CA2311921A1 - Inhibiteurs de la transferase de la farnesyl-proteine - Google Patents
Inhibiteurs de la transferase de la farnesyl-proteine Download PDFInfo
- Publication number
- CA2311921A1 CA2311921A1 CA002311921A CA2311921A CA2311921A1 CA 2311921 A1 CA2311921 A1 CA 2311921A1 CA 002311921 A CA002311921 A CA 002311921A CA 2311921 A CA2311921 A CA 2311921A CA 2311921 A1 CA2311921 A1 CA 2311921A1
- Authority
- CA
- Canada
- Prior art keywords
- substituted
- unsubstituted
- alkyl
- aryl
- heterocycle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 0 *C(c1c(C2)[n]cn1)N[C@@]2C(NCCc1cnc[n]1Cc(cc1)ccc1C#N)=O Chemical compound *C(c1c(C2)[n]cn1)N[C@@]2C(NCCc1cnc[n]1Cc(cc1)ccc1C#N)=O 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La présente invention concerne des composés qui inhibent la transférase de la farnésyl-protéine (FTase) et la farnésylation de la protéine Ras oncogène. L'invention concerne par ailleurs des compositions chimiothérapeutiques renfermant ces composés et des procédés permettant d'inhiber la transférase de la farnésyl-protéine ainsi que la farnésylation de la protéine Ras oncogène.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6755297P | 1997-12-04 | 1997-12-04 | |
US60/067,552 | 1997-12-04 | ||
GBGB9807364.6A GB9807364D0 (en) | 1998-04-06 | 1998-04-06 | Inhibitors of farnesyl-protein transferase |
GB9807364.6 | 1998-04-06 | ||
PCT/US1998/025325 WO1999027928A1 (fr) | 1997-12-04 | 1998-11-30 | Inhibiteurs de la transferase de la farnesyl-proteine |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2311921A1 true CA2311921A1 (fr) | 1999-06-10 |
Family
ID=26313441
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002311921A Abandoned CA2311921A1 (fr) | 1997-12-04 | 1998-11-30 | Inhibiteurs de la transferase de la farnesyl-proteine |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1035849A4 (fr) |
AU (1) | AU1611199A (fr) |
CA (1) | CA2311921A1 (fr) |
WO (1) | WO1999027928A1 (fr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9902987D0 (sv) | 1999-08-24 | 1999-08-24 | Astra Pharma Prod | Novel compounds |
US7211595B2 (en) | 2000-11-30 | 2007-05-01 | Abbott Laboratories | Farnesyltransferase inhibitors |
GB0104050D0 (en) | 2001-02-19 | 2001-04-04 | Astrazeneca Ab | Chemical compounds |
GB0107228D0 (en) | 2001-03-22 | 2001-05-16 | Astrazeneca Ab | Chemical compounds |
SE0103818D0 (sv) | 2001-11-15 | 2001-11-15 | Astrazeneca Ab | Chemical compounds |
KR100432577B1 (ko) | 2002-02-08 | 2004-05-24 | 주식회사유한양행 | 이미다졸 유도체의 제조방법 |
SE0301369D0 (sv) | 2003-05-09 | 2003-05-09 | Astrazeneca Ab | Chemical compounds |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5262537A (en) * | 1993-03-19 | 1993-11-16 | Anaquest, Inc. | Derivatives of 4,5,6,7-tetrahydroimidazo-[4,5-c]pyridinyl-6-carboxylic acid |
AU704139B2 (en) * | 1995-11-22 | 1999-04-15 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
WO1997027852A1 (fr) * | 1996-01-30 | 1997-08-07 | Merck & Co., Inc. | Inhibiteurs de la farnesyle transferase |
CA2250937A1 (fr) * | 1996-04-03 | 1997-10-09 | Merck & Co., Inc. | Inhibiteurs de transferase de farnesyl-proteine |
JP2000507585A (ja) * | 1996-04-03 | 2000-06-20 | メルク エンド カンパニー インコーポレーテッド | ファルネシルタンパク質トランスフェラーゼの阻害剤 |
-
1998
- 1998-11-30 CA CA002311921A patent/CA2311921A1/fr not_active Abandoned
- 1998-11-30 WO PCT/US1998/025325 patent/WO1999027928A1/fr not_active Application Discontinuation
- 1998-11-30 EP EP98960530A patent/EP1035849A4/fr not_active Withdrawn
- 1998-11-30 AU AU16111/99A patent/AU1611199A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU1611199A (en) | 1999-06-16 |
WO1999027928A1 (fr) | 1999-06-10 |
EP1035849A1 (fr) | 2000-09-20 |
EP1035849A4 (fr) | 2001-09-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued |