IL124522A0 - Quinoline derivatives - Google Patents
Quinoline derivativesInfo
- Publication number
- IL124522A0 IL124522A0 IL12452296A IL12452296A IL124522A0 IL 124522 A0 IL124522 A0 IL 124522A0 IL 12452296 A IL12452296 A IL 12452296A IL 12452296 A IL12452296 A IL 12452296A IL 124522 A0 IL124522 A0 IL 124522A0
- Authority
- IL
- Israel
- Prior art keywords
- quinoline derivatives
- quinoline
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
- C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT95MI002461 IT1276170B1 (it) | 1995-11-24 | 1995-11-24 | Derivati chinolinici |
| ITMI961689 IT1307331B1 (it) | 1996-08-02 | 1996-08-02 | Derivati chinolinici |
| PCT/EP1996/005203 WO1997021680A1 (en) | 1995-11-24 | 1996-11-22 | Quinoline derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL124522A0 true IL124522A0 (en) | 1998-12-06 |
Family
ID=26331326
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12452296A IL124522A0 (en) | 1995-11-24 | 1996-11-22 | Quinoline derivatives |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6277862B1 (de) |
| EP (1) | EP0876347B1 (de) |
| JP (1) | JP2000501104A (de) |
| KR (1) | KR19990071597A (de) |
| CN (1) | CN1207730A (de) |
| AP (1) | AP9801237A0 (de) |
| AR (1) | AR004972A1 (de) |
| AT (1) | ATE289994T1 (de) |
| BG (1) | BG102558A (de) |
| BR (1) | BR9611820A (de) |
| CA (1) | CA2238298A1 (de) |
| CZ (1) | CZ157998A3 (de) |
| DE (1) | DE69634416T2 (de) |
| EA (1) | EA002124B1 (de) |
| ES (1) | ES2236757T3 (de) |
| IL (1) | IL124522A0 (de) |
| MX (1) | MX9804107A (de) |
| NO (1) | NO311212B1 (de) |
| NZ (1) | NZ323387A (de) |
| OA (1) | OA11010A (de) |
| PL (1) | PL326967A1 (de) |
| SK (1) | SK66798A3 (de) |
| TR (1) | TR199800924T2 (de) |
| TW (1) | TW353066B (de) |
| UY (1) | UY24733A1 (de) |
| WO (1) | WO1997021680A1 (de) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2119155C (en) | 1991-10-18 | 1999-06-15 | Dennis Paul Phillion | Fungicides for the control of take-all disease of plants |
| SE9703407D0 (sv) * | 1997-09-19 | 1997-09-19 | Astra Ab | New use |
| SE9802073D0 (sv) | 1998-06-11 | 1998-06-11 | Astra Ab | New use |
| GB9825554D0 (en) | 1998-11-20 | 1999-01-13 | Smithkline Beecham Spa | Novel Compounds |
| US7037922B1 (en) * | 2000-03-10 | 2006-05-02 | Neurogen Corporation | Aryl fused 2,4-disubstituted pyridines: NK3 receptor ligands |
| EP1165542B1 (de) | 1999-03-29 | 2003-08-20 | Neurogen Corporation | 4-substituierte chinolinderivate als nk-3 und/oder gaba(a) rezeptor liganden |
| AU4802500A (en) | 1999-04-26 | 2000-11-10 | Neurogen Corporation | 2-aminoquinolinecarboxamides: neurokinin receptor ligands |
| ATE313539T1 (de) * | 2001-04-11 | 2006-01-15 | Glaxosmithkline Spa | Chinolin-4-carboxamidderivate als nk-3 und nk-2 rezeptor antagonisten |
| AU2002259147A1 (en) * | 2001-05-08 | 2002-11-18 | Schering Corporation | Use of neurokinin receptor antagonists to treat androgen-dependent diseases |
| KR101227626B1 (ko) | 2003-01-28 | 2013-02-01 | 아이언우드 파마슈티컬스, 인코포레이티드 | 위장병 치료 방법 및 위장병 치료용 조성물 |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| GB0303086D0 (en) | 2003-02-11 | 2003-03-19 | Merck Sharp & Dohme | New compounds |
| GB0419192D0 (en) | 2004-08-27 | 2004-09-29 | Merck Sharp & Dohme | Therapeutic agents |
| WO2006052722A1 (en) * | 2004-11-09 | 2006-05-18 | Smithkline Beecham Corporation | Glycogen phosphorylase inhibitor compounds and pharmaceutical compositions thereof |
| GB0425077D0 (en) * | 2004-11-12 | 2004-12-15 | Smithkline Beecham Corp | Novel compounds |
| GB0515580D0 (en) | 2005-07-29 | 2005-09-07 | Merck Sharp & Dohme | Therapeutic compounds |
| EP1915361A1 (de) * | 2005-08-11 | 2008-04-30 | AstraZeneca AB | Alkylpyridylchinolin als modulatoren des nk3-rezeptors |
