EP0880320A4 - Inhibiteurs de la farnesyl-proteine transferase - Google Patents
Inhibiteurs de la farnesyl-proteine transferaseInfo
- Publication number
- EP0880320A4 EP0880320A4 EP97904147A EP97904147A EP0880320A4 EP 0880320 A4 EP0880320 A4 EP 0880320A4 EP 97904147 A EP97904147 A EP 97904147A EP 97904147 A EP97904147 A EP 97904147A EP 0880320 A4 EP0880320 A4 EP 0880320A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- farnesyl
- inhibitors
- protein transferase
- transferase
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1086096P | 1996-01-30 | 1996-01-30 | |
US10860P | 1996-01-30 | ||
GB9605699 | 1996-03-19 | ||
GBGB9605699.9A GB9605699D0 (en) | 1996-03-19 | 1996-03-19 | Inhibitors of farnesyl-protein transferase |
PCT/US1997/001599 WO1997027752A1 (fr) | 1996-01-30 | 1997-01-27 | Inhibiteurs de la farnesyl-proteine transferase |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0880320A1 EP0880320A1 (fr) | 1998-12-02 |
EP0880320A4 true EP0880320A4 (fr) | 1999-06-16 |
Family
ID=26308951
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP97904147A Withdrawn EP0880320A4 (fr) | 1996-01-30 | 1997-01-27 | Inhibiteurs de la farnesyl-proteine transferase |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0880320A4 (fr) |
AU (1) | AU712504B2 (fr) |
CA (1) | CA2243507A1 (fr) |
WO (1) | WO1997027752A1 (fr) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5929250A (en) * | 1997-01-23 | 1999-07-27 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
JP2002519376A (ja) | 1998-07-02 | 2002-07-02 | メルク エンド カムパニー インコーポレーテッド | プレニル蛋白トランスフェラーゼ阻害薬 |
AU760028B2 (en) | 1998-07-02 | 2003-05-08 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
FR2780892B1 (fr) * | 1998-07-08 | 2001-08-17 | Sod Conseils Rech Applic | Utilisation d'inhibiteurs de prenyltransferases pour preparer un medicament destine a traiter les pathologies qui resultent de la fixation membranaire de la proteine g heterotrimerique |
US6331541B1 (en) | 1998-12-18 | 2001-12-18 | Soo S. Ko | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
US6525069B1 (en) | 1998-12-18 | 2003-02-25 | Bristol-Myers Squibb Pharma Co. | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
IL142768A0 (en) | 1998-12-18 | 2002-03-10 | Du Pont Pharm Co | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
AU2056700A (en) | 1998-12-18 | 2000-07-03 | Du Pont Pharmaceuticals Company | 2-substituted-4-nitrogen heterocycles as modulators of chemokine receptor activity |
CA2347909A1 (fr) | 1998-12-18 | 2000-06-22 | Joseph B. Santella, Iii | N-ureidoalkyl-piperidines utilisees en tant que modulateurs de l'activite des recepteurs des chimiokines |
EP1140087A4 (fr) | 1998-12-18 | 2002-04-03 | Du Pont Pharm Co | N-ureidoalkyl-piperidines utilisees en tant que modulateurs de l'activite des recepteurs des chimiokines |
US6897234B2 (en) | 1999-12-17 | 2005-05-24 | Bristol-Myers Squibb Pharma Company | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
AU2001251444A1 (en) | 2000-04-10 | 2001-10-23 | Merck And Co., Inc. | Inhibitors of prenyl-protein transferase |
DE10025782A1 (de) | 2000-05-26 | 2001-12-06 | Basf Ag | Flüssigkristalline Stoffgemenge |
EP1162194A1 (fr) * | 2000-06-06 | 2001-12-12 | Aventis Pharma Deutschland GmbH | Dérivés de (thio)-urée inhibiteurs du facteur VIIa, procédé de leur préparation et leur utilisation |
US6627629B2 (en) | 2000-06-30 | 2003-09-30 | Bristol-Myers Squibb Pharma | N-ureidoheterocycloalkyl-piperidines as modulators of chemokine receptor activity |
AU2002326948A1 (en) | 2001-09-18 | 2003-04-01 | Bristol-Myers Squibb Company | Piperizinones as modulators of chemokine receptor activity |
TW200409630A (en) | 2002-09-12 | 2004-06-16 | Bristol Myers Squibb Co | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
WO2004028530A1 (fr) | 2002-09-26 | 2004-04-08 | Bristol-Myers Squibb Company | Amines heterocycliques n-substituees, utilisees comme modulateurs de l'activite des recepteurs des chimiokines |
AU2003259007A1 (en) | 2002-10-31 | 2004-05-25 | Amersham Biosciences Ab | Use of urea variants as affinity ligands |
EP2095819A1 (fr) | 2008-02-28 | 2009-09-02 | Maastricht University | Dérivés de N-benzyle imidazole et leur utilisation comme inhibiteurs de l'aldosterone synthase |
Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996010034A2 (fr) * | 1994-09-29 | 1996-04-04 | Merck & Co., Inc. | Inhibiteurs de la transferase de proteines farnesylees exempts de thiol |
WO1996039137A1 (fr) * | 1995-06-06 | 1996-12-12 | Merck & Co., Inc. | Inhibiteurs de la farnesyl transferase |
WO1997018813A1 (fr) * | 1995-11-22 | 1997-05-29 | Merck & Co., Inc. | Inhibiteurs de la farnesyl-proteine transferase |
WO1997027854A1 (fr) * | 1996-01-30 | 1997-08-07 | Merck & Co., Inc. | Inhibiteurs de la farnesyl-proteine transferase |
WO1997027853A1 (fr) * | 1996-01-30 | 1997-08-07 | Merck & Co., Inc. | Inhibiteurs de farnesyl-proteine transferase |
WO1997027852A1 (fr) * | 1996-01-30 | 1997-08-07 | Merck & Co., Inc. | Inhibiteurs de la farnesyle transferase |
WO1997036876A1 (fr) * | 1996-04-03 | 1997-10-09 | Merck & Co., Inc. | Inhibiteurs de la farnesyl-proteine transferase |
WO1997036583A1 (fr) * | 1996-04-03 | 1997-10-09 | Merck & Co., Inc. | Inhibiteurs de la farnesyle-proteine transferase |
WO1997036892A1 (fr) * | 1996-04-03 | 1997-10-09 | Merck & Co., Inc. | Inhibiteurs de farnesyle-proteine transferase |
WO1997036584A1 (fr) * | 1996-04-03 | 1997-10-09 | Merck & Co., Inc. | Inhibiteurs de transferase de farnesyl-proteine |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4576957A (en) * | 1984-07-05 | 1986-03-18 | American Cyanamid Company | N-(Substituted phenyl)-N'-[(1H-imidazol-1-yl) and (1H-1,2,4-triazol-1-yl)alkyl]ureas |
US5576293A (en) * | 1993-09-30 | 1996-11-19 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
IL111235A (en) * | 1993-10-15 | 2001-03-19 | Schering Plough Corp | Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them |
HUT72440A (en) * | 1994-03-31 | 1996-04-29 | Bristol Myers Squibb Co | Imidazole-containing inhibitors of farnesyl protein transferase and pharmaceutical compositions containing them |
-
1997
- 1997-01-27 WO PCT/US1997/001599 patent/WO1997027752A1/fr not_active Application Discontinuation
- 1997-01-27 CA CA 2243507 patent/CA2243507A1/fr not_active Abandoned
- 1997-01-27 EP EP97904147A patent/EP0880320A4/fr not_active Withdrawn
- 1997-01-27 AU AU18516/97A patent/AU712504B2/en not_active Ceased
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996010034A2 (fr) * | 1994-09-29 | 1996-04-04 | Merck & Co., Inc. | Inhibiteurs de la transferase de proteines farnesylees exempts de thiol |
WO1996039137A1 (fr) * | 1995-06-06 | 1996-12-12 | Merck & Co., Inc. | Inhibiteurs de la farnesyl transferase |
WO1997018813A1 (fr) * | 1995-11-22 | 1997-05-29 | Merck & Co., Inc. | Inhibiteurs de la farnesyl-proteine transferase |
WO1997027854A1 (fr) * | 1996-01-30 | 1997-08-07 | Merck & Co., Inc. | Inhibiteurs de la farnesyl-proteine transferase |
WO1997027853A1 (fr) * | 1996-01-30 | 1997-08-07 | Merck & Co., Inc. | Inhibiteurs de farnesyl-proteine transferase |
WO1997027852A1 (fr) * | 1996-01-30 | 1997-08-07 | Merck & Co., Inc. | Inhibiteurs de la farnesyle transferase |
WO1997036876A1 (fr) * | 1996-04-03 | 1997-10-09 | Merck & Co., Inc. | Inhibiteurs de la farnesyl-proteine transferase |
WO1997036583A1 (fr) * | 1996-04-03 | 1997-10-09 | Merck & Co., Inc. | Inhibiteurs de la farnesyle-proteine transferase |
WO1997036892A1 (fr) * | 1996-04-03 | 1997-10-09 | Merck & Co., Inc. | Inhibiteurs de farnesyle-proteine transferase |
WO1997036584A1 (fr) * | 1996-04-03 | 1997-10-09 | Merck & Co., Inc. | Inhibiteurs de transferase de farnesyl-proteine |
Non-Patent Citations (1)
Title |
---|
See also references of WO9727752A1 * |
Also Published As
Publication number | Publication date |
---|---|
AU712504B2 (en) | 1999-11-11 |
WO1997027752A1 (fr) | 1997-08-07 |
AU1851697A (en) | 1997-08-22 |
CA2243507A1 (fr) | 1997-08-07 |
EP0880320A1 (fr) | 1998-12-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19980831 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE |
|
RHK1 | Main classification (correction) |
Ipc: C07D233/54 |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 19990503 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE |
|
17Q | First examination report despatched |
Effective date: 20010906 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20020117 |