EP0900081A4 - Inhibitoren der farnesyl-protein transferase - Google Patents

Inhibitoren der farnesyl-protein transferase

Info

Publication number
EP0900081A4
EP0900081A4 EP97917604A EP97917604A EP0900081A4 EP 0900081 A4 EP0900081 A4 EP 0900081A4 EP 97917604 A EP97917604 A EP 97917604A EP 97917604 A EP97917604 A EP 97917604A EP 0900081 A4 EP0900081 A4 EP 0900081A4
Authority
EP
European Patent Office
Prior art keywords
farnesyl
inhibitors
protein transferase
transferase
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97917604A
Other languages
English (en)
French (fr)
Other versions
EP0900081A1 (de
Inventor
Christopher J Dinsmore
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9610338.7A external-priority patent/GB9610338D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0900081A1 publication Critical patent/EP0900081A1/de
Publication of EP0900081A4 publication Critical patent/EP0900081A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP97917604A 1996-04-03 1997-03-27 Inhibitoren der farnesyl-protein transferase Withdrawn EP0900081A4 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US1479296P 1996-04-03 1996-04-03
US14792P 1996-04-03
GB9610338 1996-05-17
GBGB9610338.7A GB9610338D0 (en) 1996-05-17 1996-05-17 Inhibitors of farnesyl-protein transferase
PCT/US1997/004750 WO1997036591A1 (en) 1996-04-03 1997-03-27 Inhibitors of farnesyl-protein transferase

Publications (2)

Publication Number Publication Date
EP0900081A1 EP0900081A1 (de) 1999-03-10
EP0900081A4 true EP0900081A4 (de) 2002-01-09

Family

ID=26309349

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97917604A Withdrawn EP0900081A4 (de) 1996-04-03 1997-03-27 Inhibitoren der farnesyl-protein transferase

Country Status (5)

Country Link
EP (1) EP0900081A4 (de)
JP (1) JP2001518067A (de)
AU (1) AU707347B2 (de)
CA (1) CA2250587A1 (de)
WO (1) WO1997036591A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1090012A4 (de) 1998-07-02 2005-04-06 Merck & Co Inc Inhibitoren der prenyl-protein-transferase
JP2009508835A (ja) 2005-09-16 2009-03-05 アロー セラピューティクス リミテッド ビフェニル誘導体及びｃ型肝炎の治療におけるその使用
TW201100398A (en) 2009-03-31 2011-01-01 Arqule Inc Substituted indolo-pyridinone compounds
WO2011153359A1 (en) 2010-06-04 2011-12-08 Albany Molecular Research, Inc. Glycine transporter-1 inhibitors, methods of making them, and uses thereof

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA983495A (en) * 1972-10-11 1976-02-10 Gilbert Regnier Procede de preparation de derives du benzodioxole
US4598079A (en) * 1981-08-20 1986-07-01 Cassella Aktiengesellschaft 2-(aryl substitued)piperazinones and nootropic compositions based thereon
WO1993021186A1 (en) * 1992-04-13 1993-10-28 Fujisawa Pharmaceutical Co., Ltd. Substituted 3-pyrrolidinylthio-carbapenems as antimicrobial agents
WO1995000497A1 (en) * 1993-06-18 1995-01-05 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5382584A (en) * 1992-07-31 1995-01-17 Bristol-Myers Squibb Company Adenosine re-uptake inhibiting derivatives of diphenyl oxazoles, thiazoles and imidazoles
EP0670314A1 (de) * 1993-09-22 1995-09-06 Kyowa Hakko Kogyo Co., Ltd. Farnesyltransferase inhibitoren
WO1996030343A1 (en) * 1995-03-29 1996-10-03 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
WO1996037204A1 (en) * 1995-05-24 1996-11-28 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3915981A (en) * 1973-03-16 1975-10-28 Yoshitomi Pharmaceutical 1-{8 2-(2-Chlorobenzoyl)-4-nitrophenyl{9 -2-(diethylaminomethyl)-imidazole
US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
US4835154A (en) * 1987-06-01 1989-05-30 Smithkline Beckman Corporation 1-aralykyl-5-piperazinylmethyl-2-mercaptoimidazoles and 2-alkylthioimidazoles and their use as dopamine-βhydroxylase inhibitors
US5219856A (en) * 1992-04-06 1993-06-15 E. I. Du Pont De Nemours And Company Angiotensin-II receptor blocking, heterocycle substituted imidazoles
WO1996016057A1 (en) * 1994-11-23 1996-05-30 Neurogen Corporation Certain 1-substituted aminomethyl imidazole and pyrrole derivatives; novel dopamine receptor subtype specific ligands
US5478934A (en) * 1994-11-23 1995-12-26 Yuan; Jun Certain 1-substituted aminomethyl imidazole and pyrrole derivatives: novel dopamine receptor subtype specific ligands

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA983495A (en) * 1972-10-11 1976-02-10 Gilbert Regnier Procede de preparation de derives du benzodioxole
US4598079A (en) * 1981-08-20 1986-07-01 Cassella Aktiengesellschaft 2-(aryl substitued)piperazinones and nootropic compositions based thereon
WO1993021186A1 (en) * 1992-04-13 1993-10-28 Fujisawa Pharmaceutical Co., Ltd. Substituted 3-pyrrolidinylthio-carbapenems as antimicrobial agents
US5382584A (en) * 1992-07-31 1995-01-17 Bristol-Myers Squibb Company Adenosine re-uptake inhibiting derivatives of diphenyl oxazoles, thiazoles and imidazoles
WO1995000497A1 (en) * 1993-06-18 1995-01-05 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
EP0670314A1 (de) * 1993-09-22 1995-09-06 Kyowa Hakko Kogyo Co., Ltd. Farnesyltransferase inhibitoren
WO1996030343A1 (en) * 1995-03-29 1996-10-03 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
WO1996037204A1 (en) * 1995-05-24 1996-11-28 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9736591A1 *

Also Published As

Publication number Publication date
EP0900081A1 (de) 1999-03-10
JP2001518067A (ja) 2001-10-09
CA2250587A1 (en) 1997-10-09
WO1997036591A1 (en) 1997-10-09
AU707347B2 (en) 1999-07-08
AU2587997A (en) 1997-10-22

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 19981103

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A4 Supplementary search report drawn up and despatched

Effective date: 20011123

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18D Application deemed to be withdrawn

Effective date: 20020211