MX9800946A - Derivados de 4-mercaptopirrolidina como inhibidores de farnesil trasnferasa. - Google Patents
Derivados de 4-mercaptopirrolidina como inhibidores de farnesil trasnferasa.Info
- Publication number
- MX9800946A MX9800946A MX9800946A MX9800946A MX9800946A MX 9800946 A MX9800946 A MX 9800946A MX 9800946 A MX9800946 A MX 9800946A MX 9800946 A MX9800946 A MX 9800946A MX 9800946 A MX9800946 A MX 9800946A
- Authority
- MX
- Mexico
- Prior art keywords
- values
- transferase inhibitors
- farnesyl transferase
- heteroatoms
- pharmaceutically acceptable
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Se describen composiciones farmacéuticas que comprende un inhibidor de farnesilacion de ras de la Formula I, en donde R1 es, por ejemplo H, y otros valores segun definidos en la especificacion; R2 es, por ejemplo H, y otros valores definidos en la especificacion; R3 es, por ejemplo H, o un sustituyente que tiene valores definidos en la especificacion; p es 0-3 en donde los valores de R3 pueden ser iguales o diferentes; L es una porcion de union por ejemplo, CO-NH2- y otros valores segun definidos en la especificacion; A se selecciona de fenilo; naftilo; un anillo heteroarilo monocíclico o bicíclico de 5 a 10 miembros que contiene hasta 5 átomos heterogéneos, en donde los átomos heterogéneos independientemente se selecciona de O, N y S; o un dímero -S-S del mismo, cuando R2=H; o un enantiomero, diaestereoisomero, una sal farmacéuticamente aceptable, profármaco o solvato del mismo junto con un diluyente o vehículo farmacéuticamente aceptable. Un vaso particular es en la terapia del cáncer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9515975.2A GB9515975D0 (en) | 1995-08-04 | 1995-08-04 | Chemical compounds |
PCT/GB1996/001810 WO1997006138A1 (en) | 1995-08-04 | 1996-07-30 | 4-mercaptopyrrolidine derivatives as farnesyl transferase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9800946A true MX9800946A (es) | 1998-04-30 |
Family
ID=10778742
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9800946A MX9800946A (es) | 1995-08-04 | 1996-07-30 | Derivados de 4-mercaptopirrolidina como inhibidores de farnesil trasnferasa. |
Country Status (23)
Country | Link |
---|---|
US (2) | US6232338B1 (es) |
EP (1) | EP0842151A1 (es) |
JP (1) | JPH11510178A (es) |
KR (1) | KR100502770B1 (es) |
CN (2) | CN1101380C (es) |
AU (1) | AU720353B2 (es) |
BR (1) | BR9609701A (es) |
CA (1) | CA2226671C (es) |
CZ (1) | CZ293694B6 (es) |
GB (1) | GB9515975D0 (es) |
HU (1) | HUP9802857A3 (es) |
IL (1) | IL123155A0 (es) |
MX (1) | MX9800946A (es) |
MY (1) | MY141457A (es) |
NO (2) | NO316624B1 (es) |
NZ (1) | NZ313696A (es) |
PL (1) | PL190873B1 (es) |
RU (1) | RU2191773C2 (es) |
SK (1) | SK14598A3 (es) |
TR (2) | TR199800147T1 (es) |
TW (1) | TW345575B (es) |
WO (1) | WO1997006138A1 (es) |
ZA (1) | ZA966610B (es) |
Families Citing this family (60)
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US6310095B1 (en) | 1995-11-06 | 2001-10-30 | University Of Pittsburgh | Inhibitors of protein isoprenyl transferases |
US6204293B1 (en) | 1995-11-06 | 2001-03-20 | University Of Pittsburgh | Inhibitors of protein isoprenyl transferases |
US6693123B2 (en) | 1995-11-06 | 2004-02-17 | University Of Pittsburgh | Inhibitors of protein isoprenyl transferases |
US6221865B1 (en) | 1995-11-06 | 2001-04-24 | University Of Pittsburgh | Inhibitors of protein isoprenyl transferases |
WO1998007692A1 (en) * | 1996-08-17 | 1998-02-26 | Zeneca Limited | 3-mercaptopyrrolidines as farnesyl protein transferase inhibitors |
CA2288330C (en) | 1997-05-07 | 2014-02-11 | University Of Pittsburgh | Benzoyl amino acid derivatives useful as inhibitors of protein isoprenyl tranferases |
