HUP9903753A2 - Reaktorrendszer és eljárás szilárd fázisú peptidszintézis végrehajtására - Google Patents

Reaktorrendszer és eljárás szilárd fázisú peptidszintézis végrehajtására

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Publication number
HUP9903753A2
HUP9903753A2 HU9903753A HUP9903753A HUP9903753A2 HU P9903753 A2 HUP9903753 A2 HU P9903753A2 HU 9903753 A HU9903753 A HU 9903753A HU P9903753 A HUP9903753 A HU P9903753A HU P9903753 A2 HUP9903753 A2 HU P9903753A2
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HU
Hungary
Prior art keywords
reactor
reactor system
main
resin bed
solvents
Prior art date
Application number
HU9903753A
Other languages
English (en)
Inventor
Michael C. Stapleton
Nicholas Stepaniuk
Keith Tomazi
Original Assignee
Mallinckrodt, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt, Inc. filed Critical Mallinckrodt, Inc.
Publication of HUP9903753A2 publication Critical patent/HUP9903753A2/hu
Publication of HUP9903753A3 publication Critical patent/HUP9903753A3/hu
Publication of HU226994B1 publication Critical patent/HU226994B1/hu

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/045—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers using devices to improve synthesis, e.g. reactors, special vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00281—Individual reactor vessels
    • B01J2219/00283—Reactor vessels with top opening
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00281—Individual reactor vessels
    • B01J2219/00295—Individual reactor vessels the reactor vessels having pervious side walls
    • B01J2219/00299—Generally cylindrical reactor vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00353—Pumps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00421—Means for dispensing and evacuation of reagents using centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00423—Means for dispensing and evacuation of reagents using filtration, e.g. through porous frits
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00457—Dispensing or evacuation of the solid phase support
    • B01J2219/00459—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00457—Dispensing or evacuation of the solid phase support
    • B01J2219/00459—Beads
    • B01J2219/00466—Beads in a slurry
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00479—Means for mixing reactants or products in the reaction vessels
    • B01J2219/00488—Means for mixing reactants or products in the reaction vessels by rotation of the reaction vessels
    • B01J2219/0049—Means for mixing reactants or products in the reaction vessels by rotation of the reaction vessels by centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/005—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/0059—Sequential processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00698—Measurement and control of process parameters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Catalysts (AREA)
  • Devices And Processes Conducted In The Presence Of Fluids And Solid Particles (AREA)

Abstract

A találmány egy szilárd fázisú peptidszintézis reaktőrrendszer (1) ésegy, a reaktőrrendszer (1) működtetését szőlgáló eljárást javasől. Areaktőrrendszer (1) magában főglal egy kősarat (17), amely egy házőn(15) belül elhelyezett tengely körül főrgatható, valamint egyfőgadó/gyűjtő tartályt (5), amely főlyadékőt szállít a reaktőrba (7),illetve főlyadékőt főgad a reaktőrból (7). A kősár (17) egy perfőráltfallal (23) rendelkezik, amelyen a peptidszintézishez szükségesgyantaágyat (R) alakítanak ki. A reaktőr (7) és a főgadó/gyűjtőtartály (5) egy áramlási kört alkőtnak, amelyen keresztül az őldatőkatkeringetik. Az őldatők keringetése megakadályőzza azt, hőgy a reaktőr(7) el legyen árasztva, és így a kősár (7) nem merül bele az őldatba,és lehetővé teszi kevesebb főlyadék használatát. Ily módőn nagyőbbaminősav-kőncentrációkat lehet alkalmazni. A módszer magában főglaljaegy egyenletes vastagságú gyantaágy (R) kialakítását a kősár (17)falán (23), és az őldatőknak a gyantaágyra (R) történő bepermetezését,miközben a kősár (17) főrőg. Az őldatők keresztülhaladnak agyantaágyőn (R), és eltávőznak a főgadó/gyűjtő tartályba (5), hőgyújból keringetésre kerüljenek a reaktőrrendszerben (1) vagy areaktőrrendszerből (1) el legyenek vezetve. Mielőtt egy sőrőnkövetkező őldatőt a reaktőrrendszerbe (1) bevezetnék, az előző őldatőta reaktőrrendszerből (1) kitisztítják, hőgy ezáltal elősegítsék apeptid őldatőkkal szermbeni expőzíciós idejének szabályőzását. ŕ
HU9903753A 1997-02-11 1998-02-10 Reactor and method for solid phase peptide synthesis HU226994B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3755797P 1997-02-11 1997-02-11
PCT/US1998/002634 WO1998034633A1 (en) 1997-02-11 1998-02-10 Reactor and method for solid phase peptide synthesis

