MX2019011138A - Antagonistas del receptor de hidrocarburo de arilo y sus usos. - Google Patents
Antagonistas del receptor de hidrocarburo de arilo y sus usos.Info
- Publication number
- MX2019011138A MX2019011138A MX2019011138A MX2019011138A MX2019011138A MX 2019011138 A MX2019011138 A MX 2019011138A MX 2019011138 A MX2019011138 A MX 2019011138A MX 2019011138 A MX2019011138 A MX 2019011138A MX 2019011138 A MX2019011138 A MX 2019011138A
- Authority
- MX
- Mexico
- Prior art keywords
- receptor antagonists
- aryl hydrocarbon
- hydrocarbon receptor
- hematopoietic stem
- stem cells
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- C12N2501/999—Small molecules not provided for elsewhere
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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Abstract
La divulgación se refiere a antagonistas del receptor de hidrocarburo de arilo, tales como imidazopiridinas e imidazopirazinas sustituidas, así como métodos de expansión de células madre hematopoyéticas por cultivo de células madre o progenitoras hematopoyéticas en presencia de estos agentes. Adicionalmente, la divulgación proporciona métodos de tratamiento de diversas patologías en un paciente por administración de células madre hematopoyéticas expandidas. La divulgación también proporciona métodos de síntesis de antagonistas del receptor de hidrocarburo de arilo, tales como imidazopiridinas e imidazopirazinas sustituidas, así como kits que contienen antagonistas del receptor de hidrocarburo de arilo que se pueden usar para la expansión de células madre hematopoyéticas.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762484692P | 2017-04-12 | 2017-04-12 | |
US201862613382P | 2018-01-03 | 2018-01-03 | |
US201862625896P | 2018-02-02 | 2018-02-02 | |
PCT/US2018/027265 WO2018191476A1 (en) | 2017-04-12 | 2018-04-12 | Aryl hydrocarbon receptor antagonists and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019011138A true MX2019011138A (es) | 2020-01-27 |
Family
ID=62090081
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019011138A MX2019011138A (es) | 2017-04-12 | 2018-04-12 | Antagonistas del receptor de hidrocarburo de arilo y sus usos. |
Country Status (15)
Country | Link |
---|---|
US (4) | US10457683B2 (es) |
EP (1) | EP3609890A1 (es) |
JP (1) | JP7352807B2 (es) |
KR (1) | KR20190138837A (es) |
CN (1) | CN110785419B (es) |
AU (1) | AU2018253115B2 (es) |
BR (1) | BR112019021282A2 (es) |
CA (1) | CA3057159A1 (es) |
CO (1) | CO2019012473A2 (es) |
IL (2) | IL293956A (es) |
MX (1) | MX2019011138A (es) |
SG (1) | SG11201908624SA (es) |
TW (1) | TW201841916A (es) |
WO (1) | WO2018191476A1 (es) |
ZA (1) | ZA201906209B (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
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JP7352807B2 (ja) | 2017-04-12 | 2023-09-29 | マジェンタ セラピューティクス インコーポレイテッド | アリール炭化水素受容体アンタゴニスト及びその使用 |
EP3612030A4 (en) | 2017-04-21 | 2021-04-28 | Ikena Oncology, Inc. | AHR INDOLE INHIBITORS AND THEIR USES |
MX2020001793A (es) | 2017-08-17 | 2020-07-22 | Ikena Oncology Inc | Inhibidores del receptor de hidrocarburos de arilo (ahr) y usos de los mismos. |
CA3079405A1 (en) * | 2017-10-31 | 2019-05-09 | Magenta Therapeutics Inc. | Compositions and methods for the expansion of hematopoietic stem and progenitor cells |
WO2019136159A1 (en) * | 2018-01-03 | 2019-07-11 | Magenta Therapeutics Inc. | Compositions and methods for the expansion of hematopoietic stem and progenitor cells and treatment of inherited metabolic disorders |
US11530220B2 (en) | 2018-02-06 | 2022-12-20 | Ideaya Biosciences, Inc. | Substituted imidazo[1,5-a]pyrazines and [1,2,4]triazolo[4,3-a]pyrazines for the modulation of AhR |
AU2019359883A1 (en) * | 2018-10-17 | 2021-05-20 | Magenta Therapeutics Inc. | Methods of treating cancer with aryl hydrocarbon receptor antagonists |
EP4051298A1 (en) | 2019-11-01 | 2022-09-07 | Magenta Therapeutics, Inc. | Dosing regimens for the mobilization of hematopoietic stem and progentor cells |
CN115279764A (zh) | 2019-11-26 | 2022-11-01 | 医肯纳肿瘤学公司 | 多晶型咔唑衍生物及其用途 |
CN114369097B (zh) * | 2020-10-15 | 2023-07-14 | 山东轩竹医药科技有限公司 | 杂芳环类AhR抑制剂 |
WO2022197776A1 (en) | 2021-03-16 | 2022-09-22 | Magenta Therapeutics, Inc. | Dosing regimens for hematopoietic stem cell mobilization for stem cell transplants in multiple myeloma patients |
WO2023250431A2 (en) * | 2022-06-22 | 2023-12-28 | Children's Hospital Medical Center | Multi-cyclic irak and flt3 inhibiting compounds and uses thereof |
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2018
- 2018-04-12 JP JP2019555784A patent/JP7352807B2/ja active Active
- 2018-04-12 CA CA3057159A patent/CA3057159A1/en active Pending
- 2018-04-12 TW TW107112606A patent/TW201841916A/zh unknown
- 2018-04-12 SG SG11201908624S patent/SG11201908624SA/en unknown
- 2018-04-12 AU AU2018253115A patent/AU2018253115B2/en active Active
- 2018-04-12 CN CN201880040109.4A patent/CN110785419B/zh active Active
- 2018-04-12 MX MX2019011138A patent/MX2019011138A/es unknown
- 2018-04-12 KR KR1020197033072A patent/KR20190138837A/ko not_active Application Discontinuation
- 2018-04-12 BR BR112019021282A patent/BR112019021282A2/pt unknown
- 2018-04-12 EP EP18721236.0A patent/EP3609890A1/en active Pending
- 2018-04-12 WO PCT/US2018/027265 patent/WO2018191476A1/en unknown
- 2018-04-12 US US15/951,585 patent/US10457683B2/en active Active
- 2018-04-12 IL IL293956A patent/IL293956A/en unknown
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2019
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- 2019-11-07 CO CONC2019/0012473A patent/CO2019012473A2/es unknown
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2020
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US10351572B2 (en) | 2019-07-16 |
AU2018253115A1 (en) | 2019-10-03 |
KR20190138837A (ko) | 2019-12-16 |
SG11201908624SA (en) | 2019-10-30 |
EP3609890A1 (en) | 2020-02-19 |
US20200123161A1 (en) | 2020-04-23 |
CN110785419A (zh) | 2020-02-11 |
AU2018253115B2 (en) | 2022-08-11 |
WO2018191476A1 (en) | 2018-10-18 |
CO2019012473A2 (es) | 2020-02-18 |
US10457683B2 (en) | 2019-10-29 |
JP7352807B2 (ja) | 2023-09-29 |
CA3057159A1 (en) | 2018-10-18 |
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ZA201906209B (en) | 2024-01-31 |
IL269574A (en) | 2019-11-28 |
US20190177330A1 (en) | 2019-06-13 |
BR112019021282A2 (pt) | 2020-05-19 |
US10919900B2 (en) | 2021-02-16 |
US20210179625A1 (en) | 2021-06-17 |
IL293956A (en) | 2022-08-01 |
JP2020516639A (ja) | 2020-06-11 |
TW201841916A (zh) | 2018-12-01 |
CN110785419B (zh) | 2024-03-01 |
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