EP0880320A4 - Inhibitoren der farnesyl-protein transferase - Google Patents

Inhibitoren der farnesyl-protein transferase

Info

Publication number
EP0880320A4
EP0880320A4 EP97904147A EP97904147A EP0880320A4 EP 0880320 A4 EP0880320 A4 EP 0880320A4 EP 97904147 A EP97904147 A EP 97904147A EP 97904147 A EP97904147 A EP 97904147A EP 0880320 A4 EP0880320 A4 EP 0880320A4
Authority
EP
European Patent Office
Prior art keywords
farnesyl
inhibitors
protein transferase
transferase
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97904147A
Other languages
English (en)
French (fr)
Other versions
EP0880320A1 (de
Inventor
Christopher J Dinsmore
George D Hartman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9605699.9A external-priority patent/GB9605699D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0880320A1 publication Critical patent/EP0880320A1/de
Publication of EP0880320A4 publication Critical patent/EP0880320A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP97904147A 1996-01-30 1997-01-27 Inhibitoren der farnesyl-protein transferase Withdrawn EP0880320A4 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US1086096P 1996-01-30 1996-01-30
US10860P 1996-01-30
GBGB9605699.9A GB9605699D0 (en) 1996-03-19 1996-03-19 Inhibitors of farnesyl-protein transferase
GB9605699 1996-03-19
PCT/US1997/001599 WO1997027752A1 (en) 1996-01-30 1997-01-27 Inhibitors of farnesyl-protein transferase

Publications (2)

Publication Number Publication Date
EP0880320A1 EP0880320A1 (de) 1998-12-02
EP0880320A4 true EP0880320A4 (de) 1999-06-16

Family

ID=26308951

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97904147A Withdrawn EP0880320A4 (de) 1996-01-30 1997-01-27 Inhibitoren der farnesyl-protein transferase

Country Status (4)

Country Link
EP (1) EP0880320A4 (de)
AU (1) AU712504B2 (de)
CA (1) CA2243507A1 (de)
WO (1) WO1997027752A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5929250A (en) * 1997-01-23 1999-07-27 Smithkline Beecham Corporation IL-8 receptor antagonists
WO2000001382A1 (en) 1998-07-02 2000-01-13 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
JP2002519427A (ja) 1998-07-02 2002-07-02 メルク エンド カムパニー インコーポレーテッド プレニル蛋白トランスフェラーゼ阻害薬
FR2780892B1 (fr) * 1998-07-08 2001-08-17 Sod Conseils Rech Applic Utilisation d'inhibiteurs de prenyltransferases pour preparer un medicament destine a traiter les pathologies qui resultent de la fixation membranaire de la proteine g heterotrimerique
US6525069B1 (en) 1998-12-18 2003-02-25 Bristol-Myers Squibb Pharma Co. N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
AU3126700A (en) 1998-12-18 2000-07-03 Du Pont Pharmaceuticals Company N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
AU2056700A (en) 1998-12-18 2000-07-03 Du Pont Pharmaceuticals Company 2-substituted-4-nitrogen heterocycles as modulators of chemokine receptor activity
EP1158980B1 (de) 1998-12-18 2005-08-24 Bristol-Myers Squibb Pharma Company N-ureidoalkylpiperidine als modulatoren der aktivität der chemokinrezeptoren
US6331541B1 (en) 1998-12-18 2001-12-18 Soo S. Ko N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
TR200101859T2 (tr) 1998-12-18 2001-12-21 Dupont Pharmaceuticals Company Kemokin alıcı aktivitesinin modülatörleri olarak N-üreidoalkil-piperidinler
US6897234B2 (en) 1999-12-17 2005-05-24 Bristol-Myers Squibb Pharma Company N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
AU2001251444A1 (en) 2000-04-10 2001-10-23 Merck And Co., Inc. Inhibitors of prenyl-protein transferase
DE10025782A1 (de) 2000-05-26 2001-12-06 Basf Ag Flüssigkristalline Stoffgemenge
EP1162194A1 (de) * 2000-06-06 2001-12-12 Aventis Pharma Deutschland GmbH Auf Faktor VIIa inhibitorisch wirkende (Thio)-Harnstoff Verbindungen, Verfahren zu deren Herstellung und deren Verwendung
EP1296978A2 (de) 2000-06-30 2003-04-02 Bristol-Myers Squibb Company N-ureidoheterocycloaklylpiperidine als modulatoren der chemokinrezeptoraktivität
AU2002326948A1 (en) 2001-09-18 2003-04-01 Bristol-Myers Squibb Company Piperizinones as modulators of chemokine receptor activity
TW200409630A (en) 2002-09-12 2004-06-16 Bristol Myers Squibb Co N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
US6919356B2 (en) 2002-09-26 2005-07-19 Bristol Myers Squibb Company N-substituted heterocyclic amines as modulators of chemokine receptor activity
AU2003259007A1 (en) 2002-10-31 2004-05-25 Amersham Biosciences Ab Use of urea variants as affinity ligands
EP2095819A1 (de) 2008-02-28 2009-09-02 Maastricht University N-Benzyl-Imidazolderivate und deren Verwendung als Aldosteronsynthaseinhibitoren

