IL126456A - Reactor and method for solid phase peptide synthesis - Google Patents
Reactor and method for solid phase peptide synthesisInfo
- Publication number
- IL126456A IL126456A IL12645698A IL12645698A IL126456A IL 126456 A IL126456 A IL 126456A IL 12645698 A IL12645698 A IL 12645698A IL 12645698 A IL12645698 A IL 12645698A IL 126456 A IL126456 A IL 126456A
- Authority
- IL
- Israel
- Prior art keywords
- reactor
- solution
- basket
- resin
- amino acid
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 50
- 238000010647 peptide synthesis reaction Methods 0.000 title claims abstract description 20
- 239000007790 solid phase Substances 0.000 title claims abstract description 14
- 229920005989 resin Polymers 0.000 claims abstract description 197
- 239000011347 resin Substances 0.000 claims abstract description 197
- 150000001413 amino acids Chemical class 0.000 claims abstract description 82
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 57
- 239000002002 slurry Substances 0.000 claims abstract description 32
- 238000005859 coupling reaction Methods 0.000 claims abstract description 23
- 238000005406 washing Methods 0.000 claims abstract description 23
- 230000008878 coupling Effects 0.000 claims abstract description 18
- 238000010168 coupling process Methods 0.000 claims abstract description 18
- 230000015572 biosynthetic process Effects 0.000 claims abstract description 17
- 238000003786 synthesis reaction Methods 0.000 claims abstract description 11
- 238000009987 spinning Methods 0.000 claims abstract description 7
- 239000007822 coupling agent Substances 0.000 claims abstract description 6
- 239000012530 fluid Substances 0.000 claims description 25
- 238000001914 filtration Methods 0.000 claims description 19
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- 238000010926 purge Methods 0.000 claims description 14
- 238000004891 communication Methods 0.000 claims description 13
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- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 238000005507 spraying Methods 0.000 claims 1
- 239000000243 solution Substances 0.000 description 104
- 239000007788 liquid Substances 0.000 description 89
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 70
- 239000002245 particle Substances 0.000 description 45
- 239000002904 solvent Substances 0.000 description 44
- 238000006243 chemical reaction Methods 0.000 description 34
- 239000000376 reactant Substances 0.000 description 34
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 33
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 30
- 238000012546 transfer Methods 0.000 description 22
- 239000012508 resin bead Substances 0.000 description 21
- ADFXKUOMJKEIND-UHFFFAOYSA-N 1,3-dicyclohexylurea Chemical compound C1CCCCC1NC(=O)NC1CCCCC1 ADFXKUOMJKEIND-UHFFFAOYSA-N 0.000 description 20
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 20
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- 239000004744 fabric Substances 0.000 description 12
- 238000012360 testing method Methods 0.000 description 11
- QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 description 10
- 239000011148 porous material Substances 0.000 description 10
- -1 benzyl ester Chemical class 0.000 description 9
- 239000007787 solid Substances 0.000 description 9
- 238000002474 experimental method Methods 0.000 description 7
- FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 7
- 238000001994 activation Methods 0.000 description 6
