NO984611L - FremgangsmÕte for peptidsyntese i fast fase og reaktorsystem for gjennomf°ring av slik syntese - Google Patents
FremgangsmÕte for peptidsyntese i fast fase og reaktorsystem for gjennomf°ring av slik synteseInfo
- Publication number
- NO984611L NO984611L NO984611A NO984611A NO984611L NO 984611 L NO984611 L NO 984611L NO 984611 A NO984611 A NO 984611A NO 984611 A NO984611 A NO 984611A NO 984611 L NO984611 L NO 984611L
- Authority
- NO
- Norway
- Prior art keywords
- basket
- reactor
- solutions
- synthesis
- solution
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 238000010647 peptide synthesis reaction Methods 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 239000007790 solid phase Substances 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 239000011347 resin Substances 0.000 abstract 4
- 229920005989 resin Polymers 0.000 abstract 4
- 239000012530 fluid Substances 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 238000004064 recycling Methods 0.000 abstract 1
- 238000010532 solid phase synthesis reaction Methods 0.000 abstract 1
- 238000005507 spraying Methods 0.000 abstract 1
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/045—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers using devices to improve synthesis, e.g. reactors, special vessels
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00281—Individual reactor vessels
- B01J2219/00283—Reactor vessels with top opening
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00281—Individual reactor vessels
- B01J2219/00295—Individual reactor vessels the reactor vessels having pervious side walls
- B01J2219/00299—Generally cylindrical reactor vessels
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00353—Pumps
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00421—Means for dispensing and evacuation of reagents using centrifugation
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00423—Means for dispensing and evacuation of reagents using filtration, e.g. through porous frits
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00457—Dispensing or evacuation of the solid phase support
- B01J2219/00459—Beads
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00457—Dispensing or evacuation of the solid phase support
- B01J2219/00459—Beads
- B01J2219/00466—Beads in a slurry
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00479—Means for mixing reactants or products in the reaction vessels
- B01J2219/00488—Means for mixing reactants or products in the reaction vessels by rotation of the reaction vessels
- B01J2219/0049—Means for mixing reactants or products in the reaction vessels by rotation of the reaction vessels by centrifugation
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/005—Beads
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/0059—Sequential processes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00596—Solid-phase processes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00686—Automatic
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00698—Measurement and control of process parameters
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00725—Peptides
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- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
- Devices And Processes Conducted In The Presence Of Fluids And Solid Particles (AREA)
Abstract
eaktorsystem (1) for fastfasesyntese av peptider og fremgangsmåte for drift av reaktoren er fremskaffet. Reaktorsystemet (1) omfatter en kurv (17) som er roterbar om en akse inne i et hus (15) og en mottaker/oppsamlingstank (5) som tilfarer fluid til, og samler opp fluid fra, huset (15). Kurven (17) har en perforert sidevegg (23) som det dannes en harpikskake ()på for peptidsyntesen. Reaktoren (7) og oppsamlingstanken/- mottakeren (5) danner en sløyfe eller krets som løsningene sirkuleres gjennom. Sirkulasjon av løsningene forhindrer at reaktoren oversvømmes slik at kurven ikke neddykkes i løsningen og tillater bruk av mindre væske. Således kan også større aminosyrekonsentrasjoner benyttes. Fremgangsmåten omfatter dannelse av en harpikskake (R) med jevn tykkelse på veggen (23) på kurven (17), og sprøyting av løsningene mot harpikskaken mens kurven roteres. Løsningen vil passere gjennom harpikskaken (R) og ledes bort til oppsamlingstanken (5) for sirkulasjon eller resirkulering gjennom systemet eller fjerning fra systemet. Før en påfølgende løsning tilf øres reaktorsystemet (1), renses den foregående løsningen fra systemet for å bidra til å kontrollere peptidets eksponeringstid for løsningene.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3755797P | 1997-02-11 | 1997-02-11 | |
PCT/US1998/002634 WO1998034633A1 (en) | 1997-02-11 | 1998-02-10 | Reactor and method for solid phase peptide synthesis |
Publications (2)
Publication Number | Publication Date |
---|---|
NO984611D0 NO984611D0 (no) | 1998-10-02 |
NO984611L true NO984611L (no) | 1998-12-10 |
Family
ID=21894987
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO984611A NO984611L (no) | 1997-02-11 | 1998-10-02 | FremgangsmÕte for peptidsyntese i fast fase og reaktorsystem for gjennomf°ring av slik syntese |
Country Status (16)
Country | Link |
---|---|
US (1) | US6028172A (no) |
EP (1) | EP0909176B1 (no) |
JP (1) | JP2000511934A (no) |
KR (1) | KR100463630B1 (no) |
CN (1) | CN1171634C (no) |
AT (1) | ATE225680T1 (no) |
AU (1) | AU724694B2 (no) |
CA (1) | CA2250784C (no) |
CZ (1) | CZ294838B6 (no) |
DE (1) | DE69808579T2 (no) |
DK (1) | DK0909176T3 (no) |
HU (1) | HU226994B1 (no) |
IL (1) | IL126456A (no) |
NO (1) | NO984611L (no) |
NZ (1) | NZ332174A (no) |
WO (1) | WO1998034633A1 (no) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1184649A1 (de) * | 2000-09-04 | 2002-03-06 | Eidgenössische Technische Hochschule Zürich | Kalorimeter |
JP4297751B2 (ja) * | 2002-07-12 | 2009-07-15 | 株式会社荏原製作所 | 固体反応剤 |
US7902488B2 (en) * | 2003-06-23 | 2011-03-08 | Cem Corporation | Microwave-assisted peptide synthesis |
US7393920B2 (en) | 2003-06-23 | 2008-07-01 | Cem Corporation | Microwave-assisted peptide synthesis |
US20060105349A1 (en) * | 2004-11-12 | 2006-05-18 | Promega Corporation | Device and method for purification of biological materials |
US20060105391A1 (en) * | 2004-11-12 | 2006-05-18 | Promega Corporation | Device and method for separating molecules |
WO2008044890A1 (en) * | 2006-10-12 | 2008-04-17 | Dong Kook Pharm. Co., Ltd | A method for preparing peptides using by solid phase synthesis |
KR101014799B1 (ko) * | 2008-06-05 | 2011-02-15 | 애니젠 주식회사 | 펩타이드 합성 제조 장치 |
US8308955B2 (en) * | 2009-07-20 | 2012-11-13 | Empire Technology Development Llc | Carbon nanotube separation by reversible gelation |
KR101227176B1 (ko) * | 2010-02-05 | 2013-01-28 | 주식회사 부일켐텍 | 펩타이드 합성 제조장치 |
CN102702304B (zh) * | 2012-05-11 | 2014-06-11 | 中南大学 | 多通路预活化装置、肽核酸制备系统及预活化和合成方法 |
EP2703073A1 (en) * | 2012-08-31 | 2014-03-05 | Biotage AB | Apparatus and method for solid phase synthesis |
US9695214B2 (en) | 2013-03-15 | 2017-07-04 | Massachusetts Institute Of Technology | Solid phase peptide synthesis processes and associated systems |
US9169287B2 (en) | 2013-03-15 | 2015-10-27 | Massachusetts Institute Of Technology | Solid phase peptide synthesis processes and associated systems |
WO2017024407A1 (en) | 2015-08-11 | 2017-02-16 | The Royal Institution For The Advancement Of Learning/Mcgill University | Peptidic tgf-beta antagonists |
WO2017049128A1 (en) | 2015-09-17 | 2017-03-23 | Massachusetts Institute Of Technology | Methods and systems for solid phase peptide synthesis |
WO2017049115A1 (en) * | 2015-09-17 | 2017-03-23 | Massachusetts Institute Of Technology | Solid phase peptide synthesis methods and associated systems |
WO2018057470A1 (en) * | 2016-09-20 | 2018-03-29 | C S Bio Co. | Rapid peptide synthesis at elevated temperatures |
US20200121870A1 (en) * | 2017-04-06 | 2020-04-23 | Mylan Inc | Low-cost single use powder inhaler |
MX2019011138A (es) | 2017-04-12 | 2020-01-27 | Magenta Therapeutics Inc | Antagonistas del receptor de hidrocarburo de arilo y sus usos. |
JP7412341B2 (ja) | 2017-10-31 | 2024-01-12 | エディジーン バイオテクノロジー インコーポレイテッド | 造血幹細胞および前駆細胞の増幅のための組成物および方法 |
CN111683669A (zh) | 2017-10-31 | 2020-09-18 | 美真达治疗公司 | 用于造血干细胞和祖细胞移植疗法的组合物和方法 |
CN107881102B (zh) * | 2017-11-23 | 2021-04-09 | 希施生物科技(上海)有限公司 | 一种用于核酸dna/rna生产型自动合成仪 |
CA3083783A1 (en) | 2017-12-06 | 2019-06-13 | Magenta Therapeutics, Inc. | Dosing regimens for the mobilization of hematopoietic stem and progenitor cells |