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996010034A2 (en) * 1994-09-29 1996-04-04 Merck & Co., Inc. Thiol-free inhibitors of farnesyl-protein transferase
WO1996039137A1 (en) * 1995-06-06 1996-12-12 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
WO1997018813A1 (en) * 1995-11-22 1997-05-29 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
WO1997027853A1 (en) * 1996-01-30 1997-08-07 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
WO1997027854A1 (en) * 1996-01-30 1997-08-07 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
WO1997027852A1 (en) * 1996-01-30 1997-08-07 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
WO1997036876A1 (en) * 1996-04-03 1997-10-09 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
WO1997036892A1 (en) * 1996-04-03 1997-10-09 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
WO1997036584A1 (en) * 1996-04-03 1997-10-09 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
WO1997036583A1 (en) * 1996-04-03 1997-10-09 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4576957A (en) * 1984-07-05 1986-03-18 American Cyanamid Company N-(Substituted phenyl)-N'-[(1H-imidazol-1-yl) and (1H-1,2,4-triazol-1-yl)alkyl]ureas
WO1995009001A1 (en) * 1993-09-30 1995-04-06 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
AU1615895A (en) * 1994-03-31 1995-10-12 Bristol-Myers Squibb Company Imidazole-containing inhibitors of farnesyl protein transferase

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996010034A2 (en) * 1994-09-29 1996-04-04 Merck & Co., Inc. Thiol-free inhibitors of farnesyl-protein transferase
WO1996039137A1 (en) * 1995-06-06 1996-12-12 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
WO1997018813A1 (en) * 1995-11-22 1997-05-29 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
WO1997027853A1 (en) * 1996-01-30 1997-08-07 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
WO1997027854A1 (en) * 1996-01-30 1997-08-07 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
WO1997027852A1 (en) * 1996-01-30 1997-08-07 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
WO1997036876A1 (en) * 1996-04-03 1997-10-09 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
WO1997036892A1 (en) * 1996-04-03 1997-10-09 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
WO1997036584A1 (en) * 1996-04-03 1997-10-09 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
WO1997036583A1 (en) * 1996-04-03 1997-10-09 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9727752A1 *

Also Published As

Publication number Publication date
AU712504B2 (en) 1999-11-11
EP0880320A1 (de) 1998-12-02
AU1851697A (en) 1997-08-22
WO1997027752A1 (en) 1997-08-07
CA2243507A1 (en) 1997-08-07

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 19980831

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Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

RHK1 Main classification (correction)

Ipc: C07D233/54

A4 Supplementary search report drawn up and despatched

Effective date: 19990503

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Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20020117