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- 108010000817 Leuprolide Proteins 0.000 description 5
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- GFIJNRVAKGFPGQ-LIJARHBVSA-N leuprolide Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)CC1=CC=C(O)C=C1 GFIJNRVAKGFPGQ-LIJARHBVSA-N 0.000 description 5
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- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 4
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 125000003277 amino group Chemical group 0.000 description 3
- 230000000903 blocking effect Effects 0.000 description 3
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- 238000007086 side reaction Methods 0.000 description 3
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- 230000008961 swelling Effects 0.000 description 3
- MYRTYDVEIRVNKP-UHFFFAOYSA-N 1,2-Divinylbenzene Chemical compound C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 description 2
- BHNHHSOHWZKFOX-UHFFFAOYSA-N 2-methyl-1H-indole Chemical compound C1=CC=C2NC(C)=CC2=C1 BHNHHSOHWZKFOX-UHFFFAOYSA-N 0.000 description 2
- JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 description 2
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- 102000004169 proteins and genes Human genes 0.000 description 2
- 230000003134 recirculating effect Effects 0.000 description 2
- 238000013341 scale-up Methods 0.000 description 2
- 238000010532 solid phase synthesis reaction Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
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- ZQEBQGAAWMOMAI-ZETCQYMHSA-N (2s)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid Chemical compound CC(C)(C)OC(=O)N1CCC[C@H]1C(O)=O ZQEBQGAAWMOMAI-ZETCQYMHSA-N 0.000 description 1
- AYMLQYFMYHISQO-QMMMGPOBSA-N (2s)-3-(1h-imidazol-3-ium-5-yl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoate Chemical compound CC(C)(C)OC(=O)N[C@H](C(O)=O)CC1=CN=CN1 AYMLQYFMYHISQO-QMMMGPOBSA-N 0.000 description 1
- WXYGVKADAIJGHB-ZDUSSCGKSA-N (2s)-3-(1h-indol-2-yl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid Chemical compound C1=CC=C2NC(C[C@H](NC(=O)OC(C)(C)C)C(O)=O)=CC2=C1 WXYGVKADAIJGHB-ZDUSSCGKSA-N 0.000 description 1
- WBIIPXYJAMICNU-AWEZNQCLSA-N (2s)-5-[amino-[(4-methylphenyl)sulfonylamino]methylidene]azaniumyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoate Chemical compound CC1=CC=C(S(=O)(=O)NC(N)=NCCC[C@H](NC(=O)OC(C)(C)C)C(O)=O)C=C1 WBIIPXYJAMICNU-AWEZNQCLSA-N 0.000 description 1
- HBAHZZVIEFRTEY-UHFFFAOYSA-N 2-heptylcyclohex-2-en-1-one Chemical compound CCCCCCCC1=CCCCC1=O HBAHZZVIEFRTEY-UHFFFAOYSA-N 0.000 description 1
- 229910000619 316 stainless steel Inorganic materials 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- 108010016626 Dipeptides Proteins 0.000 description 1
- 229920001367 Merrifield resin Polymers 0.000 description 1
- 101100386053 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) cys-3 gene Proteins 0.000 description 1
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- 150000007930 O-acyl isoureas Chemical class 0.000 description 1
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- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
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- KJOZJSGOIJQCGA-UHFFFAOYSA-N dichloromethane;2,2,2-trifluoroacetic acid Chemical compound ClCCl.OC(=O)C(F)(F)F KJOZJSGOIJQCGA-UHFFFAOYSA-N 0.000 description 1
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- 229920001542 oligosaccharide Polymers 0.000 description 1