JP2001520222A (ja) | 1997-10-22 | 2001-10-30 | ゼネカ・リミテッド | イミダゾール誘導体およびファルネシルタンパク質トランスフェラーゼインヒビターとしてのそれらの使用 |
DK1025088T3 (da) | 1997-10-22 | 2001-11-12 | Astrazeneca Ab | Imidazolderivater og deres anvendelse som farnesylproteintransferaseinhibitorer |
WO1999041235A1 (en) * | 1998-02-10 | 1999-08-19 | Astrazeneca Uk Limited | Farnesyl transferase inhibitors |
GB9930317D0 (en) * | 1999-12-22 | 2000-02-09 | Zeneca Ltd | Novel compounds |
GB9930318D0 (en) | 1999-12-22 | 2000-02-09 | Zeneca Ltd | Novel compounds |
US6924276B2 (en) | 2001-09-10 | 2005-08-02 | Warner-Lambert Company | Diacid-substituted heteroaryl derivatives as matrix metalloproteinase inhibitors |
ITRM20020016A1 (it) * | 2002-01-15 | 2003-07-15 | Sigma Tau Ind Farmaceuti | Derivati di acidi fenil(alchil)carbossilici e derivati fenilalchileterociclici dionici, loro uso come medicamenti ad attivita' ipoglicemizza |
US7132100B2 (en) | 2002-06-14 | 2006-11-07 | Medimmune, Inc. | Stabilized liquid anti-RSV antibody formulations |
US7425618B2 (en) | 2002-06-14 | 2008-09-16 | Medimmune, Inc. | Stabilized anti-respiratory syncytial virus (RSV) antibody formulations |
EP1539234A4 (en) * | 2002-09-05 | 2006-02-15 | Medimmune Inc | METHODS OF PREVENTING OR TREATING CELLULAR MALIGNITES BY ADMINISTERING CD2 ANTAGONISTS |
US8034831B2 (en) * | 2002-11-06 | 2011-10-11 | Celgene Corporation | Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies |
US7563810B2 (en) * | 2002-11-06 | 2009-07-21 | Celgene Corporation | Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases |
EP2316487B1 (en) | 2003-04-11 | 2014-06-11 | MedImmune, LLC | Recombinant IL-9 antibodies & uses thereof |
JP4934426B2 (ja) | 2003-08-18 | 2012-05-16 | メディミューン,エルエルシー | 抗体のヒト化 |
US20060228350A1 (en) * | 2003-08-18 | 2006-10-12 | Medimmune, Inc. | Framework-shuffling of antibodies |
EP1667991B1 (en) | 2003-09-16 | 2008-05-14 | Astrazeneca AB | Quinazoline derivatives as tyrosine kinase inhibitors |
WO2005089515A2 (en) * | 2004-03-18 | 2005-09-29 | The Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies |
WO2005089502A2 (en) * | 2004-03-18 | 2005-09-29 | The Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies |
WO2005089504A2 (en) * | 2004-03-18 | 2005-09-29 | The Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies |
US20070293539A1 (en) * | 2004-03-18 | 2007-12-20 | Lansbury Peter T | Methods for the treatment of synucleinopathies |
WO2005089496A2 (en) * | 2004-03-18 | 2005-09-29 | The Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies |
EP2422811A2 (en) | 2004-10-27 | 2012-02-29 | MedImmune, LLC | Modulation of antibody specificity by tailoring the affinity to cognate antigens |
JP5153613B2 (ja) | 2005-03-18 | 2013-02-27 | メディミューン,エルエルシー | 抗体のフレームワーク・シャッフル |
KR20080025174A (ko) | 2005-06-23 | 2008-03-19 | 메디뮨 인코포레이티드 | 응집 및 단편화 프로파일이 최적화된 항체 제제 |
WO2007092285A2 (en) * | 2006-02-02 | 2007-08-16 | Link Medicine Corporation | Treatment of synucleinopathies |
JP5209625B2 (ja) | 2006-08-28 | 2013-06-12 | 協和発酵キリン株式会社 | アンタゴニストのヒトlight特異的ヒトモノクローナル抗体 |
AU2008232902B2 (en) | 2007-03-30 | 2013-10-03 | Medlmmune, Llc | Antibody formulation |
CN101376656A (zh) * | 2007-08-30 | 2009-03-04 | 山东轩竹医药科技有限公司 | 培南衍生物 |
KR101686247B1 (ko) | 2007-10-31 | 2016-12-14 | 메디뮨 엘엘씨 | 단백질 스캐폴드 |
US8232402B2 (en) * | 2008-03-12 | 2012-07-31 | Link Medicine Corporation | Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications |
EP2370436A1 (en) * | 2008-11-13 | 2011-10-05 | Link Medicine Corporation | Azaquinolinone derivatives and uses thereof |