CA3087527A1 (en) | 2018-01-03 | 2019-07-11 | Magenta Therapeutics, Inc. | Compositions and methods for the expansion of hematopoietic stem and progenitor cells and treatment of inherited metabolic disorders |
US11267846B2 (en) | 2018-03-13 | 2022-03-08 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | High shear solid phase synthesis |
KR20210004980A (ko) * | 2018-05-04 | 2021-01-13 | 폴리펩티드 라보라토아르 프랑스 | 재순환 루프를 갖는 자동화된 합성 반응기 시스템 |
CN108752418B (zh) * | 2018-08-08 | 2024-01-30 | 湖南科技学院 | 一种多通道多肽合成反应装置及其操作方法 |
CN111072749B (zh) * | 2018-10-22 | 2023-07-07 | 海南建邦制药科技有限公司 | 多肽合成仪 |
JP6618133B1 (ja) * | 2019-04-02 | 2019-12-11 | ヤマト科学株式会社 | 固相合成装置 |
CN110111907A (zh) * | 2019-05-10 | 2019-08-09 | 苏州市海崴生物科技有限公司 | 智能数字多肽合成系统 |
CN110283229A (zh) * | 2019-07-24 | 2019-09-27 | 上海友尹化工科技有限公司 | 一种用于多肽药物的生产系统 |
US20220401481A1 (en) | 2019-11-01 | 2022-12-22 | Magenta Therapeutics, Inc. | Dosing regimens for the mobilization of hematopoietic stem and progenitor cells |
SE2050293A1 (en) | 2020-03-17 | 2021-09-18 | Peptisystems Ab | Peptide synthesis and system thereof |
WO2022197776A1 (en) | 2021-03-16 | 2022-09-22 | Magenta Therapeutics, Inc. | Dosing regimens for hematopoietic stem cell mobilization for stem cell transplants in multiple myeloma patients |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2017351C3 (de) * | 1970-04-10 | 1974-10-10 | Lkb Instrument Gmbh, 8032 Graefelfing | Verfahren und Reaktor für chemische Umsetzungen an unlöslichen Trägern mittels einer Reaktionsflüssigkeit |
US4192798A (en) * | 1978-11-20 | 1980-03-11 | Bioresearch, Inc. | Rapid, large scale, automatable high pressure peptide synthesis |
JPH03500381A (ja) * | 1988-07-25 | 1991-01-31 | スペツィアルノエ コンストルクトルスコエ ブユロ ビオロギチェスコゴ プリボロストロエニア アカデミイ ナウク エスエスエスエル | バイオポリマーの固相合成のための反応器 |
US5186824A (en) * | 1991-09-04 | 1993-02-16 | Large Scale Biology Corporation | System for solid phase reactions |
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1998
- 1998-02-10 AT AT98905049T patent/ATE225680T1/de not_active IP Right Cessation
- 1998-02-10 CZ CZ19983178A patent/CZ294838B6/cs not_active IP Right Cessation
- 1998-02-10 EP EP98905049A patent/EP0909176B1/en not_active Expired - Lifetime
- 1998-02-10 DK DK98905049T patent/DK0909176T3/da active
- 1998-02-10 IL IL12645698A patent/IL126456A/en not_active IP Right Cessation
- 1998-02-10 AU AU62763/98A patent/AU724694B2/en not_active Ceased
- 1998-02-10 CA CA002250784A patent/CA2250784C/en not_active Expired - Fee Related
- 1998-02-10 KR KR10-1998-0708194A patent/KR100463630B1/ko not_active IP Right Cessation
- 1998-02-10 WO PCT/US1998/002634 patent/WO1998034633A1/en active IP Right Grant
- 1998-02-10 HU HU9903753A patent/HU226994B1/hu not_active IP Right Cessation
- 1998-02-10 CN CNB988001268A patent/CN1171634C/zh not_active Expired - Fee Related
- 1998-02-10 US US09/155,798 patent/US6028172A/en not_active Expired - Fee Related
- 1998-02-10 NZ NZ332174A patent/NZ332174A/xx unknown
- 1998-02-10 DE DE69808579T patent/DE69808579T2/de not_active Expired - Lifetime
- 1998-02-10 JP JP10535043A patent/JP2000511934A/ja not_active Ceased
- 1998-10-02 NO NO984611A patent/NO984611L/no unknown
Also Published As
Publication number | Publication date |
---|---|
HUP9903753A2 (hu) | 2000-03-28 |
DE69808579D1 (de) | 2002-11-14 |
CN1171634C (zh) | 2004-10-20 |
NO984611D0 (no) | 1998-10-02 |
NZ332174A (en) | 1999-03-29 |
IL126456A0 (en) | 1999-08-17 |
CA2250784C (en) | 2004-04-20 |
AU6276398A (en) | 1998-08-26 |
CZ294838B6 (cs) | 2005-03-16 |
DK0909176T3 (da) | 2003-02-17 |
KR100463630B1 (ko) | 2005-05-25 |
CZ317898A3 (cs) | 1999-08-11 |
JP2000511934A (ja) | 2000-09-12 |
DE69808579T2 (de) | 2003-06-26 |
WO1998034633A1 (en) | 1998-08-13 |
HUP9903753A3 (en) | 2000-08-28 |
HU226994B1 (en) | 2010-04-28 |
AU724694B2 (en) | 2000-09-28 |
EP0909176B1 (en) | 2002-10-09 |
EP0909176A4 (en) | 2000-04-12 |
CN1215995A (zh) | 1999-05-05 |
EP0909176A1 (en) | 1999-04-21 |
KR20000064912A (ko) | 2000-11-06 |
US6028172A (en) | 2000-02-22 |
IL126456A (en) | 2001-05-20 |
ATE225680T1 (de) | 2002-10-15 |
CA2250784A1 (en) | 1998-08-13 |
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