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- BDAWXSQJJCIFIK-UHFFFAOYSA-N potassium methoxide Chemical compound [K+].[O-]C BDAWXSQJJCIFIK-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/045—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers using devices to improve synthesis, e.g. reactors, special vessels
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00281—Individual reactor vessels
- B01J2219/00283—Reactor vessels with top opening
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00281—Individual reactor vessels
- B01J2219/00295—Individual reactor vessels the reactor vessels having pervious side walls
- B01J2219/00299—Generally cylindrical reactor vessels
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
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- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00353—Pumps
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00421—Means for dispensing and evacuation of reagents using centrifugation
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00423—Means for dispensing and evacuation of reagents using filtration, e.g. through porous frits
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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- B01J2219/00277—Apparatus
- B01J2219/00457—Dispensing or evacuation of the solid phase support
- B01J2219/00459—Beads
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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- B01J2219/00277—Apparatus
- B01J2219/00457—Dispensing or evacuation of the solid phase support
- B01J2219/00459—Beads
- B01J2219/00466—Beads in a slurry
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00479—Means for mixing reactants or products in the reaction vessels
- B01J2219/00488—Means for mixing reactants or products in the reaction vessels by rotation of the reaction vessels
- B01J2219/0049—Means for mixing reactants or products in the reaction vessels by rotation of the reaction vessels by centrifugation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/005—Beads
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/0059—Sequential processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00596—Solid-phase processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00686—Automatic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00698—Measurement and control of process parameters
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00725—Peptides
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Devices And Processes Conducted In The Presence Of Fluids And Solid Particles (AREA)
- Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3755797P | 1997-02-11 | 1997-02-11 | |
| PCT/US1998/002634 WO1998034633A1 (fr) | 1997-02-11 | 1998-02-10 | Reacteur et procede de synthese de peptide en phase solide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL126456A0 IL126456A0 (en) | 1999-08-17 |
| IL126456A true IL126456A (en) | 2001-05-20 |
Family
ID=21894987
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12645698A IL126456A (en) | 1997-02-11 | 1998-02-10 | Reactor and method for solid phase peptide synthesis |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6028172A (fr) |
| EP (1) | EP0909176B1 (fr) |
| JP (1) | JP2000511934A (fr) |
| KR (1) | KR100463630B1 (fr) |
| CN (1) | CN1171634C (fr) |
| AT (1) | ATE225680T1 (fr) |
| AU (1) | AU724694B2 (fr) |
| CA (1) | CA2250784C (fr) |
| CZ (1) | CZ294838B6 (fr) |
| DE (1) | DE69808579T2 (fr) |
| DK (1) | DK0909176T3 (fr) |
| HU (1) | HU226994B1 (fr) |
| IL (1) | IL126456A (fr) |