US20110060005A1 (en) * | 2008-11-13 | 2011-03-10 | Link Medicine Corporation | Treatment of mitochondrial disorders using a farnesyl transferase inhibitor |
US20100331363A1 (en) * | 2008-11-13 | 2010-12-30 | Link Medicine Corporation | Treatment of mitochondrial disorders using a farnesyl transferase inhibitor |
JP2012520884A (ja) | 2009-03-18 | 2012-09-10 | ザ ボード オブ トラスティーズ オブ ザ リランド スタンフォード ジュニア ユニバーシティー | フラビウイルス科ウイルス感染症を治療する方法および組成物 |
DK2668210T3 (da) | 2011-01-26 | 2020-08-24 | Celldex Therapeutics Inc | Anti-kit antistoffer og anvendelser deraf |
US9250552B2 (en) * | 2011-03-30 | 2016-02-02 | Canon Kabushiki Kaisha | Polymerizable monomer, polymeric compound, charge control agent containing the polymeric compound, and developer bearing member and toner which contain the charge control agent |
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CA2887129A1 (en) | 2012-10-09 | 2014-04-17 | Igenica, Inc. | Anti-c16orf54 antibodies and methods of use thereof |
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DK3041507T3 (da) | 2013-08-26 | 2021-07-26 | Biontech Res And Development Inc | Nukleinsyrer, der koder for humane antistoffer mod sialyl-lewis a |
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KR102614642B1 (ko) | 2014-06-04 | 2023-12-19 | 바이오엔테크 리서치 앤드 디벨롭먼트 인코포레이티드 | 강글리오사이드 gd2에 대한 사람 단클론 항체 |
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EP3319938B1 (en) * | 2015-07-10 | 2022-04-06 | University of Maryland, Baltimore | Small molecule inhibitors of the mcl-1 oncoprotein and uses thereof |
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1995
- 1995-08-04 GB GBGB9515975.2A patent/GB9515975D0/en active Pending
-
1996
- 1996-07-23 TW TW085108987A patent/TW345575B/zh active
- 1996-07-30 PL PL324819A patent/PL190873B1/pl not_active IP Right Cessation
- 1996-07-30 TR TR1998/00147T patent/TR199800147T1/xx unknown
- 1996-07-30 IL IL12315596A patent/IL123155A0/xx not_active IP Right Cessation
- 1996-07-30 RU RU98103393/04A patent/RU2191773C2/ru not_active IP Right Cessation
- 1996-07-30 SK SK145-98A patent/SK14598A3/sk unknown
- 1996-07-30 AU AU66223/96A patent/AU720353B2/en not_active Ceased
- 1996-07-30 KR KR1019980700778A patent/KR100502770B1/ko not_active IP Right Cessation
- 1996-07-30 NZ NZ313696A patent/NZ313696A/xx unknown
- 1996-07-30 WO PCT/GB1996/001810 patent/WO1997006138A1/en not_active Application Discontinuation
- 1996-07-30 JP JP9508201A patent/JPH11510178A/ja not_active Ceased
- 1996-07-30 CA CA002226671A patent/CA2226671C/en not_active Expired - Fee Related
- 1996-07-30 CZ CZ1998309A patent/CZ293694B6/cs not_active IP Right Cessation
- 1996-07-30 MX MX9800946A patent/MX9800946A/es not_active IP Right Cessation
- 1996-07-30 US US09/011,135 patent/US6232338B1/en not_active Expired - Fee Related
- 1996-07-30 BR BR9609701A patent/BR9609701A/pt not_active Application Discontinuation
- 1996-07-30 TR TR2001/01884T patent/TR200101884T2/xx unknown
- 1996-07-30 EP EP96925855A patent/EP0842151A1/en not_active Withdrawn
- 1996-07-30 HU HU9802857A patent/HUP9802857A3/hu unknown
- 1996-07-30 CN CN96197206A patent/CN1101380C/zh not_active Expired - Fee Related
- 1996-08-02 ZA ZA9606610A patent/ZA966610B/xx unknown
- 1996-08-02 MY MYPI96003186A patent/MY141457A/en unknown
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1998
- 1998-02-03 NO NO19980467A patent/NO316624B1/no unknown
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2000
- 2000-11-30 US US09/725,964 patent/US6541491B1/en not_active Expired - Fee Related
-
2002
- 2002-03-26 CN CN02108502A patent/CN1377647A/zh active Pending
- 2002-10-15 NO NO20024950A patent/NO20024950D0/no not_active Application Discontinuation
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