| AR057130A1 (es) | 2005-09-21 | 2007-11-14 | Astrazeneca Ab | Quinolinas de alquilsulfoxido y una composicion farmaceutica |
| TW200804288A (en) * | 2005-12-12 | 2008-01-16 | Astrazeneca Ab | Alkylsulphonamide quinolines |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| MX354786B (es) | 2007-06-04 | 2018-03-21 | Synergy Pharmaceuticals Inc | Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos. |
| AU2008309004A1 (en) * | 2007-09-28 | 2009-04-09 | Glaxosmithkline Llc | Glycogen phosphorylase inhibitor compound and pharmaceutical composition thereof |
| AU2008309003A1 (en) * | 2007-09-28 | 2009-04-09 | Glaxosmithkline Llc | Glycogen phosphorylase inhibitor compound and pharmaceutical composition thereof |
| CA2726917C (en) | 2008-06-04 | 2018-06-26 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| EP2321341B1 (de) | 2008-07-16 | 2017-02-22 | Synergy Pharmaceuticals Inc. | Zur behandlung von erkrankungen des magen-darm-trakts, entzündlichen erkrankungen, krebs und anderen erkrankungen geeignete agonisten von guanylatcyclase |
| CA2748607A1 (en) | 2008-12-31 | 2010-07-08 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| WO2018129556A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| US10376481B2 (en) | 2012-08-21 | 2019-08-13 | Ardelyx, Inc. | Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| WO2014029983A1 (en) | 2012-08-21 | 2014-02-27 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| WO2014151200A2 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| JP2016514671A (ja) | 2013-03-15 | 2016-05-23 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼのアゴニストおよびその使用 |
| ES2735992T3 (es) | 2013-04-12 | 2019-12-23 | Ardelyx Inc | Compuestos de unión a NHE3 y procedimientos para inhibir el transporte de fosfatos |
| CA2909752A1 (en) | 2013-04-19 | 2014-10-23 | Astrazeneca Ab | A nk3 receptor antagonist compound (nk3ra) for use in a method for the treatment of polycystic ovary syndrome (pcos) |
| CN105764916B (zh) | 2013-06-05 | 2021-05-18 | 博士医疗爱尔兰有限公司 | 鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法 |
| WO2017072629A1 (en) | 2015-10-29 | 2017-05-04 | Cadila Healthcare Limited | Pharmaceutical combination of nk3 receptor antagonist and biguanides |
| JP7292207B2 (ja) | 2017-01-09 | 2023-06-16 | アルデリックス， インコーポレイテッド | 消化管障害を処置するために有用な化合物 |
| EA201991676A1 (ru) | 2017-01-09 | 2020-01-30 | Арделикс, Инк. | Ингибиторы nhe-опосредованного антипорта |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2538388B1 (fr) * | 1982-12-24 | 1985-06-21 | Pharmuka Lab | Nouveaux derives de naphtalene- ou azanaphtalenecarboxamide, leurs procedes de preparation et leur utilisation comme medicaments |
| JPS6399057A (ja) * | 1986-06-27 | 1988-04-30 | Nippon Shinyaku Co Ltd | グリシン誘導体 |
| ES2227769T3 (es) * | 1994-05-27 | 2005-04-01 | Glaxosmithkline S.P.A. | Derivados de quinolina como antagonistas del receptor nk3 de taquiquinina. |
| IT1270615B (it) * | 1994-07-14 | 1997-05-07 | Smithkline Beecham Farma | Uso di derivati di chinolina |
-
1996
- 1996-11-22 AT AT96941023T patent/ATE289994T1/de not_active IP Right Cessation
- 1996-11-22 EA EA199800477A patent/EA002124B1/ru not_active IP Right Cessation
- 1996-11-22 US US09/077,151 patent/US6277862B1/en not_active Expired - Fee Related
- 1996-11-22 KR KR1019980703873A patent/KR19990071597A/ko not_active Withdrawn
- 1996-11-22 SK SK667-98A patent/SK66798A3/sk unknown
- 1996-11-22 WO PCT/EP1996/005203 patent/WO1997021680A1/en not_active Ceased
- 1996-11-22 JP JP9521658A patent/JP2000501104A/ja active Pending
- 1996-11-22 PL PL96326967A patent/PL326967A1/xx unknown
- 1996-11-22 BR BR9611820A patent/BR9611820A/pt not_active Application Discontinuation