| NO (1) | NO984611L (fr) |
| NZ (1) | NZ332174A (fr) |
| WO (1) | WO1998034633A1 (fr) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1184649A1 (fr) * | 2000-09-04 | 2002-03-06 | Eidgenössische Technische Hochschule Zürich | Calorimètre |
| JP4297751B2 (ja) * | 2002-07-12 | 2009-07-15 | 株式会社荏原製作所 | 固体反応剤 |
| US7902488B2 (en) * | 2003-06-23 | 2011-03-08 | Cem Corporation | Microwave-assisted peptide synthesis |
| US7393920B2 (en) | 2003-06-23 | 2008-07-01 | Cem Corporation | Microwave-assisted peptide synthesis |
| US20060105349A1 (en) * | 2004-11-12 | 2006-05-18 | Promega Corporation | Device and method for purification of biological materials |
| US20060105391A1 (en) * | 2004-11-12 | 2006-05-18 | Promega Corporation | Device and method for separating molecules |
| WO2008044890A1 (fr) * | 2006-10-12 | 2008-04-17 | Dong Kook Pharm. Co., Ltd | Procédé permettant de préparer des peptides par synthèse en phase solide |
| KR101014799B1 (ko) * | 2008-06-05 | 2011-02-15 | 애니젠 주식회사 | 펩타이드 합성 제조 장치 |
| US8308955B2 (en) * | 2009-07-20 | 2012-11-13 | Empire Technology Development Llc | Carbon nanotube separation by reversible gelation |
| KR101227176B1 (ko) * | 2010-02-05 | 2013-01-28 | 주식회사 부일켐텍 | 펩타이드 합성 제조장치 |
| CN102702304B (zh) * | 2012-05-11 | 2014-06-11 | 中南大学 | 多通路预活化装置、肽核酸制备系统及预活化和合成方法 |
| EP2703073A1 (fr) * | 2012-08-31 | 2014-03-05 | Biotage AB | Appareil et procédé de synthèse en phase solide |
| US9169287B2 (en) * | 2013-03-15 | 2015-10-27 | Massachusetts Institute Of Technology | Solid phase peptide synthesis processes and associated systems |
| US9695214B2 (en) | 2013-03-15 | 2017-07-04 | Massachusetts Institute Of Technology | Solid phase peptide synthesis processes and associated systems |
| EP3334750B1 (fr) | 2015-08-11 | 2022-10-05 | Anie Philip | Antagonistes peptidiques du tgf-bêta |
| CN108290923A (zh) | 2015-09-17 | 2018-07-17 | 麻省理工学院 | 用于固相肽合成的方法和系统 |
| JP7054922B2 (ja) * | 2015-09-17 | 2022-04-15 | マサチューセッツ インスティテュート オブ テクノロジー | 固相ペプチド合成方法および関連するシステム |
| WO2018057470A1 (fr) * | 2016-09-20 | 2018-03-29 | C S Bio Co. | Synthèse rapide de peptides à températures élevées |
| BR112019021035A2 (pt) * | 2017-04-06 | 2020-05-12 | Mylan Inc. | Inalador de pó de uso único de baixo custo |
| WO2018191476A1 (fr) | 2017-04-12 | 2018-10-18 | Magenta Therapeutics, Inc. | Antagonistes de récepteur d'hydrocarbure aryle et utilisations de ceux-ci |
| CN111542597A (zh) | 2017-10-31 | 2020-08-14 | 美真达治疗公司 | 用于扩增造血干细胞和祖细胞的组合物和方法 |
| AU2018358054A1 (en) | 2017-10-31 | 2020-05-07 | Magenta Therapeutics Inc. | Compositions and methods for hematopoietic stem and progenitor cell transplant therapy |
| CN107881102B (zh) * | 2017-11-23 | 2021-04-09 | 希施生物科技（上海）有限公司 | 一种用于核酸dna/rna生产型自动合成仪 |
| CN111712262A (zh) | 2017-12-06 | 2020-09-25 | 美真达治疗公司 | 用于动员造血干细胞和祖细胞的给药方案 |
| JP2021510150A (ja) | 2018-01-03 | 2021-04-15 | マジェンタ セラピューティクス インコーポレイテッドＭａｇｅｎｔａ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | 造血幹細胞および前駆細胞の増幅ならびに遺伝性代謝障害の処置のための組成物および方法 |
| CN112105628A (zh) * | 2018-03-13 | 2020-12-18 | 耶路撒冷希伯来大学伊森姆研究发展有限公司 | 高剪切固相合成 |
| WO2019211531A1 (fr) * | 2018-05-04 | 2019-11-07 | Polypeptide Laboratoires France | Systeme automatise de reacteur de synthese avec une boucle de recirculation |
| CN108752418B (zh) * | 2018-08-08 | 2024-01-30 | 湖南科技学院 | 一种多通道多肽合成反应装置及其操作方法 |
| CN111072749B (zh) * | 2018-10-22 | 2023-07-07 | 海南建邦制药科技有限公司 | 多肽合成仪 |
| JP6618133B1 (ja) * | 2019-04-02 | 2019-12-11 | ヤマト科学株式会社 | 固相合成装置 |
| CN110111907A (zh) * | 2019-05-10 | 2019-08-09 | 苏州市海崴生物科技有限公司 | 智能数字多肽合成系统 |
