EP0862435A4 - Inhibiteurs de la farnesyl-proteine transferase - Google Patents
Inhibiteurs de la farnesyl-proteine transferaseInfo
- Publication number
- EP0862435A4 EP0862435A4 EP96942798A EP96942798A EP0862435A4 EP 0862435 A4 EP0862435 A4 EP 0862435A4 EP 96942798 A EP96942798 A EP 96942798A EP 96942798 A EP96942798 A EP 96942798A EP 0862435 A4 EP0862435 A4 EP 0862435A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- farnesyl
- inhibitors
- protein transferase
- transferase
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D233/24—Radicals substituted by nitrogen atoms not forming part of a nitro radical
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Virology (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US749895P | 1995-11-22 | 1995-11-22 | |
US7498P | 1995-11-22 | ||
GB9604311 | 1996-02-29 | ||
GBGB9604311.2A GB9604311D0 (en) | 1996-02-29 | 1996-02-29 | Inhibitors of farnesyl-protein transferase |
PCT/US1996/018811 WO1997018813A1 (fr) | 1995-11-22 | 1996-11-18 | Inhibiteurs de la farnesyl-proteine transferase |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0862435A1 EP0862435A1 (fr) | 1998-09-09 |
EP0862435A4 true EP0862435A4 (fr) | 1999-02-03 |
Family
ID=26308829
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP96942798A Withdrawn EP0862435A4 (fr) | 1995-11-22 | 1996-11-18 | Inhibiteurs de la farnesyl-proteine transferase |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0862435A4 (fr) |
JP (1) | JP2000500502A (fr) |
AU (1) | AU704139B2 (fr) |
CA (1) | CA2238081A1 (fr) |
WO (1) | WO1997018813A1 (fr) |
Families Citing this family (86)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997027752A1 (fr) * | 1996-01-30 | 1997-08-07 | Merck & Co., Inc. | Inhibiteurs de la farnesyl-proteine transferase |
US5891889A (en) * | 1996-04-03 | 1999-04-06 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
WO1997038665A2 (fr) * | 1996-04-03 | 1997-10-23 | Merck & Co., Inc. | Inhibiteurs de la farnesyl-proteine transferase |
US6117641A (en) | 1996-04-11 | 2000-09-12 | Mitotix, Inc. | Assays and reagents for identifying anti-fungal agents and uses related thereto |
US6727082B1 (en) | 1996-04-11 | 2004-04-27 | Gpc Biotech Inc. | Assays and reagents for identifying anti-fungal agents, and uses related thereto |
JP2001513622A (ja) | 1996-04-11 | 2001-09-04 | マイトティックス インコーポレーテッド | 抗菌剤の同定のためのアッセイおよび試薬、並びにそれらに関連する利用 |
US5965570A (en) * | 1996-09-13 | 1999-10-12 | Schering Corporation | Tricyclic piperidinyl compounds useful as inhibitors of farnesyl-protein transferase |
US5972966A (en) * | 1996-12-05 | 1999-10-26 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
US5932590A (en) * | 1996-12-05 | 1999-08-03 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
US6015817A (en) * | 1996-12-05 | 2000-01-18 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
US5977134A (en) * | 1996-12-05 | 1999-11-02 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
US5958940A (en) * | 1997-09-11 | 1999-09-28 | Schering Corporation | Tricyclic compounds useful as inhibitors of farnesyl-protein transferase |
CA2311921A1 (fr) * | 1997-12-04 | 1999-06-10 | Merck & Co., Inc. | Inhibiteurs de la transferase de la farnesyl-proteine |