- 1996-11-22 NZ NZ323387A patent/NZ323387A/en unknown
- 1996-11-22 AP APAP/P/1998/001237A patent/AP9801237A0/en unknown
- 1996-11-22 CZ CZ981579A patent/CZ157998A3/cs unknown
- 1996-11-22 EP EP96941023A patent/EP0876347B1/de not_active Expired - Lifetime
- 1996-11-22 CA CA002238298A patent/CA2238298A1/en not_active Abandoned
- 1996-11-22 TR TR1998/00924T patent/TR199800924T2/xx unknown
- 1996-11-22 ES ES96941023T patent/ES2236757T3/es not_active Expired - Lifetime
- 1996-11-22 IL IL12452296A patent/IL124522A0/xx unknown
- 1996-11-22 DE DE69634416T patent/DE69634416T2/de not_active Expired - Fee Related
- 1996-11-22 CN CN96199753A patent/CN1207730A/zh active Pending
- 1996-11-23 TW TW085114500A patent/TW353066B/zh active
- 1996-11-25 AR ARP960105317A patent/AR004972A1/es not_active Application Discontinuation
-
1997
- 1997-09-30 UY UY24733A patent/UY24733A1/es not_active Application Discontinuation
-
1998
- 1998-05-22 NO NO19982331A patent/NO311212B1/no unknown
- 1998-05-22 MX MX9804107A patent/MX9804107A/es unknown
- 1998-05-22 OA OA9800061A patent/OA11010A/en unknown
- 1998-06-18 BG BG102558A patent/BG102558A/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR19990071597A (ko) | 1999-09-27 |
| DE69634416T2 (de) | 2005-12-29 |
| CZ157998A3 (cs) | 1998-12-16 |
| DE69634416D1 (de) | 2005-04-07 |
| NZ323387A (en) | 2000-02-28 |
| ES2236757T3 (es) | 2005-07-16 |
| TR199800924T2 (xx) | 1998-08-21 |
| NO982331L (no) | 1998-07-22 |
| PL326967A1 (en) | 1998-11-09 |
| AP9801237A0 (en) | 1998-06-30 |
| NO311212B1 (no) | 2001-10-29 |
| AR004972A1 (es) | 1999-04-07 |
| ATE289994T1 (de) | 2005-03-15 |
| TW353066B (en) | 1999-02-21 |
| NO982331D0 (no) | 1998-05-22 |
| EP0876347A1 (de) | 1998-11-11 |
| MX9804107A (es) | 1998-09-30 |
| OA11010A (en) | 2003-03-06 |
| CA2238298A1 (en) | 1997-06-19 |
| WO1997021680A1 (en) | 1997-06-19 |
| BG102558A (bg) | 1999-03-31 |
| EA199800477A1 (ru) | 1998-12-24 |
| JP2000501104A (ja) | 2000-02-02 |
| BR9611820A (pt) | 1999-07-13 |
| US6277862B1 (en) | 2001-08-21 |
| SK66798A3 (en) | 1999-01-11 |
| CN1207730A (zh) | 1999-02-10 |
| EP0876347B1 (de) | 2005-03-02 |
| EA002124B1 (ru) | 2001-12-24 |
| UY24733A1 (es) | 2001-08-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL124522A0 (en) | Quinoline derivatives | |
| IL113844A0 (en) | Quinoline derivatives | |
| NZ305444A (en) | 4-anilino-7-alkoxy-quinazoline derivatives | |
| IL152383A0 (en) | 5-amino-3-cyano-4-ethylsulfinyl-1- phenyl-pyrazole derivatives | |
| IL135376A0 (en) | Hydroxyalkyl-phenyl derivatives | |
| GB2306473A8 (en) | Glucoxide derivatives | |
| HU9603071D0 (en) | Purin-6-one derivatives | |
| HU9600876D0 (en) | Benzonitril- and -fluoride derivatives | |
| ZA977326B (en) | Tetrahydroquinoline derivatives | |
| ZA969812B (en) | Novel quinoline derivatives. | |
| HUP9600107A3 (en) | 9-substituted-2-(2-n-alkoxy-phenyl)-purin-6-one derivatives | |
| NZ332395A (en) | Benzonthiazole derivatives | |
| HUP9900672A3 (en) | Pyrroloazepine derivatives | |
| SI0758644T1 (en) | Sulfonyl- or sulfinyl-benzoyl-guanidine derivatives | |
| SG60005A1 (en) | 1-Fluorocyclohexene-difluorophenyl derivatives | |
| IL123621A0 (en) | Diarylalkenylamine derivatives | |
| GB9404378D0 (en) | Quinoline derivatives | |
| GR3035577T3 (en) | Benzisothiazolyl-substituted aminomethylchroman derivatives | |
| IL117858A0 (en) | 4-Indolypiperazinyl derivatives | |
| ZA954269B (en) | Quinoline derivatives | |
| GR3036572T3 (en) | 4-amino-benzoylguanidine derivatives | |
| GB9402275D0 (en) | Quinoline derivatives | |
| GB9413150D0 (en) | Quinoline derivatives | |
| HU9602324D0 (en) | Piperidinyl-methyl-oxazolidinon derivatives | |
| EP0754668A3 (de) | Fluorbenzylether-Derivate |