Publications (3)

Publication Number Publication Date
HUP9903753A2 true HUP9903753A2 (hu) 2000-03-28
HUP9903753A3 HUP9903753A3 (en) 2000-08-28
HU226994B1 HU226994B1 (en) 2010-04-28

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Family Applications (1)

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HU9903753A HU226994B1 (en) 1997-02-11 1998-02-10 Reactor and method for solid phase peptide synthesis

Country Status (16)

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US (1) US6028172A (hu)
EP (1) EP0909176B1 (hu)
JP (1) JP2000511934A (hu)
KR (1) KR100463630B1 (hu)
CN (1) CN1171634C (hu)
AT (1) ATE225680T1 (hu)
AU (1) AU724694B2 (hu)
CA (1) CA2250784C (hu)
CZ (1) CZ294838B6 (hu)
DE (1) DE69808579T2 (hu)
DK (1) DK0909176T3 (hu)
HU (1) HU226994B1 (hu)
IL (1) IL126456A (hu)
NO (1) NO984611L (hu)
NZ (1) NZ332174A (hu)
WO (1) WO1998034633A1 (hu)

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US20060105391A1 (en) * 2004-11-12 2006-05-18 Promega Corporation Device and method for separating molecules
US20060105349A1 (en) * 2004-11-12 2006-05-18 Promega Corporation Device and method for purification of biological materials
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KR101014799B1 (ko) * 2008-06-05 2011-02-15 애니젠 주식회사 펩타이드 합성 제조 장치
US8308955B2 (en) * 2009-07-20 2012-11-13 Empire Technology Development Llc Carbon nanotube separation by reversible gelation
KR101227176B1 (ko) * 2010-02-05 2013-01-28 주식회사 부일켐텍 펩타이드 합성 제조장치
CN102702304B (zh) * 2012-05-11 2014-06-11 中南大学 多通路预活化装置、肽核酸制备系统及预活化和合成方法
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CN107881102B (zh) * 2017-11-23 2021-04-09 希施生物科技（上海）有限公司 一种用于核酸dna/rna生产型自动合成仪
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Also Published As

Publication number Publication date
AU724694B2 (en) 2000-09-28
IL126456A (en) 2001-05-20
HU226994B1 (en) 2010-04-28
WO1998034633A1 (en) 1998-08-13
CZ294838B6 (cs) 2005-03-16
US6028172A (en) 2000-02-22
DK0909176T3 (da) 2003-02-17
NO984611D0 (no) 1998-10-02
NO984611L (no) 1998-12-10
EP0909176A1 (en) 1999-04-21
CA2250784C (en) 2004-04-20
DE69808579T2 (de) 2003-06-26
EP0909176A4 (en) 2000-04-12
CZ317898A3 (cs) 1999-08-11
NZ332174A (en) 1999-03-29
CA2250784A1 (en) 1998-08-13
ATE225680T1 (de) 2002-10-15
KR100463630B1 (ko) 2005-05-25
AU6276398A (en) 1998-08-26
CN1215995A (zh) 1999-05-05
IL126456A0 (en) 1999-08-17
DE69808579D1 (de) 2002-11-14
CN1171634C (zh) 2004-10-20
KR20000064912A (ko) 2000-11-06
JP2000511934A (ja) 2000-09-12
HUP9903753A3 (en) 2000-08-28
EP0909176B1 (en) 2002-10-09

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