FR2780892B1 (fr) * | 1998-07-08 | 2001-08-17 | Sod Conseils Rech Applic | Utilisation d'inhibiteurs de prenyltransferases pour preparer un medicament destine a traiter les pathologies qui resultent de la fixation membranaire de la proteine g heterotrimerique |
US6432959B1 (en) | 1998-12-23 | 2002-08-13 | Schering Corporation | Inhibitors of farnesyl-protein transferase |
FR2788274B1 (fr) * | 1999-01-11 | 2001-02-09 | Aventis Pharma Sa | Nouveaux derives de polyhydroxypyrazines, leur preparation et les compositions pharmaceutiques qui les contiennent |
US6635661B2 (en) | 2000-05-25 | 2003-10-21 | Sepracor Inc. | Heterocyclic analgesic compounds and methods of use thereof |
US7361666B2 (en) | 1999-05-25 | 2008-04-22 | Sepracor, Inc. | Heterocyclic analgesic compounds and methods of use thereof |
US6677332B1 (en) | 1999-05-25 | 2004-01-13 | Sepracor, Inc. | Heterocyclic analgesic compounds and methods of use thereof |
WO2001068604A2 (fr) | 2000-03-14 | 2001-09-20 | Sepracor, Inc. | Piperidines 3-substituees comprenant un groupement uree et procedes d'utilisation de ces dernieres |
WO2001092226A1 (fr) * | 2000-05-25 | 2001-12-06 | Sepracor, Inc. | Composes analgesiques heterocycliques et technique d'utilisation de ceux-ci |
EP1296978A2 (fr) | 2000-06-30 | 2003-04-02 | Bristol-Myers Squibb Company | N-ureidoheterocycloaklyl-piperidines utilises comme modulateurs de l'activite du recepteur de la chimiokine |
KR100432577B1 (ko) | 2002-02-08 | 2004-05-24 | 주식회사유한양행 | 이미다졸 유도체의 제조방법 |
US6924285B2 (en) | 2002-03-30 | 2005-08-02 | Boehringer Ingelheim Pharma Gmbh & Co. | Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them |
MXPA05013960A (es) | 2003-06-17 | 2006-02-24 | Pfizer | Nuevos compuestos. |
GB0317665D0 (en) | 2003-07-29 | 2003-09-03 | Astrazeneca Ab | Qinazoline derivatives |
SI1667991T1 (sl) | 2003-09-16 | 2008-10-31 | Astrazeneca Ab | Kinazolinski derivati kot inhibitorji tirozin kinaze |
EP1888050B1 (fr) | 2005-05-17 | 2012-03-21 | Merck Sharp & Dohme Ltd. | Acide cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl) cyclohexanepropanoique pour le traitement du cancer |
US8129411B2 (en) | 2005-12-30 | 2012-03-06 | Novartis Ag | Organic compounds |
GB0603041D0 (en) | 2006-02-15 | 2006-03-29 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
WO2008039327A2 (fr) | 2006-09-22 | 2008-04-03 | Merck & Co., Inc. | Procédé de traitement utilisant des inhibiteurs de synthèse d'acide gras |
US20110218176A1 (en) | 2006-11-01 | 2011-09-08 | Barbara Brooke Jennings-Spring | Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development |
EP1921070A1 (fr) | 2006-11-10 | 2008-05-14 | Boehringer Ingelheim Pharma GmbH & Co. KG | heterocycles bicycliques, medicaments á base de ces composes, leur usage et procédé pour leur preparation |
MX2009007200A (es) | 2007-01-10 | 2009-07-15 | Angeletti P Ist Richerche Bio | Indazoles sustituidos con amida como inhibidores de poli(adp-ribosa)polimerasa (parp). |
WO2008093737A1 (fr) | 2007-01-31 | 2008-08-07 | Dainippon Sumitomo Pharma Co., Ltd. | Dérivé d'amide |
JP5377332B2 (ja) | 2007-02-06 | 2013-12-25 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 二環式へテロ環、それらの化合物を含む薬剤、その使用及びその製法 |
EP2132177B1 (fr) | 2007-03-01 | 2013-07-17 | Novartis AG | Inhibiteurs de pim kinase et procédés de leur utilisation |
EP2152700B1 (fr) | 2007-05-21 | 2013-12-11 | Novartis AG | Inhibiteurs du csf-1r, compositions et procédés d'utilisation |
BRPI0813900A2 (pt) | 2007-06-25 | 2014-12-30 | Novartis Ag | Derivados de n5-(2-etoxietil)-n3-(2-piridinil)-3,5-piperidinodicarboxa mida para uso como inibidores de renina |
AU2008269154B2 (en) | 2007-06-27 | 2014-06-12 | Merck Sharp & Dohme Llc | 4-carboxybenzylamino derivatives as histone deacetylase inhibitors |
PL2245026T3 (pl) | 2008-02-07 | 2013-01-31 | Boehringer Ingelheim Int | Spirocykliczne heterocykle, leki zawierające te związki, ich zastosowanie i sposób ich produkcji |
ES2444128T3 (es) | 2008-05-13 | 2014-02-24 | Astrazeneca Ab | Nueva SAL-554 |
CA2733153C (fr) | 2008-08-08 | 2016-11-08 | Boehringer Ingelheim International Gmbh | Heterocycles a substitution cyclohexyloxy, medicaments contenant ces composes, leur utilisation et procedes pour les preparer |
WO2010114780A1 (fr) | 2009-04-01 | 2010-10-07 | Merck Sharp & Dohme Corp. | Inhibiteurs de l'activité akt |
JP6073677B2 (ja) | 2009-06-12 | 2017-02-01 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | 縮合複素環式化合物およびそれらの使用 |
US8658639B2 (en) | 2009-06-24 | 2014-02-25 | Dainippon Sumitomo Pharma Co., Ltd | N-substituted-cyclic amino derivative |
EA023838B1 (ru) | 2009-10-14 | 2016-07-29 | Мерк Шарп Энд Домэ Корп. | ЗАМЕЩЕННЫЕ ПИПЕРИДИНЫ, КОТОРЫЕ ПОВЫШАЮТ АКТИВНОСТЬ p53, И ИХ ПРИМЕНЕНИЕ |
US9180127B2 (en) | 2009-12-29 | 2015-11-10 | Dana-Farber Cancer Institute, Inc. | Type II Raf kinase inhibitors |
CA2791613A1 (fr) | 2010-03-16 | 2011-09-22 | Dana-Farber Cancer Institute, Inc. | Composes d'indazole et leurs utilisations |
EP2584903B1 (fr) | 2010-06-24 | 2018-10-24 | Merck Sharp & Dohme Corp. | Nouveaux composés hétérocycliques utilisés comme inhibiteurs de erk |
WO2012018754A2 (fr) | 2010-08-02 | 2012-02-09 | Merck Sharp & Dohme Corp. | Inhibition à médiation par interférence arn de caténine (protéine associée à cadhérine), expression du gène bêta 1 (ctnnb1) à l'aide de petit acide nucléique interférent (sian) |
CA2807307C (fr) | 2010-08-17 | 2021-02-09 | Merck Sharp & Dohme Corp. | Inhibition mediee par des arn interferents de l'expression genique du virus de l'hepatite b (vhb) a l'aide de petits acides nucleiques interferents (pani) |
EP2608669B1 (fr) | 2010-08-23 | 2016-06-22 | Merck Sharp & Dohme Corp. | Nouveaux dérivés de pyrazolo[1,5-a]pyrimidine utilisés comme inhibiteurs de mtor |
US8946216B2 (en) | 2010-09-01 | 2015-02-03 | Merck Sharp & Dohme Corp. | Indazole derivatives useful as ERK inhibitors |
EP2615916B1 (fr) | 2010-09-16 | 2017-01-04 | Merck Sharp & Dohme Corp. | Dérivés condensés de pyrazole utilisés comme nouveaux inhibiteurs erk |
US9260471B2 (en) | 2010-10-29 | 2016-02-16 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA) |
EP2654748B1 (fr) | 2010-12-21 | 2016-07-27 | Merck Sharp & Dohme Corp. | Dérivés d'indazole utiles en tant qu'inhibiteurs de erk |
