CA2250353A1 - Inhibiteurs de la farnesyl-proteine transferase - Google Patents
Inhibiteurs de la farnesyl-proteine transferase Download PDFInfo
- Publication number
- CA2250353A1 CA2250353A1 CA002250353A CA2250353A CA2250353A1 CA 2250353 A1 CA2250353 A1 CA 2250353A1 CA 002250353 A CA002250353 A CA 002250353A CA 2250353 A CA2250353 A CA 2250353A CA 2250353 A1 CA2250353 A1 CA 2250353A1
- Authority
- CA
- Canada
- Prior art keywords
- substituted
- alkyl
- aryl
- cycloalkyl
- unsubstituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Virology (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La présente invention concerne des composés qui inhibent la farnésyl-protéine transérase (FTase) et farnésylation de la protéine oncogène Ras. L'invention concerne, en outre, des compositions chimiothérapeutiques contenant les composés de cette invention et des méthodes pour inhiber la farnésyl-protéine transférase et la farnésylation de la protéine oncogène Ras.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1479896P | 1996-04-03 | 1996-04-03 | |
US60/014,798 | 1996-04-03 | ||
GBGB9609666.4A GB9609666D0 (en) | 1996-05-09 | 1996-05-09 | Inhibitors of farnesyl-protein transferase |
GB9609666.4 | 1996-05-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2250353A1 true CA2250353A1 (fr) | 1997-10-09 |
Family
ID=26309289
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002250353A Abandoned CA2250353A1 (fr) | 1996-04-03 | 1997-03-27 | Inhibiteurs de la farnesyl-proteine transferase |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0891360A4 (fr) |
JP (1) | JP2000507585A (fr) |
AU (1) | AU715603B2 (fr) |
CA (1) | CA2250353A1 (fr) |
WO (1) | WO1997036900A1 (fr) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5972966A (en) * | 1996-12-05 | 1999-10-26 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
CA2311921A1 (fr) * | 1997-12-04 | 1999-06-10 | Merck & Co., Inc. | Inhibiteurs de la transferase de la farnesyl-proteine |
ATE229017T1 (de) * | 1998-02-02 | 2002-12-15 | Lg Chemical Ltd | Farnesyltransferase-inhibitoren mit piperidinstruktur und verfahren zu ihrer herstellung |
KR100388790B1 (ko) * | 1998-03-06 | 2003-10-04 | 주식회사 엘지생명과학 | 파네실전이효소저해제로서유용한피리딘-2-온유도체 |
NZ525513A (en) | 1998-08-07 | 2004-09-24 | Pont Pharmaceuticals Du | Succinoylamino lactams as inhibitors of Abeta protein production |
HRP990246A2 (en) | 1998-08-07 | 2000-06-30 | Du Pont Pharm Co | Succinoylamino benzodiazepines as inhibitors of a beta protein production |
EP1313426A2 (fr) | 1998-12-24 | 2003-05-28 | Bristol-Myers Squibb Pharma Company | Benzodiazepines succinoylamino utilisees comme inhibiteurs de la production de proteine a-beta |
WO2000059285A2 (fr) | 1999-04-02 | 2000-10-12 | Du Pont Pharmaceuticals Company | Nouveaux inhibiteurs de lactame de metalloproteases matricielles, de tnf-alpha, et de l'aggrecanase |
US6960576B2 (en) | 1999-09-13 | 2005-11-01 | Bristol-Myers Squibb Pharma Company | Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production |
US6503902B2 (en) | 1999-09-13 | 2003-01-07 | Bristol-Myers Squibb Pharma Company | Hydroxyalkanoylaminolactams and related structures as inhibitors of a β protein production |
CA2387493A1 (fr) | 1999-10-08 | 2001-04-19 | Lorin Andrew Thompson | Amino sulfonamides de lactame utilises comme inhibiteurs de la production de proteine a.beta. |
AU2001239791A1 (en) | 2000-02-17 | 2001-08-27 | Du Pont Pharmaceuticals Company | Succinoylamino carbocycles and heterocycles as inhibitors of abeta protein production |
US6495540B2 (en) | 2000-03-28 | 2002-12-17 | Bristol - Myers Squibb Pharma Company | Lactams as inhibitors of A-β protein production |
AU2001253090A1 (en) | 2000-04-03 | 2001-10-15 | Bristol-Myers Squibb Pharma Company | Cyclic lactams as inhibitors of abeta protein production |
BR0110051A (pt) | 2000-04-03 | 2004-12-07 | Bristol Myers Squibb Pharma Co | Composto, uso do composto, composição farmacêutica e método de tratamento do mal de alzheimer |