| CN110283229A (zh) * | 2019-07-24 | 2019-09-27 | 上海友尹化工科技有限公司 | 一种用于多肽药物的生产系统 |
| US20220401481A1 (en) | 2019-11-01 | 2022-12-22 | Magenta Therapeutics, Inc. | Dosing regimens for the mobilization of hematopoietic stem and progenitor cells |
| SE2050293A1 (en) | 2020-03-17 | 2021-09-18 | Peptisystems Ab | Peptide synthesis and system thereof |
| WO2022197776A1 (fr) | 2021-03-16 | 2022-09-22 | Magenta Therapeutics, Inc. | Schémas posologiques pour la mobilisation des cellules souches hématopoïétiques en vue d'une greffe de cellules souches chez les patients atteints de myélome multiple |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2017351C3 (de) * | 1970-04-10 | 1974-10-10 | Lkb Instrument Gmbh, 8032 Graefelfing | Verfahren und Reaktor für chemische Umsetzungen an unlöslichen Trägern mittels einer Reaktionsflüssigkeit |
| US4192798A (en) * | 1978-11-20 | 1980-03-11 | Bioresearch, Inc. | Rapid, large scale, automatable high pressure peptide synthesis |
| JPH03500381A (ja) * | 1988-07-25 | 1991-01-31 | スペツィアルノエ コンストルクトルスコエ ブユロ ビオロギチェスコゴ プリボロストロエニア アカデミイ ナウク エスエスエスエル | バイオポリマーの固相合成のための反応器 |
| US5186824A (en) * | 1991-09-04 | 1993-02-16 | Large Scale Biology Corporation | System for solid phase reactions |
-
1998
- 1998-02-10 JP JP10535043A patent/JP2000511934A/ja not_active Ceased
- 1998-02-10 NZ NZ332174A patent/NZ332174A/xx unknown
- 1998-02-10 DK DK98905049T patent/DK0909176T3/da active
- 1998-02-10 CA CA002250784A patent/CA2250784C/fr not_active Expired - Fee Related
- 1998-02-10 US US09/155,798 patent/US6028172A/en not_active Expired - Fee Related
- 1998-02-10 DE DE69808579T patent/DE69808579T2/de not_active Expired - Lifetime
- 1998-02-10 WO PCT/US1998/002634 patent/WO1998034633A1/fr active IP Right Grant
- 1998-02-10 KR KR10-1998-0708194A patent/KR100463630B1/ko not_active IP Right Cessation
- 1998-02-10 IL IL12645698A patent/IL126456A/en not_active IP Right Cessation
- 1998-02-10 AT AT98905049T patent/ATE225680T1/de not_active IP Right Cessation
- 1998-02-10 AU AU62763/98A patent/AU724694B2/en not_active Ceased
- 1998-02-10 EP EP98905049A patent/EP0909176B1/fr not_active Expired - Lifetime
- 1998-02-10 HU HU9903753A patent/HU226994B1/hu not_active IP Right Cessation
- 1998-02-10 CN CNB988001268A patent/CN1171634C/zh not_active Expired - Fee Related
- 1998-02-10 CZ CZ19983178A patent/CZ294838B6/cs not_active IP Right Cessation
- 1998-10-02 NO NO984611A patent/NO984611L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO984611L (no) | 1998-12-10 |
| KR20000064912A (ko) | 2000-11-06 |
| EP0909176A1 (fr) | 1999-04-21 |
| IL126456A0 (en) | 1999-08-17 |
| CA2250784A1 (fr) | 1998-08-13 |
| HU226994B1 (en) | 2010-04-28 |
| DE69808579D1 (de) | 2002-11-14 |
| EP0909176B1 (fr) | 2002-10-09 |
| DE69808579T2 (de) | 2003-06-26 |
| EP0909176A4 (fr) | 2000-04-12 |
| JP2000511934A (ja) | 2000-09-12 |
| ATE225680T1 (de) | 2002-10-15 |
| CA2250784C (fr) | 2004-04-20 |
| NO984611D0 (no) | 1998-10-02 |
| AU6276398A (en) | 1998-08-26 |
| US6028172A (en) | 2000-02-22 |
| CZ294838B6 (cs) | 2005-03-16 |
| WO1998034633A1 (fr) | 1998-08-13 |
| HUP9903753A3 (en) | 2000-08-28 |
| KR100463630B1 (ko) | 2005-05-25 |
| HUP9903753A2 (hu) | 2000-03-28 |
| DK0909176T3 (da) | 2003-02-17 |
| CN1171634C (zh) | 2004-10-20 |
| CN1215995A (zh) | 1999-05-05 |
| CZ317898A3 (cs) | 1999-08-11 |
| AU724694B2 (en) | 2000-09-28 |
| NZ332174A (en) | 1999-03-29 |
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| MM9K | Patent not in force due to non-payment of renewal fees |