AU2012245971A1 (en) | 2011-04-21 | 2013-10-17 | Piramal Enterprises Limited | A crystalline form of a salt of a morpholino sulfonyl indole derivative and a process for its preparation |
US9023865B2 (en) | 2011-10-27 | 2015-05-05 | Merck Sharp & Dohme Corp. | Compounds that are ERK inhibitors |
AU2012340200B2 (en) | 2011-11-17 | 2017-10-12 | Dana-Farber Cancer Institute, Inc. | Inhibitors of c-Jun-N-Terminal Kinase (JNK) |
EP3453762B1 (fr) | 2012-05-02 | 2021-04-21 | Sirna Therapeutics, Inc. | Compositions d'acide nucléique interférent court (sina) |
JP6280554B2 (ja) | 2012-09-28 | 2018-02-14 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | Erk阻害剤である新規化合物 |
WO2014063068A1 (fr) | 2012-10-18 | 2014-04-24 | Dana-Farber Cancer Institute, Inc. | Inhibiteurs de cycline-dépendante kinase 7 (cdk7) |
WO2014063054A1 (fr) | 2012-10-19 | 2014-04-24 | Dana-Farber Cancer Institute, Inc. | Inhibiteurs de kinase moelle osseuse sur chromosome x (bmx) et leurs utilisations |
WO2014063061A1 (fr) | 2012-10-19 | 2014-04-24 | Dana-Farber Cancer Institute, Inc. | Petites molécules marquées de façon hydrophobe en tant qu'inducteurs de la dégradation de protéine |
ME02925B (fr) | 2012-11-28 | 2018-04-20 | Merck Sharp & Dohme | Compositions et procédés pour traiter le cancer |
TW201429969A (zh) | 2012-12-20 | 2014-08-01 | Merck Sharp & Dohme | 作爲hdm2抑制劑之經取代咪唑吡啶 |
EP2951180B1 (fr) | 2013-01-30 | 2018-05-02 | Merck Sharp & Dohme Corp. | Purines 2,6,7,8-substituées utilisées en tant qu'inhibiteurs de hdm2 |
CN112500338A (zh) | 2013-03-15 | 2021-03-16 | 全球血液疗法股份有限公司 | 化合物及其用于调节血红蛋白的用途 |
US20160194368A1 (en) | 2013-09-03 | 2016-07-07 | Moderna Therapeutics, Inc. | Circular polynucleotides |
ES2676734T3 (es) | 2013-10-18 | 2018-07-24 | Syros Pharmaceuticals, Inc. | Compuestos heteroatómicos útiles para el tratamiento de enfermedades proliferativas |
JP6491202B2 (ja) | 2013-10-18 | 2019-03-27 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | サイクリン依存性キナーゼ7(cdk7)の多環阻害剤 |
EA201992707A1 (ru) | 2013-11-18 | 2020-06-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
WO2015164604A1 (fr) | 2014-04-23 | 2015-10-29 | Dana-Farber Cancer Institute, Inc. | Inhibiteurs de janus kinase marqués de manière hydrophobe et utilisations associées |
WO2015164614A1 (fr) | 2014-04-23 | 2015-10-29 | Dana-Farber Cancer Institute, Inc. | Inhibiteurs de janus kinase et leurs utilisations |
JO3589B1 (ar) | 2014-08-06 | 2020-07-05 | Novartis Ag | مثبطات كيناز البروتين c وطرق استخداماتها |
EP3236959A4 (fr) | 2014-12-23 | 2018-04-25 | Dana Farber Cancer Institute, Inc. | Inhibiteurs de la kinase cycline-dépendante 7 (cdk7) |
CA2978518C (fr) | 2015-03-27 | 2023-11-21 | Nathanael S. Gray | Inhibiteurs de kinases cycline-dependantes |
AU2016276963C1 (en) | 2015-06-12 | 2021-08-05 | Dana-Farber Cancer Institute, Inc. | Combination therapy of transcription inhibitors and kinase inhibitors |
CA2996978A1 (fr) | 2015-09-09 | 2017-03-16 | Dana-Farber Cancer Institute, Inc. | Inhibiteurs de kinases cycline-dependantes |
JOP20190055A1 (ar) | 2016-09-26 | 2019-03-24 | Merck Sharp & Dohme | أجسام مضادة ضد cd27 |
EP3609922A2 (fr) | 2017-04-13 | 2020-02-19 | Aduro Biotech Holdings, Europe B.V. | Anticorps anti-sirp alpha |