CA2404273A1 (fr) | 2000-04-11 | 2001-10-18 | Bristol-Myers Squibb Pharma Company | Lactames substitues utilises en tant qu'inhibiteurs de production de proteine a.beta. |
CA2379445C (fr) | 2000-06-01 | 2007-08-21 | Bristol-Myers Squibb Pharma Company | Lactames substitues par des succinates cycliques en tant qu'inhibiteurs de la production de la proteine .beta. |
US6710058B2 (en) | 2000-11-06 | 2004-03-23 | Bristol-Myers Squibb Pharma Company | Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors |
US6974869B2 (en) | 2001-09-18 | 2005-12-13 | Bristol-Myers Squibb Pharma Company | Piperizinones as modulators of chemokine receptor activity |
TW200307667A (en) | 2002-05-06 | 2003-12-16 | Bristol Myers Squibb Co | Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors |
WO2004101523A1 (fr) | 2003-05-17 | 2004-11-25 | Korea Research Institute Of Bioscience And Biotechnology | Nouveaux composes 2-oxo-heterocycliques et compositions pharmaceutiques contenant ces composes |
JP4914719B2 (ja) * | 2003-05-17 | 2012-04-11 | コリア リサーチ インスティテュート オブ バイオサイエンス アンド バイオテクノロジー | 新規な2−オキソ複素環化合物およびそれを含有する薬剤組成物 |
JP4799408B2 (ja) * | 2003-07-15 | 2011-10-26 | コリア リサーチ インスティテュート オブ バイオサイエンス アンド バイオテクノロジー | 新規な2−オキソ複素環化合物およびそれを含有する薬剤組成物の使用 |
US20070123508A1 (en) * | 2005-05-27 | 2007-05-31 | Roger Olsson | PAR2-modulating compounds and their use |
BRPI1010024A2 (pt) | 2009-06-05 | 2019-09-24 | Link Medicine Corp | derivados de aminopirrolidinona e uso dos mesmos |
WO2015130958A1 (fr) * | 2014-02-26 | 2015-09-03 | Howard University | Utilisation de dérivés de 5-oxopyrrolidine comme inhibiteurs de l'intégrase du vih |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL69407A (en) * | 1982-08-23 | 1987-10-20 | Warner Lambert Co | 2(1h)-pyridinones,their preparation and pharmaceutical compositions containing them |
DE3336024A1 (de) * | 1983-10-04 | 1985-04-18 | Boehringer Ingelheim KG, 6507 Ingelheim | 4-amino-l-benzyl-pyrrolidinone und ihre saeureadditionssalze, verfahren zu ihrer herstellung und arzneimittel |
DE3433953A1 (de) * | 1984-09-15 | 1986-03-27 | A. Nattermann & Cie GmbH, 5000 Köln | Neue, eine imidazol-gruppe enthaltende 3,4-dihydro-2(1h)-pyridone und2(1h)-pyridone, verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
US4749713A (en) * | 1986-03-07 | 1988-06-07 | Ciba-Geigy Corporation | Alpha-heterocycle substituted tolunitriles |
US5015653A (en) * | 1989-07-10 | 1991-05-14 | Hoffmann-La Roche Inc. | [(5-oxo)-2-pyrrolidinyl)methyl]cyclohexaneacetamides, compositions and use |
US5055467A (en) * | 1989-11-13 | 1991-10-08 | Allergan, Inc. | Pharmaceutical epinephrine-pilocarpine compounds |
US5264449A (en) * | 1989-11-13 | 1993-11-23 | Allergan, Inc. | N-substituted derivatives of 3R,4R-ethyl-[(1-methyl-1H-imidazol-5-yl)methyl]-2-pyrrolidinone |
CA2126086C (fr) * | 1991-12-18 | 2000-03-28 | Neng-Yang Shih | Imidazoylalkyle substitue par un compose heterocyclique azote a six cycles |
US5463074A (en) * | 1991-12-18 | 1995-10-31 | Schering Corporation | Imidazolyl or imidazoylalkyl substituted with a four or five membered nitrogen containing heterocyclic ring |
TW218017B (fr) * | 1992-04-28 | 1993-12-21 | Takeda Pharm Industry Co Ltd |
-
1997
- 1997-03-27 CA CA002250353A patent/CA2250353A1/fr not_active Abandoned
- 1997-03-27 AU AU25988/97A patent/AU715603B2/en not_active Ceased
- 1997-03-27 WO PCT/US1997/005235 patent/WO1997036900A1/fr not_active Application Discontinuation
- 1997-03-27 JP JP9535510A patent/JP2000507585A/ja active Pending
- 1997-03-27 EP EP97917738A patent/EP0891360A4/fr not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
WO1997036900A1 (fr) | 1997-10-09 |
AU2598897A (en) | 1997-10-22 |
JP2000507585A (ja) | 2000-06-20 |
EP0891360A1 (fr) | 1999-01-20 |
AU715603B2 (en) | 2000-02-03 |
EP0891360A4 (fr) | 2002-05-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |