CA2243507A1 - Inhibiteurs de la farnesyl-proteine transferase - Google Patents

Inhibiteurs de la farnesyl-proteine transferase Download PDF

Info

Publication number
CA2243507A1
CA2243507A1 CA 2243507 CA2243507A CA2243507A1 CA 2243507 A1 CA2243507 A1 CA 2243507A1 CA 2243507 CA2243507 CA 2243507 CA 2243507 A CA2243507 A CA 2243507A CA 2243507 A1 CA2243507 A1 CA 2243507A1
Authority
CA
Canada
Prior art keywords
hydrogen
alkyl
substituted
aryl
unsubstituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2243507
Other languages
English (en)
Inventor
Christopher J. Dinsmore
George D. Hartman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9605699.9A external-priority patent/GB9605699D0/en
Application filed by Individual filed Critical Individual
Publication of CA2243507A1 publication Critical patent/CA2243507A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles

Abstract

Composés inhibants la farnésyl-protéine transférase (FTase) et la farnésylation du Ras protéique oncogène. L'invention porte en outre sur des compositions chimiothérapeutiques renfermant les composés de cette invention et sur des méthodes d'inhibitions de la farnésyl-protéine transférase et de la farnésylation du Ras protéique oncogène.
CA 2243507 1996-01-30 1997-01-27 Inhibiteurs de la farnesyl-proteine transferase Abandoned CA2243507A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US1086096P 1996-01-30 1996-01-30
US60/010,860 1996-01-30
GB9605699.9 1996-03-19
GBGB9605699.9A GB9605699D0 (en) 1996-03-19 1996-03-19 Inhibitors of farnesyl-protein transferase

Publications (1)

Publication Number Publication Date
CA2243507A1 true CA2243507A1 (fr) 1997-08-07

Family

ID=26308951

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2243507 Abandoned CA2243507A1 (fr) 1996-01-30 1997-01-27 Inhibiteurs de la farnesyl-proteine transferase

Country Status (4)

Country Link
EP (1) EP0880320A4 (fr)
AU (1) AU712504B2 (fr)
CA (1) CA2243507A1 (fr)
WO (1) WO1997027752A1 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5929250A (en) * 1997-01-23 1999-07-27 Smithkline Beecham Corporation IL-8 receptor antagonists
WO2000001382A1 (fr) 1998-07-02 2000-01-13 Merck & Co., Inc. Inhibiteurs de prenyl-proteine transferase
JP2002519427A (ja) 1998-07-02 2002-07-02 メルク エンド カムパニー インコーポレーテッド プレニル蛋白トランスフェラーゼ阻害薬
FR2780892B1 (fr) * 1998-07-08 2001-08-17 Sod Conseils Rech Applic Utilisation d'inhibiteurs de prenyltransferases pour preparer un medicament destine a traiter les pathologies qui resultent de la fixation membranaire de la proteine g heterotrimerique
US6525069B1 (en) 1998-12-18 2003-02-25 Bristol-Myers Squibb Pharma Co. N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
AU3126700A (en) 1998-12-18 2000-07-03 Du Pont Pharmaceuticals Company N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
AU2056700A (en) 1998-12-18 2000-07-03 Du Pont Pharmaceuticals Company 2-substituted-4-nitrogen heterocycles as modulators of chemokine receptor activity
EP1158980B1 (fr) 1998-12-18 2005-08-24 Bristol-Myers Squibb Pharma Company N-ureidoalkyl-piperidines utilisees en tant que modulateurs de l'activite des recepteurs des chimiokines
US6331541B1 (en) 1998-12-18 2001-12-18 Soo S. Ko N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
TR200101859T2 (tr) 1998-12-18 2001-12-21 Dupont Pharmaceuticals Company Kemokin alıcı aktivitesinin modülatörleri olarak N-üreidoalkil-piperidinler
US6897234B2 (en) 1999-12-17 2005-05-24 Bristol-Myers Squibb Pharma Company N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
AU2001251444A1 (en) 2000-04-10 2001-10-23 Merck And Co., Inc. Inhibitors of prenyl-protein transferase
DE10025782A1 (de) 2000-05-26 2001-12-06 Basf Ag Flüssigkristalline Stoffgemenge
EP1162194A1 (fr) * 2000-06-06 2001-12-12 Aventis Pharma Deutschland GmbH Dérivés de (thio)-urée inhibiteurs du facteur VIIa, procédé de leur préparation et leur utilisation
EP1296978A2 (fr) 2000-06-30 2003-04-02 Bristol-Myers Squibb Company N-ureidoheterocycloaklyl-piperidines utilises comme modulateurs de l'activite du recepteur de la chimiokine
AU2002326948A1 (en) 2001-09-18 2003-04-01 Bristol-Myers Squibb Company Piperizinones as modulators of chemokine receptor activity
TW200409630A (en) 2002-09-12 2004-06-16 Bristol Myers Squibb Co N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
US6919356B2 (en) 2002-09-26 2005-07-19 Bristol Myers Squibb Company N-substituted heterocyclic amines as modulators of chemokine receptor activity
AU2003259007A1 (en) 2002-10-31 2004-05-25 Amersham Biosciences Ab Use of urea variants as affinity ligands
EP2095819A1 (fr) 2008-02-28 2009-09-02 Maastricht University Dérivés de N-benzyle imidazole et leur utilisation comme inhibiteurs de l'aldosterone synthase

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4576957A (en) * 1984-07-05 1986-03-18 American Cyanamid Company N-(Substituted phenyl)-N'-[(1H-imidazol-1-yl) and (1H-1,2,4-triazol-1-yl)alkyl]ureas
WO1995009001A1 (fr) * 1993-09-30 1995-04-06 Merck & Co., Inc. Inhibiteurs de farnesyl-proteine transferase
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
AU1615895A (en) * 1994-03-31 1995-10-12 Bristol-Myers Squibb Company Imidazole-containing inhibitors of farnesyl protein transferase
EP0783517A2 (fr) * 1994-09-29 1997-07-16 Merck & Co. Inc. Inhibiteurs de la transferase de proteines farnesylees exempts de thiol
US5756528A (en) * 1995-06-06 1998-05-26 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
CA2238081A1 (fr) * 1995-11-22 1997-05-29 S. Jane Desolms Inhibiteurs de la farnesyl-proteine transferase
US6066738A (en) * 1996-01-30 2000-05-23 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
EP0877610A4 (fr) * 1996-01-30 1999-09-15 Merck & Co Inc Inhibiteurs de farnesyl-proteine transferase
AU704087B2 (en) * 1996-01-30 1999-04-15 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
AU716153B2 (en) * 1996-04-03 2000-02-17 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
EP0891334A1 (fr) * 1996-04-03 1999-01-20 Merck & Co., Inc. Inhibiteurs de la farnesyl-proteine transferase
AU715604B2 (en) * 1996-04-03 2000-02-03 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
EP0935464A1 (fr) * 1996-04-03 1999-08-18 Merck & Co., Inc. Inhibiteurs de transferase de farnesyl-proteine

Also Published As

Publication number Publication date
EP0880320A4 (fr) 1999-06-16
AU712504B2 (en) 1999-11-11
EP0880320A1 (fr) 1998-12-02
AU1851697A (en) 1997-08-22
WO1997027752A1 (fr) 1997-08-07

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Legal Events

Date Code Title Description
FZDE Dead