WO2019094311A1 (fr) | 2017-11-08 | 2019-05-16 | Merck Sharp & Dohme Corp. | Inhibiteurs de prmt5 |
WO2019148412A1 (fr) | 2018-02-01 | 2019-08-08 | Merck Sharp & Dohme Corp. | Anticorps bispécifiques anti-pd-1/lag3 |
US11993602B2 (en) | 2018-08-07 | 2024-05-28 | Merck Sharp & Dohme Llc | PRMT5 inhibitors |
EP3833667B1 (fr) | 2018-08-07 | 2024-03-13 | Merck Sharp & Dohme LLC | Inhibiteurs de prmt5 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0197840A1 (fr) * | 1985-03-26 | 1986-10-15 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | (Imidazolyl-4) piperidines, leur préparation et leur application en thérapeutique |
WO1991009030A1 (fr) * | 1989-12-12 | 1991-06-27 | Rhone-Poulenc Sante | 4,5-diphenyle-imidazoles substituees en position 2 |
WO1993012107A1 (fr) * | 1991-12-18 | 1993-06-24 | Schering Corporation | Imidazoylalkyle substitue par un cycle heterocyclique contenant de l'azote a six elements |
WO1995000507A1 (fr) * | 1993-06-22 | 1995-01-05 | Knoll Ag | Derives d'amine azolyl-cyclique a activite immunomodulatrice |
EP0675112A1 (fr) * | 1994-03-31 | 1995-10-04 | Bristol-Myers Squibb Company | Inhibiteurs de farnésyl-protéine-transférase contenant l'imidazole |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB889225A (fr) * | 1959-07-01 | |||
FR2710066B1 (fr) * | 1993-09-14 | 1995-10-20 | Synthelabo | Dérivés de 1-[2-amino-5-[1-(triphénylméthyl-1H-imidazol-4-yl]-1-oxopentyl]piperidine, leur préparation et leur utilisation comme intermédiaires de synthèse. |
-
1996
- 1996-11-18 AU AU11626/97A patent/AU704139B2/en not_active Ceased
- 1996-11-18 CA CA002238081A patent/CA2238081A1/fr not_active Abandoned
- 1996-11-18 JP JP9519941A patent/JP2000500502A/ja active Pending
- 1996-11-18 EP EP96942798A patent/EP0862435A4/fr not_active Withdrawn
- 1996-11-18 WO PCT/US1996/018811 patent/WO1997018813A1/fr not_active Application Discontinuation
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0197840A1 (fr) * | 1985-03-26 | 1986-10-15 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | (Imidazolyl-4) piperidines, leur préparation et leur application en thérapeutique |
WO1991009030A1 (fr) * | 1989-12-12 | 1991-06-27 | Rhone-Poulenc Sante | 4,5-diphenyle-imidazoles substituees en position 2 |
WO1993012107A1 (fr) * | 1991-12-18 | 1993-06-24 | Schering Corporation | Imidazoylalkyle substitue par un cycle heterocyclique contenant de l'azote a six elements |
WO1995000507A1 (fr) * | 1993-06-22 | 1995-01-05 | Knoll Ag | Derives d'amine azolyl-cyclique a activite immunomodulatrice |
EP0675112A1 (fr) * | 1994-03-31 | 1995-10-04 | Bristol-Myers Squibb Company | Inhibiteurs de farnésyl-protéine-transférase contenant l'imidazole |
Non-Patent Citations (1)
Title |
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See also references of WO9718813A1 * |
Also Published As
Publication number | Publication date |
---|---|
EP0862435A1 (fr) | 1998-09-09 |
AU704139B2 (en) | 1999-04-15 |
AU1162697A (en) | 1997-06-11 |
CA2238081A1 (fr) | 1997-05-29 |
WO1997018813A1 (fr) | 1997-05-29 |
JP2000500502A (ja) | 2000-01-18 |
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