甲基吡咯烷酮颗粒度的检测系统及检测方法
CN113340894B (zh) * 2021-05-28 2023-04-07 上海睿钰生物科技有限公司 一种非透明微粒的检测方法
CN115482643B (zh) * 2022-08-24 2024-02-02 清华大学 火灾烟雾探测器及其探测方法

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3975084A (en) 1973-09-27 1976-08-17 Block Engineering, Inc. Particle detecting system
US3939350A (en) * 1974-04-29 1976-02-17 Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing total reflection for activation
US4157498A (en) * 1977-08-01 1979-06-05 Miles Laboratories, Inc. Flow-through type particle analyzing apparatus
NL7807532A (nl) 1978-07-13 1980-01-15 Akzo Nv Metaal-immunotest.
US4420558A (en) 1981-02-12 1983-12-13 Janssen Pharmaceutica N.V. Bright field light microscopic method of enumerating and characterizing subtypes of white blood cells and their precursors
GB2095258B (en) 1981-03-19 1984-09-05 Janssen Pharmaceutica Nv A bright field light microscopic method of localizing tissue antigens
US4480042A (en) 1981-10-28 1984-10-30 E. I. Du Pont De Nemours And Company Covalently bonded high refractive index particle reagents and their use in light scattering immunoassays
US4597944A (en) * 1983-10-18 1986-07-01 Cottingham Hugh V Agglutination reagent detection system
US4752567A (en) 1984-06-21 1988-06-21 Janssen Pharmaceutica N.V. Method of visualizing individual submicroscopic metal particles
US4647544A (en) * 1984-06-25 1987-03-03 Nicoli David F Immunoassay using optical interference detection
US4983834A (en) * 1985-10-10 1991-01-08 Quantex Corporation Large area particle detector system
US5501949A (en) * 1985-12-10 1996-03-26 Murex Diagnostics Corporation Particle bound binding component immunoassay
CA1291031C (en) 1985-12-23 1991-10-22 Nikolaas C.J. De Jaeger Method for the detection of specific binding agents and their correspondingbindable substances
US4851329A (en) 1986-06-06 1989-07-25 Massachusetts Institute Of Technology Immunoassay employing optical pulse particle size analysis
AU7385387A (en) * 1986-06-09 1987-12-10 Ortho Diagnostic Systems Inc. Immunoassay using detection of colloidal gold
US5514602A (en) 1986-06-09 1996-05-07 Ortho Diagnostic Systems, Inc. Method of producing a metal sol reagent containing colloidal metal particles
US5017009A (en) * 1986-06-26 1991-05-21 Ortho Diagnostic Systems, Inc. Scattered total internal reflectance immunoassay system
GB8623072D0 (en) * 1986-09-25 1986-10-29 Amersham Int Plc Particle analysis
US5015580A (en) * 1987-07-29 1991-05-14 Agracetus Particle-mediated transformation of soybean plants and lines
US5202231A (en) * 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
US5110727A (en) * 1987-04-03 1992-05-05 Cardiovascular Diagnostics, Inc. Method for performing coagulation assays accurately, rapidly and simply, using dry chemical reagents and paramagnetic particles
GB8803000D0 (en) 1988-02-10 1988-03-09 Ekins Roger Philip Determination of ambient concentrations of several analytes
US5079172A (en) 1988-11-04 1992-01-07 Board Of Trustees Operating Michigan State University Method for detecting the presence of antibodies using gold-labeled antibodies and test kit
US5100805A (en) * 1989-01-26 1992-03-31 Seradyn, Inc. Quantitative immunoassay system and method for agglutination assays
US5338353A (en) * 1989-04-07 1994-08-16 Nippon Shokubai Kagaku Kogyo Method for production of powder of fine inorganic particles
US5120135A (en) * 1989-12-13 1992-06-09 Syntex (U.S.A.) Inc. Method and apparatus for keeping particles in suspension
JP2899360B2 (ja) 1990-05-21 1999-06-02 興和株式会社 流体中の粒子計測方法及びその装置
US5350697A (en) * 1990-08-28 1994-09-27 Akzo N.V. Scattered light detection apparatus
US5294369A (en) 1990-12-05 1994-03-15 Akzo N.V. Ligand gold bonding
JP3115641B2 (ja) 1991-04-24 2000-12-11 シスメックス株式会社 粒子計数方法
US5286452A (en) 1991-05-20 1994-02-15 Sienna Biotech, Inc. Simultaneous multiple assays
JP2523227Y2 (ja) 1991-07-30 1997-01-22 株式会社堀場製作所 異物検査装置
US5516670A (en) * 1991-09-30 1996-05-14 Kuehnle; Adelheid R. Magnetophoretic particle delivery method and apparatus for the treatment of cells
US5151956A (en) 1991-12-20 1992-09-29 The United Staes Of America As Represented By The Secretary Of The Army Waveguide polarizer using localized surface plasmons
US5248772A (en) * 1992-01-29 1993-09-28 Coulter Corporation Formation of colloidal metal dispersions using aminodextrans as reductants and protective agents
US5305073A (en) 1992-02-12 1994-04-19 Precision Detectors, Inc. Methods and apparatus for molecular characterization
US5451525A (en) * 1992-02-14 1995-09-19 Coulter Corporation Method and materials for determining particle count in a flow cytometer
US5357320A (en) * 1992-09-04 1994-10-18 Canon Kabushiki Kaisha Electrophotographic apparatus
DE69331570T2 (de) * 1992-10-21 2002-10-02 Dade Behring Inc., Deerfield Agglutinationstest unter Anwendung eines multivalenten Liganden
JP3410777B2 (ja) * 1993-09-13 2003-05-26 株式会社東芝 超微粒子無機蛍光体標識特異的結合物質およびこれを用いた検出方法
DE4414166C1 (de) * 1994-04-22 1995-12-07 Lorenz Mesgeraetebau Verfahren und Vorrichtung zur Messung der Lichtstreuung an Partikeln
US5734498A (en) * 1994-05-09 1998-03-31 The Regents Of The University Of California Illuminator elements for conventional light microscopes
JPH0881678A (ja) * 1994-09-14 1996-03-26 Toshiba Corp 無機蛍光体および特異的結合物質
US5599668A (en) * 1994-09-22 1997-02-04 Abbott Laboratories Light scattering optical waveguide method for detecting specific binding events
US5851777A (en) * 1996-02-05 1998-12-22 Dade Behring Inc. Homogeneous sol-sol assay
DE69836734D1 (de) * 1997-02-20 2007-02-08 Univ California Plasmon-schwingteilchen, methode und vorrichtung

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RU2251572C2 (ru) 2005-05-10
IL126544A0 (en) 1999-08-17
DE69737513D1 (de) 2007-05-03
WO1997040181A1 (en) 1997-10-30
BR9710836A (pt) 2000-10-24
JP2009236921A (ja) 2009-10-15
CN1262667C (zh) 2006-07-05
JP2007263974A (ja) 2007-10-11
EP1021554B1 (de) 2007-03-21
AU736340B2 (en) 2001-07-26
CA2253710A1 (en) 1997-10-30
EP1021554A1 (de) 2000-07-26
JP2000510582A (ja) 2000-08-15
US6214560B1 (en) 2001-04-10
AU2805697A (en) 1997-11-12
DE69737513T2 (de) 2007-12-13
ATE357663T1 (de) 2007-04-15
CN1223692A (zh) 1999-07-21
EP1021554A4 (de) 2004-06-30

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