IL123155A0 - 4-mercaptopyrrolidine derivatives as farnesyl transferase inhibitors - Google Patents

4-mercaptopyrrolidine derivatives as farnesyl transferase inhibitors

Info

Publication number
IL123155A0
IL123155A0 IL12315596A IL12315596A IL123155A0 IL 123155 A0 IL123155 A0 IL 123155A0 IL 12315596 A IL12315596 A IL 12315596A IL 12315596 A IL12315596 A IL 12315596A IL 123155 A0 IL123155 A0 IL 123155A0
Authority
IL
Israel
Prior art keywords
transferase inhibitors
farnesyl transferase
mercaptopyrrolidine
derivatives
mercaptopyrrolidine derivatives
Prior art date
Application number
IL12315596A
Other languages
English (en)
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of IL123155A0 publication Critical patent/IL123155A0/xx
Priority to IL14825302A priority Critical patent/IL148253A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL12315596A 1995-08-04 1996-07-30 4-mercaptopyrrolidine derivatives as farnesyl transferase inhibitors IL123155A0 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL14825302A IL148253A0 (en) 1995-08-04 2002-02-19 Process for the preparation of 4-sulfanylpyrrolidin-2-yl

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9515975.2A GB9515975D0 (en) 1995-08-04 1995-08-04 Chemical compounds
PCT/GB1996/001810 WO1997006138A1 (fr) 1995-08-04 1996-07-30 Derives de 4-mercaptopyrrolidine en tant qu'inhibiteurs de farnesyle transferase

Publications (1)

Publication Number Publication Date
IL123155A0 true IL123155A0 (en) 1998-09-24

Family

ID=10778742

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12315596A IL123155A0 (en) 1995-08-04 1996-07-30 4-mercaptopyrrolidine derivatives as farnesyl transferase inhibitors

Country Status (23)

Country Link
US (2) US6232338B1 (fr)
EP (1) EP0842151A1 (fr)
JP (1) JPH11510178A (fr)
KR (1) KR100502770B1 (fr)
CN (2) CN1101380C (fr)
AU (1) AU720353B2 (fr)
BR (1) BR9609701A (fr)
CA (1) CA2226671C (fr)
CZ (1) CZ293694B6 (fr)
GB (1) GB9515975D0 (fr)
HU (1) HUP9802857A3 (fr)
IL (1) IL123155A0 (fr)
MX (1) MX9800946A (fr)
MY (1) MY141457A (fr)
NO (2) NO316624B1 (fr)
NZ (1) NZ313696A (fr)
PL (1) PL190873B1 (fr)
RU (1) RU2191773C2 (fr)
SK (1) SK14598A3 (fr)
TR (2) TR199800147T1 (fr)
TW (1) TW345575B (fr)
WO (1) WO1997006138A1 (fr)
ZA (1) ZA966610B (fr)

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US6310095B1 (en) 1995-11-06 2001-10-30 University Of Pittsburgh Inhibitors of protein isoprenyl transferases
US6693123B2 (en) 1995-11-06 2004-02-17 University Of Pittsburgh Inhibitors of protein isoprenyl transferases
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EP0986384B1 (fr) 1997-05-07 2012-02-22 University Of Pittsburgh Inhibiteurs de proteines isoprenyle transferases
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Also Published As

Publication number Publication date
NO20024950D0 (no) 2002-10-15
CA2226671C (fr) 2005-04-05
MY141457A (en) 2010-04-30
TW345575B (en) 1998-11-21
KR19990036110A (ko) 1999-05-25
US6232338B1 (en) 2001-05-15
WO1997006138A1 (fr) 1997-02-20
GB9515975D0 (en) 1995-10-04
NO980467L (no) 1998-04-03
PL190873B1 (pl) 2006-02-28
PL324819A1 (en) 1998-06-22
CN1101380C (zh) 2003-02-12
RU2191773C2 (ru) 2002-10-27
NO20024950L (no) 1998-04-03
CZ293694B6 (cs) 2004-07-14
TR200101884T2 (tr) 2002-06-21
KR100502770B1 (ko) 2007-03-15
ZA966610B (en) 1997-02-04
HUP9802857A3 (en) 1999-05-28
CZ30998A3 (cs) 1998-06-17
AU6622396A (en) 1997-03-05
NO980467D0 (no) 1998-02-03
CN1377647A (zh) 2002-11-06
NZ313696A (en) 2000-01-28
US6541491B1 (en) 2003-04-01
HUP9802857A2 (hu) 1999-04-28
SK14598A3 (en) 1998-09-09
MX9800946A (es) 1998-04-30
EP0842151A1 (fr) 1998-05-20
CN1197453A (zh) 1998-10-28
JPH11510178A (ja) 1999-09-07
CA2226671A1 (fr) 1997-02-20
TR199800147T1 (xx) 1998-04-21
NO316624B1 (no) 2004-03-15
AU720353B2 (en) 2000-06-01
BR9609701A (pt) 1999-03-23

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